• Title/Summary/Keyword: Time-of-flight(TOF)

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Low-noise fast-response readout circuit to improve coincidence time resolution

  • Jiwoong Jung;Yong Choi;Seunghun Back;Jin Ho Jung;Sangwon Lee;Yeonkyeong Kim
    • Nuclear Engineering and Technology
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    • v.56 no.4
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    • pp.1532-1537
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    • 2024
  • Time-of-flight (TOF) PET detectors with fast-rise-time scintillators and fast-single photon time resolution silicon photomultiplier (SiPM) have been developed to improve the coincidence timing resolution (CTR) to sub-100 ps. The CTR can be further improved with an optimal bandwidth and minimized electronic noise in the readout circuit and this helps reduce the distortion of the fast signals generated from the TOF-PET detector. The purpose of this study was to develop an ultra-high frequency and fully-differential (UF-FD) readout circuit that minimizes distortion in the fast signals produced using TOF-PET detectors, and suppresses the impact of the electronic noise generated from the detector and front-end readout circuits. The proposed UF-FD readout circuit is composed of two differential amplifiers (time) and a current feedback operational amplifier (energy). The ultra-high frequency differential (7 GHz) amplifiers can reduce the common ground noise in the fully-differential mode and minimize the distortion in the fast signal. The CTR and energy resolution were measured to evaluate the performance of the UF-FD readout circuit. These results were compared with those obtained from a high-frequency and single ended readout circuit. The experiment results indicated that the UF-FD readout circuit proposed in this study could substantially improve the best achievable CTR of TOF-PET detectors.

Usefulness estimating of Time of flight(TOF) during Carotid angio inspection including Aortic arch (Aortic arch를 포함한 Carotid angio 검사 시 Time of flight(TOF)의 유용성 평가)

  • Yoo, Yeong-Jun
    • Korean Journal of Digital Imaging in Medicine
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    • v.15 no.1
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    • pp.1-7
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    • 2013
  • Purpose : The Carotid Angio inspection including Aortic arch applied to wide area is conducted as the Contrast Enhance MR Angiography(CEA) which is using a contrast medium. However it is a burden not only for someone such as infants, pregnant women and patients suffering from kidney failure but continuous use of contrast medium also can be a burden for patients who has been taken follow up inspection since diagnose lesion already. The purpose of this study is to estimate a usefulness of the Time of Flight (TOF) by comparing with CEA. Materials and methods : 10 patients with an average age of 58 (from 45 to 75) who had MRA inspection in our hospital were studied using 3.0 Tesla Aachieva (Philips, Netherland) MRI system and Sense Neuro-Vascular 16 Channels Coil. The same patient was inspected both TOF and CEA simultaneously. The TOF inspection included from Aortic arch to Willis Circle by connecting 3 TOF stacks and so did CEA inspection. The quantitative analysis was conducted through signal to noise ratio(SNR) and contrast to noise ratio(CNR) with soft tissue by setting up an area of interest on CCA bifurcatoin, ICA, ECA, MCA and VA concerning obtained image. In case of qualitative analysis, 3 radiological technologists and 1 radiologist evaluated 4 items (1: Visibility of the blood vessel, 2: Image distortion measure, 3: Overlapping measure with vein, 4: Peripheral blood vessel description measure) into five points scale (1: Very bad, 2: Bad, 3: Normal 4: Good, 5: Very good). Results : Results for the quantitative analysis was obtained by calculating the average of 5 ROIs in case of SNR and CNR separately. Results of SNR, TOF were generally measured higher than CEA (In case of TOF were 166.1, 205.2, 154.39, 172.23, 161.95, and CEA were 92.05, 95.43, 84.76, 73.69, 88.3). But according to the result of CNR, both TOF and CEA were measured similarly as 67.62, 106.71, 55.9, 73.74, 63.46 for TOF and 67.82, 71.19, 60.52, 49.45, 64.07 for CEA. Throughout every results of each ROI, SNR showed statistically meaningful consequence (0.050.05). In case of qualitative analysis the average of each evaluated item was 4.2points and 4.28points in the item1, 2.93points and 4.55points in the item2, 4.6points and 3.13points in the item3, 2.88points and 4.6points in the item4. According to the results TOF was measured higher in the item3 while in the item2 and item4 CEA was higher and in case of the item1, both CEA and TOF were similar. To sum up statistically meaningful results (p<0.05) were shown in the item2, item3 and item4 but not in the item1 (p>0.05). Conclusions : Both TOF and CEA are complementary because each inspection has pros and cons, but when inspect wide area including Aortic arch normally CEA is conducted. But TOF inspection also can be considered as alternative in terms of patients who has difficulty in the contrast medium such as infants, pregnant women and patients suffering from kidney failure and patients during follow up.

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High-resolution Depth Generation using Multi-view Camera and Time-of-Flight Depth Camera (다시점 카메라와 깊이 카메라를 이용한 고화질 깊이 맵 제작 기술)

  • Kang, Yun-Suk;Ho, Yo-Sung
    • Journal of the Institute of Electronics Engineers of Korea SP
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    • v.48 no.6
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    • pp.1-7
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    • 2011
  • The depth camera measures range information of the scene in real time using Time-of-Flight (TOF) technology. Measured depth data is then regularized and provided as a depth image. This depth image is utilized with the stereo or multi-view image to generate high-resolution depth map of the scene. However, it is required to correct noise and distortion of TOF depth image due to the technical limitation of the TOF depth camera. The corrected depth image is combined with the color image in various methods, and then we obtain the high-resolution depth of the scene. In this paper, we introduce the principal and various techniques of sensor fusion for high-quality depth generation that uses multiple camera with depth cameras.

Preliminary study of time-of-flight measurement for 3D position sensing system based on acoustic signals

  • Kim, Heung-Gi;Park, Youngjin
    • 제어로봇시스템학회:학술대회논문집
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    • 2002.10a
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    • pp.79.4-79
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    • 2002
  • Our goal is the development of a system that estimates the location of interested point in a room with accuracy and low cost. Non-contacting position estimating method is widely used in various areas. Among these methods, acoustic signal-based method is the cheapest and provides reasonably accurate estimation as a result of many research efforts. Most of the acoustic-signal-based three-dimensional location estimators such as 3D sonic digitizer are using the ultrasound, and are organized with two procedures; time-of-flight (TOF) estimation and localization estimation. Since the errors in estimating the TOF could be accumulated with that of localization estimate, accuracy of TOF estimate is as...

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Development of a Rapid and Accurate Identification Method for Citrobacter Species Isolated from Pork Products Using a Matrix-Assisted Laser-Desorption Ionization Time-of-Flight Mass Spectrometry (MALDITOF MS)

  • Kwak, Hye-Lim;Han, Sun-Kyung;Park, Sunghoon;Park, Si Hong;Shim, Jae-Yong;Oh, Mihwa;Ricke, Steven C.;Kim, Hae-Yeong
    • Journal of Microbiology and Biotechnology
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    • v.25 no.9
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    • pp.1537-1541
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    • 2015
  • Previous detection methods for Citrobacter are considered time consuming and laborious. In this study, we have developed a rapid and accurate detection method for Citrobacter species in pork products, using matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry (MS). A total of 35 Citrobacter strains were isolated from 30 pork products and identified by both MALDI-TOF MS and 16S rRNA gene sequencing approaches. All isolates were identified to the species level by the MALDI-TOF MS, while 16S rRNA gene sequencing results could not discriminate them clearly. These results confirmed that MALDITOF MS is a more accurate and rapid detection method for the identification of Citrobacter species.

Evaluation of Uncertainty in Burning Rate Measurement of Solid Propellant using Ultrasound (초음파를 이용한 고체추진제 연소속도 측정 불확실도 평가)

  • Kang, To;Song, Sung-Jin;Kim, Hak-Joon;Ko, Sun-Feel;Oh, Hyun-Taek;Kim, In-Chul;Yoo, Ji-Chang;Jung, Jung-Yong
    • Proceedings of the Korean Society of Propulsion Engineers Conference
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    • 2008.05a
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    • pp.199-202
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    • 2008
  • The advantage of ultrasonic burning rate measurement of solid propellant is measuring burning rates with wide range of pressure in a single test. In the ultrasonic method, instantaneous thickness of solid propellants as function of pressure or time were measured using time of flight(TOF) of ultrasonic signals. So, uncertainties of the measured burning rates by ultrasonic method have to evaluate with variation of pressure, TOF and initial propellant thickness. In this study, we evaluated uncertainties of ultrasonic method for measuring burning rates on the types 317 and the 318 propellants.

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Low Resolution Depth Interpolation using High Resolution Color Image (고해상도 색상 영상을 이용한 저해상도 깊이 영상 보간법)

  • Lee, Gyo-Yoon;Ho, Yo-Sung
    • Smart Media Journal
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    • v.2 no.4
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    • pp.60-65
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    • 2013
  • In this paper, we propose a high-resolution disparity map generation method using a low-resolution time-of-flight (TOF) depth camera and color camera. The TOF depth camera is efficient since it measures the range information of objects using the infra-red (IR) signal in real-time. It also quantizes the range information and provides the depth image. However, there are some problems of the TOF depth camera, such as noise and lens distortion. Moreover, the output resolution of the TOF depth camera is too small for 3D applications. Therefore, it is essential to not only reduce the noise and distortion but also enlarge the output resolution of the TOF depth image. Our proposed method generates a depth map for a color image using the TOF camera and the color camera simultaneously. We warp the depth value at each pixel to the color image position. The color image is segmented using the mean-shift segmentation method. We define a cost function that consists of color values and segmented color values. We apply a weighted average filter whose weighting factor is defined by the random walk probability using the defined cost function of the block. Experimental results show that the proposed method generates the depth map efficiently and we can reconstruct good virtual view images.

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MALDI TOF MS for the identification of Salmonella spp. from swine (돼지유래 Salmonella속 균의 동정을 위한 MALDI TOF MS 활용)

  • Sohn, Jun Hyung;Jeon, Woo Jin;Lee, Young Mi;Kim, Seon Soo
    • Korean Journal of Veterinary Service
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    • v.39 no.4
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    • pp.247-251
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    • 2016
  • Salmonella is one of the most common bacteria that causes heavy losses in swine industry and major causative pathogen of food poisoning in public health. Various methods for the identification of Salmonella such as Gram staining, agglutination test, enzyme-linked immunosorbent assay (ELISA), polymerase chain reaction (PCR) have been used. Several studies have demonstrated that Matrix Assisted Laser Desorption Ionization Time of Flight (MALDI TOF) Mass Spectrometry (MS) identification is an efficient and inexpensive method for the rapid and routine identification of isolated bacteria. In this study, MALDI TOF MS could provide rapid, accurate identification of Salmonella spp. from swine compared with end point PCR and real time PCR.