• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.30 no.1
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• pp.1-16
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• 2004

The use of artificial nerve conduit containing viable Schwann cells is one of the most promising strategies to repair the peripheral nerve injury. To fabricate an effective nerve conduit whose microstructure and internal environment are more favorable in the nerve regeneration than existing ones, a new three-dimensional Schwann cell culture technique using $Matrigel^{(R)}$. and dorsal root ganglion (DRG) was developed. Nerve conduit of three-dimensionally arranged Schwann cells was fabricated using direct seeding of freshly harvested DRG into a $Matrigel^{(R)}$ filled silicone tube (I.D. 1.98 mm, 14 mm length) and in vitro rafting culture for 2 weeks. The nerve regeneration efficacy of three-dimensionally cultured Schwann cell conduit (3D conduit group, n=6) was assessed using SD rat sciatic nerve defect of 10 mm, and compared with that of silicone conduit filled with $Matrigel^{(R)}$ and Schwann cells prepared from the conventional plain culture method (2D conduit group, n=6). After 12 weeks, sciatic function was evaluated with sciatic function index (SFI) and gait analysis, and histomorphology of nerve conduit and the innervated tissues of sciatic nerve were examined using image analyzer and electromicroscopic methods. The SFI and ankle stance angle (ASA) in the functional evaluation were $-60.1{\pm}13.9$, $37.9^{\circ}{\pm}5.4^{\circ}$ in 3D conduit group (n=5) and $-87.0{\pm}12.9$, $32.2^{\circ}{\pm}4.8^{\circ}$ in 2D conduit group (n=4), respectively. And the myelinated axon was $44.91%{\pm}0.13%$ in 3D conduit group and $13.05%{\pm}1.95%$ in 2D conduit group to the sham group. In the TEM study, 3D conduit group showed more abundant myelinated nerve fibers with well organized and thickened extracellular collagen than 2D conduit group, and gastrocnemius muscle and biceps femoris tendon in 3D conduit group were less atrophied and showed decreased fibrosis with less fatty infiltration than 2D conduit group. In conclusion, new three-dimensional Schwann cell culture technique was established, and nerve conduit fabricated using this technique showed much improved nerve regeneration capacity than the silicone tube filled with $Matrigel^{(R)}$ and Schwann cells prepared from the conventional plain culture method.

• Journal of the Korean Wood Science and Technology
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• v.34 no.1
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• pp.15-22
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• 2006

ln order to manage efficiently many ancient wooden buildings, which have been preserved as cultural properties in Korea, the internal state of wood members should be evaluated exactly and periodically by a NDE (non-destructive evaluation) method. A research project was planned to develop an X-ray CT (computed tomography) system as a NDE method for wood, which could be easily applied in field. This paper includes the first part of this project. First of all, to establish a measuring procedure of wood density using X-ray radiography, the correlation between X-ray intensity and the film brightness was evaluated. Also, initial X-ray intensity was quantified with various radiate conditions controlled by the tube voltage and tube current. And then, the effects of density, annual ring angle, and thickness on the mass attenuation coefficient of wood were examined. Finally, Beer's law was modified with the above results and adopted to calculate the density of wood. As a result of this study, the measuring procedure of wood density was established using a portable soft X-ray device and this procedure was verified with some small wood specimens. This results will he used valuably for the following researches to develop a portable X-ray CT system.

• Journal of Korean Society of Steel Construction
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• v.26 no.1
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• pp.55-68
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• 2014

In this study, the beam-to column connections of concrete-encased-and-filled steel tube columns were tested under cyclic loading. Two specimens using steel beams and two specimens using precast concrete beams were tested. The dimension of the column cross section was $670mm{\pm}670mm$. The beam depths were 488mm and 588mm for the steel beams and 700mm for the precast concrete beams. The longitudinal bar ratios of the precast concrete beams were 1.1% and 1.5%. For the connections to the steel beams, continuity plates were used in the tube columns. For the connections to the PC beams, couplers were used for beam re-bar connections. The test results showed that except for a specimen, deformation capacities of the specimens were greater than 4% rotation angle, which is the requirement for the Special Moment Frame. Particularly, specimens using precast concrete beam showed excellent performances in the strength, deformation, and energy dissipation.

• Journal of radiological science and technology
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• v.43 no.6
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• pp.475-480
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• 2020

The purpose of this study was to reconstruct diffusion tensor tractography (DTT) using stem of garlic and asparagus for in vitro phantom of diffusion tensor imaging (DTI), and to compare and evaluate the fractional anisotropy (FA) value and the apparent diffusion coefficient (ADC) value to determine whether it can be used as materials for in vitro phantoms. Among various plant fibers such as stem of garlic, palmae, cotton, asparagus, etc., stem of garlic and asparagus, which are considered to be the most suitable for making phantoms, and whose shape is considered to be the most suitable for making phantoms, were selected and tests were conducted. Holes were made in a plastic bucket at an angle of 0°, 30°, 60°, 90°, and 120°, then tubes were inserted. In the tube, asparagus and stem of garlic were inserted as far in as possible, and the inserted tube was inserted into the center of the heat bathed gelatin to harden. We were able to reproduce DTT images in asparagus and stem of garlic. Fiber tissues of asparagus and stem of garlic did not show complete connectivity, but the reconstructed images of DTT showed good connectivity. The FA values of asparagus in the tubes were 0.198 at 0° (straight), 0.207 at 30°, 0.187 at 60°, 0.231 at 90°, and 0.204 at 120°. In addition, the FA values of stem of garlic in the tubes were 0.235 at 0°, 0.236 at 30°, 0.216 at 60°, 0.218 at 90°, and 0.257 at 120°. The ADC values of asparagus in the tubes were 1.545 at 0°, 1.677 at 30°, 1.629 at 60°, 1.535 at 90°, and 1.725 at 120°. In addition, the ADC values of stem of garlic in the tubes were 1.252 at 0°, 1.396 at 30°, 1.698 at 60°, 1.756 at 90°, and 1.466 at 120°. For the best expressed DTT reconstruction image, it showed the longest connectivity in the straight line as we hypothesized. In addition, when comparing the FA values and ADC values of fiber tissues of stem of garlic and asparagus, FA value was generally higher in stem of garlic and ADC value was slightly higher in asparagus.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.28 no.6A
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• pp.861-872
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• 2008

Concrete-filled glass fiber reinforced polymer tubes are often used for marine structures with the benefit of good durability and high resistance against corrosion under severe chemical environment. Current research presents results of a comprehensive experimental investigation on the behavior of axially loaded circular concrete-filled glass fiber reinforced polymer tubes. This paper is intended to examine several aspects related to the usage of glass fiber fabrics and filament wound layers used for outer shell of piles subjected to axial compression. The objectives of the study are as follows: (1) to evaluate the effectiveness of filament winding angle of glass fiber layers (2) to evaluate the effect of number of GFRP layers on the ultimate load and ductility of confined concrete (3) to evaluate the effect of loading condition of specimens on the effectiveness of confinement and failure characteristics as well, and (4) to propose a analytical model which describes the stress-strain behavior of the confined concrete. Three different types of glass fiber layers were chosen; fabric layer, ${\pm}45^{\circ}$ filament winding layer, and ${\pm}85^{\circ}$ filament winding layer. They were put together or used independently in the fabrication of tubes. Specimens that have various L:D ratios and different diameters have also been tested. Totally 27 GFRP tube specimens to investigate the tension capacity, and 66 concrete-filled GFRP tube specimens for compression test were prepared and tested. The behavior of the specimens in the axial and transverse directions, failure types were investigated. Analytical model and parameters were suggested to describe the stress-strain behavior of concrete under confinement.

• Progress in Medical Physics
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• v.27 no.1
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• pp.1-7
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• 2016

In this work, we considered a compressed-sensing (CS)-based image deblurring scheme with a total-variation (TV) regularization penalty for improving image characteristics in digital tomosynthesis (DTS). We implemented the proposed image deblurring algorithm and performed a systematic simulation to demonstrate its viability. We also performed an experiment by using a table-top setup which consists of an x-ray tube operated at $90kV_p$, 6 mAs and a CMOS-type flat-panel detector having a $198-{\mu}m$ pixel resolution. In the both simulation and experiment, 51 projection images were taken with a tomographic angle range of ${\theta}=60^{\circ}$ and an angle step of ${\Delta}{\theta}=1.2^{\circ}$ and then deblurred by using the proposed deblurring algorithm before performing the common filtered-backprojection (FBP)-based DTS reconstruction. According to our results, the image sharpness of the recovered x-ray images and the reconstructed DTS images were significantly improved and the cross-plane spatial resolution in DTS was also improved by a factor of about 1.4. Thus the proposed deblurring scheme appears to be effective for the blurring problems in both conventional radiography and DTS and is applicable to improve the present image characteristics.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.44 no.7
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• pp.585-592
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• 2016

Visualization was done by using $CH^*$ chemiluminescence images and PMT measurements in order to understand the origin of fluctuating pressure and chemical luminosity at about 500 Hz frequency even in stable combustion, which was observed in recent experimental tests, and to find the physical correlation leading to Low Frequency Instability(LFI) in terms of phase angle. In stable combustion, chemical reactions are distributed along the shear layer flow showing a negative coupling(about 180 degree in phase angle) with combustion pressure. However, phase difference is shifted to a positive coupling showing less than 90 degree in unstable case. Also a periodic change in the distribution of chemical reactions is observed along with local flame extinction and the appearance of big scale vortex flow. In the transition to LFI, local flame extinction and small vortex flow start to appear in a row. As seen in the bluff body wake in reactive flow, the periodic appearance of vortex flow seems to share the same physical process of BVK(Bernard Von Karman) instability generation. Thus, the appearance of local extinction in 500 Hz fluctuations is gradually amplified to complete extinctions of about 20 Hz, and it leads into LFI.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.32 no.4
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• pp.295-307
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• 2006

Styela clava, called non-native tunicate or sea squirt, is habitat which include bays and harbors in Korea and several sites in the sea faced world. We fabricate cellulose membrane nerve conduit (CMNC) from this native sea squirt skin, and evaluate the capacity of promoting peripheral nerve regeneration in the rat sciatic nerve defect model. After processing the pure cellulose membrane from the sea squirt skin as we already published before, CMNC was designed as a non-tubular sheet with 14 mm length and 4 mm width. Total eleven male Spraque-Dawley rats (12 weeks, weighing 250 to 300g) were divided into sham group (n=2), silicone tube grafted control group (n=3) and experimental group (n=6). Each CMNC grafted nerve was evaluated after 4, 8 and 12 weeks in the experimental group, and after 12 weeks, sciatic function was evaluated with sciatic function index (SFI) and gait analysis, and histomorphology of nerve conduit and the innervated tissues of sciatic nerve were all examined using image analyzer and electromicroscopic methods in the all groups. The regenerated axon and nerve sheath were found only in the inner surface of the CMNC after 4 weeks and became more thicker after 8 and 12 weeks. In the TEM study, CMNC grafted group showed more abundant organized myelinated nerve fibers with thickened extracellular matrix than silicone conduit grafted group after 12 weeks. The sciatic function index (SFI) and ankle stance angle (ASA) in the functional evaluation were $-47.2{\pm}3.9$, $35.5^{\circ}{\pm}4.9^{\circ}$ in CMNC grafted group (n=2) and $-80.4{\pm}7.4$, $29.2^{\circ}{\pm}5.3^{\circ}$ in silicone conduit grafted group (n=3), respectively. And the myelinated axon was 41.59% in CMNC group and 9.51% in silicone conduit group to the sham group. The development of a bioactive CMNC to replace autogenous nerve grafts offers a potential and available approach to improved peripheral nerve regeneration. As we already published before, small peptide fragment derived from the basement membrane matrix proteins of squirt skin, which is a kind of anchoring protein composed of glycocalyx, induced the effective axonal regeneration with rapid growth of Schwann cells beneath the inner surface of CMNC. So the possibilities of clinical application as a peripheral nerve regeneration will be able to be suggested.

• Journal of the Korean Society of Radiology
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• v.10 no.3
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• pp.215-222
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• 2016

X-ray mammography is the most effective method for the diagnosis of calcified lesions of various breast diseases. To reduce patient dose and to obtain optimal image required for diagnosis, the performance of the mammography system should be maintained continuously. Because the target (anode) angle of the X-ray tube is measured from the central X-ray, the effective angle can be slightly different in view of the position on the detector, which can result in degrading spatial resolution of the imaging within the field of view. In this study, we measured the MTF to examine spatial resolution for positions on the detector in the digital mammography system. For a tungsten wire of $50{\mu}m$ diameter, the highest spatial frequency was obtained. It meant that a wire diameter for measuring MTF through LSF should be small compared to the pixel size of the detector used in the mammography system. The spatial resolution showed slightly different performance according to positions on the detector. The center position gave the best spatial resolution and positions away from the center showed the degraded performance although the difference of the spatial resolution was small. The effective focal spot size of the full width at half maximum also showed similar result. It concluded that the slightly increase of the effective focal spot size gave the degradation of the spatial resolution for positions on the detector.

• Journal of the Korean Society of Radiology
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• v.16 no.3
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• pp.319-325
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• 2022

The Study In order to obtain a sharpness Image from Skull PA axial projection (Haas) in a head axial X-ray Examination, this study changed the posture angle using Skull Phantom and evaluated the image subjectively to 5 radiologists who worked in the Department of Imaging at University Hospital. In the prone position, the head was lowered 4 cm from the back of the head, entered 25° toward the head, and the image evaluation score was high with 20 points, such as the back bone, dorsum sellae projected in the large hole, and posterior clinoid process. In addition, the score significance was verified, and the Cronbach Alpha value was evaluated to have good reliability of 0.789. As a result of calculating the signal-to-noise ratio (SNR) by setting the region of interest (ROI) of the image, it was the highest at 5.957 for 25° incident at the back of the head and 6.430 for 30° incident at the back of the head. As a result of the study, in order to obtain a sharp image of the back of the head bone, dorsum sellae, and posterior clinoid process when shooting in the axial direction after the head, it is filmed by tilting 25° toward the head from 4 cm below the back of the head. In order to obtain a sharp image of rock pyramid symmetry, petrous ridge, sagittal suture, and lambdoid suture, it is thought that it will be helpful for clinical use if you shoot it 8cm down from the back of the head and tilt it 30° toward the head.