• Journal of Ginseng Research
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• 제35권1호
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• pp.52-59
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• 2011

Recently, new ginseng cultivars having superior agricultural traits have been developed in Korea. For newly developed plant cultivars, the identification of distinctiveness is very important factors not only in plant cultivar management but also in breeding programs. Thus, eighty-five inter simple sequence repeat (ISSR) primers were applied to detect polymorphisms among six major Korean ginseng cultivars and two foreign ginsengs. A total of 197 polymorphic bands with an average 5.8 polymorphic bands and 2.9 banding patterns per assay unit across six Korean ginseng cultivars and foreign ginsengs from 236 amplified ISSR loci with an average 6.9 loci per assay unit were generated by 34 out of 85 ISSR primers. Three species of Panax ginseng including the Korean ginseng cultivars, P. quinquefolius, and P. notoginseng, could be readily discriminated using most tested primers. UBC-821, UBC-868, and UBC-878 generated polymorphic bands among the six Korean ginseng cultivars, and could distinguish them from foreign ginsengs. Sequence characterized amplified region (SCAR) marker system was introduced in order to increase the reproducibility of the polymorphism. One SCAR marker, PgI821C650, was successfully converted from the randomly amplified polymorphism by UBC-821. It showed the expected dominant polymorphism among ginseng samples. In addition, the specific polymorphism for Sunwon was generated by treating Taq I restriction enzyme to polymerase chain reaction products of PgI821C650. These results will serve as useful DNA markers for identification of Korean ginseng, especially Sunwon cultivar, seed management, and molecular breeding program supplemented with marker-assisted selection.

• 전산구조공학
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• 제5권1호
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• pp.91-96
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• 1992

내진구조는 건축규준에 의하여 강제성을 띤 이후 많은 발전을 하였으나 아직도 완전하게 이해되지는 않고 있다. 본 논문은 실제로 발생하였던 두 지진의 지반운동을 10층의 철골조에 적용시켜 얻은 결과를 비교하였다. 1989년 California의 Loma Prieta에서 발생한 규모 7.1의 지진기록 12세트와 1985년 Chile의 Valparaiso에서 발생한 규모 7.8의 지진기록 9세트를 UBC의 지진지역 2B에 알맞게 조절하였다. 비슷한 규모를 가진 두 지진의 지반변위를 건물에 직접 적용시켜서 비교한 결과 그 지속시간이 긴 Chile지진이 상대적으로 지속시간이 짧은 California지진보다 약 2배 정도 큰 영향을 건물에 미치는 것이 발견되었다. 내진구조의 설계에 있어서 최대지반운동과 더불어 지반운동의 지속시간도 매우 중요하게 고려되어야 할 사항이다.

• 한국지진공학회논문집
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• 제8권4호
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• pp.11-20
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• 2004

반응수정계수의 핵심구성요소인 연성계수를 토질조건에 따라 제시하였다. 47개의 지진에서 얻어진 총 1,860개의 지진기록이 사용되었으며, 지반 전단파의 평균속도에 따라 4가지의 토질조건을 고려하였다. 이러한 분류는 현재 사용되고 있는 UBC(1997), NEHRP(1997) 및 IBC 200(1997)의 토질조건과 일치한다. 통계적 회귀분석으로부터, 토질조건에 따른 연성계수를 평가하기 위한 단순화된 식이 제안되었다. 제안된 식은 상대적으로 간단하면서도 평균연성계수와 잘 일치하는 결과를 보였다. 제안된 식에 근거하여, 현재의 기준과 일치하는 토질조건에 따른 연성계수를 평가할 수 있을 것으로 기대한다

• BMB Reports
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• 제48권1호
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• pp.25-29
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• 2015

Ubiquitination is a post translational modification which mostly links with proteasome dependent protein degradation. This process has been known to play pivotal roles in the number of biological events including apoptosis, cell signaling, transcription and translation. Although the process of ubiquitination has been studied extensively, the mechanism of polyubiquitination by multi protein E3 ubiquitin ligase, SCF complex remains elusive. In the present study, we identified UbcH5a as a novel stimulating factor for poly-ubiquitination catalyzed by $SCF^{hFBH1}$ using biochemical fractionations and MALDI-TOF. Moreover, we showed that recombinant UbcH5a and Cdc34 synergistically stimulate $SCF^{hFBH1}$ catalyzed polyubiquitination in vitro. These data may provide an important cue to understand the mechanism how the SCF complex efficiently polyubiquitinates target substrates.

• Tuberculosis and Respiratory Diseases
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• 제80권1호
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• pp.11-20
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• 2017

Approximately one in four patients with chronic obstructive pulmonary disease (COPD) have asthmatic features consisting of wheezing, airway hyper-responsiveness or atopy. The Global initiative for Asthma/Globalinitiative for chronic Obstructive Lung Disease committee recently labelled these patients as having asthma-COPD overlap syndrome or ACOS. ACOS also encompasses patients with asthma, ${\geq}40$ years of age, who have been cigarette smokers (more than 5-10 pack years) or have had significant biomass exposure, and demonstrate persistent airflow limitation defined as a post-bronchodilator forced expiratory volume in 1 second ($FEV_1$)/forced vital capacity of <70%. Data over the past 30 years indicate that patients with ACOS have greater burden of symptoms including dyspnea and cough and show higher risk of COPD exacerbations and hospitalizations than those with pure COPD or pure asthma. Patients with ACOS also have increased risk of rapid $FEV_1$ decline and COPD mortality. Paradoxically, experimental evidence to support therapeutic decisions in ACOS patients is lacking because traditionally, patients with ACOS have been systematically excluded from therapeutic COPD and asthma trials to maintain homogeneity of the study population. In this study, we summarize the current understanding of ACOS, focusing on definitions, epidemiology and patient prognosis.

• 한국지진공학회논문집
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• 제17권1호
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• pp.11-19
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• 2013

This research presents that seismic performance of steel moment resisting frame building designed by past provision(UBC, Uniform Building Code) before and after retrofitted with BRB (Buckling-Restrained Brace) was evaluated using response modification factor (R-factor). In addition, the seismic performance of the retrofitted past building was compared with that specified in current provision. The past building considered two different connections: bilinear connection, which was used by structural engineer for building design, and brittle connection observed in past earthquakes. The nonlinear pushover analysis and time history analysis were performed for the analytical models considered in this study. The R-factor was calculated based on the analytical results. When comparing the R-factor of the current provision with the calculated R-factor, the results were different due to the hysteresis characteristics of the connection types. After retrofitted with BRBs, the past buildings with the bilinear connection were satisfied with the seismic performance of the current provision. However, the past buildings with the brittle connection was significantly different with the R-factor of the current provision.

• 대한전자공학회논문지TC
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• 제41권3호
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• pp.179-179
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• 2004

가까운 미래에 우리는 기존의 정액제 요금에서 종량제가 첨가되는 것과 같은 인터넷서비스의 요금체계에 변화를 맞이할 것이다. 본 논문은 이와 같은 움직임에 대비하여 차세대 네트워크에서 서비스품질이 보장되는 인터넷 서비스에 대한 사용량기반의 과금체계를 제안하고자 한다. 먼저, IP 네트워크에서 가장 주류를 이룰 Assured service에 의해서 발생되는 적응성이 있는 트래픽의 특성을 살펴보고, 이어서 네트워크 대역의 사용량에 기반한 과금방안을 제안한다. 그리고, 어떤 형태의 Assured service에도 적용 가능한 과금함수를 제안하고, 간단한 수치계산을 통하여 제안하는 방법의 유효성에 대하여 기술한다.

• 대한전자공학회논문지TC
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• 제41권3호
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• pp.21-28
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• 2004

가까운 미래에 우리는 기존의 정액제 요금에서 종량제가 첨가되는 것과 같은 인터넷서비스의 요금체계에 변화를 맞이할 것이다. 본 논문은 이와 같은 움직임에 대비하여 차세대 네트워크에서 서비스품질이 보장되는 인터넷 서비스에 대한 사용량기반의 과금체계를 제안하고자 한다. 먼저, IP 네트워크에서 가장 주류를 이룰 Assured service에 의해서 발생되는 적응성이 있는 트래픽의 특성을 살펴보고, 이어서 네트워크 대역의 사용량에 기반한 과금방안을 제안한다. 그리고, 어떤 형태의 Assured service에도 적용 가능한 과금함수를 제안하고, 간단한 수치계산을 통하여 제안하는 방법의 유효성에 대하여 기술한다.

• 자원리싸이클링
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• 제9권2호
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• pp.3-10
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• 2000

알루미늄 폐캔은 중요한 재활용 자원으로서 알루미늄 캔용 원소재 판재는 물론 알루미늄의 국내소요량을 전량 수입에 의존하고 있는 우리나라로서는 활용 가능한 알루미늄폐캔의 재활용율을 높여야 하는 것은 외화절약과 환경보호 측면에서 대단히 중요하다. 사용한 알루미늄 캔을 다시 캔으로 재활용 하는 단계는 폐캔의 수집, 파쇄, 선별, 도료제거, 용해 및 2차지금을 제조하는 단계와 이 2차지금을 이용하여 열처리, 열간 및 냉간압연, 중간소둔처리 등을 거쳐 다시 캔을 성형하는 2단계로 나눌수 있다. 본 자료에서는 이러한 알루미늄 캔의 재활용 기술에 대한 우리나라와 선진국들의 현황과 전망을 소개하였다.

• International Journal of Industrial Entomology and Biomaterials
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• 제9권2호
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• pp.207-215
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• 2004

The present study was carried out to evaluate the ISSR and RAPD markers for their efficiency as genetic marker systems to establish the relationships between 18 mulberry genotypes. A total of 36 from 56 (64%) RAPD primers and 12 from 48 (25%) ISSR primers produced reproducible amplification patterns. A high proportion of polymorphic bands ranging from 44 to 91% was observed respectively with RAPD and ISSR markers. The average Resolving Power (Rp) of ISSR primers was higher than RAPD primers. The ISSR primers, UBC 825, 868 and 873, and RAPD primers, UBC 712, 720 and 729, possessed the highest Rp values and could in each instance distinguish all the 18 genotypes. Similarity matrix values were estimated based on Jaccards coefficient, considering 109 polymorphic ISSR and 212 polymorphic RAPD bands and two dendrograms were constructed. The dendrograms obtained with ISSR and RAPD markers distinguished the eight exotic genotypes from the ten indigenous (Indian) genotypes. A significant correlation value (r=0.959; p=0.001) for the cophenetic matrix between the RAPD and ISSR matrices was observed. The results indicated that the ISSR and RAPD markers could assist in the differentiation of genotypes and permit the determination of genetic distances that might be exploited by mulberry breeders in improvement programs.