• 대한기계학회논문집A
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• 제38권2호
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• pp.193-203
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• 2014

터빈의 운전온도와 세라믹 입자크기를 고려한 경사기능재료(FGM)로 만들어진 회전하는 가스터빈 블레이드의 열전달해석 및 응력해석을 수행하였다. 경사기능성 블레이드는 벽 두께에 따라서 연속적인 재료물성 변화를 나타낸다. 이러한 경사기능재료의 특성과 온도에 따른 열전 재료물성 변화를 고려하여 블레이드의 시스템 강성을 얻기 위해 블레이드의 열전달해석을 먼저 수행하였다. 이 열전달해석으로 얻은 시스템 강성으로부터 복합 변형 변수를 사용한 회전하는 가스터빈 블레이드의 운동방정식을 유도하였다. 유도된 운동방정식은 상용 유한요소 모델과 해석결과 비교를 통해 그 정확성을 입증하였으며 회전주파수와 구배 지수에 따른 최대 응력의 변화를 조사하였다. 또한, 열전달해석을 통해 가장 낮은 블레이드 온도를 나타내는 구배 지수를 조사하였다.

• Journal of Korean Neurosurgical Society
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• 제38권6호
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• pp.450-455
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• 2005

Objective : Pituitary apoplexy is a rare clinical syndrome caused by pituitary hemorrhage, hemorrhagic infarction, or ischemic infarction within a pituitary tumor or surrounding structure. We analyzed surgical outcomes of pituitary apoplexy. Methods : From 1995 to 2004, we reviewed our experience of 29 cases with pituitary apoplexy. In all patients, pre- and postoperative clinical presentation were checked and endocrine study were performed. Results : The most frequent symptoms were visual disturbance [24 cases, 82.8%] and headache [22 cases, 75.9%]. After surgery, headache improved in 86.4%, 88.9% among 18cases who had preoperative reduction in visual acuity and 75.0% among 12 cases who had preoperative reduction in visual field improved. In endocrine study, long-term steroid and thyroid hormone replacement therapy was necessary in 42.9% of 14 cases presenting preoperative hypopituitarism. Postoperative transient hypopituitarism developed in 5 cases [33.3%] and they all recovered in follow up study. Postoperative endocrinological recovery were in 77.9% of 9 cases with preoperative prolactinoma, 1 case in 2 cases with acromegaly and one case with Cushing disease. Postoperative complications were diabetes inspidus[DI] in 1 case [3.4%]. cerebrospinal fluid[CSF] leakage in 2 cases [6.8%] and death in 1 case [3.4%] due to sepsis, Conclusion : We report good results through surgery of pituitary apoplexy in a clinical and endocrine outcomes. The surgery should be performed as soon as possible to be a suitable method for treating pituitary apoplexy.

• Journal of Korean Neurosurgical Society
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• 제38권6호
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• pp.413-418
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• 2005

Objective : Although an encephaloduroarteriosynangiosis procedure using the superficial temporal artery [STA-EDAS] is an effective indirect bypass method in children with moyamoya disease[MMD], there is still a need for an additional bypass operation that can cover the area of the posterior circulation. The goal of this study is to evaluate the efficacy of the EDAS procedure using the occipital arteries [OA-EDAS]. Methods : From August 2003 to April 2004, We performed OA-EDAS in sixteen patients with MMD who have a circulatory insufficiency in the territory of the posterior cerebral artery[PCA]. The medical records were reviewed retrospectively. The surgical outcomes, including the changes in neurological status and imaging studies, with the degree of neovascularization on the cerebral angiogram, and the hemodynamic changes on single-photon emission computed tomography[SPECT], were analyzed. Results : These 16 children consisted of 5 boys and 11 girls aged 2 to 9 years. The clinical outcome of their PCA symptoms, such as visual transient ischemic attacks[TIAs] or visual field defect, was favorable in 14 patients of 16. Nine patients of 11 who underwent follow up magnetic resonance imaging[MRI] showed favorable MRI changes. On angiogram most of the patients exhibited good or fair revascularization of the PCA territory [7 of 8]. The hemodynamic changes on SPECT in the PCA territory after surgery showed improved vascular reserve in 13 of the 16 territories. Conclusion : OA-EDAS is a safe and efficacious revascularization procedure in patients with MMD who have compromised cerebral perfusion in PCA territory, or with visual TIAs.

• Journal of Korean Neurosurgical Society
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• 제43권2호
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• pp.97-104
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• 2008

Objective: Transient receptor potential vanilloid subfamily type 1 (TRPV1), a most specific marker of the nociceptive primary afferent, is expressed in peptidergic and non-peptidergic primary afferents innervating skin and viscera. However, its expression in sensory fibers to skeletal muscle is not well known. In this study, we studied the neurochemical characteristics of TRPV1-positive primary afferents to skeletal muscles. Methods: Sprague-Dawley rats were injected with total $20{\mu}l$ of 1% fast blue (FB) into the gastrocnemius and erector spinae muscle and animals were perfused 4 days after injection. FB-positive cells were traced in the L4-L5 (for gastrocnemius muscle) and L2-L4 (for erector spinae muscle) dorsal root ganglia. The neurochemical characteristics of the muscle afferents were studied with multiple immunofluorescence with TRPV1, calcitonin gene-related peptide (CGRP) and $P2X_3$. To identify spinal neurons responding to noxious stimulus to the skeletal muscle, 10% acetic acids were injected into the gastrocnemius and erector spinae muscles and expression of phospho extracellular signal-regulated kinase (pERK) in spinal cords were identified with immunohistochemical method. Results: TRPVl was expressed in about 49% of muscle afferents traced from gastrocnemius and 40% of erector spinae. Sixty-five to 60% of TRPV1-positive muscles afferents also expressed CGRP. In contrast, expression of $P2X_3$ immnoreaction in TRPV1-positive muscle afferents were about 20%. TRPV1-positive primary afferents were contacted with spinal neurons expressing pERK after injection of acetic acid into the muscles. Conclusion: It is consequently suggested that nociception from skeletal muscles are mediated by TRPV1-positive primary afferents and majority of them are also peptidergic.

• 한국정보통신학회논문지
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• 제11권11호
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• pp.2078-2082
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• 2007

현재 교통사고의 통계를 보면 야간에 발생하는 교통사고는 주간과 비슷하게 일어나지만, 치사율은 주간에 비해 1.5배 높은 실정이다. 이러한 문제점은 야간에 운전자의 시야확보가 불리하여 적절한 사고 대응을 하지 못하는데 기인한다. 그러므로 본 논문에서는 밝기, 연색성, 광효율이 우수한 자동차 전조등을 마이크로컨트롤러에 의한 디지털 제어방식을 적용하여 주어진 요구조건 및 주변 환경에 최적으로 적용할 수 있도록 전자식 지능형 적응제어시스템을 설계하였다. 특히, 자동차용 조명장치의 경우 기본적인 역할은 물론 주행조건, 도로조건 및 기후조건에 가장 적합한 조명 패턴으로 자동적으로 전환 및 이동시켜 줄 수 있는 지능적인 조명장치를 구현하여야 한다. 따라서 본 논문에서는 이러한 지능형 자동차의 구현에 초점을 맞추어 운전자의 편의성과 안전성을 더욱 향상시킨 조명장치 시스템의 개발에 목표를 두었다.

• Nuclear Engineering and Technology
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• 제18권2호
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• pp.107-116
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• 1986

새로이 개발된 망상구조 충전탑에서의 중수증류성능해석 및 설계를 위한 정상 및 비정상상태 모델을 수립하였다. 정상상태 모델은 MESH 방정식에 각단의 압력강하를 고려하여 설정하고, Equation Tearing방법으로 그 해를 구하여 중수중류탄내의 농도, 온도 및 압력구배를 얻었다. 비정상상태 거동해석을 위하여 Cohen의 이상단 모델을 수정한 평형단 전이모델을 세웠으며, 그 모델식의 해석적 해를 구함으로써 시간에 따른 중수 농축과정을 예측할 수 있게 되었다. 설정된 모델들은 전환류 중수증류탑에서의 실험결과와 매우 잘 일치하였으며 개발된 충전물임이 높은 이론단수에 낮은 압력강하, 저체류량을 갖는 우수한 중수농축용 충전물임이 확인되었다.

• Asian-Australasian Journal of Animal Sciences
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• 제31권12호
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• pp.1852-1862
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• 2018

Objective: The purpose of this study was to investigate a single step genome-wide association study (ssGWAS) for identifying genomic regions affecting reproductive traits in Landrace and Large White pigs. Methods: The traits included the number of pigs weaned per sow per year (PWSY), the number of litters per sow per year (LSY), pigs weaned per litters (PWL), born alive per litters (BAL), non-productive day (NPD) and wean to conception interval per litters (W2CL). A total of 321 animals (140 Landrace and 181 Large White pigs) were genotyped with the Illumina Porcine SNP 60k BeadChip, containing 61,177 single nucleotide polymorphisms (SNPs), while multiple traits single-step genomic BLUP method was used to calculate variances of 5 SNP windows for 11,048 Landrace and 13,985 Large White data records. Results: The outcome of ssGWAS on the reproductive traits identified twenty-five and twenty-two SNPs associated with reproductive traits in Landrace and Large White, respectively. Three known genes were identified to be candidate genes in Landrace pigs including retinol binding protein 7, and ubiquitination factor E4B genes for PWL, BAL, W2CL, and PWSY and one gene, solute carrier organic anion transporter family member 6A1, for LSY and NPD. Meanwhile, five genes were identified to be candidate genes in Large White, two of which, aldehyde dehydrogenase 1 family member A3 and leucine rich repeat kinase 1, associated with all of six reproduction traits and three genes; retrotransposon Gag like 4, transient receptor potential cation channel subfamily C member 5, and LHFPL tetraspan subfamily member 1 for five traits except W2CL. Conclusion: The genomic regions identified in this study provided a start-up point for marker assisted selection and estimating genomic breeding values for improving reproductive traits in commercial pig populations.

• 한국항공우주학회지
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• 제49권9호
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• pp.749-757
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• 2021

쿼드로터를 활용한 운송 임무에서 임의의 유상하중을 장착하게 되면 질량, 관성모멘트, 무게중심의 위치와 같은 모델 파라미터가 변화하게 된다. 더욱이 유상하중이 기체에 장착되는 위치가 기체의 무게중심과 일치하지 않는 경우 무게중심의 변화는 야기되며 이는 제어 성능에 악영향을 미치게 된다. 이에 본 논문에서는 유상하중에 따른 모델의 불확실성을 보상하기 위하여, 선형 제차 조정기(Linear Quadratic Regulator, LQR) 기반의 모델 참조 적응 제어기법(Model Reference Adaptive Control, MRAC)을 제안한다. 먼저 고정된 유상하중을 고려한 쿼드로터의 동역학 모델을 유도하고, 선형 제차 조정기를 이용하여 기준제어기를 선정한다. 참조 모델은 과도응답을 향상하기 위해 폐루프 참조 모델을 사용하였으며, 선형 제차 조정기를 통하여 선정하였다. 또한, 안정성 분석을 통하여 모델 파라미터를 추정하기 위한 적응 제어기법을 설계하였다. 제안하는 제어기의 성능을 확인하기 위하여 모델 파라미터의 불확실성이 존재하는 상황에서 선형 재차 조정기와 성능을 비교하였다. 그리고 외란이 있는 상황에서 기존의 모델 참조 적응 제어기법과도 제안한 제어기의 결과를 비교하여 과도응답과 강건성에 대해서도 분석하였다.

• 한국항공우주학회지
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• 제49권4호
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• pp.311-320
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• 2021

무인기용 터보제트엔진의 운전 중 발생하는 고장을 실시간으로 진단하기 위한 방안 및 성능 열화와 관련된 건정성 추정에 관해 연구하였다. 이를 위해서, 동적 열역학 가스경로해석을 통한 비선형 동특성 방정식으로부터 실시간 선형모델을 도출하였고, 연출된 운전상황과 고장 발생을 실시간으로 진단하기 위해 칼만필터와 가설 검증에 기초한 확률적 판단 기법을 적용하였다. 이 결과, 분명한 고장 검출과 분리 성능을 보임으로써 그 효용성을 확인하였다. 측정변수를 통한 건전성 추정과 관련하여, 실제 엔진 구성품의 성능 열화 추이를 모사하였고, 적응형 칼만필터를 적용하여 추정 기법의 타당성을 입증함으로써, 상태 기반 고장 진단 및 정비 기법에 효과적으로 사용될 수 있음을 보였다.

• 한국기계가공학회지
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• 제20권6호
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• pp.33-43
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• 2021

A60 class bulkhead penetration piece is a fire resistance system installed on a bulkhead compartment to protect lives and to prevent flame diffusion in a fire accident on a ship and offshore plant. This study focuses on the approximate optimization of the fire resistance design of the A60 class bulkhead penetration piece using a multi-island genetic algorithm. Transient heat transfer analysis was performed to evaluate the fire resistance design of the A60 class bulkhead penetration piece. For approximate optimization, the bulkhead penetration piece length, diameter, material type, and insulation density were considered discrete design variables; moreover, temperature, cost, and productivity were considered constraint functions. The approximate optimum design problem based on the meta-model was formulated by determining the discrete design variables by minimizing the weight of the A60 class bulkhead penetration piece subject to the constraint functions. The meta-models used for the approximate optimization were the Kriging model, response surface method, and radial basis function-based neural network. The results from the approximate optimization were compared to the actual results of the analysis to determine approximate accuracy. We conclude that the radial basis function-based neural network among the meta-models used in the approximate optimization generates the most accurate optimum design results for the fire resistance design of the A60 class bulkhead penetration piece.