• 생물정신의학
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• 제24권4호
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• pp.188-195
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• 2017

Objectives Schizophrenia is characterized by disturbances in perception and cognition. Attenuated mismatch negativity (MMN) reflects central auditory dysfunction in schizophrenia. The aim of this study is to compare MMN changes before and after treatment in schizophrenia patients and to assess their association with treatment response. Methods Twenty-three schizophrenia patients underwent an oddball paradigm. MMN was calculated by the difference waveforms of the event-related potentials (ERPs) elicited by subtracting standard from deviant stimulus. The clinical symptoms were measured by the Positive and Negative Syndrome Scale (PANSS), the Psychotic Symptom Rating Scale (PSYRATS). Follow-up evaluation was conducted when the PANSS total score decreased by 30% or more (treatment response group) or before discharge (non-response group). Results The treatment response group showed significantly larger MMN amplitude improvement and latency reduction than the non-response group after treatment (Fz ; mean amplitude p = 0.035, FCz ; p = 0.041). The auditory hallucination group showed shorter latency than that of the group without hallucinations. Additionally, auditory hallucination was associated with prolonged MMN latency and shortened after treatment in the auditory hallucination response group (Fz ; p = 0.048). Conclusions These results suggest that the attenuated MMN amplitude reflects the progression of the disease. The increment of MMN amplitude and shortening of latency after treatment may reflect cognitive functional recovery of central auditory sensory processing.

• 대한방사선기술학회지:방사선기술과학
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• 제41권4호
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• pp.313-319
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• 2018

The purpose of this study was to investigate the influence of metabolic syndrome (MS) on the lower urinary tract symptoms (LUTS), prostate specific antigen (PSA), and prostate volume in Korean men. We analyzed the data from 2654 men over the age of 40 who visited our health promotion center for regular health checkups. Of the total 2654 men, mean age, PSA level, International Prostate Symptom Score (IPSS), and prostate volume were 54.6 years, 1.21ng/ml, 6.2 points, and 27.8ml, respectively. All examinees were divided into MS group (46.5%, 1235 men) and non-MS group (53.5%, 1419). Age and prostate volume were significantly higher in the MS group. The patients were divided into three groups according to their ages: 40's, 50's, and over 60 years old. Prostate volume of the MS group in the younger age groups (40-49 years and 50-59 years) was significantly larger than that of the non-MS group. However, no difference was revealed in the age group of 60-69 years. No significant differences were found in the PSA level and LUTS between the MS and non-MS groups. In the multivariate regression analysis, central obesity was the strongest risk factor for the enlargement of prostate over 30ml among the metabolic components.

• Archives of Plastic Surgery
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• 제37권2호
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• pp.191-194
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• 2010

Treatments of severely incurved toenails cause anatomical changes and cosmetic problems, even though they provide adequate symptom relief. Incurved toenail patients treated with a K-D$^{(R)}$ (S&C Biotech, Seoul, South Korea) the new device for correcting curved nail deformity were investigated retrospectively. This study surveyed 12 patients(18 cases) who had been treated for severe ingrown toenails using K-D$^{(R)}$ from May 2008 to March 2009, and examined their subjective satisfaction before and after the treatment. The average age of the participants was 39 (ranging from 27 to 52), and 8 of them were male and 4 female. The treatment was applied after the patients were given a thorough explanation about the tool and the treatment, and questionnaire surveys were conducted before the treatment and after 3 months on the average from the treatment. In the survey, the respondents were asked about pain, restriction on activities, and the selection of shoes. For each item, symptoms with a given point were presented, and the respondents' scores were compared between the surveys before and after the treatment. According to the results of the questionnaire survey, pain increased from 14 out of 40 before the treatment to 39 after, activity restriction increased from 11 to 30, and shoe selection increased from 20 to 30. The average total score increased from 45 to 98, and this suggests a considerable enhancement in the patients' subjective satisfaction. The average period of the application of K-D$^{(R)}$ was $20.3{\pm}9.4$ days, and in all the cases, ingrown toenails were corrected within three weeks.

• 한국보건간호학회지
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• 제17권1호
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• pp.35-46
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• 2003

The purpose of this study was to examine the self-rated health and to find various factors affecting it for elderly women in a rural community, to provide data necessary to establish health promotion programs for elderly. The subjects of the study included a total of 245 women with above 70 years of age reside in one rural community. VAS (Visual Analogue Scale) for self-rated health, Lawton's physical & instrumental activity of daily living scales, social network were evaluated. The results of the study were as follows: 1. The self-rated health of the elderly women were measured on a 100 point(VAS) scale and the score was 53.6, indicating that women rated their health as moderate. 2. Factors such as income(p=0.008), family size(p=0.031), the level of ADL(p=0.039), urinary symptom(p=0.039), nocturia(p=0.001), visual difficulty(p=0.023), the number of chronic diseases(p=0.015), presence of arthritis or neuralgia(p=0.015), social network(p=0.002), housework assistant(p=0.008), emotional support(p=0.031) were significantly related to self-rated health. 3. Through the stepwise multiple regression, social network, family size, visual difficulty, and housework assistant were identified as significant predictors of self-rated health(p<0.05), explaining $21.0\%$ of the variance of the dependent variable. Better understanding of the determinants of healthy aging hopefully will lead to effective interventions to improve the quality of life of the elderly.

• 대한한방소아과학회지
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• 제20권1호
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• pp.1-14
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• 2006

Objective : As prevalence of atopic dermatitis(AD) rises and medicine of atopic dematitis develops, the methods of measurement for atopic dermatitis have developed. Therefore, we aimed to establish a new sconring system in oriental medicine for a childhood atopic dematitis, by comparison, analysis of various sconing systems. Method : We searched for the data related to severity sconing systems of atopic dermatitis in Entrez PubMed on abroad thesis and KISS(Korenstdued Information Service System) on domestic thesis from 1990 to 2005. Result : Severity sconing systems for atopic dermatitis satisfy validity, reliability, sensitivity of change and verification of this. The essential items of severity sconing systems are extent, intensity and subjective symptoms. The lesion is divided into 9 areas(head and neck, upper limbs, elbow, hands, trunk, hip and inguinal, lower limbs, knee, feet). The items of intensity are erythema, oedema and induration and papulation, oozing and weeping and erosion, excorition, scaling, lichenification. The subjective symptom is pruritis, evaluated according to sleep loss and obstruction of play and study. The extent and intensity is evaluated in combination. We suggested that extent and intensity occupied for 70% and subject symptoms accounted for 30% of total score.

• 수면정신생리
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• 제2권2호
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• pp.146-155
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• 1995

Jet lag can be defined as the cumulative physiological and psychological effects of rapid air travel across multiple time zone. The consequences of jet lag include fatigue, general malaise, sleep disturbances, and reductions of cognitive and psychomotor performance, all of which have been documented in experimental biological and air crew personnel studies. Thus authors tried to study the jet lag of natural travellers by modified self reporting sleep log. Total 61 healthy travellers was studied for 3 days before and 7 days after jet-flights across seven to ten time zone. The eastbound travelling group was 38 persons, aged 19 -70 and westbound travelling group was 23 persons, aged 13 - 69. Sleep onset time, wake-up time, sleep latency, awakening frequency on night sleep, awakening duration on night sleep, sleepiness at wake-up and nap length were evaluated. Our results suggested that the 7 to 10 time zone shift gave significant influence to traveller's sleep-wake cycles. The date which subjective physical condition was recovered on was $5.16{\pm}1.50$ day after arrivals for eastbound, while for westbound, $4.91{\pm}1.62$ day. In eastbound travelling, sleep onset time became later than baselines and could not recover until 7th day. But in westbound, it became earlier than baseline and could recover until 6th day. The mean score of 24-hour sleepiness was greater in eastboumd than westbound. Therefore the eastbound travelling caused more sleep-wake cycle disturbance and daytime dysfunction than westbound travelling. In other parameters, there was no definite difference between east and westbound. From our results, it was suggested that the symptom severity of jet lag was dependent on the travelling direction. To demonstrate more definite evidence, large sized data collections and comparision by age difference were needed.

• 디지털융복합연구
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• 제14권6호
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• pp.347-353
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• 2016

건성안은 다양한 환경노출로 인해 생길 수 있다. 본 연구에서는 눈에 자극감을 줄 수 있는 자외선 차단제와 건성안의 연관성에 대해 조사하고자 하였다. 총 30명(남28명, 여2명)을 대상으로 하여 비침입성 눈물막 파괴시간 검사(NIBUT)와 맥모니 설문, 자각설문을 실시하였다. 자외선 차단제를 바른 후의 NIBUT값이 바르기 전보다 감소하는 것을 알 수 있었고, NIBUT값의 차이가 심했던 C제품이 자각 설문에서도 가장 불편했다고 답변하였다. 자각 설문에서 자극이 있다고 답한 대상자는 15명(50%), 자극이 없다고 답한 대상자는 15명(50%) 이였으며, 자극이 있는 집단의 맥모니 설문 점수가 높게 나왔다. 건성의안 기준에서도 위와 같은 결과이었으며, 모두 경계성 유의성을 나타냈다(p=0.049, p=0.051). 본 연구를 통해 자외선 차단제가 눈에 영향을 줄 수 있고, 건성안에 연관이 있다는 것을 알 수 있었다. 디지털 환경 요인들로 인해서도 눈에 자극증상과 변화를 줄 수 있으므로 환경유해물질 및 디지털 환경이 눈건강에 미치는 영향을 파악하는 융합 연구가 필요할 것이다.

• 대한임상독성학회지
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• 제7권2호
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• pp.97-104
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• 2009

Purpose: Antivenin is a standard therapy in snakebite victims. While the required antivenin dose can be easily estimated, based on the initial symptoms, this strategy may be unsuccessful if the initial symptoms progressively worsen. The purpose of this study was to identify the progression rate of the initial symptoms following snakebite and its associated factors. Methods: The medical records of 44 patients treated for snakebite from give the actual dates of the study period were retrospectively examined. Thirty-two of these patients were enrolled. Demographic data, local wound grade and local effect score at initial presentation (G-0 and LES-0, respectively) and 12 hours after admission (G-12 and LES-12, respectively) were reviewed, along with laboratory data. Results: The 32 patients had an average age of $54.0{\pm}14.5$ years and were predominantly male (n=26) and presented mainly during summer. Compared to G-0 and LES-0, re-evaluated G-12 and LES-12 were significantly increased despite initial administration of proper antivenin dosage (p=0.001 and p=0.000, respectively). Total amounts of antivenin correlated with LES-12 (correlation co-efficiency 0.558, p<0.05). However, factors associated with symptom progression were not revealed. Conclusion: Initial snakebite symptoms might progressively worsen within hours despite acceptable initial antivenin therapy. Therefore, re-evaluation within several hours must be considered if when the initial snakebite symptoms are minimal or mild.

• Clinics in Shoulder and Elbow
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• 제21권1호
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• pp.30-36
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• 2018

Background: The Korean Shoulder Scoring System (KSS) is a reliable and valid procedure for discriminative assessment of the clinical status of patients with rotator cuff tears. This study evaluates the correlation between the preoperative KSS and factors in patients with rotator cuff tears. Methods: From November 2009 to June 2016, 970 patients who underwent arthroscopic rotator cuff repair were retrospectively evaluated. A total of 490 patients met the study criteria. Preoperative factors included age, sex, symptom duration, mediolateral (ML) and anteroposterior (AP) tear size, acromiohumeral distance (AHD), tangent sign, tendon involvement (type I, supraspinatus; type II, supraspinatus and subscapularis; type III, supraspinatus and infraspinatus; type IV, all 3 tendons), fatty infiltration of rotator cuff muscles (group I, Goutallier stages 0 and 1; group II, Goutallier stages 2, 3, and 4), and KSS. Results: Old age, ML tear size, and AP tear size negatively correlated with the preoperative KSS (p<0.001). AHD showed a positive correlation with the preoperative KSS (p<0.001). A significantly inferior preoperative KSS was found in females and type III tendon involvement (p<0.001). For supraspinatus and infraspinatus, the preoperative KSS of group II fatty infiltration showed a significantly lower score than group I fatty infiltration (p<0.05). Conclusions: A relatively lower preoperative KSS was associated with old age, large tear size, narrow AHD, female, type III tendon involvement, and group II fatty infiltration of the supraspinatus and infraspinatus. Our study indicates that preoperative KSS can be a good measurement for the preoperative status of patients with rotator cuff tears.

• Journal of Ginseng Research
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• 제39권1호
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• pp.7-13
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• 2015

Background: Many patients with glaucoma have difficulty using antiglaucoma eye drops because of dry eye symptom. In this prospective, randomized, double-blind, placebo-controlled study, we evaluated the effect of Korean Red Ginseng on dry eye syndrome in patients with glaucoma treated with antiglaucoma eye drops. Methods: Forty-nine participants were allocated to the Korean Red Ginseng (3 g/day; n = 24) or placebo (n = 25) groups for 8 weeks. Tear film stability, fluorescein corneal staining, conjunctival hyperemia, tear production, grade of meibomian gland dysfunction, and dry eye questionnaire (Ocular Surface Disease Index) were evaluated at baseline and on completion of the treatment. Results: Almost all patients displayed dry eye symptoms and signs at baseline. After the 8-week intervention, Korean Red Ginseng supplementation significantly improved the tear film stability and total Ocular Surface Disease Index score, as compared to placebo (p < 0.01). Conclusion: Korean Red Ginseng supplementation may provide an additional treatment option for dry eye and patients with glaucoma using antiglaucoma eye drops.