Journal of Pharmaceutical Investigation
- Volume 24 Issue 4
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- Pages.297-300
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- 1994
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Studies on Diet Regimens for the Developement of Hyperlipidemic Animal Model
고지혈증 동물모델 설정을 위한 식이처방의 실험적 연구
- Ro, Hwan-Seong (College of Medicine, University of Ulsan) ;
- Kim, Oon-Ja (Asan Institute for Life Science) ;
- Park, Kun-Ku (Asan Institute for Life Science) ;
- Cho, Young-Hwan (Dept. of Pharmacy Asan Medical Center) ;
- Park, Hyung-Sup (College of Medicine, University of Ulsan)
- 노환성 (울산대학교 의과대학) ;
- 김운자 (아산생명과학 연구소 민간요법연구실) ;
- 박건구 (아산생명과학 연구소 민간요법연구실) ;
- 조영환 (아산재단 서울중앙병원 약제과) ;
- 박형섭 (울산대학교 의과대학)
- Published : 1994.12.20
Abstract
Development of hyperlipidemic animal model is prerequisite for the screening of drugs lowering the blood lipoprotein level. In this study, two kinds of diet regimens were tried for the hyperlipidemic effect. The model will be used for the screening of current prescriptions to a variety of diseases related to hyperlipidemia by practioner of traditional herbal medicine. Fifteen male Wister rats of 200g were divided into three groups, and given normal, or either one of the two high cholesterol diets for up to 2 weeks. Regimen HC-1 and regimen HC-2 contained I% and 2% cholesterol in diet, respectively. Total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL) and lower density lipoprotein cholesterol (LDL) levels in the serum were measured before the start of the diet, at 1 week after the start, and at 2 week point. Both regimens resulted in hyperlipidemia with the typical characteristics of increase in TC and LDL, and reduction in HDL, and showed no observable side effects such as diarrhea. In conclusion, both of HC-1 and HC-2 regimens appeared appropriate as diet regimens for the hyperlipidemic rat model.