• Korean Journal of Acupuncture
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• v.41 no.3
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• pp.79-89
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• 2024

Objectives : We aimed to identify the effects of acupuncture treatment on alleviating pain and depression and modulating brain neural activity in the neuropathic pain and depression comorbidity mouse model (PDCM). Methods : We performed partial sciatic nerve ligation on the right hind paw of mice to induce neuropathic pain and injected reserpine (2 mg/kg, intraperitoneal) for 10 days from the day of the surgery to induce pain and depression. Acupuncture treatment was performed for 10 days at the following locations: 1) ST36 and SP6 (Joksamni and Sameumgyo; JS), 2) KI1 and HT7 (Yongcheon and Sinmun; YS), 3) LR1, PC9, KI10, and PC3 (Pericardium tonification; PT), or 4) LR1, HT9, KI10, and HT3 (Heart tonification; HT). Pain-like behavior was measured using the von Frey test and depressive-like behavior was assessed using the open field test. Then, the c-Fos expression was analyzed in the brain regions of neocortex, striatum, hypothalamus, hippocampus, midbrain, and medulla to examine brain neural activity. Results : In PDCM, pain-like behavior was alleviated by acupuncture treatment on the JS, YS, PT, and HT, and depressive-like behavior was improved by acupuncture treatment on the JS and YS. JS and YS were derived as an optimized acupoint combination for improving neuropathic pain and depression comorbidity. Brain neural activities in the neocortex (infralimbic cortex) and hypothalamus (paraventricular hypothalamic nucleus; PVN) were commonly altered by both JS and YS acupuncture treatments. In addition, neural activities in the neocortex (prelimbic cortex; PrL) and midbrain (substantia nigra, lateral part of the dorsal raphe nucleus) were altered exclusively by JS acupuncture treatment, while changes in the area 2 of the anterior cingulate cortex and the cornu ammonis 3 of the hippocampus were specific to YS acupuncture treatment. Brain neural activity in the PrL and PVN regions was significantly correlated with changes in pain behavior. Conclusions : Both JS and YS acupuncture treatments alleviated pain and depressive-like behaviors, which were associated with modulation of neural activities in the neocortex, hypothalamus, hippocampus, and midbrain.

• Women's Health Nursing
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• v.15 no.4
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• pp.372-380
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• 2009

Purpose: The purpose of this study was to examine the effects of aroma hand massage on Sleep, depression and quality of life in the institutionalized elderly women. Methods: This study was a nonequivalent control group pretest-posttest design. The data was collected from June 23 to August 10 of 2009. Fifty - Six elderly women were divided into two groups, 27 institutionalized elderly women for the experimental group and 29 institutionalized elderly women for the control group. As for experimental treatment, the experimental group went through aroma hand massage with blended oil-a mixture of Lavender, Bergamot, Chamomile Roman in the ratio of 1 : 1 : 1, which was diluted 2.0% with jojoba carrier oil 20mL-on each hand for 5 minutes, three times a week during two weeks. Control group went non-treatment. Results: The aroma hand massage experimental group showed more significant differences in the charge of sleep score (t=3.83, p=.00) and depression (t=-3.54, p=.00). Conclusion: Aroma hand massage had a positive effect on sleep and depression in Institutionalized elderly women.

• Korean Journal of Biological Psychiatry
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• v.11 no.2
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• pp.77-87
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• 2004

Due to the high population prevalence of major depression and the strong emphasis on pharmacotherapy for this disorder, antidepressants are among the most frequently prescribed pharmacological agents. But the clinicians are still unable to predict accurately the response of their depressed patients to medication. This article reviews the biological predictors of treatment response including monoamine, neuroendocrine, pharmacogenetic, and psychophysiologic markers. The biological predictors of response, despite some interesting leads that may in the long term be of considerable importance, are not yet sufficiently established to be of routine clinical usefulness. Many of the predictive factors explored in this article are examples of mediators and moderators that affect outcomes. Each one alone may not provide definitive answers for predicting response to treatment, but each must be taken into account at the outset of treatment. It is clear that treatments must be individualized for each patient. It would be necessary to develop the algorithm in order to predict the responsiveness of antidepressant treatment with integration of the results from the previous studies.

• Women's Health Nursing
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• v.11 no.1
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• pp.58-66
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• 2005

Purpose: The purpose of this study was to identify the patterns of activities of daily living (ADL) functional status and to examine the relationships between sense of coherence(SOC), depression, and uncertainty in gynecologic cancer patients who were receiving chemotherapy. Method: A prospective, longitudinal design with repeated measures was utilized. Women reported depression, SOC, and uncertainty at the beginning of the first cycle of chemotherapy, and they recorded ADL functional status everyday for two consecutive treatment cycles. the The instruments used were the Karnofsky Performance Status Index, Orientation to Life Questionnaire, Beck Depression Inventory, and Mishel Uncertainty in Illness Scale-Adult Form. Result: Data from 42 women showed that the ADL functional status during the second cycle was better than that of the first cycle with significant improvement each week. However, it did not completely recover to the baseline level even three weeks after the treatment ended in both cycles. SOC was correlated with depression(r=-.64, p<.001) and uncertainty(r=-.62, p<.001). Uncertainty was related to depression (r=.66, p<.001) and to functional status during the second cycle(r=-.45, p<.05), while the scores of the functional status during the two cycles were not related. Conclusion: Changing patterns and level of functional status during the treatment phase would be useful information for cancer patients to prepare coping strategies for positive health outcomes.

• The Journal of the Korean life insurance medical association
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• v.20
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• pp.70-77
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• 2001

Some characteristics of depression in the aged were elucidated. Compared with the previous thoughts, much more attention was given to the biological aspects of depression. However, we have to face up to and solve a variety of enigmas about depression in the aged people. They are:locations and underlying mechanisms in the cerebrum responsible for depression;relationship of senile depression to the presenile one;possible difference(s) between depression with and without psychotic features;possible neurotransmitter differences between senile and presenile depressions. New insights into these areas could bring some lights in the under standing and treatment of depresseion in the aged.

• Journal of Oriental Neuropsychiatry
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• v.23 no.4
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• pp.199-214
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• 2012

Objectives : The purpose of this study is to evaluate the effects of Daeyeongjeongami-bang on menopausal disorder patients. Methods : We recruited 3 menopausal disorder patients who have been suffering from hot flush, fatigue and depression. In addition, the patients had been administrated Daeyeongjeongami-bang. The patients of menopausal disorder had been estimated with Kupperman's index, Menopause rating scale, Beck's depression Inventory, Self rating depression scale, Visual analogue scale and Heart rate variability. We measured Kupperman's index, Menopause rating scale, Beck's depression inventory and Self rating depression scale for every seven days. Heart rate variability was estimated twice, before and after the treatment. Results : After the treatments, symptoms of menopausal disorder were decreased. Conclusions : This study suggests that Daeyeongjeongami-bang is significantly effective on menopausal disorder patients with hot flush, fatigue and depression.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.5
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• pp.2823-2828
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• 2013

Background: This study was performed to evaluate relationships between different demographic variables and hopelessness and depression in end of life Turkish cancer patients. This study was a descriptive survey with repeated measures conducted a university hospital in the city of Erzurum, in the eastern part of Turkey. The study enrolled 216 patients undergoing palliative treatment at the hospital. Materials and Methods: Data were collected using questionnaires (demographic questionnaire, Beck Hopelessness Scale (BHS), Beck Depression Scale (BDS) and analyzed for demographic and disease-related variable effects on hopelessness and depression. Results: Th hopelessness score was significantly high in female, illiterate, married, and living in rural areas cancer patients. Both hopelessness and depression scores were significantly higher with longer disease duration, receiving radiotherapy treatment, and having metastatic disease. Conclusions: These findings demonstrate the coexistence of the physical, psychological, and cognitive problems faced by patients with cancer. Nurses can conduct brief screening assessments to identify patients with probable distress and and psychosocial support, as well as referrals to support services.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.23 no.1
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• pp.15-25
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• 2020

Prevalence of pediatric obesity has increased worldwide in the last 20 years. Obese children suffer not only physical complications but also mental health problems such as depression, attention deficit hyperactivity disorder (ADHD), and eating disorders, as well as psychosocial impairments, such as school adjustment problems, bullying, and low self-esteem. Recently, there have been some studies on the association of mental health problems and pediatric obesity. In the treatment of pediatric obesity, many previous studies suggest multidisciplinary treatment. However, cognitive behavioral therapy (CBT) has attracted attention because obese children are accompanied by body image distortion, emotion dysregulation, and difficulties in stimulus control. This review is a narrative summary of the recent studies on mental health problems and CBT in pediatric obesity. The relationship between depression/anxiety and pediatric obesity is still inconsistent but recent studies have revealed a bidirectional relation between depression and obesity. Additionally, some studies suggest that obese children may have eating disorder symptoms, like loss of control eating, and require therapeutic intervention for pediatric obesity treatment. Furthermore, impulsivity and inattention of ADHD symptom is thought to increase the risk of obesity. It has also been suggested that CBT can be very effective for mental health problems such as depression, impulsivity, and body image distortion, that may coexist with pediatric obesity, and use of multimedia and application can be useful in CBT.

• Research in Community and Public Health Nursing
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• v.31 no.4
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• pp.472-480
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• 2020

Purpose: This study identified the effects of chronic disease number, quality of sleep and, serum serotonin concentration on the elderly's depression in order to provide basic data for the development of intervention program to effectively prevent and manage depression of the elderly living in the community. Methods: The study surveyed 207 people aged 65 or older living in the community. The general characteristics of the subjects, the number of chronic diseases, the quality of sleep (PSQI-K), the hematological test (Serotonin) and the depression (K-GDS) were statistically analyzed using SPSS/WIN 23.0. Results: It was shown that the elderly's depression differed significantly depending on the number of chronic diseases, the quality of sleep, and serum serotonin concentration, and that the variable that most affected depression was the quality of sleep. Next, the number of chronic diseases and serum serotonin levels were the variables affecting the depression of the elderly. Conclusion: In order to prevent and manage the depression of the elderly in the future, treatment and education for diseases and depression should be provided to the subjects. In particular, nursing interventions are needed to improve the quality of sleep for the elderly. Health care programs should also be provided, such as providing nutritional supplements to provide serotonin and increasing daytime activities.

• Asian Oncology Nursing
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• v.6 no.2
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• pp.133-142
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• 2006

Purpose: The purpose of this study was to identify factors influencing depression in breast cancer patients. Method: A descriptive correlational study design was used. A convenience sample of 155 subjects was recruited from the outpatient for breast cancer patients at one hospital in Gyeonggi, South Korea. Body image was measured with the category of "Body image" from the EORTC QLQ-BR23(European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Breast cancer version) and sexual function was measured with category of "sexual function" from it. Depression was measured with Korean version of Beck Depression Inventory(BDI). Results: The mean score of body image was relatively low(M = 54.44, SD = 30.92), of sexual function was low (M = 24.82, SD = 22.50), and of depression was relatively low(M =14.90, SD = 8.00). Depression had a significant relationship with body image(r = -.363, p = <.001), however, there was no significant relationship between depression and sexual function(r = -.137, p = .103). In the regression analysis, depression was found to be influenced significantly by monthly income and body image, these variables explained 28.8% of the variance in depression(F = 4.662. p = <.001). Conclusion: It suggests that nurses need to take into consideration body image and economic status in management depression in breast cancer survivors.