• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.27 no.4
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• pp.330-336
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• 2001

Angiogenesis is an essential process for the growth, invasion and metastasis of cancer. However, it is uncertain that antiangiogenic effects can be a major treatment strategy of oral cancer. The aim of this study was to investigate whether thalidomide, which is known to be a potent inhibitor of angiogenesis, have inhibitory effect on the growth and antiangiogenic effects of oral squamous cell carcinoma(OSCC) xenografted in nude mice and whether antiangiogenesis of thalidomide can be included as a major treatment strategy of oral cancer. After human oral squamous cell carcinoma strain KB was subcutaneously implanted in 20 nude mice, the volume of tumor was measured every three days. When the tumor mass reached $75{\sim}100mm^3$, thalidomide(200mg/kg/d) was administered into 10 experimental nude mice and the same volume of distilled water was administered into 10 control nude mice and the tumor volume was measured every three days. The excised tumor masses on the 30th day after administration were frozen and processed for immunohistochemistry using vascular endothelial growth factor(VEGF) and CD31. We evaluated microvessel density and VEGF expression. The results were as follows ; 1. Thalidomide retarded the growth of human OSCC as compared with the control group, but it was not statistically significant. 2. A statistically significant lower microvessel density was observed in the thalidomide-treated group than in the control group(p<0.01) and thalidomide significantly reduced VEGF expression (p<0.01). Thalidomide exhibited significantly antiangiogenic effect, but did not inhibit the growth of human OSCC effectively. Antiangiogenic therapy of thalidomide alone is not likely to be effective in the treatment of human OSCC, but might be regarded as adjuvant chemotherapeutic strategy.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.17 no.9
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• pp.2055-2062
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• 2013

Digital evidence which is the new form of evidence to crime makes little difference in value and function with existing evidences. As time goes on, digital evidence will be the important part of the collection and the admissibility of evidence. Usually a digital forensic investigator has to spend a lot of time in order to find clues related to the investigation among the huge amount of data extracted from one or more potential containers of evidence such as computer systems, storage media and devices. Therefore, these evidences need to be ranked and prioritized based on the importance of potential relevant evidence to decrease the investigate time. In this paper we propose a methodology which prioritizes order in which evidences are to be examined in order to help in selecting the right evidence for investigation. The proposed scheme is based on Fuzzy Multi-Criteria Decision Making, in which uncertain parameters such as evidence investigation duration, value of evidence and relation between evidence, and relation between the case and time are used in the decision process using the aggregation function in fuzzy set theory.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.20 no.4
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• pp.412-418
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• 2011

Reliability-based Topology optimization(RBTO) is to get an optimal design satisfying uncertainties of design variables. Although RBTO based on homogenization and density distribution method has been done, RBTO based on BESO has not been reported yet. This study presents a reliability-based topology optimization(RBTO) using bi-directional evolutionary structural optimization(BESO). Topology optimization is formulated as volume minimization problem with probabilistic displacement constraint. Young's modulus, external load and thickness are considered as uncertain variables. In order to compute reliability index, four methods, i.e., RIA, PMA, SLSV and ADL(adaptive-loop), are used. Reliability-based topology optimization design process is conducted to obtain optimal topology satisfying allowable displacement and target reliability index with the above four methods, and then each result is compared with respect to numerical stability and computing time. The results of this study show that the RBTO based on BESO using the four methods can effectively be applied for topology optimization. And it was confirmed that DLSV and ADL had better numerical efficiency than SLSV. ADL and SLSV had better time cost than DLSV. Consequently, ADL method showed the best time efficiency and good numerical stability.

• Information Systems Review
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• v.10 no.2
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• pp.21-48
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• 2008

The Korean on-line game industry is going through a rapid change. The future business environments for potential on-line game companies are very uncertain due to the new service and the different market trends. In this paper, I propose the use of morphological analysis approach for scenario generation about the future of the On-line game industry. The stages of research process were as follows; Firstly, digital contents analysis and key issues were drawn on IPTV in the on-line game industry. Secondly, each key issue was analyzed and the influence factors and directivity flow were found. Thirdly, highly probable future on-line game industry scenarios were derived. In this case, morphological analysis. On the basis of the developed scenarios, I formulated some implications for business strategy of a potential on-line game companies.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.18 no.spc
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• pp.75-87
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• 2020

The Korea Atomic Energy Research Institute (KAERI) has developed geological repository systems for the disposal of high-level wastes and spent nuclear fuels (SNFs) in South Korea. The purpose of the most recently developed system, the improved KAERI Reference Disposal System Plus (KRS⁺), is to dispose of all SNFs in Korea with improved disposal area efficiency. In this paper, a system-level safety assessment model for the KRS⁺ is presented with long-term assessment results. A system-level model is used to evaluate the overall performance of the disposal system rather than simulating a single component. Because a repository site in Korea has yet to be selected, a conceptual model is used to describe the proposed disposal system. Some uncertain parameters are incorporated into the model for the future site selection process. These parameters include options for a fractured pathway in a geosphere, parameters for radionuclide migration, and repository design dimensions. Two types of SNF, PULS7 from a pressurized water reactor and Canada Deuterium Uranium from a heavy water reactor, were selected as a reference inventory considering the future cumulative stock of SNFs in Korea. The highest peak radiological dose to a representative public was estimated to be 8.19×10^-4 mSv·yr^-1, primarily from ¹²⁹I. The proposed KRS⁺ design is expected to have a high safety margin that is on the order of two times lower than the dose limit criterion of 0.1 mSv·yr^-1.

• The Journal of the Korea Contents Association
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• v.20 no.9
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• pp.271-284
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• 2020

Good reviews that Half-Life: Alyx received created a turning point for the vitalization of the VR market with an uncertain future due to the absence of a revenue model together with the increased sales of VR equipment. Based on previous studies, this study categorized the characteristics of VR games according to graphs, first-person system, interface, controller, interaction technology, sound and stories. The analysis results show that the seven elements corresponded with "interactions" and "virtual images," which represent the completion level of games as part of VR components, and were connected to one another, which led to the proposal of an upper-rank concept "presence" to put them together. "Immersiveness," which represents users' emotions as part of VR components, was analyzed with the immersion theory to assign tasks of proper difficulty level for users' abilities. In the research process, the Delphi technique and FGI were administered to a panel of 15 experts to ensure objectivity. Finally, "presence" and "immersiveness" are characteristics in proportion to each other and can be valid concepts in future analysis of VR games as well as Half-Life: Alyx, which led to the proposal a new concept framework called 'presence effects' by combining the two words.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.33 no.9B
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• pp.745-750
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• 2008

In a cognitive radio based system, quality of service (QoS) for the secondary user must be maintained as much as possible even while that of the primary user is protected all he time. In particular, switching wireless links for the secondary user during the transmission of multimedia data causes delay and information loss, and QoS degradations occur inevitably. The efficient resource management scheme is necessary to support the seamless multimedia service to the secondary user. This paper proposes a novel frequency selection method based on Multi-Criteria Decision Making (MCDM), in which uncertain parameters such as received signal strength, cell load, data rate, and available bandwidth are considered during the decision process for the frequency selection with the fuzzy set theory. Through simulation, we show that our proposed frequency selection method provides a better performance than the conventional methods which consider the received signal strength only.

• KSCI Review
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• v.14 no.2
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• pp.159-164
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• 2006

MES(Manufacturing Execution System) is a control system which supports basic activities(scheduling, working process and qualify management, etc) to execute working on the shop floor. As especially MES is a system to decrease the gap between production planning and operating, it executes functions that make decision between management and labor using real-time data. MES for real-time information processing requires certain conditions such as data modeling of RFID, which has recently attracted attentions, and monitoring of each product unit from manufacture to sales. However, in the middle of processing the unit with a RFID tag, transponders(readers) can't often read the tag due to reader's malfunctions, intentional damages, loss and the circumstantial effects; for that reason, users are unable to confirm the location of the product unit. In this case, users cannot avoid tracing the path of units with uncertain clues. In this paper, we suggest that the unique MES based on RFID and Bayesian Network can immediately track the product unit, and show how to evaluate it.

• Korean Business Review
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• v.2
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• pp.171-204
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• 1989

The adaptive accounting control system can be regarded as an realistic control system which can adapt itself to uncertain enviromental changes. It has characters that can measure the extend to which we attain our goals and give intelligence, which is essential to planning for the future and for decision making. The budget should present the aim of the compilation of the budget and synthesize the limit through the systematic plan about the utilization of resources, because is a financial plan that is used as estimate of future management operations and as a control of it. If we would like to make good use of this business budget as a tool for planning, we should try to opimize all over the business by relating business operation as far as the effective use of the economic resources in business and the supplying of it are concerned and financial budgets to the responsibility unit center. As this paper is about the budgetary management pattern of marketing based on the adaptive accounting control system, I shall begin with a description of the feature and role of responsible accounting system in management accounting. I shall also deal with the Ex ante accounting system and the Ex post optimum accounting system which are essential to the control stage of business budgeting. And finally, accounting to the control process of adaptive accounting system that fit in with the reality, I shall design a budgetary management pattern of marking section. I wish this paper would be helpful to the activity of budgetary management. A budget is an important step of diverging point. Consequently, when we set up a budgetary pattern based on the adaptive accounting system as far as the control accounting is concerned. I believe that the step of responsible accounting will be a more elaborate and scientific step of management.

• Korean Journal of Construction Engineering and Management
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• v.6 no.4 s.26
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• pp.71-79
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• 2005

As construction projects have been extremely enormous, complex and special, risk factors have been increased consistently. Therefore, it is very important to identify and cope with the uncertain risk factors in such building constructions for successful project accomplishment. The purpose of this research is to approach practical affairs directly and show detail alternatives of risk factors by extracting the risk factors throughout construction process of curtain wall that is largely influenced on cost, quality, schedule ,safety and following activity. Also, extracting these risk factors make it possible to analyze quantitative risk and decide the priority raking of risk factors. Especially, this research is aimed to provide efficient management of scheduling risk that can make the risk minimize to practical workers who have different degree of knowledge and experience to the construction cite when the risk brings out suddenly.