• 생명과학회지
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• 제18권8호
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• pp.1147-1153
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• 2008

본 연구에서는 트랜스 지방 섭취가 마우스의 혈청, 심장, 간 및 신장의 중성지질, 총콜레스테롤, LDL-콜레스테롤 및 HDL-콜레스테롤의 함량에 미치는 영향과 트랜스 지방 섭취에 따른 지방산 조성 변화에 대하여 n-3 적절군과 n-3 결핍군과 비교하여 검토하였다. 혈청, 간 및 신장 균질물들에서 n-3 결핍군과 트랜스군의 중성지질의 함량은 n-3 적절군보다 유의적으로 높았다(p<0.05). 총콜레스테롤과 LDL-콜레스테롤의 경우에서도 n-3 결핍군과 트랜스군의 혈청에서 n-3 적절군보다 유의적으로 높은 함량을 나타내었다 (p<0.05). 특히 간과 심장에서는 트랜스군의 총콜레스테롤과 LDL-콜레스테롤 함량이 n-3 결핍군과 비교했을 때 유의적으로 높았다(p<0.05). 한편, HDL-콜레스테롤 함량의 경우, 트랜스군의 간에서 가장 낮은 함량을 나타내었고 다음으로 n-3 결핍군이며 n-3 적절군의 경우 가장 높은 함량을 나타내었다. 혈청을 비롯한 모든 조직에서 트랜스 지방 섭취는 트랜스 지방산의 함량을 증가시켰다. 혈청에서 n-3 결핍군과 비교했을 때 트랜스군의 트랜스 지방산들을 제외하고 거의 모든 지방산 조성에 유의적 차이가 없었으나 18:2n-6cis와 20:2n-6의 경우 n-3 결핍군에 비해 높은 함량을 나타내었다(p<0.05). 심장, 간 및 신장의 지방산 조성에서 n-3 결핍군과 트랜스군은 n-3 적절군에 비해 총monounsaturated 함량은 높았고 총포화지방산 함량은 유의적으로 낮았다(p<0.05). 트랜스군은 n-3 결핍군과 비교했을 때 거의 모든 지방산 조성에 유의적 차이가 없었으나 n-6 지방산종들 중 18:2n-6cis와 20:2n-6의 함량은 n-3 결핍군에 비하여 높았다(p<0.05). DHA 함량의 경우 n-3 결핍군과 트랜스군간에 유의적 차이가 없었으나 n-3 적절군에 비해 매우 낮았다. 따라서 트랜스 지방 섭취는 관상동맥질환의 중요한 위험인자인 중성지질, 총콜레스테롤 및 LDL-콜레스테롤 함량을 증가시키므로 발병률을 더 상승시킬 것으로 예상된다.

• 동의생리병리학회지
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• 제22권1호
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• pp.89-95
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• 2008

This experimental study was designed to investigate the effects of Ijin-tang add Atractylodis rhizoma and Atratcylodis macrocephalae rhizoma (IJTAA) on the change of weight and serum total cholesterol, HDL-cholesterol, LDL-cholesterol, triglyceride, free fatty acid, total lipid and phospholipid level in obese mice induced by high fat diet. Experimental groups were as follows ; Normal group was fed normal diet and administered distilled water during 7 weeks, Control group was fed high fat diet and administered distilled water during 7 weeks, Sample A group was fed high fat diet and administered IJTAA 500 ㎎/㎏/day/mouse during 7 weeks, Sample B group was fed high fat diet and administered IJTAA 700 ㎎/㎏/day/mouse during 7 weeks. The results were as follows ; 1. In Sample A group and Sample B group, There were significantly decreased in body weight, serum total cholesterol level, serum triglyceride level, serum free fatty acid level, serum total lipid level and serum phospholipid level in comparison with Control group. 2. In Sample A group and Sample B group, There were significantly increased in serum HDL-cholesterol level in comparison with Control group. 3. In Sample A group and Sample B group, There were decreased in serum LDL-cholesterol level in comparison with Control group. According to above results, I suggest IJTAA is able to be used for managing obesity by controllong body weight, serum total cholesterol level, serum triglyceride level, serum free fatty acid level, serum total lipid level and serum phospholipid level.

• 한국식품위생안전성학회지
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• 제4권2호
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• pp.133-153
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• 1989

콜레스테롤과 Vitamin D2로 유발시킨 동맥경화증 랫트에 칠성장어유와 옥수수유의 급여에 따른 예방적 효과를 조사할 목적으로 다음 네 개의 식이군으로 나누어 실험한 바, 첫째군은 정상대조군, 둘째군은 콜레스테롤(40/kg) 과 Vitamin D2(300,000 IU/kg)를 시험개시 1일부터 연속적으로 4일간 투여한 동맥 경화증 대조군, 셋째군은 동맥경화증 유발 처치와 함께 15% 칠성 장어유 식이(w/w)를 8일간 급여한 칠성장어유 식이군, 넷째군은 동맥경화증 유발처치와 함께 15% 옥수수유 식이 (w/w)를 8일간 급여한 옥수수유 식이군으로 하여 다음과 같은 결과를 얻었다. 동맥경화증 대조군은 정상대조군에 비하여 혈청 중의 총지질, 인지질. 총콜레스테롤, HDL-cholesterol, LDL-chlesterol 치의 현저한 증가를 보였고 (p<0.01), 또한 심장의 중성지방 및 콜레스테롤치의 증가(p<0.01), 대동맥의 중성지방(p<0.01) 및 콜레스테롤치 (p<0.05)를 보였다. 한편 대동맥은 심한 손상으로 내피세포의 탈락 및 내막과 중막에 석회화, 괴사, 지방 침착을 보였고, 관상동맥은 석회화, 괴사, 백혈구의 침윤이 현저하게 관찰되었다. 칠성장어유 식이군은 정상대조군에 비하여 혈청 중성지방치의 r마소 (p<0.01), 혈청 HDL-cholesterol 치의 증가(p<0.01), 심장콜레스테롤치 (p<0.05),의 증가를 보였고, 동맥경화증 대조군에 비하여는 혈청 중의 총지질, 중성지방, 인지질, 총콜레스테롤, LDL-cholesterol , VLDL-cholesterol 치 (p<0.01), 및 LDL치의 감소(p<0.05), 또한 간장 콜레스테롤치의 증가(p<0.05), 심장의 중성지방 (p<0.01) 및 콜레스테롤치 (p<0.05)의 r마소, 대동맥 중성지방 (p<0.01) 및 콜레스테롤치 (p<0.05) 의 감소를 보였다. 또한 옥수수유 식이군에 비하여 혈청 총지질(p<0.05)의 감소, 총콜레스테롤 및 HDL-cholesterol 치의 감소 (p<0.01), 심장중성지방치의 감소 , 대동맥 중성지방치의 감소 (p<0.01)를 보였다. 한편 대동맥은 동맥경화증 대조군에 비하여 미약한 석회화와 괴사된 thru을 보였으나 칠성장어유 식이군에서와 같이 지방침착은 관찰되지 않았고 관상동맥에서도 동맥경화증 대조군에 비해 미약한 석회화와 괴사된 소견을 보였다. 이상의 결과에서 불포화지방산을 다량으로 함유한 칠성장어유 및 옥수수유는 동맥경화증 랫트에 있어 생체내 지질대사에 영향을 미침으로써 혈청지질치를 저하시키고 동맥벽내에 지방침착을 억제시켰으며, 이러한 효과는 n-6계 다불포화지방산을 많이 함유하고 있는 옥수수유보다 n-3rP 다불포화지방산을 다량으로 함유한 칠성장어유에 더욱 크게 나타났다

• 대한본초학회지
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• 제22권3호
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• pp.109-116
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• 2007

Objective : In order to elucidate hyperlipidemic effects of the fruits of Poncirus trifoliata and Citrus aurantium, our experimental study was performed on hyperlipidemia rats induced by Triton WR-1339. Method : The hyperlipidemia rats induced by intraperitonial injection of triton WR-1339 were treated with the fruits of P. trifoliata (rare and preparata) and C. aurantium 50 and 200mg/kg. The amount of triglyceride. total cholesterol. HDL-cholesterol, LDL-cholesterol, AST. and ALT levels were measured. Results: The levels of triglyceride. total cholesterol and LDL-cholesterol were significantly reduced in fruits of P. trifoliata (rare and preparata) and C. aurantiu. Simvastatine treated group compared with those of control but the level of HDL-cholesterol was incresed. The level of AST and ALT were not significantly reduced by the treatment to the fruits of P. trifoliata (rare and preparata) and C. aurantium. Conclusion : In the hyperlipidemia rats induced by triton WR-1339. the fruits of P. trifoliata (rare and preparata) and C. aurantium showed a hyperlipidemic effect.

• 대한한방내과학회지
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• 제35권3호
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• pp.244-261
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• 2014

Objectives: This experiments were performed to determine the effects of the Jehasuogamibang (製何首烏加味方: JHGB) on antioxidationactivity and hyperlipidemia induced by a hypercholesterolemic diet in mice. Methods: After treatment with JHGB expert safety in cytotoxicity and toxicity of Human fibroblast cells and liver and kidney, effect on Reactive Oxygen Species, serum total cholesterol, LDL-cholesterol, triglyceride, glucose, HDL-cholesterol, lipid peroxid of liver tissue, significantly increased SOD and catalase. Results: 1. JHGB showed safety in cytotoxicity and toxicity of human fibroblast cells and liver and kidney. 2. JHGB showed significant inhibitory effect on reactive oxygen species. 3. JHGB significantly decreased serum total cholesterol, LDL-cholesterol, triglyceride, and glucose, and significantly increased serum HDL-cholesterol. 4. JHGB significantly decreased lipid peroxide of liver tissue and significantly increased SOD and catalase. Conclusions: These results suggest that Jehasuogamibang is effective in antioxidationactivity and dietary hyperlipidemia-induced mice.

• Journal of Nutrition and Health
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• 제33권1호
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• pp.49-58
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• 2000

The purpose of this study was to investigate the relationship among urn leptin, nutritional status, and urn lipids, glucose of 99 middle school girls residing in Kyluggi-do, Korea. Subjects were assigned to one of three groups such as underweight(BMI < 20, n=38), normal(20$\leq$BMI<25, n=36) and over weight(BMI$\geq$25, n=25) groups. The nutritional status of the subjects was evaluated by anthropometric measurements, questionnaires, 24-hr dietary recalls and blood anal),sis. The results were as follows : The mean age, body weight, height and BMI were 13.93 years, 55.19kg, 158.40cm and 21.96kg/㎡ respectively. The mean menarche age of the subjects was 12.64 years and the mean daily energy intake was 94.22% off RDA for Koreans. The energy ratio from carbohydrate fat and protein was 63: 24: 13. Underweight group showed the lowest intakes of oils and fats among three groups(p<0.05). The mean serum levels of leptin, glucose, total cholesterol, HDL-cholesterol. LDL-cholesterol and triglyceride were 10.57ng/ml 78.80mg/dl, 12.29mg/dl, 48.07mg/dl, 93.50mg/dl and 78.61mg/d1, respectively. The mean atherogenic index was 2.37. There were significant increases in serum leptin, glucose, LDL-cholesterol, triglyceride and atherogenic index of subjects with increases in their BMIs. Serum leptin showed a significantly positive correlation with BMI(p<0.001), body fat percent(p<0.001). When BMI was adjused, serum leptin showed a significantly positive partial correlations with intakes of animal protein(p<0.05), milks and animal foods(p<0.05), Serum leptin showed a significantly positive correlation with serum glucose(p<0.05) total cholesterol(p<0.01), LDL-cholesterol(p<0.001), triglyceride(p<0.001) and atherogenic index(p<0.001), however, it had significantly negative correlations with HDL-cholesterol(p<0.05). Therefore, these results suggest that the increase of serum levels of leptin may elevate the risk of cardiovascular disease and lipids and some nutrient intakes may be related with serum leptin levels. (Korean J Nutrition 33(1) : 49-58, 2000)

• Physical Therapy Rehabilitation Science
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• 제10권3호
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• pp.320-327
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• 2021

Objective: The community has implemented a variety of exercise programs for the elderly population. However, studies comparing changes in the cardiovascular system through body composition and blood analysis after applying aqua aerobic exercise are insufficient. The purpose of this study was to investigate the effect of a 12 weeks aqua exercise on body composition and cardiovascular index in elderly women. Design: Non-equivalence pre-post design. Methods: Thirty elderly women were assigned to aquarobic group(n=15) and control group(n=15). The aquarobic exercise was 60 minutes per every session, 2times per week, for 12weeks. Weight, skeletal muscle mass, body fat percentage, total cholesterol, triglyceride, HDL cholesterol, and LDL cholesterol were measured before and after the exercise program. Paired and independent t-tests were performed using SPSS program. Results: The result showed was weight(p<0.05), body fat percentage(p<0.05), total cholesterol(p<0.05), triglyceride(p<0.05), HDL cholesterol(p<0.05), and LDL cholesterol(p<0.05) were significantly decreased and skeletal muscle mass(p>0.05) was not significantly increased after aquatic exercise program. Conclusions: According to the study result, aqua exercise program made a positive effect in the improvement of obesity and cardiovascular function in elderly women. Therefore, we suggest that you actively consider implementing the Aquarobic exercise program when operating the community health promotion program in the future. In addition, in future studies, comparative studies according to various ages and genders and studies on the effects of aqua aerobic exercise as a community exercise program for chronically illness patients are needed.

• 한국가금학회지
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• 제36권4호
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• pp.311-316
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• 2009

본 시험은 하여 산란계 사료내 누에고치 산가수분해물 첨가시 생산성, 계란 품질, 혈액 성상에 미치는 영향을 조사하기 위하여 수행하였다. 41주령 Hy-Line Brown 갈색계 240수를 공시하여, 4주간 사양 시험을 실시하였다. 일반 무첨가 사료를 대조구로 하여 SP1(일반 사료+누에고치 산가수분해물 0.05%), SP2(일반 사료+누에고치 산가수분해물 0.1%), SP3 (일반 사료+누에고치 산가수분해물 0.2%)으로 총 4개 처리구였으며, 처리 당 5반복, 반복 당 12수씩 완전 임의 배치하였다. 산란율과 난중에 있어서 전체 시험 기간 동안 누에고치 산가수분해물 첨가 수준에 따라 처리구간의 차이를 보이지 않았다. 난각 특성을 나타내는 난각 강도와 두께는 처리구간에 유의적인 차이를 보이지 않았으나, 난황고와 Haugh unit에 있어서는 누에고치 산가수분해물을 첨가 급여한 처리구가 유의적으로 높게 나타났다(P<0.05). 면역 물질인 IgG 함량과 WBC 함량은 누에고치산가수분해물을 첨가한 SP1, SP2, SP3 처리구가 대조구와 비교하여 유의적으로 높게 나타났다(P<0.05). 누에고치 산가수분해물 첨가 급여는 산란계에서 혈액 내 총 단백질, 알부민 함량에 영향을 미치지 않았다. 그러나 혈청 내 인지질, HDL-cholesterol, LDL-cholesterol, total cholesterol 함량을 높여주었다. 사료 내 누에고치 산가수분해물 0.05% 이상 첨가 급여 시 계란의 신선도를 증가시키고, 산란계의 면역과 지질 대사에도 영향을 미치는 것으로 사료된다.

• Journal of Pharmaceutical Investigation
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• 제24권4호
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• pp.297-300
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• 1994

Development of hyperlipidemic animal model is prerequisite for the screening of drugs lowering the blood lipoprotein level. In this study, two kinds of diet regimens were tried for the hyperlipidemic effect. The model will be used for the screening of current prescriptions to a variety of diseases related to hyperlipidemia by practioner of traditional herbal medicine. Fifteen male Wister rats of 200g were divided into three groups, and given normal, or either one of the two high cholesterol diets for up to 2 weeks. Regimen HC-1 and regimen HC-2 contained I% and 2% cholesterol in diet, respectively. Total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL) and lower density lipoprotein cholesterol (LDL) levels in the serum were measured before the start of the diet, at 1 week after the start, and at 2 week point. Both regimens resulted in hyperlipidemia with the typical characteristics of increase in TC and LDL, and reduction in HDL, and showed no observable side effects such as diarrhea. In conclusion, both of HC-1 and HC-2 regimens appeared appropriate as diet regimens for the hyperlipidemic rat model.

• 대한약침학회지
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• 제10권1호통권22호
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• pp.109-119
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• 2007

In order to study the effects of Pinus densiflora on hyperlipidemia and lipid in rats, we divided the rats into groups(Normal group, Control group and Sample group) and perfomed the experimental research. Hyperlipidemia and lipid in rats were induced by high fat diets for 8weeks. The sample group was administerd the extract of Pinus densiflora for 14 days and control group was administerd equal dose of oral. And then we measured the amount of serum triglyceride, Total cholesterol, LDL-cholesterol, HDL-cholesterol, Free Fatty Acid, phospholipid, Insuline, Laptin, Body weight, epididymis fat weight & rate, epididymis fat cell, Cardiac Risk Factor(CRF). The results were as followers : 1. Sample Group showed decreasing effects on Total cholesterol, Trigylceride, LDL-cholesterol, and Phospholipid levels in serum and CRF significantly. 2. Sample Group showed increasing effects on HDL-cholesterol level in serum significantly. 3. Sample Group showed decreasing effects on Insuline in serum significantly. 4. Sample Group showed increasing effects on Laptin in serum significantly. 5. Sample Group showed decreasing effects on Body weight, epididymis fat weight & rate, epididymis fat cell significantly. According to the above results, Pinus densiflora showed significant decreasing effects on hyperlipidemia and lipid in rats, it is considered that it is appropriate to apply for hyperlipidemia, obesity.