• Journal of Periodontal and Implant Science
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• 제33권4호
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• pp.693-703
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• 2003

The present study evaluated the effects of guided tissue regeneration using xenograft material(deproteinated bovine bone powder), with and without Calcium sulfate membrane in beagle dogs. Contralateral fenestration defects (6 ${\times}$ 4 mm) were created 4 mm apical to the buccal alveolar crest of maxillary premolar teeth in 5 beagle dogs. Deproteinated bovine bone powders were implanted into fenestration defect and one randomly covered Calcium sulfate membrane (experimental group). Calcium sulfate membrane was used to provide GTR. Tissue blocks including defects with soft tissues which were harvested following four & eight weeks healing interval, prepared for histo-phathologic analysis. The results of this study were as follows, 1. In control group, at 4 weeks after surgery, new bony trabecular contacted with interstitial tissue and osteocytes lie cell were arranged in new bony trabecule. Bony lamellation was not observed. 2. In control group , at 8 weeks after surgery, scar-like interstitial tissue was filled defect and bony trabecule form lamellation. New bony trabecular was contacted with interstitial tissue but defect was not filled yet. 3. In experimental group, at 4 weeks after surgery, new bony trabecular partially recovered around damaged bone. But new bony trabecule was observed as irregularity and lower density. 4. In experimental group, at 8 weeks after surgery, lamella bone trabecular developed around bone cavity and damaged tissue was replaced with dense interstitial tissue. In conclusion, new bone formation regenerated more in experimental than control groups and there was seen observe more regular bony trabecular in experimental than control groups at 4 weeks after surgery. In control group, at 8 weeks after surgery, the defects was filled with scar-like interstitial tissue but, in experimental group, the defects was connected with new bone. Therefore xenograft material had osteoconduction but could not fill the defects. We thought that the effective regeneration of periodontal tissue, could be achieved using GTR with Calcium sulfate membrane.

• 대한기계학회논문집B
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• 제36권11호
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• pp.1081-1090
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• 2012

외상성 관절염 발생시 슬관절에서의 해면골 미세구조 변화 특성에 대한 연구는 부족한 실정이다. 따라서 본 연구에서는 생체 내 미세 단층 촬영을 통해, 소동물(SD rat; 10 마리)의 경골 골단 해면골 미세구조 변화패턴을 연속적으로 추적 관찰하여 정량적으로 분석하였다. 외상성 관절염 군(5 마리)에는 전방십자인대절제술을 실시하였고, 정상군(5 마리)에는 아무런 외과적 처치를 가하지 않았다. 외상성 관절염군은 정상군과 비교시 수술후 8 주까지 약 4-16%의 유의한 골 미세구조 차이를 나타내었다(P<0.05). 동일 기간 동안 골 밀집 정도 및 골 형성 정도는 5-15% 정도로 유의한 차이를 나타내었다(P<0.05). 본 연구는 외상성 관절염 발생에 의한 경골 골단 해면골의 골 미세구조 변화 특성 기준 정립 및 외상성 관절염의 이해와 치료에 도움이 될 것으로 기대된다.

• 대한의용생체공학회:의공학회지
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• 제37권2호
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• pp.90-103
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• 2016

본 연구는 유한 요소 법을 이용한 노화되어 강성/강도가 저하되는 요추 체의 얇은 피질과 해면 골의 하중 분담 비율 분석과 사용된 탄성계수들의 평가가 목적이다. 해면 골의 나은 해석을 위하여, 20년마다 압축 시험에서 얻은 탄성계수를 체적 공극 비율로 나눈 유효 탄성계수를 사용하였다. 이와 상응하는 피질 쉘도 공극 비율을 포함한 빔 이론의 수식들로부터 유효 탄성계수를 구한 후에 적용하였다. 또한 p-요소를 사용하여 수치 오차를 최소화하였다. 보고된 논문들을 참고하여 후관절 부분이 제거된 매개 변수적인 퇴행된 L3 척추 형상을 만들어 유한 요소 모델링 하였다. 일정 변위의 압축 조건을 가한 후에 여덟 조각의 부피 별로 각 뼈에서 탄성 변형률 에너지와 수직 하중의 비율을 사용하여 하중 분담 비율을 계산하였다. 결과로는 1) 20대에서 80대까지 해면 골의 하중 비율은 55%에서 49%로 감소하였다; 2) 피질 쉘은 중간 면에서 최고 비율을, 해면 골은 종판에서 최고 비율을 나타냈다; 3) 다공성 얇은 피질과 해면 골을 위한 유효 탄성계수의 사용은 적절하였다; 4) 두 방법을 이용하여 얻은 하중 분담 비율의 차이는, 전체 비율은 1% 미만 내에서 같지만 각 위치에서의 비율 값들은 약간 달랐다.

• 한방재활의학과학회지
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• 제27권2호
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• pp.19-27
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• 2017

Objectives Osteoporosis is a common disease in adults with prevalence rate of more than 40%, and occurs more to female than to male. The purpose of this study is to identify the effect of Bia-hwan ($F{\acute{e}}i{\acute{e}}r$-$w{\acute{a}}n$) on the osteoporosis of ovariectomized rats. Methods 24 female rats were randomly assigned to a SHAM group, a control group, and a BAH group. Ovaries of the control group and the BAH group were extracted. After than, general animal feed were given to the SHAM group and the control group, animal feed contained BAH were given to the BAH group through mouths of them. After 8 weeks, rats were sacrificed and their weight, calcium, phosphorus, estradiol, total-cholesterol, triglyceride, ALP, albumin, AST, ALT, the weight of femur and tibia ash per body ratio, both area and thickness of trabecular bone, the area of osteoblast and the number of osteoclast were measured. Results The level of calcium, phosphorus, AST in the serum of the BAH group increased significantly compared to the control group. There was no significant difference between the control group and the BAH group in the level of estradiol, total-cholesterol, triglyceride, ALP, albumin, and ALT in the serum. There was no significant difference between the control group and the BAH group in the weight of femur and tibia ash per body ratio. The thickness of trabecular of the BAH group increased significantly compared to the control group, but there was no significant difference in the trabecular area. The area of osteoblast and the number of osteoclast of the BAH group decreased significantly compared to the control group. Conclusions From the results of the above study, oral intake of BAH can inhibit the decrease of calcium, phosphorus in blood and prevent the thinning process of the trabecular by suppressing activation of osteoclast. Thus, BAH may have effects on the treatment and prevention of osteoporosis.

• 대한한방부인과학회지
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• 제25권4호
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• pp.1-11
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• 2012

Objectives: Osteoporosis, which occurs after menopause, is a kind of metabolic bone disorder. It develops when the bone mass begins to decrease radically, and its main symptoms are bone fracture and height-shortening. This thesis aims at what effects the Cuscutae Semen Extract(CSE) has on the prevention of osteoporosis in SD-rat that is caused by ovariectomy. Methods: The 24 female white rats, after removing their ovaries, were divided into the Normals, the Control group, and the CSE administrated group. For the next 8 weeks, distilled water to the normals and the control, and the CSE(45.9 mg/100 g) to the CSE administrated group were given in the mouths of them. After 8 weeks the rats were sacrificed. Weight, albumin, aspartate aminotransferase, alanine aminotransferase, total-cholesterol, triglyceride, phosphorus, calcium, tetraiodothyronine, estradiol, the weight of the femur, the amount of tibia ash, the area of trabecular bone, and the thickness of trabecular bone were measured. Results: The serum analysis shows that the calcium and phosphorous of the CSE administrated group significantly increased compared to that of the control group. Aspartate aminotransferase, alkalinephosphatase, total cholesterol, tetraiodothyronine of CSE group were decreased, but not so significant. Albumin, alanine aminotransferase, triglyceride and estradiol of the group showed the tendency to increase, but the significance wasn't admitted. Regarding the variation of bone, the femur weight and the ash content of tibia, CSE group was more increased than the control group but the significance wasn't admitted. The histological observation shows that the trabecular thickness was more increased than the control group, and trabecular area increased significantly compared to those of the control group. The number of osteoclast and osteoblast area of the CSE groups decreased significantly compared to those of the control group. Conclusions: From the result of the above study, CSE should be effective for the osteoporosis cure and precaution and deeper study through bedside and clinical demonstration is much needed from now on.

• Journal of Nutrition and Health
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• 제48권5호
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• pp.381-389
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• 2015

본 연구는 성장기 동물모델의 고과당 식이섭취가 골성장 (bone growth) 및 성숙 (bone maturation)에 미치는 영향을 연구하기 위해 수행되었다. 이를 평가하기 위해 생화학적 표지자 (biochemical markers), 경골의 구조학적 파라미터 (structural parameters) 및 골밀도 (BMD), 신장의 조직학적 변화를 측정하였고, 결과를 요약하면 다음과 같다. 1) 30% 고과당 섭취 (8주 동안) 및 30% 고과당 + 45 kcal% 고지방 섭취는 경골 내 해면골 (Tibia trabecular bone)의 부피비 (BV/TV), 해면골의 평균 개수 (Tb.N) 및 패턴요소 (Tb.Pf)를 향상시켰다. 2) 45 kcal% 고지방 섭취는 경골 내 피질골 (Tibia trabecular bone)의 부피를 향상시켰다. 3) 30% 고과당 섭취는 신장의 출혈 (interstitial bleeding), 공포화 변성 (vacuolation), 사구체 울혈 (glomerular congestion) 등의 병변을 유발하지 않았다. 4) 30% 고과당 섭취는 혈중 OC 농도를 낮추었고, 요 중 DPD농도에는 영향을 주지 않았다. 5) 8주 동안의 30% 고과당 섭취는 유의한 경향의 체중증가를 유도하였고, 45 kcal% 고지방 섭취는 유의적인 체중증가를 나타내었다. 본 연구 결과에 따르면 고과당의 섭취는 신기능의 손상 없이 성장기 해면골을 더욱 치밀하게 만드는 것으로 나타났다. 많은 선행연구들을 통하여 설탕이나 포도당의 과잉 섭취가 골 소실을 유발한다고 보고되어 왔으며, 본 연구를 포함한 이전 연구들을 종합해보면 고과당 섭취는 설탕이나 포도당 과잉 섭취가 유발하는 골 소실을 유발하지는 않는 것으로 보인다. 하지만 이러한 결과가 고과당 섭취가 골형성을 돕는다는 것을 의미하지는 않는다. 따라서 본 연구의 결과는 골의 형성 및 성숙에 중요한 시기인 청소년기에 안전한 과당섭취 가이드라인을 위한 초석을 다지는데 참고자료로서 사용될 수 있으며, 설탕이나 포도당 등을 과당으로 대체하여 섭취하는 것이 골 건강에 도움이 될 수 있을지는 향후 추가적인 연구가 필요할 것으로 보인다.

• 대한자기공명의과학회:학술대회논문집
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• 대한자기공명의과학회 1996년도 추계학술대회 초록집
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• pp.31-56
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• 1996

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2006년도 추계학술대회 논문집
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• pp.555-556
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• 2006

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2006년도 추계학술대회 논문집
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• pp.453-454
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• 2006

• 대한기계학회:학술대회논문집
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• 대한기계학회 2003년도 추계학술대회
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• pp.1368-1372
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• 2003

PMMA which is used as the bone cement for vertebroplasty is able to be a supporter, as a fixing supporter role, for broken trabecular structure, caused by the compressed fracture of spine on aged osteoporosis. In this thesis, as experimenting apparent density of bone pieces, we have figured out support extent of Young's modulus as classifying the bone pieces injected PMMA and the others which are not. In case of low apparent density of PMMA in some bone, Young's modulus seems to be more supportable to bone. On the other hand, if apparent density of bones is normal, injection of PMMA is not very effective on improvement in Young's modulus of bone cement injection.