• Korean Journal of Construction Engineering and Management
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• v.6 no.6 s.28
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• pp.133-141
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• 2005

In the resent years, the importance of VE (value engineering) and LCC (life cycle cost) analysis for apartment building construction projects has been fully recognized. Accordingly theoretical models, guidelines, and supporting software systems were developed for the value engineering and life cycle cost analysis for construction management including large building systems. However, the level of consensus on VE and LCC analysis results is still low due to the lack of reliable data on maintenance. This paper presents time dependent LCC model based value analysis method for rational investment decision making and design alternative selection for construction of apartment building. The proposed method incorporates a time dependent LCC model and a performance evaluation technique by fuzzy logic theory to properly handle the uncertainties associated with statistics data and to analyze the value of alternatives more rationally. The presented time dependent VE and LCC analysis procedure were applied to a real world project, and this case study is discussed in the paper. The model and the procedure presented in this study can greatly contribute to design value engineering alternative selection, the estimation of the life cycle cost, and the allocation of budget for apartment building construction projects.

• The Korean Journal of Physiology and Pharmacology
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• v.6 no.4
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• pp.187-191
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• 2002

Tamoxifen, an antiestrogen, has previously been shown to induce apoptosis in HepG2 human hepatoblastoma cells through activation of the pathways independent of estrogen receptors, i.e., intracellular $Ca^{2+}$ increase and generation of reactive oxygen species (ROS). However, the mechanism of tamoxifen to link increased intracellular $Ca^{2+}$ to ROS generation is currently unknown. Thus, in this study we investigated the possible involvement of calmodulin, a $Ca^{2+}$ activated protein, and $Ca^{2+}$/calmodulin-dependent protein kinase II in the above tamoxifen-induced events. Treatment with calmodulin antagonists (calmidazolium and trifluoroperazine) or specific inhibitors of $Ca^{2+}$/calmodulin-dependent protein kinase II (KN-93 and KN-62) inhibited the tamoxifen-induced apoptosis in a dose-dependent manner. In addition, these agents blocked the tamoxifen-induced ROS generation in a concentration-dependent fashion, which was completely suppressed by intracellular $Ca^{2+}$ chelation. These results demonstrate for the first time that, despite of its well-known direct calmodulin-inhibitory activity, tamoxifen may generate ROS and induce apoptosis through indirect activation of calmodulin and $Ca^{2+}$/calmodulin-dependent protein kinase II in HepG2 cells.

• The Korean Journal of Physiology and Pharmacology
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• v.22 no.5
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• pp.597-605
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• 2018

In this study, we demonstrated the inhibitory effect of the Class Ic antiarrhythmic agent propafenone on voltage-dependent $K^+$ (Kv) channels using freshly isolated coronary artery smooth muscle cells from rabbits. The Kv current amplitude was progressively inhibited by propafenone in a dose-dependent manner, with an apparent $IC_{50}$ value of $5.04{\pm}1.05{\mu}M$ and a Hill coefficient of $0.78{\pm}0.06$. The application of propafenone had no significant effect on the steady-state activation and inactivation curves, indicating that propafenone did not affect the voltage-sensitivity of Kv channels. The application of train pulses at frequencies of 1 or 2 Hz progressively increased the propafenone-induced inhibition of the Kv current. Furthermore, the inactivation recovery time constant was increased after the application of propafenone, suggesting that the inhibitory action of propafenone on Kv current is partially use-dependent. Pretreatment with Kv1.5, Kv2.1 or Kv7 inhibitor did not change the inhibitory effect of propafenone on the Kv current. Together, these results suggest that propafenone inhibits the vascular Kv channels in a dose- and use-dependent manner, regardless of $Na^+$ channel inhibition.

• Korean Journal of Pharmacognosy
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• v.15 no.1
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• pp.24-29
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• 1984

It was previously reported from our laboratory that the rate of deterioration of contractile force was slower in the heart of the ginseng extract treated rats. It was also found that ginseng may have an ability to sustain the normal function of the heart by sustaining Ca accumulation by sarcoplasmic reticulum. $Ca^{++}-dependent$ ATPase plays the central role in movement of $Ca^{++}$ ion from sarcoplasm into sarcoplasmic reticulum. In this investigation, the fragment of sarcoplasmic reticulum was prepared from rat heart treated with ginseng water extract orally 100mg/kg/day for 7 to 10 days and from normal rat heart. $Ca^{++}-dependent$ APTase activity was estimated by a modified method of Fiske and Subbarow's procedure. Experimental groups were divided into 6 groups, depending on the preincubation time, 5, 30 and 60min. at ${25}^{\circ}C$ and ${37}^{\circ}C$ respectively. In both of the groups of ${25}^{\circ}C$ and ${37}^{\circ}C$, $Ca^{++}-dependent$ ATPase activities of the ginseng treated rat hearts were higher than that of normal hearts. Therefore, it can be concluded that $Ca^{++}-dependent$ ATPase activities in sarcoplasmic reticulum of rat hearts were increased by the treatment with ginseng extract.

• Journal of Korean Institute of Industrial Engineers
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• v.33 no.1
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• pp.26-32
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• 2007

This study deals with waiting-time dependent backordering rate during stock-out period in the EconomicProduction Quantity (EPQ) model. Assuming that the backordering rate follows an exponentially decreasingfunction of the waiting time, the backorder rate is developed under First-Come-First-Served (FCFS) andLast-Come-First-Served (LCFS) Policy. The mathematical models are developed based on differential equations.Through numerical examples, the validity of the developed models is illustrated.

• Bulletin of the Korean Chemical Society
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• v.33 no.10
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• pp.3391-3396
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• 2012

Two-dimensional infrared (2D-IR) spectroscopy can probe the fast structural evolution of molecules under thermal equilibrium. Vibrational frequency fluctuation caused by structural evolution produced the time-dependent line shape change in 2D-IR spectrum. A variety of methods has been used to connect the evolution of 2D-IR spectrum with Frequency-Frequency Correlation Function (FFCF), which connects the experimental observables to a molecular level description. Here, a new method to extract FFCF from 2D-IR spectra is described. The experimental observable is the time-dependent frequency shift of maximum peak position in the slice spectrum of 2D-IR, which is taken along the excitation frequency axis. The direct relation between the 2D-IR peak shift and FFCF is proved analytically. Observing the 2D-IR peak shift does not need the full 2D-IR spectrum which covers 0-1 and 1-2 bands. Thus data collection time to determine FFCF can be reduced significantly, which helps the detection of transient species.

• Steel and Composite Structures
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• v.18 no.4
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• pp.909-924
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• 2015

This paper investigates the vibration phenomenon of a nanobeam subjected to a time-dependent heat flux. Material properties of the nanobeam are assumed to be graded in the thickness direction according to a novel exponential distribution law in terms of the volume fractions of the metal and ceramic constituents. The upper surface of the functionally graded (FG) nanobeam is pure ceramic whereas the lower surface is pure metal. A nonlocal generalized thermoelasticity theory with dual-phase-lag (DPL) model is used to solve this problem. The theories of coupled thermoelasticity, generalized thermoelasticity with one relaxation time, and without energy dissipation can extracted as limited and special cases of the present model. An analytical technique based on Laplace transform is used to calculate the variation of deflection and temperature. The inverse of Laplace transforms are computed numerically using Fourier expansion techniques. The effects of the phase-lags (PLs), nonlocal parameter and the angular frequency of oscillation of the heat flux on the lateral vibration, the temperature, and the axial displacement of the nanobeam are studied.

• Proceedings of the KIEE Conference
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• 2004.11c
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• pp.702-704
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• 2004

This paper focuses on the problem of asymptotic stabilization for uncertain time-delay systems with saturating actuator. We propose a state feedback controller which maximizes the delay bound for guaranteeing stability of the system. Then, based on the Lyapunov method, a delay-dependent stabilization criterion is devised by taking the relationship between the terms in the Leibniz-Newton formula into account. The criterion is represented in terms of LMIs, which can be solved by various efficient convex optimization algorithm. Numerical examples are given to illustrate our main method.

• The Transactions of the Korean Institute of Electrical Engineers D
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• v.55 no.4
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• pp.147-153
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• 2006

In this paper, we propose a new delay-dependent criterion on the robust stability of time-delayed linear systems having norm bounded uncertainties. Based on new form of Lyapunov-Krasovskii functional and the Newton-Leibniz formula, we drive a result in the form of LMI which guarantees the robust stability without any model transformation. The Newton-Leibniz equation was used to relate the cross terms with free matrices. Finally, we show the usefulness of our result by two numerical examples.

• Journal of Korean Institute of Industrial Engineers
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• v.25 no.3
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• pp.351-359
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• 1999

We present a new approach to the analysis of mobile cellular communication systems under the environment of mixed platforms adopting a guard channel scheme. We assume general cell residence time distributions according to platform-types. Our system model is based on a heterogeneous M/G/c loss system with customer-dependent guard channels, where heterogeneous customers with different service time distributions have different numbers of their own guard channels. We develop the general formula of steady state probabilities for the heterogeneous M/G/c loss system with customer-dependent guard channels. The mean channel occupancy times of new and handoff calls are rigorously derived under a general setting. Finally, our numerical results show that the blocking probability and the forced termination probability are sensitive to the cell residence time distributions.