• Journal of the HCI Society of Korea
• /
• v.1 no.2
• /
• pp.1-8
• /
• 2006

This paper presents a development of new haptic API (Application Programming Interface) that is called K-$Touch^{TM}$ haptic API. It is designed in order to allow users to interact with objects by kinesthetic and tactile modalities through haptic interfaces. The K-$Touch^{TM}$ API would serve two different types of users: high level programmers who need an easy to use haptic API for creating haptic applications and researchers in the haptic filed who need to experiment or develop with new devices and new algorithms while not wanting to re-write all the required code from scratch. Since the graphic hardware based kinesthetic rendering algorithm implemented in the K-$Touch^{TM}$ API is different from any other conventional kinesthetic algorithms, this API can provide users with haptic interaction for various data representations such as 2D, 2.5D depth(height field), 3D polygon, and volume data. In addition, this API supports kinesthetic and tactile interaction simultaneously in order to allow users with realistic haptic interaction. With a wide range of applicative characteristics, therefore, it is expected that the proposed K-$Touch^{TM}$ haptic API will assists to have deeper recognition of the environments, and enhance a sense of immersion in environments. Moreover, it will be useful development toolkit to investigate new devices and algorithms in the haptic research field.

• Korean Journal of Clinical Pharmacy
• /
• v.6 no.2
• /
• pp.19-23
• /
• 1996

Carbamazepine is an anticonvulsant drug that has been shown to be as effective as phenytoin or phenobarbital in treatment of grand mal and complex partial seizures and is also approved as the drug of choice for treatment of the pain associated with trigerminal neuralgia. And the therapeutic or toxic effects of carbamazepine are better related to plasma concentration than to dosage, which can be attributed to interindividual variability in the pharmacokinetics. A slow rate of carbamazepine dissolution in the gastrointestinal tract is believed to be the cause of its relatively slow and erratic rate of absorption. For these reasons pharmacokinetic evaluation of newly formulated carbamazepine is neccessary. In this study, the bioequivalence in carbamazepine between the $TegretoI^{TM}$ CR tablet (Geigy Co.) and $Carmazepine^{TM}$ CR tablet (Myung In Co.) was evaluated. 12 normal volunteers (age $21\~27$ years old) was divided into two groups, and a randomized cross-over study was employed. The pharmacokinetic parameters ($C_{max},\;T_{max}$ and AUC) obtained of oral administration of each formulatim of carbamazepine 400 mg were evaluated and ANOVA was utilized for the statistical analysis of parameters. $C_{max}\;is\;8.26{\pm}3.1{\mu}g/ml\;(C.V.\;37.3\%)\;in\;TegretoI^{TM}\;and\;9.39\{pm}2.9{\mu}g/ml\;(C.V.\;30.5\%)$ in $Carmazepine^{TM},\;T_{max}\;is\;28.0{\pm}5.9\;hrs(C.V.\;21.1\%)$ in $Tegretol^{TM}\;and\;24.0{\pm}7.2\;hrs(C.V.\;30.2\%)$ in $Carmazepine^{TM}$ and AUC is $786.4{\pm}360.5{\mu}g{\cdot}hr/ml\;(C.V.\;45.8\%)$ in $TegretoI^{TM}\;and\;792.8{\pm}228.6{\mu}g{\cdot}hr/ml\;(C.V.\;28.8\%)$ in $Carmazepine^{TM}$, respectively. As the result of the data, two formulations are bioequvalent, and the lower C.V. of $Carmazepine^{TM}$ in every individual can be merit.

• Analytical Science and Technology
• /
• v.17 no.2
• /
• pp.108-116
• /
• 2004

The adsorption characteristics of raw and crosslinked chitosan for rare earth elements (REEs) have been studied. The range of optimum pH for the maximum adsorption was observed: pH 4.5~5.5 for $Nd^{3+}$, $Tm^{3+}$ on raw and crosslinked chitosan; pH 4.0~5.5 for $La^{3+}$ and $Ce^{3+}$ on crosslinked chitosan and pH 2.0 for those on raw chitosan. The adsorption rate of REE at pH 4.0 has been found in the order of $Er^{3+}$ > $Gd^{3+}$ > $Yb^{3+}$ > $Nd^{3+}$ > $Lu^{3+}$ > $Eu^{3+}$ > $Tm^{3+}$ > $Ho^{3+}$ > $Dy^{3+}$ > $La^{3+}$ > $Ce^{3+}$ > $Y^{3+}$ > $Pr^{3+}$ in single metal system and that of $Lu^{3+}$ > $Yb^{3+}$ > $Tm^{3+}$ > $Dy^{3+}$ > $Ho^{3+}$ > $Er^{3+}$ > $Eu^{3+}$ > $Gd^{3+}$ > $Nd^{3+}$ > $Y^{3+}$ > $La^{3+}=Ce^{3+}=Pr^{3+}$ in multi metal system. In the competitive adsorption of multi metal system, the amount of metal adsorption generally increased with increasing atomic number and with decreasing ionic radius. On the adsorption studies of metal ions on chitosan, the time of equilibrium adsorption which was reached at the maximum adsorption was about 5 hours. 83~95 % for $Nd^{3+}$ ion and 90~106 % for $Tm^{3+}$ ion, were recovered from the crosslinked chitosan.

• Journal of the korean academy of Pediatric Dentistry
• /
• v.39 no.4
• /
• pp.383-388
• /
• 2012

The aim of this study was to compare the compressive strength and the surface microhardness of Beautifil flow (Shofu, Kyoto, Japan) with $Filtek^{TM}$ Z350, Z350XT (3M ESPE, USA). Fifteen specimens from each material were fabricated for testing. Compressive strength was measured by using a universal testing machine at a crosshead speed of 1 mm/min. Surface microhardness values were measured by using Vickers hardness tester under 4.9 N load and 10 seconds dwelling time. The compressive strength of Group 2 $Filtek^{TM}$ Z350XT shows the highest value as $218.7{\pm}18.4$ MPa and Group 1 $Filtek^{TM}$ Z350 was $205.5{\pm}27.1$ MPa. Group 3 Beautifil flow F00 was $176.5{\pm}30.3$ MPa, and Group 4 Beautifil flow F10 was $173.4{\pm}26.2$ MPa. The compressive strength of Group 2 is higher than Group 3 and 4 (p < 0.05). The surface microhardness of Group 2 $Filtek^{TM}$ Z350XT shows the highest value as $39.1{\pm}2.1$ and Group 4 Beautifil flow F10 was $27.9{\pm}1.8$. And Group 3 Beautifil flow F00 was $23.1{\pm}1.1$, Group 1 $Filtek^{TM}$ Z350 was $20.4{\pm}0.9$. There was a statistical significant difference in surface microhardness between all groups (p < 0.05). In conclusion, the compressive strength of giomer was below the level of flowable composite resin. However, the surface microhardness of giomer is comparable to that of flowable composite resin. Giomer would be the good alternative to composite resin, if there is improvement of the compressive strength of giomer.

• Journal of Pharmaceutical Investigation
• /
• v.33 no.3
• /
• pp.229-235
• /
• 2003

The purpose of the present study was to evaluate the bioequivalence of two enalapril maleate tablets, $Renitec^{TM}$ (MSD Korea Ltd.) and $Enalace^{TM}$ (Welfide Korea Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). Twenty-four normal male volunteers, $22.33{\pm}2.55$ year in age and $66.54{\pm}8.30$ kg in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After two tablets containing 10 mg of enalapril maleate per tablet were orally administered, blood was taken at predetermined time intervals and concentrations of enalapril in plasma were determined using LC-MS-MS. Pharmacokinetic parameters such as $AUC_t,\;C_{max}\;and\;T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_t,\;and\;C_{max}$ untransformed $T_{max}$. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals for the log transformed data were acceptance range of log0.8 to log1.25$(e.g.,\;log1.02{\sim}log1.14\;and\;log1.03{\sim}log1.19\;for\;AUC_t\;and\;C_{max},\;respectively)$. The major parameters, $AUC_t,\;and\;C_{max}$, met the criteria of KDFA for bioequivalence indicating that $Enalace^{TM}$ tablet is bioequivalent to $Renitec^{TM}$ tablet.

• Journal of Pharmaceutical Investigation
• /
• v.29 no.1
• /
• pp.61-66
• /
• 1999

Bioequivalence of two terazosin tablets, the $Hytrine^{TM}$ (Il-Yang Pharmaceutical Co., Ltd.) and the $Hytrine^{TM}$ (Daewon Pharmaceutical Co., Ltd.), was evaluated according to the guideline of KFDA. Sixteen normal male volunteers $(21{\sim}30\;years\;old)$ were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After one tablet containing 2 mg of terazosin was orally administered, blood was taken at predetermined time intervals and the concentration of terazosin in serum was determined with a HPLC method using spectrofluorometric detector. The pharmacokinetic parameters $(AUC_t,\;C_{max}\;and\;T_{max})$ were calculated and ANOVA was utilized for the statistical analysis of the parameters. The results showed that the differences in $AUC_t$ $C_{max}$ and $T_{max}$ between two tablets were 6.02%,3.44% and -3.67%, respectively. The powers $(1-{\beta})$ for $AUC_t$, $C_{max}$ and $T_{max}$ were 98.05%, 98.34% and 29.81 %, respectively. Detectable differences $({\Delta})$ and confidence intervals were all less than ${\pm}20%$ except $T_{max}$. $AUC_t$ and $C_{max}$ met the criteria of KFDA for bioequivalence, indicating that $Terasin^{TM}$ tablet is bioequivalent to $Hytrine^{TM}$ tablet.

• Journal of Sensor Science and Technology
• /
• v.10 no.5
• /
• pp.314-319
• /
• 2001

In this study, the highly sensitive $CaSO_4$:Tm-PTFE TLDs has been fabricated for the purpose of measurement of high energy electron. $CaSO_4$:Tm phosphor powder was mixed with polytetrafluoroethylene(PTFE) powder and moulded in a disk type(diameter 8.5mm, thickness $90mg/cm^2$) by cold pressing. The batch uniformities were average deviation 3.1%. The TLDs were applied to measurement of absorbed dose distribution for high energy electron, the ranges were determined to be $R_{100}=14.5mm$, $R_{50}=24.1mm$ and $R_p=31.8mm$, respectively. The beam flatness were 4.5% as the variation of dose relative to the central axis over the central 80% of the field size at a maximum dose depth in a plane perpendicular to the central axis.

• Restorative Dentistry and Endodontics
• /
• v.22 no.2
• /
• pp.680-692
• /
• 1997

New bonding agent systems have been supplied which operators can simply apply to conditioned tooth surfaces. The purpose of this study was to evaluate the shear bond strengths and the microleakages of three bonding agents and composite resins to dentin. Seventy-five extracted human maxillary and mandibular molar teeth were used in this study. For the shear bond strength test, the entire occlusal dentin surfaces of thirty teeth were exposed with Diamond Wheel Saw and smoothed with Lapping and Polishing Machine (South Bay Technology Co., U.S.A). For the microleakage test, Class V cavities were prepared in the buccal surfaces of fourtyfive teeth. They were randomly assigned into 3 groups according to dentin bonding agents ($Scotchbond^{TM}$ Multi-Purpose plus, ONE-$STEP^{TM}$ and Prime & $Bond^{TM}$)and composite resins (Z-100, $Aelitefil^{TM}$ and TPH $Spectrum^{TM}$) to be used. Bonding agents and composite resins were bonded to exposed dentin surfaces of the tooth crown and to Class V cavities on the buccal surfaces respectively according to manufacturer's directions. The shear bond strengths were measured by universal testing machine($U^{TM}$ AGS-100, Japan). In addition, the degree of micro leakage at the occlusal and gingival margin was examined by 2 % methylene blue and stereomicroscope(Olymous SZH 10, Japan). The results were as follows: 1. The shear bond strength to dentin was the highest value in SBMP-Plus group($16.68{\pm}7.38$ MPa) and the lowest value in Prime & Bond group($11.61{\pm}5.82$ MPa), but there was no significant difference of shear bond strength among three groups. 2. The degree of microleakage at both occlusal and gingival margin was showed the lowest in SBMP-Plus group and the highest in ONE-STEP group. 3. At both occlusal and gingival margin, there was significant difference of microleakage between SBMP-Plus and ONE-STEP/ Prime & Bond groups(p<0.05), but no significant difference of microleakage between ONE-STEP and Prime & Bond group(p>0.05).

• Geophysics and Geophysical Exploration
• /
• v.14 no.3
• /
• pp.185-190
• /
• 2011

In marine controlled-source electromagnetic (CSEM) modeling, it may be difficult to evaluate primary fields accurately using conventional linear filters because they decay very rapidly with distance. However, since there exists a closed-form solution to the Hankel transform in TM mode for a homogeneous half space, we can assess the accuracy of linear filters for evaluating the Hankel transform. As a result, only nine out of 36 source-receiver pairs show that EM fields decrease linearly in semi-log scale with an increase of source-receiver distance, while EM fields are either 0 or not reduced significantly due to an effect of the air layer. There also exist closed-form solutions for the nine pairs, and the others can be evaluated accurately with a relatively short filter. This paper proposes a method which uses closed-form solutions for TM-mode Hankel transforms and a filter with 61 coefficients for TE-mode ones.

• Korean Journal of Remote Sensing
• /
• v.21 no.3
• /
• pp.173-188
• /
• 2005

The present study aims to derive and compare narrow and broad bandwidths of ocean color sensor’s algorithms for the study of monitoring highly dynamic coastal oceanic environmental parameters using high-resolution imagery acquired from Multi-spectral Camera (MSC) on KOMPSAT-2. These algorithms are derived based on a large data set of remote sensing reflectances ($R_{rs}$) generated by using numerical model that relates $b_b/(a + b_b)$ to $R_{rs}$ as functions of inherent optical properties, such as absorption and backscattering coefficients of six water components including water, phytoplankton (chl), dissolved organic matter (DOM), suspended sediment (SS) concentration, heterotropic organism (he) and an unknown component, possibly represented by bubbles or other particulates unrelated to the first five components. The modeled $R_{rs}$ spectra appear to be consistent with in-situ spectra collected from Korean waters. As Kompsat-2 MSC has similar spectral characteristics with Landsat-5 Thematic Mapper (TM), the model generated $R_{rs}$ values at 2 ㎚ interval are converted to the equivalent remote sensing reflectances at MSC and TM bands. The empirical relationships between the spectral ratios of modeled $R_{rs}$ and chlorophyll concentrations are established in order to derive algorithms for both TM and MSC. Similarly, algorithms are obtained by relating a single band reflectance (band 2) to the suspended sediment concentrations. These algorithms derived by taking into account the narrow and broad spectral bandwidths are compared and assessed. Findings suggest that there was less difference between the broad and narrow band relationships, and the determination coefficient $(r^2)$ for log-transformed data [ N = 500] was interestingly found to be $(r^2)$ = 0.90 for both TM and MSC. Similarly, the determination coefficient for log-transformed data [ N = 500] was 0.93 and 0.92 for TM and MSC respectively. The algorithms presented here are expected to make significant contribution to the enhanced understanding of coastal oceanic environmental parameters using Multi-spectral Camera.