• Natural Product Sciences
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• 제21권2호
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• pp.128-133
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• 2015

Lindera obtusiloba has been widely used as a traditional medicine for the treatment of lots of diseases, including abdominal pain, bruise, and hepatocirrhosis. Here in this study, we elucidated the lifespan-extending effect of methanolic extract of Lindera obtusiloba (MLO) using Caenorhabditis elegans model system. We found that MLO has potent lifespan extension activities under normal culture condition. Then, we determined the protective effects of MLO on the stress conditions such as osmotic, thermal and oxidative stress. To reveal possible mechanism of MLO-mediated lifespan, we further investigated the effect of MLO on the antioxidant enzyme activities and intracellular ROS levels. Our results demonstrated that superoxide dismutase and catalase activities were significantly up-regulated by MLO treatment, resulted in reduced intracellular ROS levels. In this work, we also tested whether MLO-mediated longevity activity was associated with aging-related factors such as food intake and growth. Our data revealed that both of pharyngeal pumping rate and body length were significantly shifted by MLO treatment, indicating these factors were involved in MLO's lifespan-extension effects. Although MLO induces reduction in food intake, the body movement of MLO-fed aged worms was not decreased, compared to untreated control worms, indicating MLO might extend lifespan without affecting healthspan.

• Biomolecules & Therapeutics
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• 제26권6호
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• pp.568-575
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• 2018

In order to discover lifespan-extending compounds made from natural resources, activity-guided fractionation of Zingiber officinale Roscoe (Zingiberaceae) ethanol extract was performed using the Caenorhabditis elegans (C. elegans) model system. The compound 6-gingerol was isolated from the most active ethyl acetate soluble fraction, and showed potent longevity-promoting activity. It also elevated the survival rate of worms against stressful environment including thermal, osmotic, and oxidative conditions. Additionally, 6-gingerol elevated the antioxidant enzyme activities of C. elegans, and showed a dose-depend reduction of intracellular reactive oxygen species (ROS) accumulation in worms. Further studies demonstrated that the increased stress tolerance of 6-gingerol-mediated worms could result from the promotion of stress resistance proteins such as heat shock protein (HSP-16.2) and superoxide dismutase (SOD-3). The lipofuscin levels in 6-gingerol treated intestinal worms were decreased in comparison to the control group. No significant 6-gingerol-related changes, including growth, food intake, reproduction, and movement were noted. These results suggest that 6-gingerol exerted longevity-promoting activities independently of these factors and could extend the human lifespan.

• 복합신소재구조학회 논문집
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• 제5권2호
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• pp.21-26
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• 2014

This paper introduces general concepts of jointless bridges and field construction case of semi-integral bridge with psc girder integrating end-diaphragm. The expansion joints need to satisfy thermal and safety conditions of bridges. General bridges with joints have some problems, which are frequently replacement cycle time from mechanical damage or unstable movement, maintenance cost and more. To solve these problems, Integral Abutment Bridges(IAB) have been applied overseas in the 1930s. In Korea, first IAB was constructed in the early 2000s and precast IAB systems was invented and applied lately. Kyungshin overpass bridge in Incheon is the Semi-IAB constructed, the span length is 2@35=70m and the width is 13.9m. The original plan was to use general joint bridge but design field changed with expectations for advanced economic estimation and maintenance. This changed method of B.I.B bridge construction provided not only workability, construction cost but also safety improvement at the same time.

• 생약학회지
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• 제48권1호
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• pp.25-30
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• 2017

This study was performed to evaluate the lifespan extending effects of the dried ginger (Zingiber officnale Roscoe, Zingiberaceae). Ethanol extract of the dried ginger was successively partitioned as methylene chloride, ethyl acetate, n-butanol and $H_2O$ soluble fractions, and lifespan-extending effects of the fractions were investigated using Caenorhabditis elegans model system. Ethyl acetate-soluble fraction showed the most potent longevity property. Furthermore, ethyl acetate-soluble fraction elevated thermal stress tolerance, and increased expression of stress resistance protein. Further studies were performed to investigate several aging-related factors such as reproduction, food intake, growth and movement of C. elegans. The results revealed that there were no significant changes in aging-related factors including reproduction, food intake and growth, however, ethyl acetate-soluble fraction treatment led to an up-regulation of locomotory ability of aged worms, suggesting ethyl acetate-soluble fraction affected healthspan as well as lifespan of nematode.

• 한국강구조학회 논문집
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• 제20권3호
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• pp.365-375
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• 2008

yLRC 합성기둥은 기존 합성기둥의 장점과 거푸집 공사의 절감을 가져올 수 있으며, CFT와 비교하였을 때 강재량 감소의 효과와 함께 콘크리트의 충전상태를 육안으로 쉽게 확인할 수 있는 등의 장점을 가지고 있다. 실험결과와 연구를 통하여 yLRC 합성기둥의 구조체로서의 내력은 검증이 되었으나 내화성능에 관한 연구는 수행되지 않았다. 이에 본 논문에서는 yLRC 합성기둥의 내화성능 평가를 위해 콘크리트 면적비, 보강판, 피복유무 등을 변수로 두어 실험과 해석을 수행하였으며, 실험과 해석결과를 비교 고찰하여 내화 성능 평가를 하였다.

• 대한의용생체공학회:의공학회지
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• 제28권3호
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• pp.348-354
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• 2007

Polymer actuators, which are also called as smart materials, change their shapes when electrical, chemical, thermal, or magnetic energy is applied to them and are useful in wide variety of applications such as microelectromechanical systems (MEMS), machine components, and artificial muscles. For this study, Polyaniline/carbon-nanotube polymer actuator that is one of electroactive polymer actuators was prepared. Since the nonlinear phenomena of hysteresis and a step response are essential considerations for practical use of polymer actuators, we have investigated the movement of the Polyaniline/carbon-nanotube polymer actuator and have developed an integrated model that can be used for simulating and predicting the hysteresis and a step response during actuation. The Preisach hysteresis model, one of the most popular phenomenological models of hysteresis, were used for describing the hysteretic behavior of Polyaniline/carbon-nanotube polymer actuator while the ARX method, one of system identification techniques, were used for modeling a step response. In this paper, we first expain details in preparation of the Polyaniline/carbon-nanotube polymer then present the mathematical description of our model, the extraction of the parameters, simulation results from the model, and finally a comparison with measured data.

• 대한의용생체공학회:의공학회지
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• 제37권5호
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• pp.168-177
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• 2016

In this paper we present an implantable pressure sensor to measure real-time blood pressure by monitoring mechanical movement of artery. Sensor is composed of inductors (L) and capacitors (C) which are formed by microfabrication and direct bonding on two biocompatible substrates (quartz). When electrical potential is applied to the sensor, the inductors and capacitors generates a LC resonance circuit and produce characteristic resonant frequencies. Real-time variation of the resonant frequency is monitored by an external measurement system using inductive coupling. Structural and electrical simulation was performed by Computer Aided Engineering (CAE) programs, ANSYS and HFSS, to optimize geometry of sensor. Ultrafast laser (femto-second) cutting and MEMS process were executed as sensor fabrication methods with consideration of brittleness of the substrate and small radial artery size. After whole fabrication processes, we got sensors of $3mm{\times}15mm{\times}0.5mm$. Resonant frequency of the sensor was around 90 MHz at atmosphere (760 mmHg), and the sensor has good linearity without any hysteresis. Longterm (5 years) stability of the sensor was verified by thermal acceleration testing with Arrhenius model. Moreover, in-vitro cytotoxicity test was done to show biocompatiblity of the sensor and validation of real-time blood pressure measurement was verified with animal test by implant of the sensor. By integration with development of external interrogation system, the proposed sensor system will be a promising method to measure real-time blood pressure.

• 한국농공학회지
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• 제32권3호
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• pp.39-46
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• 1990

This paper was analized the thermal conductivity of polystylene (TENSAR- GEOGRID) embeding into the subbase through frost penetration depth, frost heave, change of bearing capacity, and soil moisture movement due to freezing, thawing and icing actions, and their results were as follows : 1.The change of temperature into the sub-base was much increased by the Tensar-Geogrid insertion, and the frost penetration and frost heave were decreased as the thinner of the insulation thickness but the thawing velocity of melting period was appeared to be faster in case of non-insulated. 2.The frost heave had a close relationship with the thickness of insulations which was reasonably included anti-frost effects. 3.The moisture content during the freezing period of upper layer of the insulation insertion was increased by 15 per cent but it was returned to initial state of the thawing period, and at the down layer temporarily increased by 10 per cent and returned to the original state at once. 4.The insulation was acted as a function of distribution of surcharge, and the settlement of the sub-base was about 1.5 mm under 15 tonnage of load and which was included within the allowable limits. 5.The sliding resistance due to the icing which was induced by the insulation insertion into the sub-base was appeared as more 40 per cent than noninsulation area, so that the insulations should be restricted on the place such as mountains, curved and cross area which were required the braking power under the traffics.

• 한국철도학회논문집
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• 제12권1호
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• pp.25-30
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• 2009

본 연구에서는 철도 화재 시 구난역에서의 화재 연기의 거동을 파악하기 위하여 상용코드를 사용하여 수치해석 하였다. 화원의 모사와 화재로 인한 생성물의 거동을 예측하기 위해 stoichiometric상태에서 연료 소모량에 따른 연소생성물의 생성률과 산소 소모율을 VHS 모델에 적용하고 종의 보존 방정식을 해석하는 HVHS 모델을 이용하였다. 해석결과 화재 연기는 온도에 따른 밀도 차에 의해 터널의 천장을 따라 이동 하였으며 열원으로부터 멀어지면서 하강하는 형태를 확인 할 수 있었다. 또한 터널 내 공기는 화원으로 집중되었으며 비사고 터널과 사고 터널의 압력 차에 의해 화재연기는 별다른 환기 시스템 없이도 비사고 터널로 유입되지 않았다.

• 한국전산구조공학회논문집
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• 제26권4호
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• pp.309-318
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• 2013

본 논문에서는 일체식 교대 교량의 장대화 및 내진성능 향상을 위해 가장 중요한 역할을 하는 교대-H형 강말뚝 연결부의 성능을 향상시키기 위하여 기존의 연결부의 균열형상을 파악하고, 이를 기반으로 새로운 형태의 연결부를 제안하기 위하여 철근을 활용하여 강성을 증가시키는 방법과 강말뚝의 형상을 개선하여 연성을 개선시키는 방법을 모색하였다. 먼저, 기존 연결부의 성능을 향상시키기 위하여 연결부 주변에 PennDOT에 규정된 철근상세와 나선철근의 배치와 HSS 튜브를 사용하였으나, PennDOT의 철근 상세와 HSS 튜브는 연결부의 성능을 향상시키지 못 했으나, 나선철근은 균열을 효과적으로 차단시키는 것을 확인할 수 있었다. 하지만, 철근의 구속효과로 인해 강말뚝의 저항력이 변위에 선형적으로 비례하여 증가하므로 교량의 상부구조에 축력을 발생시키는 효과를 가져왔다. 따라서, 강말뚝의 형상을 개선하기 위하여 콘크리트 교대에 매입된 부분의 플랜지를 제거하는 방법과 콘크리트 외부에서 플랜지의 폭을 축소시키는 형태를 검토하였다. 두 가지 방안 모두 균열을 억제하는데 효과적인 방법이었으나, 플랜지를 제거하는 쪽의 연결부가 더욱 효과적이었다.