• Archives of Reconstructive Microsurgery
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• v.19 no.1
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• pp.46-49
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• 2010

Purpose: It has been reported that the ear perfusion can maintain by a very small pedicle because the ear has good vascularized system. Replantation of an amputated ear with vascular anastmosis, has been reported before and offers the succeessful reconstructive results. But, in this paper we report a case of complete nonmicrosurgical salvage of a nearly amputated ear based on 7 mm-wide small skin pedicle with adjunctive therapies. Methods: A 49-year-old man was referred with a nearly complete detachment of left ear. The blood supply to the ear was maintained exclusively on 7 mm-wide small skin pedicle in the lobule. After we identified the fresh bleeding at the distal margin of the detached ear, we performed the primary repair. At the end of the procedure, the areas of the concha bowl and helical root appeared to be congested. So the immediate postoperative treatment for improving the tissue survival was done with Lipo-Prostaglandin E1 (Eglandin$^{(R)}$) injection, leech apply and antibiotics medications. Results: Assessment of the replanted ear on postoperative day 14 revealed a nearly viable auricle including the helical root. The ear appeared to be entirely healed, with excellent projection and fully restored normal elasticity. Conclusion: We found the complete salvage of a nearly amputated ear based on 7 mm-wide small skin pedicle with adjunctive therapies including Lipo-Prostaglandin E1 (Eglandin$^{(R)}$) injection, leech apply and antibiotics without microsurgery.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.4
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• pp.1253-1259
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• 2012

The 14-3-3 proteins are highly conserved, ubiquitous molecules involved in a variety of biologic phenomena, such as cell cycle control, and apoptosis. However, their expression in cholangiocarcinoma has not been previously characterized. In this paper, immunohistochemistry using specific anti-14-3-3 monoclonal antibodies was performed on formalin-fixed;, paraffin embedded archival tissue from 86 patients of cholangiocarcinoma. We also examined the correlation between expression and survival rate and clinicopathologic factors such as tumor location, tumor size, pathologic differentiation, lymphatic permeation, lymph node metastasis, and tumor stage. Positive 14-3-3 proteins expression was observed for 6 isoforms (${\beta}$, ${\sigma}$, ${\gamma}$, ${\theta}$, ${\delta}$, ${\eta}$) of these proteins in 86 patients of cholangiocarcinoma. ${\beta}$ and ${\sigma}$ isoform immunoreactivity was correlated with lymph node metastasis, tumor stage and patients' survival rate. In addition, ${\delta}$ isoform immunoreactivity showed trends with tumor location, tumor size, pathologic differentiation and tumor stage, while the ${\theta}$ isoform was correlated with pathologic differentiation. These results indicated that upregulated expression of some isoforms of 14-3-3 may be a common mechanism for evading apoptosis in cholangiocarcinoma, so that targeting 14-3-3 may be a novel promising strategy for the treatment of this tumor.

• Korean Journal of Poultry Science
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• v.14 no.2
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• pp.89-96
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• 1987

The purpose of this paper to present morphological normal chick chromosomes and develope avian cytogenetic techniques including chromosome preparation and banding technique. The early chick embryos provide a consistent source of material with hish mitotic cells. Although chick embryo tissue gives excellent preparations, the 4-5 days embryo is somewhat incovenient materials, Most imp of ant for avian Chromosome analysis are the technical protocols to achieve adequate preservation, spreading, and staining of the full chromosome complement. To precise chromosome analysis, pro-metaphase states are required. Best results of banding will be obtained from air dried slides prepared from early chick embryos that have been aged at least 1 week. Good G-banding differentiation is achieved by adequate trypsin digestion fellowed by staining in Goe,sa dye. The results of C-banding is influenced by many factors including the conditions of Ba(OH)$_2$, HCl treatment, and state of rinsing. In addition to precisely interprets banding patterns, the densitometric analysis is recommended.

• Archives of Craniofacial Surgery
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• v.13 no.2
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• pp.139-142
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• 2012

Purpose: To reconstruct the midface, local flaps such as nasolabial flaps have been frequently used. These local flaps, however, have the shortcomings of requiring a secondary operation or limitations in the movement of the flap. Thus, new methods have been developed. This paper reports a case wherein the basal cell carcinoma on the cheek was resected and the skin and soft tissue defect was successfully treated using a facial artery perforator flap. Methods: A 68-year-old female consulted the authors on the basal cell carcinoma that developed on her cheek. The mass was fully resected and revealed a $2.3{\times}2.3cm$ defective region. Using a Doppler ultrasonography, the facial artery path was traced, and using a loupe magnification, the facial artery perforator flap was elevated and the defective region was covered with the flap. Results: The flap developed early venous congestion, but it disappeared without any treatment. Six months after the surgery, the patient was satisfied with the postoperative result. Conclusion: The facial artery perforator flap has a thin pedicle. It offers a big arc of the rotation that allows free movement and one-stage operation. These strengths make the method useful for the reconstruction of the midface among other procedures.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.38 no.6
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• pp.721-734
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• 2001

This paper proposed automated methods for the detection of breast mass. We analysed characteristic of the mass by using the features on mammograms. The homogeneity was used to distinguish mass and abnormal homogeneous tissue from the Cooper's ligament and multiple threshold method was used to deal with the high density candidates. By using the 8-connectivity, the first step candidates were selected. We generated the dualistic images of each candidate in which we regard the gray value as topographic height information. From these candidates, the second candidates were selected by comparing the circularity and the distribution rates. The final detection was done with the method in which we generated the template of each candidate and compared each other. From these methods, we grade the order from the candidate. We applied the algorithm to the 136 mammograms and compared to the radiologist's outlines of the leisions. The detection resulted that the sensitivity of the proposed methods was 93.38% and 97.63% FP(False positive) which we can segmented mass in the first grade in the 124 cases.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.46 no.12
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• pp.102-107
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• 2009

As technology gets developed, medical equipments are also modernized and leading-edge systems, such as PACS become popular. Many scientists noticed importance of medical image processing technology. Technique of region segmentation is the first step of digital medical image processing. Segmentation technique helps doctors to find out abnormal symptoms early, such as tumors, edema, and necrotic tissue, and helps to diagnoses correctly. Segmentation of white matter, gray matter and CSF of a brain image is very crucial part. However, the segmentation is not easy due to ambiguous boundaries and inhomogeneous physical characteristics. The rate of incorrect segmentation is high because of these difficulties. Fuzzy-based segmentation algorithms are robust to even ambiguous boundaries. In this paper a modified Fuzzy-based segmentation algorithm is proposed to handle the noise of MR scanners. A proposed algorithm requires minimal computations of mean and variance of neighbor pixels to adjust a new neighbor list. With the addition of minimal compuation, the modified FCM(mFCM) lowers the rate of incorrect clustering below 30% approximately compared the traditional FCM.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.44 no.2 s.314
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• pp.10-17
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• 2007

The echo signal on ultrasonic transducer is a mixed signal from tissues, blood vessel walls, blood cells and noise. In this mixed-signal, the signal reflected from tissues and blood vessel walls is called clutter. It is necessary to extract pure blood signal from this mixed-signal, when measuring blood flow velocity with medical ultrasonic system The quality of measured blood flow velocity is highly dependent on sufficient attenuation of the clutter signals. In this paper, we suggest a clutter rejection method using ICA For simulation, the echo signals are generated by Field n ultrasonic simulation program In this echo signals, independent signals are separated by using ICA Then the blood signal is obtained from the separated signals. Blood flow velocity is measured by 2D autocorrelation method. We compare ICA clutter rejection method with PCA-based eigen filter method using both measured blood flow velocity profiles by 2D autocorrelation. In simulation results, ICA clutter rejection method can be better applied measuring blood flow velocity in noisy echo signals.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.28 no.4
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• pp.279-285
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• 2017

In this paper, the resonator with a parallel plate capacitor is newly proposed around sub-microwave frequency band and applied to earlobe for non-invasive glucose monitoring the human biological tissue. The capacitor including the earlobe as dielectric material is connected to inductive slot in the ground plane of the microstrip line. Based on the simulation, one port resonator circuit is designed and fabricated as a prototype. Three step glucose concentration levels(0, 250, 500 mg/dL) was tested, and its reflection coefficients($S_{11}$) were measured. Owing to high Q resonator more than 100, resonant frequency shift of about 9 MHz per glucose level of 250 mg/dL has been successfully measured. This proves that the proposed sensor is applicable to a blood glucose sensor.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.38 no.3
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• pp.166-170
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• 2012

Calcifying epithelial odontogenic tumor (CEOT) is a rarely reported benign tumor, accounting for 0.4-3% of all odontogenic tumors. Approximately 150 cases have been reported in the literature between 1958 and 2003. The age range of CEOT varies from 8 to 92 years with mean of 36.9 years, and the occurrence of the lesion in both genders is almost equal. It has 2 clinico-topographic variants: the intraosseous (94%) and the extraosseous (6%) type. The intraosseous type has a predilection for mandible (maxilla : mandible ratio of 1 : 2). The intraosseous CEOT commonly associated with non-erupted teeth accounts for more than half (52%) of the cases and usually appears as painless swelling that causes bony expansion. The location of diffused round-shaped calcifying material is inside the connective tissue stroma and epithelial islands. The tumors tend to be located toward the tooth crown, which usually has a unilocular radiolucent region containing variant radiopaque materials radiologically. In this paper, we report a case of CEOT occurring in the left mandibular first premolar of a 23-year-old female and present a brief review of the literature.

• The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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• v.18 no.2
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• pp.9-21
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• 2012

Background: The purpose of this study was to analysis and to give information about the type of orthopedic manual physical therapy research by KAOMPT Journal from 1995 (Volume 1) to 2011 (Volume 17). The number of research paper were total 212 studies. Method: The studies were analysed with retrospective descriptive study. The results of data analysis was as follow; Results & Conclusion: 1. The studies was analysed 6 study field; manual therapy for disease field (130 studies), the therapeutic (16 studies), the effects of manual therapy education method, learning model (7 studies), medical insurance, history, politics of manual therapy (3 studies), and others (19 studies). 2. In the manual therapy of disease field, there were 4 groups of disease; bone disease (43 studies), soft tissue and muscles disease (57 studies), nerve disease(24 studies), and the others (6 studies). The main disease were low back pain, stroke, HIVD. 3. In the assessment, and intervention field, there were only 5 studies during from 1995 to 2000, but the studies from 2001 to 2011 were more increased 21 studies. 4. In the effects of manual therapy education method, learning model, there were very few studies (7 studies), so it will be needed more studies in this field. 5. In the other fields such as more political issue, history, medical insurance for the manual therapy there were few studies, so it will be needed more advanced studies in this field.