• Title/Summary/Keyword: Time Dependent

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Time-Dependent Effects of Prognostic Factors in Advanced Gastric Cancer Patients

  • Kwon, Jin-Ok;Jin, Sung-Ho;Min, Jae-Seok;Kim, Min-Suk;Lee, Hae-Won;Park, Sunhoo;Yu, Hang-Jong;Bang, Ho-Yoon;Lee, Jong-Inn
    • Journal of Gastric Cancer
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    • v.15 no.4
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    • pp.238-245
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    • 2015
  • Purpose: This study aimed to identify time-dependent prognostic factors and demonstrate the time-dependent effects of important prognostic factors in patients with advanced gastric cancer (AGC). Materials and Methods: We retrospectively evaluated 3,653 patients with AGC who underwent curative standard gastrectomy between 1991 and 2005 at the Korea Cancer Center Hospital. Multivariate survival analysis with Cox proportional hazards regression was used in the analysis. A non-proportionality test based on the Schoenfeld residuals (also known as partial residuals) was performed, and scaled Schoenfeld residuals were plotted over time for each covariate. Results: The multivariate analysis revealed that sex, depth of invasion, metastatic lymph node (LN) ratio, tumor size, and chemotherapy were time-dependent covariates violating the proportional hazards assumption. The prognostic effects (i.e., log of hazard ratio [LHR]) of the time-dependent covariates changed over time during follow-up, and the effects generally diminished with low slope (e.g., depth of invasion and tumor size), with gentle slope (e.g., metastatic LN ratio), or with steep slope (e.g., chemotherapy). Meanwhile, the LHR functions of some covariates (e.g., sex) crossed the zero reference line from positive (i.e., bad prognosis) to negative (i.e., good prognosis). Conclusions: The time-dependent effects of the prognostic factors of AGC are clearly demonstrated in this study. We can suggest that time-dependent effects are not an uncommon phenomenon among prognostic factors of AGC.

Time Dependent Analysis Considering the Construction Sequences in Bridges of Movable Scaffolding System (MSS) (시공단계를 고려한 MSS 공법 교량의 시간의존적 거동해석)

  • Kwak Hyo-Gyoung;Son Je-Kuk
    • Proceedings of the Computational Structural Engineering Institute Conference
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    • 2005.04a
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    • pp.167-174
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    • 2005
  • Through time-dependent analyses of RC bridges constructed by a movable scaffolding system (MSS) considering the construction sequence and creep deformation of concrete, structural responses related to the member forces are reviewed. On the basis of the compatibility condition and equilibrium equation at every construction stage, basic equations that can describe the moment variation with time in movable scaffolding construction are derived. By using the introduced relations, the design moment and its variation over time can easily be obtained with only the elastic analysis results and without additional time-dependent analyses considering the construction sequences. In addition, the design moments determined by the introduced equations are compared with the results from a rigorous numerical analysis with the objective of establishing the relative efficiencies of the introduced equations.

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The Time-dependent Effects of Changes in Private Education on the Developmental Trajectories of Academic Achievement Among Early Adolescents (아동의 학업성취 발달궤적에 대한 사교육의 시간 의존적 효과)

  • Lee, Ju-Lie
    • Korean Journal of Child Studies
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    • v.31 no.6
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    • pp.1-13
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    • 2010
  • This study examined the time-dependent effects of changes in private education on the trajectories of academic achievement among early adolescents. Five-wave data was employed from the KYPS; the participants being 2844 (1524 boys, 1320 girls). All were 4th graders in 2004 and became 8th graders in 2008. Latent growth curve model indicated that academic achievement significantly decreased over the five time points, but there were significant individual differences as well. Participants who reported higher initial levels of academic achievement tended to decrease in academic achievement more slowly over time compared to participants who reported lower levels of initial academic achievement. The effects of private education on academic achievement were at their most powerful when participants were in the 4th grade. Private educational experiences among 6th graders had relatively less influence upon the academic achievement of 7th graders.

A study on algorithms to minimize makespan of sequence-dependent jobs (작업준비시간을 고려한 총작업완료시간 최소화 해법에 관한 연구)

  • 안상형
    • Korean Management Science Review
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    • v.12 no.2
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    • pp.77-87
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    • 1995
  • In this paper we develop an efficient heuristic algorithm for the problem of scheduling n sequence-dependent jobs on a basic processor to minimize makespan. Efficient solution methods are already known for the sequence- independent case. But for the sequence-dependent case, this problem belongs to a set of strong NP-complete problems. We present a heuristic which is similar to shortest setup time heuristic but opportunity cost of setup time rather than shortest setup time is used for choosing next job. This heuristic algorithm has same computational complexity and worst case ratio as the shortest setup time heuristic. We used Wilcoxon signed rank test to show that our heuristic is superior to nearest setup time heuristic in term of average behavior.

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Time-dependent reliability analysis of coastal defences subjected to changing environments

  • Chen, Hua-Peng
    • Structural Monitoring and Maintenance
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    • v.2 no.1
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    • pp.49-64
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    • 2015
  • This paper presents a method for assessing the risk of wave run-up and overtopping of existing coastal defences and for analysing the probability of failure of the structures under future hydraulic conditions. The recent UK climate projections are employed in the investigations of the influence of changing environments on the long-term performance of sea defences. In order to reduce the risk of wave run-up and overtopping caused by rising sea level and to maintain the present-day allowances for wave run-up height and overtopping discharge, the future necessary increase in crest level of existing structures is investigated. Various critical failure mechanisms are considered for reliability analysis, i.e., erosion of crest by wave overtopping, failure of seaside revetment, and internal erosions within earth sea dykes. The time-dependent reliability of sea dykes is analysed to give probability of failure with time. The results for an example earth dyke section show that the necessary increase in crest level is approximately double of sea level rise to maintain the current allowances. The probability of failure for various failure modes of the earth dyke has a significant increase with time under future hydraulic conditions.

Bootstrap methods for long-memory processes: a review

  • Kim, Young Min;Kim, Yongku
    • Communications for Statistical Applications and Methods
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    • v.24 no.1
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    • pp.1-13
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    • 2017
  • This manuscript summarized advances in bootstrap methods for long-range dependent time series data. The stationary linear long-memory process is briefly described, which is a target process for bootstrap methodologies on time-domain and frequency-domain in this review. We illustrate time-domain bootstrap under long-range dependence, moving or non-overlapping block bootstraps, and the autoregressive-sieve bootstrap. In particular, block bootstrap methodologies need an adjustment factor for the distribution estimation of the sample mean in contrast to applications to weak dependent time processes. However, the autoregressive-sieve bootstrap does not need any other modification for application to long-memory. The frequency domain bootstrap for Whittle estimation is provided using parametric spectral density estimates because there is no current nonparametric spectral density estimation method using a kernel function for the linear long-range dependent time process.

Design of $H_{\infty}$ Control of Time-Delayed Linear Systems Using Model Transformation (모델변환을 이용한 시간지연 선형시스템의 지연종속 $H_{\infty}$ 제어)

  • Ma, Sam-Sun;Lee, Hee-Song;Kim, Jin-Hoon
    • The Transactions of the Korean Institute of Electrical Engineers D
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    • v.50 no.9
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    • pp.409-416
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    • 2001
  • This paper deals with the design of delay-dependent $H_{\infty}$ control for time-delayed linear systems. We propose the two different model transformations to handle efficiently the time delay and derive conditions linear matrix inequalities (LMI's) of which are dependent on the size of time-delay and its time-derivative. The $H_{\infty}$ controller is obtained by checking the feasibility of these LMI's. Finally, we show the usefulness and applicability of our results by an example.

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Dynamic Programming Algorithms for Scheduling Jobs with Sequence-Dependent Processing Times (순서 의존적인 작업시간을 갖는 작업들의 스케쥴링을 위한 동적계획법)

  • Lee, Moon-Kyu;Lee, Seung-Joo
    • Journal of Korean Institute of Industrial Engineers
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    • v.24 no.3
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    • pp.431-446
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    • 1998
  • In this paper, we consider the problem of scheduling n jobs with sequence-dependent processing times on a set of parallel-identical machines. The processing time of each job consists of a pure processing time and a sequence-dependent setup time. The objective is to maximize the total remaining machine available time which can be used for other tasks. For the problem, we first propose a dynamic programming(DP) algorithm for sequencing jobs processed on a single machine. The algorithm is then extended to handle jobs on parallel-identical machines. Finally, we developed an improved version of the algorithm which generates optimal solutions using much smaller amount of memory space and computing time. Computational results are provided to illustrate the performance of the DP algorithms.

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Analysis of the strain energy release rate for time-dependent delamination in multilayered beams with creep

  • Rizov, Victor I.
    • Advances in materials Research
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    • v.11 no.1
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    • pp.41-57
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    • 2022
  • This paper is focused on delamination analysis of a multilayered inhomogeneous viscoelastic beam subjected to linear creep under constant applied stress. The viscoelastic model that is used to treat the creep consists of consecutively connected units. Each unit consists of one spring and two dashpots. The number of units in the model is arbitrary. The modulus of elasticity of the spring in each unit changes with time. Besides, the modulii of elasticity and the coefficients of viscosity change continuously along the thickness, width and length in each layer since the material is continuously inhomogeneous in each layer of the beam. A time-dependent solution to the strain energy release rate for the delamination is derived. A time-dependent solution to the J-integral is derived too. A parametric analysis of the strain energy release rate is carried-out by applying the solution derived. The influence of various factors such as creep, material inhomogeneity, the change of the modulii of elasticity with time and the number of units in the viscoelastic model on the strain energy release rate are clarified.

Experiments on Interfacial Properties Between Ground and Shotcrete Lining (지반과 숏크리트 라이닝의 인터페이스 특성에 관한 실험적 연구)

  • Chang, Soo-Ho;Lee, Seok-Won;Bae, Gyu-Jin;Choi, Soon-Wook;Park, Hae-Geun;Kim, Jae-Kwon
    • Proceedings of the Korean Geotechical Society Conference
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    • 2004.03b
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    • pp.407-414
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    • 2004
  • Interfacial properties between rock mass and shotcrete play a significant role in the transmission of loads from the ground to shotcrete. These properties have a major effect on the behaviours of rock mass and shotcrete. They, however, have merely been assumed in most of numerical analyses, and little care has been taken in identifying them. This paper aimed to identify interfacial properties including cohesion, tension, friction angle, shear stiffness, and normal stiffness, through direct shear tests as well as interface normal compression tests for shotcrete/rock cores obtained from a tunnel sidewall. Mechanical properties such as compression strength and elastic modulus were also measured to compare them with the time-dependent variation of interfacial properties. Based on experiments, interfacial properties between rock and shotcrete showed a significant time-dependent variation similar to those of its mechanical properties. In addition, the time-dependent behaviours of interfacial properties can be well regressed through exponential and logarithmic functions of time.

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