• Molecules and Cells
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• v.19 no.2
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• pp.289-293
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• 2005

BAF53 is an actin-related protein that shuttles between nucleus and cytoplasm. In the nucleus, it constitutes an integral component of many chromatin-modifying complexes such as the SWI/SNF, TIP60, TRRAP, and TIP48/49 complexes. BAF53 is essential for growth, but its function remains elusive. BAF53 homologues from yeast to humans have a conserved N-terminal motif, MS_(G/A)(G/A)__(V/L)YGG, which is unique to these proteins. Previously we showed that over-expression of an N-terminal deletion mutant of BAF53 ($BAF53_-{\Delta}N$) reduced the viability of HEK293 and HeLa cells. When we replaced the serine 2 and tyrosine 6 of this N-terminal motif with alanine, over-expression of the alanine-replaced BAF53 strongly impaired the growth of HEK293 cells whereas replacement with aspartate/glutamate had no effect. The alanine-replaced BAF53 mutants also stimulated p53-dependent transcription, in which the SWI/SNF and TRRAP complexes are involved. Our results demonstrate that serine 2 and tyrosine 6 play important roles in BAF53 activity.

• Archives of Plastic Surgery
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• v.43 no.1
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• pp.46-52
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• 2016

Background The loss of nasal tip support is caused by many factors and eventually results in the collapse and eventual dropping of the nasal tip. This reduces the nasolabial (NL) angle and negatively affects respiratory functions and one's appearance. Methods The aim of this retrospective study, which was conducted on 52 patients, was to present and popularize a simple and effective method for the reconstruction of a weakened columella by inserting an autologous ear cartilage graft using a sublabial approach. Results Of all the patients, three patients experienced transplant rejection. The period of follow-up observation was one to five years (mean, 27 months). The results were objectively evaluated by measuring the NL angle in standardized photos before and after the procedure at different time intervals over the follow-up period. We observed a significant increase of the NL angle (mean, $20^{\circ}$), and found these results to be durable over the long term. Of the 52 patients included in this study observed patients, three were dissatisfied (due to immediate infection and shifting of the strut), 28 were satisfied, and 21 were very satisfied. Conclusions The surgical method described here is simple and can be learned quickly. It has very good results with few complications, and is our method of choice for complex and serious cases seen in everyday rhinosurgical practice.

• Fire Science and Engineering
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• v.25 no.3
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• pp.63-71
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• 2011

In this study, it was evaluated the fire risk of an electric heater as representative seasonal appliances. Two type of electric heaters were used in experiments. When electric heaters were operated, temperature variation was measured around the heater. Internal structure was understood by Nondestructive inspection. It was evaluated the tire risk of electric heaters, when flammable materials were positioned ear a heater. It was also estimated the probability of a tire in case of malfunction of a safety tip-over witch. When a heater was operated in a normal condition, temperature was maintained under $80^{\circ}C$ around the heater. The possibility of a fire is very high, when a heater is covered with flammable materials or malfunction of safety parts (safety tip-over switch, anti-overheating devices).

• Transactions of the Korean Society of Automotive Engineers
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• v.15 no.3
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• pp.47-53
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• 2007

To suppress the bubble generated in the liquid LPG direct injector is the most important to develop the LPDi engine. It was found in the previous study that bubbling phenomenon in the injector of the LPDi engine is decisively influenced by pressure of fuel and temperature around the injector. Therefore, in this study, the effect on suppressing the bubbling in the LPDi injector by high pressurization of fuel is analyzed and the spray characteristics are also studied. As a result, it is found that the bubbling in the LPDi injector is radically suppressed when the pressure of fuel is over 50MPa. The bubbling is suppressed when the pressure of fuel is over 3MPa if the inserted position of the injector is considered. Also, it is confirmed that the higher the pressure of fuel is the longer spray tip penetration and is the larger spray angle. As the ambient pressure increases, spray tip penetration decreases and spray angle increases due to the increase of drag force.

• Ocean Systems Engineering
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• v.5 no.2
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• pp.125-138
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• 2015

In this study, hydrodynamic performance of a 400 mm diameter horizontal axis marine current turbine model was tested in a cavitation tunnel with 1.21 m x 0.8 m cross-section for over a range of tip speed ratios. Torque and thrust data, as well as cavitation visualizations, for certain operating conditions were acquired. Experimental results indicated that the turbine can be exposed to significant amount of sheet and cloud cavitation over the blades along with vortex cavitation at the blade tips. Inception and distribution of cavitation along the blades of the model turbine were then modelled numerically for design operating conditions using a vortex lattice method. The method was also applied to a turbine tested previously and obtained results were compared with the data available. The comparison between simulation results and experimental data showed a slight difference in terms of span-wise extent of the cavitation region. The cloud and tip vortex cavity observed in experiments cannot be modelled due to the fact that the VLM lacks the ability to predict such types of cavitation. Notwithstanding, the use of such prediction methods can provide a reasonably accurate approach to estimate, therefore take the hydrodynamic effects of cavitation into account in design and analysis of marine current turbines.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.28 no.3
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• pp.330-337
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• 2004

Analysis of flow phenomena in a centrifugal compressor impeller has been carried out with numerical simulation to understand the physics of flow near stall. Near stall point, tip leakage flow spills ahead of the leading edge of adjacent blade and other leakage flow passes over the clearance of the adjacent blade instead of rolling up into vortex within the passage. The tip leakage flow at the mid chord of impeller blade impinges against the pressure surface of the adjacent blade and then rolls up into vortex within the passage, which blocks the flow passage and generates viscous loss. The spillage of leakage flow ahead of the adjacent blade generates the recirculation of flow entering the impeller, which causes the power transferred into the flow by the impeller to decrease and blocks the flow passage. Near diffuser hub wall, flow recirculation occurs. As operating point goes to stall point, the core of recirculation approaches the impeller exit The length rises to peak point and then drops with mass flow reduction, while the height steadily rises.

• Journal of the Korean Society for Precision Engineering
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• v.21 no.12
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• pp.167-173
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• 2004

Recently, it has been reported that frictional behavior at nanometer scale can be different from that at macro scale. In this article, friction and wear tests were conducted using an AFM to investigate the effect of real contact area on the coefficient of friction and wear property. SiO$_2$, Hica, and SiGe were used in friction test and the AFM tip was Si$_3$N$_4$. The real contact area between an AFM tip and flat surface was calculated by the Johnson-Kendall-Roberts (JKR) theory. Wear specimen was Mica, and the diamond tip was used. We found that the coefficient of friction is constant below a critical area, but it is degraded over the area. Moreover, it is found that wear depth increased rapidly from a certain load and was degraded as a function of the number of the scanning cycles. Also, the range of scanning velocity used in this study had little effect on the wear depth.

• Journal of Ocean Engineering and Technology
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• v.16 no.6
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• pp.18-24
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• 2002

The vibrational system in this study consists of a cantilever pipe conveying fluid, the moving mass upon it, and an attached tip mass. The equation of motion is derived by using the Lagrange equation. The influences of the velocity and the velocities of fluid flow in the pipe have been studied on the dynamic behavior of a cantilever pipe using a numerical method. While the moving mass moves upon the cantilever pipe, the velocity of fluid flow and the nozzle angle increase; as a result, the tip displacement of the cantilever pipe, conveying fluid, is decreased. After the moving mass passes over the cantilever pipe, the tip displacement of the pipe is influenced by the potential energy of the cantilever pipe and the deflection of the pipe; the effect is the result of the moving mass and gravity. As the velocity of fluid flow and nozzle angle increases, the natural frequency of he system is decreased at the second mode and third mode, but it is increased at the first mode. As the moving mass increases, the natural frequency of the system is decreased at all modes.

• Corrosion Science and Technology
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• v.11 no.1
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• pp.29-36
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• 2012

The resistance spot welding of high strength steel degrades the weldability because of its high strength with rich chemical composition and coating layer to protect from corrosion. During the each resistance welding process the electrodes tip reacts with coating layer, then subsequently deteriorates and shorten electrode life. In this study, the Al-coated HPF (Hot Press Forming) steels and Zn-coated TRIP steels were used to investigate the electrode life for resistance spot welding. Experimental results show that the reactivity of Al-coating on HPF steels to electrode tip surface behaviors different from the conventional Zn-coated high strength steels. The electrode tip diameter and nugget size in electrode life test of Al-coated HPF steels are observed to be constant with respect to weld numbers. For Al-coated HPF steels, the hard aluminum oxide layer being formed during high temperature heat treatment process reduces reactivity with copper electrode during the resistance welding process. Eventually, the electrode life in resistance spot welding of Al-coated HPF steels has the advantage over the galvanized steel sheets.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.7 no.1
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• pp.7-11
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• 2006

Through SCM modeling, we found that the depletion layer in silicon was of a form of a spherical capacitor with the SCM tip biased. Two-dimensional (2D) finite differential method code with a successive over relaxation (SOR) solver has been developed to model the measurements by SCM of a semiconductor wafer that contains an ion-implanted impurity region. Then, we theoretically analyzed the spherical capacitor and determined the total depleted-volume charge Q, capacitance C, and the rate of capacitance change with bias dC/dV. It is very important to observe the depleted carriers' movement in the silicon layer by applying the bias to the tip. So, we calculated the depleted-volume charge, considering different factors such as tip size, oxide thickness, and applied bias (dc+ac), which have an influence on potential and depletion charges.