• 한국항공우주학회지
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• 제39권12호
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• pp.1174-1180
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• 2011

Field Programmble Gate Array(FPGA)는 설계 시간 단축, 재구성 가능성 등의 이유로 우주용 시스템에 사용이 늘고 있다. 그러나, Static Random Access Memory (SRAM) 구조를 가지는 FPGA의 경우 우주 방사능 환경으로 인해 발생하는 single event upset (SEU)로 인한 영향에 더 취약한 단점을 가지고 있다. 과학기술위성 3호 온보드 컴퓨터에서는 SEU로 발생되는 영향을 감소시키기 위하여 triple modular redundancy (TMR)과 Scrubbing scheme (기법)을 사용하고 있다. 실제 방사선 조사 실험 결과, TMR과 Scrubbing 기법을 통하여 문턱 에너지 값이 10.6 MeV에서 20.3 MeV로 개선됨을 확인하였으며, 과학기술위성 3호 위성 궤도 환경을 시뮬레이션 한 결과와 실험 결과를 이용하여 1.23 bit-flips/day의 에러율을 얻었다.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2008년도 추계학술대회A
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• pp.1467-1470
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• 2008

An upper tibial opening wedge osteotomy is an operation to cure a malalignment and a degenerate arthritis. To prevent the postoperative malalignment caused by the upper tibial opening wedge osteotomy, the research to define the relationship between a Hinge Axis Angle and a Posterior Slope Angle is needed. The effect of the relationship between the hinge axis angle and the gap angle on the posterior slope angle is studied. After 3-D Compute Tomography (CT) scanning image is reconstructed, the virtual surgery is performed by the reconstructed 3-D tibia model. It was proved that the relationship between the hinge axis angle and the gap angle were constant and the simple mathematical model could be derived. To verify the suggested mathematical model, it compared with the measured data from the virtual surgery. In conclusion, while the deviation between the data from the virtual surgery and ones of the mathematical model under the gap angle<$10^{\circ}$ was less than 1%.

• Archives of Pharmacal Research
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• 제28권4호
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• pp.451-457
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• 2005

Experimental studies have demonstrated that the triple combination of amantadine (A)/ ursodeoxycholic acid (UDCA, U)/ biphenyl dimethyl dicarboxylate (DDB, D) might have a preferential antiviral effect compared with that observed in interferon-induced antiviral signal pathways, such as those of $STAT1\alpha$ and the 6-16 genes. To confirm the results, this study examined whether th signal transduction for the antiviral activity in HepG2 2.2.15 was induced dependently or independently of interferon. To accomplish this, the correlation between the $STAT1\alpha$ and 6-16 genes, and nitric oxide, for the mediation of the antiviral activity was assessed. The increase in nitric oxide in the UDCA groups suggests that the inhibition of viral gene replication was enhanced by the amantadine combinations (AU and AUD), and might be more effective if incubated for longer periods. It was found that $STAT1\alpha$ was activated by the amantadine combination, although to a lesser extent than that of $interferon-\alpha$, and the primary endpoints examined for the inhibition of gene expression (HBsAg and HBcAg) were remarkably well regulated. This suggests that the amantadine triple, or at least the double, combination had better clinical benefits than those of $IFN-\alpha$ and the nucleoside analogue single treatment. This demonstrates that the amantadine combination might be a substitute for the existing HBV therapy if the results of in vivo and in vitro studies concur.

• Restorative Dentistry and Endodontics
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• 제44권2호
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• pp.21.1-21.8
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• 2019

Objectives: The purpose of the present study was to evaluate the effect of calcium hydroxide with 2% chlorhexidine gel (HCX) or distilled water (HCA) compared to triple antibiotic paste (TAP) on push-out bond strength and the cement/dentin interface in canals sealed with White MTA Angelus (WMTA) or Biodentine (BD). Materials and Methods: A total of 70 extracted human lower premolars were endodontically prepared and randomly divided into 4 groups according to the intracanal medication, as follows: group 1, HCX; group 2, TAP; group 3, HCA; and group 4, control (without intracanal medication). After 7 days, the medications were removed and the cervical third of the specimens was sectioned into five 1-mm sections. The sections were then sealed with WMTA or BD as a reparative material. After 7 days in 100% humidity, a push-out bond strength test was performed. Elemental analysis was performed at the interface, using energy-dispersive spectroscopy. The data were statistically analyzed using analysis of variance and the Tukey test (p < 0.05). Results: BD presented a higher bond strength than WMTA (p < 0.05). BD or WMTA in canals treated with calcium hydroxide intracanal medications had the highest bond strength values, with a statistically significant difference compared to TAP in the WMTA group (p < 0.05). There were small amounts of phosphorus in samples exposed to triple antibiotic paste, regardless of the coronal sealing. Conclusions: The use of intracanal medications did not affect the bond strength of WMTA and BD, except when TAP was used with WMTA.

• Earthquakes and Structures
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• 제20권3호
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• pp.295-307
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• 2021

The gap provided between adjacent structures in the metropolitan cities is mostly narrow due to architectural and financial issues. Consequently, structural pounding occurs between adjacent structures during earthquakes. It causes damages, ranging from minor local to more severe ones, especially in the case of seismically isolated buildings, due to their higher displacements. However, due to the increased flexibility of isolated buildings, the problem could become more detrimental to such structures. The effect of the seismic pounding of moat walls on the response of buildings isolated by Triple Friction Pendulum Bearing (TFPB) is investigated in this paper. To this propose, two symmetric three-dimensional models, including single-story and five-story buildings, are modeled in Opensees. Nonlinear Time History Analyses (NTHA) are performed for seismic evaluation. Also, five different sizes with four different sets of friction coefficients are considered for base isolators to cover a whole range of base isolation systems with various geometry configurations and fundamental period. The results are investigated in terms of base shear, buildings' drift, and roof acceleration. Results indicated a profound effect of poundings against moat walls. In situations of potential pounding, in some cases, the influence of impact on seismic responses of multistory buildings was more remarkable.

• 대한통합의학회지
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• 제10권2호
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• pp.115-123
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• 2022

Purpose : The hamstring is a group of three muscles, biceps femoris, semitendinosus, and semimembranosus, placed behind the thigh. The hamstring is one of the most commonly injured muscles and usually occurs during high-speed, high-intensity exercise. The purpose of this study was to investigate the effect of static stretching and eccentric exercise of hamstrings on flexibility, strength, and functional performance. Methods : This study was conducted on 28 healthy adults. Subjects were divided into a static stretching group (n=15) and an eccentric exercise group (n=13). Subjects measured hamstring flexibility (active knee extension test), hamstring strength (concentric and eccentric peak torque), and functional performance (triple hop for distance and modified 20 m sprint). The intervention was conducted three times a week for six weeks. To compare the difference between values before and after the intervention, paired t-test was used, and an independent t-test was used to compare between groups. Results : In both groups, the active knee extension test, concentric peak torque, triple hop test, and 20 m sprint significantly increased after the intervention compared to before the intervention (p<.05). However, no significant difference was found in eccentric peak torque after intervention in both groups (p>.05). No significant difference was found between the two groups in the effect on the variables (p>.05). Conclusion : Both interventions were found to be effective for flexibility, concentric strength, and functional performance. Eccentric exercise and static stretching are recommended to improve the flexibility and functional performance of the hamstring. This study's results will be considered essential data on the effectiveness of static stretching and eccentric exercise.

• Restorative Dentistry and Endodontics
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• 제48권2호
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• pp.18.1-18.10
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• 2023

Objectives: This study aimed to determine whether collagen triple helix repeat containing-1 (CTHRC1), which is involved in vascular remodeling and bone formation, can stimulate odontogenic differentiation and angiogenesis when administered to human dental pulp stem cells (hDPSCs). Materials and Methods: The viability of hDPSCs upon exposure to CTHRC1 was assessed with the WST-1 assay. CTHRC1 doses of 5, 10, and 20 ㎍/mL were administered to hDPSCs. Reverse-transcription polymerase reaction was used to detect dentin sialophosphoprotein, dentin matrix protein 1, vascular endothelial growth factor, and fibroblast growth factor 2. The formation of mineralization nodules was evaluated using Alizarin red. A scratch wound assay was conducted to evaluate the effect of CTHRC1 on cell migration. Data were analyzed using 1-way analysis of variance followed by the Tukey post hoc test. The threshold for statistical significance was set at p < 0.05. Results: CTHRC1 doses of 5, 10, and 20 ㎍/mL had no significant effect on the viability of hDPSCs. Mineralized nodules were formed and odontogenic markers were upregulated, indicating that CTHRC1 promoted odontogenic differentiation. Scratch wound assays demonstrated that CTHRC1 significantly enhanced the migration of hDPSCs. Conclusions: CTHRC1 promoted odontogenic differentiation and mineralization in hDPSCs.

• 대한치과보철학회지
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• 제57권4호
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• pp.321-327
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• 2019

목적: 본 연구는 단일구조 지르코니아 크라운의 소결 후 소성 과정이 변연 및 내면 적합도에 미치는 영향에 대하여 3차원으로 평가해 보고자 하였다. 재료 및 방법: 타이타늄 지대치 모형을 제작하여 10개의 단일구조 지르코니아 크라운을 제작하였다. 제작된 단일구조 지르코니아 크라운을 소결 한 상태를 대조군으로, 소결 후 광택을 위해 추가적인 소성단계를 거친 후를 실험군으로 설정하였다. 각 군에서 triple-scan protocol을 이용하여 협설과 근원심으로 단면을 형성하고 변연 및 내면 적합도를 계측하여 통계 분석하였으며, 삼차원 표면 비교를 시행하였다 (${\alpha}=.05$). 결과: 변연과 내면 적합도를 분석한 결과 근심 축벽에서 대조군($32.0{\pm}24.3{\mu}m$)과 실험군 간($17.0{\pm}10.8{\mu}m$)의 통계적 유의한 차이가 있었고 (P < .020), 원심 축벽에서 대조군($60.2{\pm}24.3{\mu}m$)과 실험군($71.8{\pm}21.5{\mu}m$)간의 통계적으로 유의한 차이가 있었다 (P < .01). 나머지 측점지점에서는 통계적으로 유의한 차이가 없었다. 결론: 단일구조 지르코니아 크라운에서의 소결 후 추가적인 소성은 내면의 변형에 큰 영향을 미치지 않았고 임상적으로 허용 가능한 범위에 있었다.

• 공업화학
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• 제34권2호
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• pp.161-169
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• 2023

본 연구는 allbanggae starch (ABS), polyvinyl alcohol (PVA), alginic acid (SA)를 이용하여 naproxen (NP) 각인 starch 기반 다층 바이오소재를 제조하고, 물리화학적 특성과 약물 방출 제어 효과를 조사하였다. 또한, FE-SEM과 FT-IR 분석에 의해 제조한 다층 바이오소재의 특성을 조사하였다. 약물 방출 제어 효과와 경피 약물 전달 시스템의 적용 가능성을 확인하기 위해 NP 각인 다층 바이오소재로부터 NP 방출 특성을 사람의 체온인 36.5 ℃에서 다양한 pH buffer solution과 인공 피부를 이용하여 확인하였다. NP는 낮은 pH보다 높은 pH에서 1.3배 더 빠른 방출을 나타냈고, single-layer 바이오소재에서보다 multi-layer 바이오소재에서 약 4.0배 느린 방출이 일어남을 확인하였다. 인공 피부 방출에서도 동일하게 single-layer 바이오소재보다 multi-layer 바이오소재에서 약 4.0배 더 느린 약물 방출 결과를 나타내었다. 또한, double-layer와 triple-layer 바이오소재 모두 12시간 동안 지속적으로 NP가 방출되었음을 확인 하였다. NP 방출 mechanism을 규명하기 위해 수학적 모델링에 적용하여 비교했을 때, pH buffer solution에서의 방출은 Fickian diffusion mechanism, 인공 피부 방출은 empirical mechanism에 적합한 것을 확인하였다.

• 한국연소학회지
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• 제7권2호
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• pp.1-6
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• 2002

Characteristics of laminar lifted flames of propane highly-diluted with nitrogen have been investigated at various temperatures of coflow air. At various fuel mole fractions, the base of laminar lifted flames has the structure of tribrachial (or triple) flame. The liftoff heights are correlated well with the stoichiometric laminar burning velocity considering initial temperature at a given coflow velocity. It shows that lifted flames are stabilized on the basis of the balance mechanism between local flow velocity and the propagation speed of tribrachial flame, regardless of the temperature of coflow and fuel mole fraction. Lifted flames exist for a jet velocity even smaller than the stoichiometric laminar burning velocity, and liftoff velocity increases more rapidly than stoichiometric laminar burning velocity as coflow temperature increases. These can be attributed to the buoyancy effect due to the density difference.