Journal of the Korean Association of Oral and Maxillofacial Surgeons
- Volume 27 Issue 4
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- Pages.330-336
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- 2001
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- 2234-7550(pISSN)
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- 2234-5930(eISSN)
ANTI-TUMOR AND ANTI-ANGIOGENIC EFFECT OF THALIDOMIDE ON ORAL SQUAMOUS CELL CARCINOMA XENOGRAFTS IN NUDE MICE
누드마우스에 이종이식된 구강편평상피세포암종에 대한 thalidomide의 항암효과와 혈관형성억제에 관한 연구
- Kim, Su-Gon (Department of Oral and Maxillofacial Surgery, College of Dentistry, Seoul National University) ;
- Myoung, Hoon (Department of Oral and Maxillofacial Surgery, College of Dentistry, Seoul National University) ;
- Kim, Myung-Jin (Department of Oral and Maxillofacial Surgery, College of Dentistry, Seoul National University)
- Published : 2001.08.31
Abstract
Angiogenesis is an essential process for the growth, invasion and metastasis of cancer. However, it is uncertain that antiangiogenic effects can be a major treatment strategy of oral cancer. The aim of this study was to investigate whether thalidomide, which is known to be a potent inhibitor of angiogenesis, have inhibitory effect on the growth and antiangiogenic effects of oral squamous cell carcinoma(OSCC) xenografted in nude mice and whether antiangiogenesis of thalidomide can be included as a major treatment strategy of oral cancer. After human oral squamous cell carcinoma strain KB was subcutaneously implanted in 20 nude mice, the volume of tumor was measured every three days. When the tumor mass reached