• Journal of the Optical Society of Korea
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• v.18 no.3
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• pp.261-273
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• 2014

In this paper, metal insulator metal (MIM) plasmonic slot cavity narrow band-pass filters (NBPFs) are studied. The metal and dielectric of the structures are silver (Ag) and air, respectively. To improve the quality factor and attenuation range, two novel NBPFs based on tapered structures and double cavity systems are proposed and numerically analyzed by using the two-dimensional (2-D) finite difference time domain (FDTD) method. The impact of different parameters on the transmission spectrum is scrutinized. We have shown that increasing the cavities' lengths increases the resonance wavelength in a linear relationship, and also increases the quality factor, and simultaneously the attenuation of the wave transmitted through the cavities. Furthermore, increasing the slope of tapers of the input and output waveguides decreases attenuation of the wave transmitted through the waveguide, but simultaneously decreases the quality factor, hence there should be a trade-off between loss and quality factor. However, the idea of adding tapers to the waveguides' discontinuities of the simple structure helps us to improve the device total performance, such as quality factor for the single cavity and attenuation range for the double cavity. According to the proposed NBPFs, two, three, and four-port power splitters functioning at 1320 nm and novel ultra-compact two-wavelength and triple-wavelength demultiplexers in the range of 1300-1550 nm are proposed and the impacts of different parameters on their performances are numerically investigated. The idea of using tapered waveguides at the structure discontinuities facilitates the design of ultra-compact demultiplexers and splitters.

• Genomics & Informatics
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• v.21 no.2
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• pp.19.1-19.13
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• 2023

Liver cancer, particularly hepatocellular carcinoma (HCC), poses a significant global threat to human lives. To advance the development of innovative diagnostic and treatment approaches, it is essential to examine the hidden features of HCC, particularly its 3D genome architecture, which is not well understood. In this study, we investigated the 3D genome organization of four HCC cell lines-Hep3B, Huh1, Huh7, and SNU449-using in situ Hi-C and assay for transposase-accessible chromatin sequencing. Our findings revealed that HCC cell lines had more long-range interactions, both intra-and interchromosomal, compared to human mammary epithelial cells (HMECs). Unexpectedly, HCC cell lines displayed cell line-specific compartmental modifications at the megabase (Mb) scale, which could potentially be leveraged in determining HCC subtypes. At the sub-Mb scale, we observed decreases in intra-TAD (topologically associated domain) interactions and chromatin loops in HCC cell lines compared to HMECs. Lastly, we discovered a correlation between gene expression and the 3D chromatin architecture of SLC8A1, which encodes a sodium-calcium antiporter whose modulation is known to induce apoptosis by comparison between HCC cell lines and HMECs. Our findings suggest that HCC cell lines have a distinct 3D genome organization that is different from those of normal and other cancer cells based on the analysis of compartments, TADs, and chromatin loops. Overall, we take this as evidence that genome organization plays a crucial role in cancer phenotype determination. Further exploration of epigenetics in HCC will help us to better understand specific gene regulation mechanisms and uncover novel targets for cancer treatment.

• The Journal of the Convergence on Culture Technology
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• v.8 no.6
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• pp.435-439
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• 2022

ROK has a lot to benchmark from how Ukraine is fighting Russia back with its tactical wins. They have taken a targeted strategy to strike Russia's top generals with high precision. To carry out this strategy, Ukraine is operating a Special Operations Force, which utilizes US/NATO forces, civilian and own resources for maximum impact. Of note, they utilize Starlink for seamless connection from detection, decision-making to strike to maximize operational efficiency. As ROK faces security threat of weapons of mass destruction, Ukraine's military intelligence organization set-up, weapons system and operations can provide some guidance on how to leverage its various SOF as well.

• Mycobiology
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• v.51 no.6
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• pp.379-387
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• 2023

In this study, twenty-five yeast strains were isolated from soil samples collected in the gold mining ore in Gia Lai, Vietnam. Among them, one isolate named GL1^T could highly tolerate Cu²⁺ up to 10 mM, and the isolates could also grow in a wide range of pH (3-7), and temperature (10-40 ℃). Dried biomass of GL1 was able to remove Cu²⁺ effectively up to 90.49% with a maximal biosorption capacity of 18.1 mg/g at pH 6, temperature 30 ℃, and incubation time 60 min. Sequence analysis of rDNA indicated this strain was closely related to Rhodotorula mucilaginosa but with 1.53 and 3.46% nucleotide differences in the D1/D2 domain of the 28S rRNA gene and the ITS1-5.8S rRNA gene-ITS2 region sequence, respectively. Based on phylogenetic tree analysis and the biochemical characteristics, the strain appears to be a novel Rhodotorula species, and the name Rhodotorula aurum sp. nov. is proposed. This study provides us with more information about heavy metal-tolerant yeasts and it may produce a new tool for environmental control and metal recovery operations.

• Proceedings of the Korean Vacuum Society Conference
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• 2012.08a
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• pp.184-184
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• 2012

Recently, InGaN/GaN multi-quantum well grown on GaN pyramid structures have attracted much attention due to their hybrid characteristics of quantum well, quantum wire, and quantum dot. This gives us broad band emission which will be useful for phosphor-free white light emitting diode. On the other hand, by using quantum dot emission on top of the pyramid, site selective single photon source could be realized. However, these structures still have several limitations for the single photon source. For instance, the quantum efficiency of quantum dot emission should be improved further. As detection systems have limited numerical aperture, collection efficiency is also important issue. It has been known that micro-cavities can be utilized to modify the radiative decay rate and to control the radiation pattern of quantum dot. Researchers have also been interested in nano-cavities using localized surface plasmon. Although the plasmonic cavities have small quality factor due to high loss of metal, it could have small mode volume because plasmonic wavelength is much smaller than the wavelength in the dielectric cavities. In this work, we used localized surface plasmon to improve efficiency of InGaN qunatum dot as a single photon emitter. We could easily get the localized surface plasmon mode after deposit the metal thin film because lnGaN/GaN multi quantum well has the pyramidal geometry. With numerical simulation (i.e., Finite Difference Time Domain method), we observed highly enhanced decay rate and modified radiation pattern. To confirm these localized surface plasmon effect experimentally, we deposited metal thin films on InGaN/GaN pyramid structures using e-beam deposition. Then, photoluminescence and time-resolved photoluminescence were carried out to measure the improvement of radiative decay rate (Purcell factor). By carrying out cathodoluminescence (CL) experiments, spatial-resolved CL images could also be obtained. As we mentioned before, collection efficiency is also important issue to make an efficient single photon emitter. To confirm the radiation pattern of quantum dot, Fourier optics system was used to capture the angular property of emission. We believe that highly focused localized surface plasmon around site-selective InGaN quantum dot could be a feasible single photon emitter.

• International Journal of Industrial Entomology and Biomaterials
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• v.12 no.2
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• pp.57-61
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• 2006

Suppressor of cytokine signaling (SOCS) is known to be as a negative feedback regulator in Janus kinase signal transducer and activator of transcription signaling. Highly conserved SOCS box domain was cloned from a Korean malaria vector, Anopheles sinensis. Sequence analysis indicates that it has identity to Anopheles gambiae (96%), Aedes aegypti (94%), Drosophila melanogaster (78%), Mus musculus (72%) and Homo sapiens (72%), respectively. Tissue specificity RT-PCR demonstrated that the expression level of AsSOCS transcript was high at abdomen, midgut, and ovary, whereas developmental expression patterns showed that the level of AsSOCS was high at egg, early pupae, and adult female. On the other hand, RT-PCR analysis after bacterial challenge showed that SOCS mRNA was strongly induced in larvae. In addition, it was also induced by various immune elicitors such as lipoteicoic acid, CpG-DNA, and laminarin. It seems that AsSOCS, repressor of JAK-STAT pathway, is highly conserved in mosquito, and may play an important role in mosquito innate immune response.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.14 no.9
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• pp.3639-3662
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• 2020

The network capability to accomplish its functions in a timely fashion under failures and attacks is known as survivability. Ad hoc routing protocols have been studied and extended to various domains, such as Intelligent Transport Systems (ITSs), Unmanned Aerial Vehicles (UAVs), underwater acoustic networks, and Internet of Things (IoT) focusing on different aspects, such as security, QoS, energy. The existing solutions proposed in this domain incur substantial overhead and eventually become burden on the network, especially when there are fewer attacks or no attack at all. There is a need that the effectiveness of these routing protocols be analyzed in the presence of Denial of Service (DoS) attacks without any intrusion detection or prevention system. This will enable us to establish and identify the inherently stable routing protocols that are capable to survive longer in the presence of these attacks. This work presents a DoS attack case study to perform theoretical analysis of survivability on node and network level in the presence of DoS attacks. We evaluate the performance of reactive and proactive routing protocols and analyse their survivability. For experimentation, we use NS-2 simulator without detection or prevention capabilities. Results show that proactive protocols perform better in terms of throughput, overhead and packet drop.

• Journal of Ocean Engineering and Technology
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• v.21 no.3 s.76
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• pp.46-51
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• 2007

A multi-purpose environmental monitoring system has been developed as a commercially available standard using the technique of hetero-core spliced fiber optic sensors, for the purposes of monitoring large-scale structures and preserving natural environments. The monitoring system has been tested and evaluated in a possible outdoor condition, in view of the full-scale operation at actual sites to be monitored. Additionally, the developed system in this work conveniently provides us with various options of sensor modules intended for monitoring such physical quantities as displacement, distortion, pressure, binary states, and liquid adhesion. Two channels of optical fiber line were monitored in each channel, three displacement sensor modules were connected in series, in order to examine the performance to a pseudo-cracking experiment in the outdoor situation and to clarify temperature influences an the system, in terms of the coupling of optical connectors and the OTDR stability. The results from the pseudo-cracking experiment agreed with the actual cracks, by means of calculation, based an the detected displacement values and their geometrical arrangement of the used sensor modules. The temperature change, ranging from 10 to $20^{\circ}C$ resulting from the 10-days free running operation, was found to influence the system stability of ${\pm}10{\mu}m$, primarily due to the coupling instability of the used optical connectors. It was found that fusion splicing, rather than the use of connectors, reduced the fluctuation dawn to ${\pm}2{\mu}m$. The specification and performance of various option modules have been demonstrated to show the capability of inspecting various physical quantities by use of the single system, which would be suitable for multi-purpose environmental monitoring.

• Journal of the Society of Naval Architects of Korea
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• v.53 no.2
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• pp.127-134
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• 2016

This paper presents practical issues for test and evaluation(T&E) methods to develop defense systems. Our argument is motivated by several domestic defense cases and the cases lead us to discuss two main factors for reliable defense systems development: 1) statistical approaches and 2) technical schemes. Specifically, statistical approaches enable to provide credible interpretations about T&E results in the decision-making process. With practical T&E results of the “Red Shark” torpedo, we performed statistical hypothesis tests and suggest a minimum sample size to accept the hypothesis. Next, technical schemes have more direct effects on improving reliability of developed defense systems and we shortly introduce tools development for systems verification that is required to integrate several sub-systems, e.g., combat, sensor, weapon, and communication systems, within a defense system. We additionally summary some domain cases using modeling and simulation techniques for successful T&E. In closing, we expect that the paper shows empirical investigation and lessons learned with these two practical issues, which provides a guide those who desire to make decisions about reliable defense systems development.

• BMB Reports
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• v.40 no.6
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• pp.861-869
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• 2007

The enzyme 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR; EC1.1.1.34) catalyzes the first committed step of isoprenoids biosynthesis in MVA pathway. Here we report for the first time the cloning and characterization of a full-length cDNA encoding HMGR (designated as CgHMGR, GenBank accession number EF206343) from hazel (Corylus avellana L. Gasaway), a taxol-producing plant species. The full-length cDNA of CgHMGR was 2064 bp containing a 1704-bp ORF encoding 567 amino acids. Bioinformatic analyses revealed that the deduced CgHMGR had extensive homology with other plant HMGRs and contained two transmembrane domains and a catalytic domain. The predicted 3-D model of CgHMGR had a typical spatial structure of HMGRs. Southern blot analysis indicated that CgHMGR belonged to a small gene family. Expression analysis revealed that CgHMGR expressed high in roots, and low in leaves and stems, and the expression of CgHMGR could be up-regulated by methyl jasmonate (MeJA). The functional color assay in Escherichia coli showed that CgHMGR could accelerate the biosynthesis of $\beta$-carotene, indicating that CgHMGR encoded a functional protein. The cloning, characterization and functional analysis of CgHMGR gene will enable us to further understand the role of CgHMGR involved in taxol biosynthetic pathway in C. avellana at molecular level.