• Microbiology and Biotechnology Letters
• /
• v.50 no.4
• /
• pp.522-532
• /
• 2022

Cheonggukjang is a traditional fermented food in Korea, which is known to exert beneficial effects on health. In this study, we evaluated the effects of cheonggukjang fermented by Bacillus subtilis SCGB 574 (B574) on high fat diet (HFD)-deteriorated large intestinal health. Rats were fed with HFD or HFD supplemented with 10.1% cheonggukjang (B574). Fecal microbiota was analyzed based on 16S rRNA gene sequences, and the fecal and serum metabolome were measured using GC-MS. Our results showed that SCGB574 intake significantly reduced body weight, restored tight junction components, and ameliorated inflammatory cell infiltration. SCGB574 also shifted gut microbiota by increasing the abundance of short chain fatty acid producers such as Alistipes and Flintibacter, although it decreased the abundance of Lactobacillus. Serum and fecal metabolome analyses showed significantly different metabolic profiles between the groups. The top five metabolites increased by SCGB574 were i) arginine biosynthesis, ii) alanine, aspartate, and glutamate metabolism; iii) starch and sucrose metabolism; iv) neomycin, kanamycin, and gentamicin biosynthesis; and v) galactose metabolism. These results showed that cheonggukjang fermented by SCGB574 ameliorates adverse effects of HFD through improving intestinal health.

• Journal of Biomedical Engineering Research
• /
• v.45 no.1
• /
• pp.20-25
• /
• 2024

Extracellular vesicles (EVs) are nano-sized lipid bilayer vesicles released by cells. EVs act as messengers for cell-to-cell communication. Inside, it contains various substances that show biological activity, such as proteins, lipids, nucleic acids, and metabolites. The study of EVs extracted from terrestrial organisms and stem cells on inflammatory environments and tissue regeneration have been actively conducted. However, marine organisms-derived EVs are limited. Therefore, we have extracted EVs from sea urchins belonging to the Echinoderm group with their excellent regenerative ability. First, we extracted extracellular matrix (ECM) from sea urchin gonads treated with hypotonic buffer, followed by collagenase treatment, and filtration to collect ECM-bounded EVs. The size of sea urchin gonad-derived EVs (UGEVs) is about 20-100 nm and has a round shape. The protein content was higher after EVs burst than before, which is evidence that proteins are contained inside. In addition, proteins of various sizes are distributed inside. PKH-26 was combined with UGEVs, which means that UGEVs have a lipid membrane. PHK-26-labeled UGEVs were successfully uptaken by cells. UGEVs can be confirmed to have the same characteristics as traditional EVs. Finally, it was confirmed that Schwann cells were not toxic by increasing proliferation after treatment.

• The Journal of KAIRB
• /
• v.4 no.1
• /
• pp.16-22
• /
• 2022

Purpose: The traditional ethical study only suggests a blurred insight on the research using medical big data, especially in this rapid-changing and demanding environment which is called "4th Industry Revolution." Current institutional/ethical issues in big data research need to approach with the thoughtful insight of past ethical study reflecting the understanding of present conditions of this study. This study aims to examine the ethical issues that are emerging in recent health care big data research. So, this study aims to survey the public perceptions on of health care big data as part of the process of public discourse and the acceptance of the utility and provision of big data research as a subject of health care information. In addition, the emerging ethical challenges and how to comply with ethical principles in accordance with principles of the Belmont report will be discussed. Methods: Survey was conducted from June 3th August to 6th September 2020. The online survey was conducted through voluntary participation through Internet users. A total of 319 people who completed the survey (±5.49%P [95% confidence level] were analyzed. Results: In the area of the public's perspective, the survey showed that the medical information is useful for new medical development, but it is also necessary to obtain consents from subjects in order to use that medical information for various research purposes. In addition, many people were more concerned about the possibility of re-identifying personal information in medical big data. Therefore, they mentioned the necessity of transparency and privacy protection in the use of medical information. Conclusion: Big data on medical care is a core resource for the development of medicine directly related to human life, and it is necessary to open up medical data in order to realize the public good. But the ethical principles should not be overlooked. The right to self-determination must be guaranteed by means of clear, diverse consent or withdrawal of subjects, and processed in a lawful, fair and transparent manner in the processing of personal information. In addition, scientific and ethical validity of medical big data research is indispensable. Such ethical healthcare data is the only key that will lead to innovation in the future.

• Journal of the Korean Wood Science and Technology
• /
• v.36 no.6
• /
• pp.105-112
• /
• 2008

Grading of the urushi lacquer is quite difficult because of large variations depending on origin, growing conditions, time acquisition, storage conditions. It is urgently required to establish a grading system of urushi lacquer by combining traditional method with scientific methods. Traditional grading of urushi lacquer was done by visual inspection of 10 experts who are working on urushi lacquer industry. Common aspects of the experts were color, odor, viscosity, spread properties on Hanji, color and drying properties on glass based the traditional grading system. In addition, rubbing on Hannj and heating with alcohol lamp was also used to grade urushi lacquer. The grading results of 10 experts showed that chinese urushi lacquer (E) of 7.03, japanese urushi lacquer (C) of 6.84, domestic urushi lacquer of (A) of 6.41 and another chinese urushi lacquer (D) of 5.27, and domestic urushi lacquer (B) of 2.50 in descending order. The degree of spread on Hanji was not consistent among 10 experts. These results indicated that the traditional grading system was pretty much personal and required of developing more objective method based on scientific background.

• The Journal of Traditional Korean Medicine
• /
• v.15 no.1
• /
• pp.128-144
• /
• 2006

This Study aims at looking into the use of oriental medical services in treating hypertension. The first objective to be explored through this study is the morbidity caused by the disease, classifying them by age, gender, and occupation. The second is to determine the regular use of anti-hypertensive medicine and their efficacy in controlling blood-pressure. The third is to investigate the use-rate and satisfaction of oriental medical service. 838 households across the country, were asked to answer questionnaires for the period of time from Apr. to Jun. 2005. The conclusion from the survey can be summarized as following. The age of which the first medical diagnosis of hypertension were made showed lower in males, those with higher education and income. The study showed females were more active in blood-pressure control, with their frequent monitoring of blood-pressure for the past year. With age, people in under 50 age group proved to be less active. The management of high blood pressure was more effective in group with regular dosage compared to group with irregular use of anti-hypertensive medication, but their difference was minimal. Also, group with no medication showed signs of blood-pressure control. The use of oriental medical service for the past year, were more frequent in groups with lower education, either low or high income, old age, females and occupations in agriculture, forestry and fishing industry. Results were similar in both general population and high blood-pressure patient group. Females, people over 51 years old and with lower education showed more intentions in utilizing oriental medical services in the future. Results were similar in both general population and high blood-pressure patient group. It is necessary to offer a more accurate information on oriental medical treatments. Also, a systematic reform to reduce the patient's share of the treatment cost, as well as, heightening public awareness on the infirmity of present blood-pressure management system is crucial.

• Journal of Life Science
• /
• v.27 no.12
• /
• pp.1500-1506
• /
• 2017

Plants are reservoirs of naturally occurring chemical compounds and of structurally diverse bioactive molecules. The aim of this investigation was to screen for the presence of phytochemicals responsible for the lipolysis activity in mulberry (Morus alba) leaves, which are important in traditional Asian medicinal plants. Powdered mulberry leaves were extracted with hexane, ethyl acetate, and methanol. Daucosterol was isolated from the EtOAc extract of mulberry leaves, and its structure was elucidated by NMR spectral analyses. The NMR assignments for the compound were determined using $^1H$, $^{13}C$, DEPT, COSY, HSQC, and HMBC NMR spectral data. Daucosterol showed a concentration-dependent lipolysis activity that may impart medicinal properties that can be exploited by medical practitioners for the treatment of various diseases. However, further studies should be conducted to elucidate additional mechanisms of daucosterol.

• The Journal of Korean Medical History
• /
• v.30 no.2
• /
• pp.45-61
• /
• 2017

Objectives : This research aims to investigate the consumer's interest in the Korean Medicine (KM) industry by using Google-trends and Naver-Data lab. A quick and uncomplicated way for those who are already involved with KM industry but do not have expertise in utilizing Big-data searches, is introduced. Methods : 'Direct keyword' was set by FGI (Focus Group Interview) and 'Detailed keyword' was set by using relevant word search and autocomplete search functions in the search engine. By inquiring Naver-Data lab, keyword search volumes are compared by age and sex, date range, and originating region of the researcher. It is possible to determine whether the data is reliable or authentic through examining the associated query. Selected direct keywords used through FGI (Focus Group Interview) were 'Acupuncture', 'Herbal Medicine', 'Cupping', 'Musculoskeletal Disease', 'Diet', and 'Stemina'. Based on these keywords, the following results were derived from the keyword analysis. Results : From August 2016, there was a noticeable surge of interest in men's 'Cupping'. The search for 'Diet' increased in the second quarter of 2016 from all ages. The search volume of 'Stemna' for individuals in their 20s is higher than that of those in their 30s or 40s'. Researchers from the region of Chungcheongbuk-do had a higher level of interest in analgesics and less interest in Korean Medicine. There is a greater interest in the KM market from European countries and America, than from Korea, China, and other Asian countries. Discussion : Despite the limitations of the research, it is meaningful to introduce a quick and easy data search method to compare information by age, sex, and region. Conclusion : The future of research into Korea Medicine and this market is confirmed by our data results which indicate interest from Europe, the United States, and other western countries, but less interest from Korea, China and other Asian countries.

• Korean Institute of Interior Design Journal
• /
• v.15 no.5 s.58
• /
• pp.141-148
• /
• 2006

Recently, human's life is more longer and the birth rate continually decrease by the development of medical technology. In 2026 the ratio of the elderly will come up to 20.8% and be a 'post-aged society'. Development of economy and industrialization not only accelerate the urbanization and formation of nuclear family, but also change the changing of traditional society and one's value. So the issue of society and value's changing in the elderly increase the centralizing in the silver industry, and by the recent research about the elderly, they not want to live with their children, but want to live independently. This study is meaningful at the next generation of Ubiquitous society and post-aged society, proposing the smart silver town in urban type and let the elderly keeping the existing life in city. It realize the concept of 'Aging in Place' and propose the smart silver town in urban type which appropriate to behavior of the elderly, and being satisfy with various requirements of the elderly. This study point up the combination of physical elements and electronic elements through the smart technology, and making an smart environment to compose the smart silver town in urban type which react the behavior of the elderly.

• Journal of Welding and Joining
• /
• v.33 no.3
• /
• pp.40-46
• /
• 2015

Welding is one of the most fundamental and necessary work in the industry that demand sophistication of skilled workers. This study is to introduce welding simulator as a training tool, to verify its effectiveness and to measure satisfaction of the trainees. A group of freshman students at a Korea Polytechnics College in their twenties with less experience of welding participated in the study. They were divided into two groups and took a traditional training course (comparison group) and a training course with welding simulator applied reality/haptic technology (experimental group) for same hours respectively. To evaluate training effect, a national certificate test and a survey based on Phillips' ROI (Return on Investment) methodology were conducted by the students and the college respectively. And satisfaction survey among the students based on Kirkpatrick's Four-Level Evaluation Model was also carried out. The results showed that all students in the experimental group passed the national certificate test and the ROI of the experimental group for five years were 110% higher than the comparison group. Furthermore, 25% more students in the experimental group replied "very satisfied" about the overall training course and 75% more students in the same group found that the simulation was very similar to the real welding.

• Journal of the Korea Computer Industry Society
• /
• v.7 no.3
• /
• pp.263-270
• /
• 2006

Magnetic nerve stimulation treatment is much backward real condition than other field. Specially, successful medical treatment introduction of magnetic field (MF) can was refered long ago in Avicenna's work, and is thought as age of medicine magnetology development recently. These development is achieved through biologist and biophysicist and clinician's joint effort, but, new mountings and relationship air tassel are developed steadily. Magnetic nerve stimulation treatment field designs treatment system by each function during long wave high-amplitude (traditional magneto therapy of greatly great that strong that) short time that CMF, VMF, PMF field etc. are representative but are HPMT technology in this research and manufacture and special quality did comparative analysis.