• Korean Journal of Clinical Pharmacy
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• v.23 no.3
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• pp.239-247
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• 2013

Background: Fixed drug combinations are formulations containing two or more active ingredients in a single dosage form. Such combination therapies are commonly applied to improve efficacy, reduce adverse events and replace co-administration, etc. National and international guidelines for hypertension treatment recommend addition of other classes of antihypertensive drugs rather than incremental dose of mono-therapy, when blood pressure is not adequately controlled. Thus, many dual combinations of antihypertensive drugs have been approved and pharmaceutical companies are recently interested in developing antihypertensive triple combinations. Clinical trial designs for the fixed combinations are various depending on the target patients, dosage and clinical endpoints. Thereby, further discussions for the clinical trials of antihypertensive triple therapies are required regarding the indication claimed. Conclusion: This article provides a review for the assessment of the label and medical reports of the clinical trials on antihypertensive triple therapies in advanced foreign countries.

• Proceedings of the Korean Society Of Semiconductor Equipment Technology
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• 2008.05a
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• pp.23-29
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• 2008

- High Density Plasma Source-CCP-Dual/Triple, RF Frequency Control - Radical/Flux Analysis - Low Pressure Process - Chamber Design (Process gap/Wall gap) - Chamber Temp. Control. - ESC Dielectric Materials - Uniform Gas Injection

• Geotechnical Engineering
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• v.22 no.12
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• pp.10-16
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• 2006

• Transactions of the Korean Society of Mechanical Engineers
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• v.9 no.6
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• pp.732-742
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• 1985

Measurements of mean velocity and turbulence characteristics are obtained with a linearized constant temperature hot-wire anemometer in a two-dimensional turbulent jet discharging parallel to a flate. Wall static pressure distribution is also measure. The Reynolds number based on the jet nozzle width (D) is about 42,000 and the step height is 2.5D. The reattachment length is found to be 7.5D by using both wool tuft and oil methods. Upstream of the reattachment point, there exist double coherent structures and mean velocity, Reynolds stresses and triple product profiles are asymmetric about jet center line due to the influence of streamline curvature and recirculating flow region. Near the reattachment point, wall static pressure and turbulence quantities change its shape rapidly because of the large eddies by the solid wall. Especially, turbulence intensity has a maximum value in the reattachment regin, then decreases slowly in the redeveloping wall jet ragion. Downstream of X/D=14, a single large scale eddy structure is formed. Far downstream affer the reattachment(X/D.geq.18) mean velocity profile, the decay of maximum velocity and the variation of jet half width are nearly similar to those of plane wall jet, but the Reynolds stresses are higher than those of the latter.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.26 no.10
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• pp.1370-1377
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• 2002

This study analyzed the design performance of the bottoming system of combined cycle power plants using a once-through heat recovery steam generator. For a parallel arrangement of the main heater and reheater, parametric analyses were carried out to present the criteria for determining the reheater pressure and the location of the starting point of the reheater in the HRSG. The performance of the bottoming system was presented fer a range from high subcritical to supercritical pressure. The steam turbine power is as high as that of conventional triple-pressure bottoming systems. The serial arrangement of heat exchangers with division of each heater into several segments can achieve similar power level.

• Journal of Powder Materials
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• v.9 no.2
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• pp.116-123
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• 2002

The characteristics of two commercial 2xxx series Al alloy powders, AMB2712 and 201AB, were evaluated and their compacting and sintering characteristics were discussed in tems of compacting pressure. The particle shapes of both two powder mixtures were irregular and their particle size distributions were broad. The compactibility of AMB2712 was superior to that of 201AB because of better fluidity. The sintered density was higher than the green density at low compacting pressure, however, it was lower than the green density when the samples were compacted at higher pressure due to the selling during sintering. The sintered density was alomost the same as the green density at the "homogeneous deformation" stage. It was observed that pores were created at the triple points due to the rapid diffusion of Cu in Al. Cu in Al.

• Transactions of the Korean Society of Mechanical Engineers
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• v.9 no.4
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• pp.403-413
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• 1985

Hot-wire measurements of second and third-order mean products of velocity fluctuations have been made in the separated, reattached, and redeveloping boundary layer behind a vertical fence. Mean velocity, wall static pressure distributions have also been measured in the whole flow field. Upstream of the reattachment point, the separated shear layer developes as a free mixing layer, but the gradient of the maximum slope thickness, turbulent intensities and the Reynolds shear stress are higher than that of the mixing layer due to initial streamline curvature and the effects of highly turbulent recirculating flow region. In the reattachment region, Reynolds shear stress and triple products near the surface is far more rapid than the decrease of the shear stress; that is the presence of the solid wall has a marked effect on the apparent gradient diffusivity of intensity or shear stress and throws doubts upon the usefulness of the simple gradient diffusivity model in this region.

• Journal of the Korean GEO-environmental Society
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• v.6 no.4
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• pp.59-64
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• 2005

Although high pressure discharge method is widely used for improving soft ground, it has various problems including lack of strength increase and the possibility of water pollution and soil contamination. MJM(Morta Jet Method) uses sand in addition to cement as the injection material. MJM uses triple rods with a built-in nozzle that allows easier discharge of the slime, resulting in higher replacement area ratio and more uniform formation of pillar hydrates, and thus results in significant increase in strength. MJM is expected to perform especially well as piles in marine clays. This study investigates the field applicability of the MJM through extensive laboratory and field tests.

• Transactions of the Korean Society of Automotive Engineers
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• v.12 no.5
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• pp.40-57
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• 2004

The effects of triple (pilot, main and after) injection on combustion and emission characteristics in a HSDI (High-Speed Direct Injection) diesel engine were investigated using a single-cylinder optical diesel engine equipped with a common-rail injection system. The pilot injection affected the spray and combustion evolution of the following main injection. It was found that the pilot injection reduced the ignition delay, which led to lowered NOx (Nitric Oxides) level, and increased IMEP (Indicated Mean Effective Pressure) due to slow combustion pace during an expansion stroke. The after-injection was shown to be effective in reducing PM (Particulate Matter) even when a small amount of fuel was added. The results suggest that a proper combination of individual injection strategy could bring about a good synergetic effect on engine performance and emission.

• Proceedings of the KSME Conference
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• 2001.11b
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• pp.872-877
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• 2001

This study analyzed the design performance of the bottoming system of combined cycle power plants adopting a single-pressure once-through heat recovery steam generator with reheat. A computer program was constructed and parametric analyses were carried out to present the criteria for determining the reheat pressure and the location of the starring point of the reheater in the HRSG. The performance of the bottoming system was presented for the range from high subcritical to supercritical pressures. It was founded that the power of the bottoming system can be as high as that of the present triple-pressure bottoming system even with a higher exhaust gas temperature. A requirement for this high performance is a proper arrangement of the reheater.