• Communications for Statistical Applications and Methods
• /
• v.16 no.3
• /
• pp.397-408
• /
• 2009

The development of microarray technology makes possible to analyse many thousands of genes simultaneously. While it is important to test each gene whether it shows changes in expression associated with a phenotype, human diseases are thought to occur through the interactions of multiple genes within a same functional cafe-gory. Recent research interests aims to directly test the behavior of sets of functionally related genes, instead of focusing on single genes. Gene set enrichment analysis(GSEA), significance analysis of microarray to gene-set analysis(SAM-GS) and parametric analysis of gene set enrichment(PAGE) have been applied widely as a tool for gene-set analyses. We describe their problems and propose an alternative method using a parametric analysis by adopting normal score transformation of gene expression values. Performance of the newly derived method is compared with previous methods on three real microarray datasets.

• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.1
• /
• pp.31-37
• /
• 2013

Background: Throughout Indonesia, thyroid cancer is one of the ten commonest malignancies, with papillary thyroid carcinoma (PTC) in our hospital accounting for about 60% of all thyroid nodules. Although fine needle aspiration biopsy (FNAB) is the most reliable diagnostic tool, some nodules are diagnosed as indeterminate and second surgery is common for PTC. The aim of this study was to establish the diagnostic value and feasibility of testing the BRAF T1799A mutation on FNA specimens for improving PTC diagnosis. Materials and Methods: This prospective study enrolled 95 patients with thyroid nodules and future surgery planned. Results of mutational status were compared with surgical pathology diagnosis. Results: Of the 70 cases included in the final analysis, 62.8% were PTC and the prevalence of BRAF mutation was 38.6%. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for BRAF mutation analysis were 36%, 100%, 100% and 48%, respectively. With other data findings, nodules with "onset less than 5 year" and "hard consistency" were proven as diagnostic determinants for BRAF mutation with a probability of 62.5%. This mutation was also a significant risk factor for extra-capsular extension. Conclusions: Molecular analysis of the BRAF T1799A mutation in FNAB specimens has high specificity and positive predictive value for PTC. It could be used in the selective patients with clinical characteristics to facilitate PTC diagnosis and for guidance regarding extent of thyroidectomy.

• Structural Monitoring and Maintenance
• /
• v.2 no.1
• /
• pp.19-34
• /
• 2015

One of the main causes of a limited use of nondestructive evaluation (NDE) technologies in bridge deck assessment is the speed of data collection and analysis. The paper describes development and implementation of the RABIT (Robotics Assisted Bridge Inspection Tool) for data collection using multiple NDE technologies. The system is designed to characterize three most common deterioration types in concrete bridge decks: rebar corrosion, delamination, and concrete degradation. It implements four NDE technologies: electrical resistivity (ER), impact echo (IE), ground-penetrating radar (GPR), and ultrasonic surface waves (USW) method. The technologies are used in a complementary way to enhance the interpretation. In addition, the system utilizes advanced vision to complement traditional visual inspection. Finally, the RABIT collects data at a significantly higher speed than it is done using traditional NDE equipment. The robotic system is complemented by an advanced data interpretation. The associated platform for the enhanced interpretation of condition assessment in concrete bridge decks utilizes data integration, fusion, and deterioration and defect visualization. This paper concentrates on the validation and field implementation of two NDE technologies. The first one is IE used in the delamination detection and characterization, while the second one is the USW method used in the assessment of concrete quality. The validation of performance of the two methods was conducted on a 9 m long and 3.6 m wide fabricated bridge structure with numerous artificial defects embedded in the deck.

• Wind and Structures
• /
• v.23 no.4
• /
• pp.313-350
• /
• 2016

Taipei 101 Tower, which has 101 stories with height of 508 m, is located in Taipei where typhoons and earthquakes commonly occur. It is currently the second tallest building in the world. Therefore, the dynamic performance of the super-tall building under strong wind actions requires particular attentions. In this study, Large Eddy Simulation (LES) integrated with a new inflow turbulence generator and a new sub-grid scale (SGS) model was conducted to simulate the wind loads on the super-tall building. Three-dimensional finite element model of Taipei 101 Tower was established and used to evaluate the wind-induced responses of the high-rise structure based on the simulated wind forces. The numerical results were found to be consistent with those measured from a vibration monitoring system installed in the building. Furthermore, the equivalent static wind loads on the building, which were computed by the time-domain and frequency-domain analysis, respectively, were in satisfactory agreement with available wind tunnel testing results. It has been demonstrated through the validation studies that the numerical framework presented in this paper, including the recommended SGS model, the inflow turbulence generation technique and associated numerical treatments, is a useful tool for evaluation of the wind loads and wind-induced responses of tall buildings.

• Research in Community and Public Health Nursing
• /
• v.29 no.1
• /
• pp.11-20
• /
• 2018

Purpose: To test the reliability and validity of the Korean version of the Person-centered Climate Questionnaire-staff version (KPCQ-S) in long-term care institutions. Methods: A total of 297 staff in long-term care institutions including nine nursing homes (NHs) and 4 long-term care hospitals (LTCHs) were included. The KPCQ-S was developed following the WHO guidelines of the process of translation and adaptation of instruments. An internal consistency using Cronbach's ${\alpha}$ was tested for reliability. Exploratory factor analysis (EFA) was used to examine the construct validity. Convergent and discriminant validity were examined using Pearson correlation. Results: EFA demonstrated the construct validity of the 14-item KPCQ-S with three-factor solutions, specifically three factors (safety, everydayness, and community) in NHs and four factors (safety, everydayness, community, and comprehensibility) in LTCHs. Convergent validity was found in the correlation with the work satisfaction (r=.55). The KPCQ-S showed satisfactory internal consistency reliability (Cronbach's ${\alpha}=.91$). Conclusion: The KPCQ-S is found to be a reliable and valid tool for measuring staff perceptions of the person centeredness of long-term care environments.

• Journal of Korean Academy of Nursing
• /
• v.24 no.3
• /
• pp.461-472
• /
• 1994

The main purpose of this study was to test the validity and reliability of FIPS as an assessment tool for pain in children. The subject were 81 children whose ages ranged from 3 to 14 years old who were experiencing pain from an intramuscular injection. 40 were being seen in a local primary hospital and 41 in a university hospital. The data were collected in two settings at a 6 month interval, the first was on Nov. 5th 1991 in a local clinic by one doctor, the second was on May 1st. 1992 in a university hospital by two nurse. McGrath's(1985) face interval cards and weight box scale which is a numeral scale that contains from one to five boxes of cards were used as measures. To analyze the subject's ability to use the face scale and weight box scale, statistical frequency was employed. To determine the difference in the rated pain in-tensity on the face interval scale and the weight box, Pearson correlation coefficient and t-test were employed. To compare the difference in the rated pain intensity of the face interval scale and the weight box scale according to subject's general characteristics, X²-test was employed. The findings were as follows : 1. The subject's ages were from 3 to 14 with a mean age of 8.3 years old. There were 54(66.7%) male children and 27(33.3%) female children. 2. The number of subjects who correctly displayed cards ranging from none to severe pain was 66(81.5%) and the number who correctly compared two cards 3 times was 73(90.l％). 3. Correlation coefficients between each level card of the FIPS and WBS (Weight Box Scale) were r=.52∼.80 P<0.01. 4. There was no statistical difference in rating of the intensity on the FIPS and WBS.(t=1.12∼l.02, P<0.22∼0.45). 5. The differences in rating pain intensity according to the children's general characteristics were re-lated to age(X²=8.94, P<0.05), but not to sex (X²=0.23, P=0.80).

• The Journal of Korean Institute for Practical Engineering Education
• /
• v.2 no.1
• /
• pp.64-70
• /
• 2010

The purpose of this study is to understand students' use intentions of Web Based Collaborative Learning (WBCL) system. To meet this purpose, we developed a research model based on the Decomposed TPB. This model contains 5 influencing factors: Explicit social influence(EXSI) and Implicit social influence(IMSI), Perceived Usefulness (PU), Perceived easy of use(PEOU), Perceived Playfulness(PP). Data was collected 254 university students from two different institutions. Also, the analysis is conducted to do the hypothesis testing by using PLS 3.0. The result shows that influence factors except PEOU have a important and significant impact on user Behavior Intention(BI). Using WBCL system and learning tool, team leader(that is referent) and members can be a good interaction. For these same reasons, We found that especialy Explicit social influence(EXSI) and Implicit social influence(IMSI) are special influence factors in reference group.

• Journal of Korea Game Society
• /
• v.15 no.5
• /
• pp.49-56
• /
• 2015

As the popularity of casual games, they are increasing the needs to satisfy personal dispositions and the gameplay requirements of the various users in the game development process. These require analysis of action patterns of gameplay of various users in the testing phase of the game development. In this paper, we propose a method to analyze action patterns of gameplay through Petri net model simulation with gameplay metrics data. The proposed method has practical simulation environments because of using gameplay metrics data, and it can analyze diversely like reachability, coverbility, and liveness given by Petri net model analysis. An application example of the proposed method using a Petri net modeling tool GPenSIM v4.0 is given to analyze the patterns of gameplay in game Pacman. The results of simulations is presented. The presented results show that the proposed method can analysis patterns of gameplay diversely.

• Transactions of the Korean Society of Machine Tool Engineers
• /
• v.16 no.5
• /
• pp.1-6
• /
• 2007

This paper presents a new experimental Servo-Parameter tuning technique for a 6-axes articulated robot manipulator, especially considering robot's dynamics. First of all, investigation for proportional gain of velocity control loop by using a Dynamic Signal Analyzer(DSA) is performed. Using the FUNCTION characteristic of DSA based on the Bode plot, the Bode plot of open loop transfer function can be obtained. In turn, the integral gain of a servo controller can be found out by using the integration time constant extracted from the Bode plot of open loop transfer function. In the meanwhile, the positional gain of the servo controller can be obtained by using the Bode plot of the closed loop transfer function. Using the experimental gain tuning technique proposed in this paper, the testing linear motion of DR6-II robot has been shown to be more accurate rather than the motion with a conventional(empirical) gain tuning technique in Doosan Mecatec Co., Ltd., by improving the dynamic response of the robot as well as synchronizing each joint velocity according to the positional command of an end-effector.

• Women's Health Nursing
• /
• v.16 no.1
• /
• pp.69-77
• /
• 2010

Purpose: This study aimed to develop a sexual rights awareness scale for female adults and to further examine the differences after educational sessions for sexual rights awareness with female adults. Methods: Convenient sampling was employed to recruit 152 participants. A self administered questionnaire was developed to explore adult females' understanding of sexual rights awareness. In the next phase, education was provided over 3 consecutive sessions to 28 female university students. Factor analysis and Cronbach's alpha were performed in order to test validity and reliability of the educational sessions. The Wilcoxon rank test was used to identify the differences between pretesting of sexual rights awareness knowledge and post testing after educational sessions was provided. Results: After conducting factor analysis, 5 factors explained 63.3% of the total variance, namely: I) sexuality education, II) prejudice & biasaberration, III) sexual satisfaction, IV) safe & equal sexuality, and V) sexual autonomy. A Cronbach's alpha of 17 items was 0.80. After the education sessions, there was a significant increase in sexual rights awareness. Conclusion: The Sexual rights awareness questionnaire is acceptable as a tool for measuring the level of education in studies. Future research should aim at conducting comparison studies of sexual rights awareness between sexes and cultural differences with larger populations which will further help to develop and to strengthen the rigor with in methodologies.