• Journal of Ginseng Research
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• 제31권3호
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• pp.159-174
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• 2007

Pharmacology of Korean Red ginseng gives us unique possibility to develop new class of antiepileptic drugs today and to improve one's biological activity. The chemical structures of ginsenosides (GS) have some principal differences from well-known antiepileptic new generation drugs. The antiepileptic effect of GS was also demonstrated in all models of epilepsy in rats (young and adult), which have studied, in all models of epilepsy including status epilepticus (SE), induced by lithium - pilocarpine. In our experiments in rats new evidences on protective effects were exerted as a result of premedication by GS. Pre-treatment of several GS could induce decrease of the seizures severity and brain structural damage (by MRI), neuronal degeneration in hippocampus. Wave nature of severity of motor seizures during convulsive SE was observed during lithium-pilocarpine model of SE in rats (the first increase of seizures was 30 min after the beginning of SE and the second - 90 min after. The efficacy of treatment on SE by ginsenoside as expected was observed after no less 3 weeks by daily GS i.p. administration. It is blocked SE or significantly decrease the severity of seizures during SE. The implication of presented data is that combination of ginsenosides from Korean Red ginseng and ginseng cell culture Dan25 that could be applied for prevention of epileptical status development. However, a development of optimal ratio of different ginsenosides $(Rb_1$ Rc, Rg, Rf,) should consummate in the new antiepileptic drug development.

• 한국식품과학회지
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• 제29권5호
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• pp.999-1005
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• 1997

김치 발효중 대장균군의 잔존 현상을 확인하였고 대장균군을 가식 기간에서도 조기에 사멸시킬 수 있는 방법을 모색하였으며 동시에 nisin의 김치 발효에서의 역할을 평가하였다. 대장균(E. coli B34)을 김치 제조시 $10^6\;CFU/g$이 되도록 접종하였을 때 pH, 산도의 변화, 총균수, 총젖산균수, Leuconostoc속 젖산균의 수 등에 차이가 거의 없었다. AITC 그 자체나 AITC를 생성하게 하는 고추냉이, 그리고 김치제조시 정상적으로 첨가하는 마늘이 대장균군에 대한 조기사멸효과가 있었는데, 마늘은 2.0% 이상, AITC는 50ppm이상, 고추냉이가루 0.4%이상에서 대장균군의 사멸효과가 좋게 나타났으나, nisin의 경우는 $100{\sim}2000\;I.U./g$에서 대장균군이 대조구보다 더 오랫동안 잔존하였으며 김치의 저장성 연장효과는 미미하였다. MMTSOO나 겨자가루는 대장균군 조기사멸효과가 나타나지 않았다. 김치 재료로 쓰이는 원료중에서 절인 배추에는 $10^4$, 깐마늘에는 $10^2{\sim}10^5$, 고춧가루에는 $10^4{\sim}10^5$, 생강에는 $10^7$, 그리고 파에는 $10^3{\sim}10^5\;CFU/g$의 대장균군이 존재하였다. 통마늘과 공장생산 고춧가루에는 대장균군이 검출되지 않았다.

• 대한한의진단학회지
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• 제9권2호
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• pp.110-122
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• 2005

Background: The basic concept of thermographic interpretation is the thermologic equality of both side in normal person. But both sides diseases were limited diagnostic values by thermographic interpretation, and this interpretation does not apply to the case in thermal temperature of each part of body. Nevertheless, the measurement conditions are not standardized. So, for its clinical applications are extended, we think that the measurement conditions are considered the individual variations. Objectives: The purpose of this study is to examine the optimum conditions thermal temperature of the time period and region are not effected by internal and external variables. Methods: After the subjects took off their clothes, the filming were repeatedly five times made on duration of 5minutes during 20minutes. We selected nine regions around acupoints including Yin dang[印堂, HN1], Sugu[水溝, GV26], Ch’ondol[天突, CV22], Chonjung[CV17], Chung-wan[中脘, CV12], Ch’onch'u[天樞 S25], No-gung[勞宮, P8], and calculated based on the utility of R.O.I.(Region of Integer) in our system these points temperature. We measured the optimal time period and region that has little variation of thermal temperature. Results: The results shows that the optimal time period is 20minutes after undressed, and the optimal region is the region around acupoints including Sugu[水溝, GV26]. Conclusions: we obtained the measurement conditions were considered the individual variations. And also, this study offers basic sources for that the measurement conditions would be standardized. Furthermore, based on this results, we expect that clinical applications using thermography would be extended.

• Journal of Chest Surgery
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• 제18권4호
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• pp.718-731
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• 1985

Renal dysfunction is a common complication of open-heart surgery: a form of controlled hemorrhagic shock, and successful perioperative management of renal dysfunction depends on recognition of the risk factors and optimal management of factors influencing renal function, including cardiopulmonary bypass, and early detection of renal failure. Changes in renal functional parameters including Ccr, Cosm, CH2O, FENa, and RFI were observed prospectively in forty five patients operated on at Dept. of Thoracic and Cardiovascular Surgery, S.N.U.H., from April to June, 1985. They were 23 males and 22 females with 35 acquired and 10 congenital heart diseases and the mean age and body surface area of them were 38.010.3 years [22-63] and 1.5518 M2[1.151.92] respectively. Followings are the conclusion. 1. The Ccr, representative of renal function, is significantly improved from 90.231.3 ml/min/M2 preoperatively to 101.536.4 ml/min/M2 postoperative and day [P<0.05], and all patients were classified as postoperative renal functional class I of Abel, which representing adequate renal protection during our cardiopulmonary bypass. 2. The Cosm is significantly elevated at immediate postperfusion time and remained high at postoperative one day representing osmotic diuresis at that time, but CH2O shows no significant changes at immediate postperfusion period and is decreased significantly at postoperative one day, representing recovery of renal concentrating ability at that time with decreasing urine flow. 3. The absolute value and changing tendency in FENa and RFI during perioperative period shows no diagnostic reliability on these parameters, but those of CH2O appear to reveal future renal function more accurately than Ccr 4. The depth of hypothermia may be protective upon renal function against the ill effects of prolonged nonpulsatile cardiopulmonary bypass. 5. The depth of the hypothermia, pump time of more than 150 minutes, poor cardiac function, and intraoperative events such as embolism appear to be related with immediate postperfusion renal function. 6. Hemoglobinuria and hemolysis, poor preoperative renal function, history of cardiac surgery, and massive transfusion associated with bleeding appear not to be related with renal dysfunction.

• 한국토양비료학회지
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• 제44권4호
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• pp.559-564
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• 2011

Soil microbial functions are considered to be effective in assessing the severity of heavy metal pollution. Therefore, this study was carried out to examine the effect of heavy metals on nitrogen mineralization by measuring the releasing pattern of inorganic nitrogen ($NH_4^+$-N and $NO_3^-$-N) in a soil treated with heavy metals. A factorial combination of two heavy metals (Zn and Cd) treated with three concentrations (50, 100 and $150{\mu}mol\;g^{-1}$ soils) was used in a laboratory incubation. Nitrogen mineralization was determined at 3, 7, 14, 21, 28, 42 and 56 days after the treatments replicated four times. Soil sample free from heavy metals was served as the control. The amount of nitrogen mineralization from heavy metal treated soils was found to be decreased at an increasing rate during the first 21 days of incubation. However, as the incubation progressed, nitrogen mineralization was found to be decreased at decreasing rates. Furthermore, during this period, nitrogen mineralization in Cd treated soils was significantly lower ($P{\leq}0.05$) than that of the control. Soils treated with Cd at the concentration of $150{\mu}mol\;g^{-1}$ showed the lowest N mineralization throughout the incubation. Nitrogen mineralization in Zn treated soils ($50{\mu}mol\;g^{-1}$) was found to be higher than the other heavy metal treated soils. On the base of present findings, nitrogen mineralization of soil could be considered as a viable assessment of the degree of heavy metal pollution.

• 식품보건융합연구
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• 제5권1호
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• pp.13-19
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• 2019

Proximate analysis of Ipomea batatass L. grown in two different locations in Imo State were investigated. Standard soil analytical method was used to determine the physiochemical contents of the two soil sample collected from Mgbidi and Orji Ipomea batatass L. farm land. The soil sand from Ipomea batatass L. root in Orji farm recorded highest percentage value of 75.00% compared to the soil sand Ipomea batatass L. root in Mgbidi farm with 27.00% value. The percentage value of silt was different as the soil Ipomea batatass L. root in Mgbidi farm had high value of 29.40% while soil silt of Ipomea batatass L. root in Orji farm had 13.40%. The soil clay, pH, Phosphorus and Nitrogen from Ipomea batatass L. root in Mgbidi farm recorded highest percentage value of 43.60%, 5.7, 23.20 and 0.35 compared to the soil sand Ipomea root in Orji farm with 11.60%, 5.4, 16.70 and 0.09 value respectively. Ca, Mg, K, and Na analyzed followed the same trend as the soil from Ipomea root in Mgbidi farm had high percentage value of Ca (10.00), Mg (1.60), K (0.54) and Na (0.43) respectively. The systematic study of physiochemical of the Ipomea soils could help in understanding the nutritional composition, the basic characteristics of the soils and the constraints associated with the management of the soils from the two locations.

• 한국해양바이오학회지
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• 제12권2호
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• pp.108-114
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• 2020

A variety of shellfish species sold for human consumption are available for purchase in the domestic fish market. The microalgae families inhabit the ocean, where planktons supply the main nutritional resource for the growth of shellfish. Some phytoplanktons produce toxic compounds that are accumulated in shellfish and ultimately cause toxicity in humans. This article reports the cytotoxicity of commercially available shellfish species. Accordingly, hot water extract (HWE) and an aqueous fraction of 50% methanol extract (MEE-AF) showed no significant cytotoxicity on the two cell lines (i.e., HL-60 and Vero cell lines), but 50% methanol extract (MEE) in 3, 6 samples showed 50% cytotoxic effects on HL-60 cells, and 1, 4 samples showed 40%, 20% cytotoxic effects on Vero cells, respectively. In addition, their consequential dichloromethane fractions (MEE-DF) exhibited significant toxicities at the highest concentration (1,000 ㎍/ml) on HL-60 and Vero cells. Since the shellfish samples showed cytotoxicity in the dichloromethane fraction, it is possible that the dichloromethane fraction contains marine toxins. Further research will be needed to identify the toxic components from each sample.

• Nuclear Engineering and Technology
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• 제54권3호
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• pp.1062-1070
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• 2022

In the present communication, pure and stable α-Bismuth Oxide (Bi₂O₃) nanoparticles (NPs) were synthesized by low temperature solution combustion method using urea as a fuel and calcined at 500℃. The synthesized sample was characterized by using powder X-ray Diffraction (PXRD), Scanning Electron Microscopy (SEM), Energy dispersive X-ray analysis (EDAX), Transmission Electron Microscopy (TEM), Fourier Transform Infrared Spectroscopy (FTIR) and UV-Visible absorption spectroscopy. The PXRD pattern confirms the formation of mono-clinic, stable and low temperature phase α-Bi₂O₃. The direct optical energy band gap was estimated by using Wood and Tauc's relation which was found to be 2.81 eV. The characterized sample was studied for X-ray/gamma ray shielding properties in the energy range 0.081-1.332 MeV using NaI (Tl) detector and multi channel analyzer (MCA). The measured shielding parameters agrees well with the theory, whereas, slight deviation up to 20% is observed below 356 keV. This deviation is mainly due to the influence of atomic size of the target medium. Furthermore an accurate theory is necessary to explain the interaction of X-ray/gamma ray with the NPs.The present work opens new window to use this facile, economical, efficient, low temperature method to synthesize nanomaterials for X-ray/gamma ray shielding purpose.

• 한국작물학회지
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• 제26권1호
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• pp.40-44
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• 1981

답잡초 돌피 외 19종을 대상으로 병원균군, 접종방법 및 잡율의 생육시기를 달리하여 벼흰빛잎마름병의 기주범국 구명시험에서 얻어진 결과를 요약하면 다음과 같다. 1. 나도겨풀, 강아지풀, 독새풀 등은 밀양 2003에 준한 이병성을 나타냈으며, 그 밖에 바랭이, 왕바램이 알방동산이, 너도방동산이, 바람하늘지기 등에서 이병성을 보였으나 광엽잡초에는 전혀 이병되지 않았다. 2. 생육초기에 이병성을 크게 보인 강아지풀, 나도겨풀, 독새풀은 생육전기간을 통해서 이병성이 컸으며, 균군간에는 제일군이 병원성이 다소 큰 것 같았다. 3. 접종방법별로는 유상접종인 핀 및 가위 접종이 무상접종의 분무접종보다 이병성이 켰다.

• 디자인학연구
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• 제18권2호
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• pp.243-254
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• 2005

조기디자인' 교육을 장기적인 정책과제로 관심을 가지고 체계적으로 실천하고 있는 영국을 비롯한 미국, 핀란드 등 선진국들의 다양한 목적의 초등디자인교육 학습프로그램 사례에 관한 연구는 우리나라의 초등디자인교육 관련 프로그램 개발을 위한 기초적인 참고자료로 활용을 위채 필요하다고 판단된다. 따라서 본 연구는 아동디자인교육 중에서도 영국의 초등학교 디자인교육의 프로그램사례 조사와 그 분석결과를 제시하였다. 영국은 국가교육과정으로 법정.:P.과인 '미술과 디자인', 그리고 '디자인과 기술'의 두 교과에서 초등디자인교육을 하고 있는데, 두 교과의 디자인관련 단원학습프로그램의 분석결과는 '디자인과 기술'교과의 디자인 관련 단원학습프로그램들은 4개의 식품관련 단원을 제외한 20개 단원들의 대부분이 '과학적이고 공학적인 '내용영역'을 중심으로 체계적이고 과학적인 방법으로 '문제해결'을 해 나가는 '과정'중심의 '디자인과정'을 기반으로 하는 '행동유형'들과 관련성을 보여주고 있으며, 일부 단원은 부분적으로 '실용적이고 기능적'인 '내용영역'과 관련성이 있는 것으로 나타났다. 그러나 '미술과 디자인'교과는 19단원 중에서 주로 '미적이고 상징적'인 '내용영역'의 순수미술과 건축 관련 단원을 제외한 직접적으로 디자인과 관련된 6개 단원은 주로 '미적이고 상징적'이거나 아니면 '실용적이고 기능적'인 '내용영역에 따른 '행동유형'에 비중을 두었기 때문에 '과학적이고 공학적'인 '내용영역'과의 관련성은 '디자인과 기술'교과에 비교해서 매우 적은 것으로 분석되었다. 이것은 영국의 '디자인과정'을 기반으로 한 '과학적이고 공학적'인 '창의성 개발과'과 '문제해결' 중심의 초등학교 디자인교육은 '디자인과 기술'교과에서 이루어지고 있음을 실증하는 것으로, 특히, 본 연구에서 분석하고 제시한 영국 초등학교의 '디자인과 기술'교과의 디자인관련 단원학습프로그램 사례들은, 우리나라의 초등교사를 비롯한 초등디자인교육에 직, 간접적으로 관련된 개인이나 교육기관 등에서 초등 디자인교육 프로그램 개발을 위한 하나의 기초 참고자료로써 활용될 수 있기를 기대한다.