• 한국도로학회논문집
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• 제13권1호
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• pp.239-249
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• 2011

섬유보강 콘크리트를 이용하여 도로 포장의 기층을 형성하고 그 위에 아스팔트 또는 콘크리트로 표층을 구성함으로써 기능적인 측면과 구조적인 측면 모두에서 우수한 공용성을 발휘할 수 있는 복합포장 공법을 개발하기 위한 기초 연구로써 본 연구에서는 섬유보강 콘크리트 기층이 환경하중을 받을 때의 거동을 수치 해석을 통해 중점적으로 분석하였다. 이를 위해 2차원 유한요소해석 모델을 개발하였으며 이러한 모델을 사용하여 기층 슬래브 두께, 열팽창계수, 탄성계수, 인장 및 압축강도 등의 변수에 대하여 민감도 분석을 수행하였다. 기층의 거동으로는 균열간격과 균열틈 등 균열 특성을 선정하였다. 수치 해석 결과 고려한 변수가 균열간격 및 균열틈에 미치는 일반적인 영향을 파악할 수 있었으며, 기층 거동에 민감한 영향을 미치는 인자를 선정할 수 있었다. 이러한 결과는 표층 재료와 적절히 조합될 수 있는 섬유보강 콘크리트 기층의 재료 특성을 결정하는 기반이 될 것이다.

• Nuclear Engineering and Technology
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• 제52권4호
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• pp.742-754
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• 2020

Zircaloy cladding oxidation is an important phenomenon for both design basis accident and severe accidents, because it results in cladding embrittlement and rapid fuel temperature escalation. For this reason during the last decade, many experts have been conducting experiments to identify the oxidation phenomena that occur under design basis accidents and to develop mathematical analysis models. However, since the study of design extension conditions (DEC) is relatively insufficient, it is essential to develop and validate a physical and mathematical model simulating the oxidation of the cladding material at high temperatures. In this study, the QUENCH-05 and -06 experiments were utilized to develop the best-fitted oxidation model and to validate the SPACE code modified with it under the design extension condition. It is found out that the cladding temperature and oxidation thickness predicted by the Cathcart-Pawel oxidation model at low temperature (T < 1853 K) and Urbanic-Heidrick at high temperature (T > 1853 K) were in excellent agreement with the data of the QUENCH experiments. For 'LOCA without SI' (Safety Injection) accidents, which should be considered in design extension conditions, it has been performed the evaluation of the operator action time to prevent core melting for the APR1400 plant using the modified SPACE. For the 'LBLOCA without SI' and 'SBLOCA without SI' accidents, it has been performed that sensitivity analysis for the operator action time in terms of the number of SIT (Safety Injection Tank), the recovery number of the SIP (Safety Injection Pump), and the break sizes for the SBLOCA. Also, with the extended acceptance criteria, it has been evaluated the available operator action time margin and the power margin. It is confirmed that the power can be enabled to uprate about 12% through best-estimate calculations.

• 한국정보통신학회논문지
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• 제10권9호
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• pp.1641-1647
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• 2006

나노입자 크기를 가진 얇은 $SnO_2$ 박막을 이용하여 CO 및 $H_2S$에 대한 우수한 감도를 가지는 복합 마이크로 가스센서 어레이를 제작하였다. 나노입자의 박막을 만들기 위해서 약 $2500{\AA}$ 두께의 $SnO_2,\;SnO_2(+Pt),\;SnO_2(+CuO)$ 막을 셰도우마스크를 사용하여 형성 한 후, 이를 $600{\sim}800^{\circ}C$의 온도에서 산화하므로서 나노입자의 $SnO_2$ 모물질의 가스감지 박막을 형성하였다. 실리콘 기판의 마이크로센서의 형태로 제작된 $SnO_2(Pt)$ 및 $SnO_2(+CuO)$ 가스센서는 각각 CO 및 $H_2S$ 가스에 대한 매우 우수한 감도를 나타내는 것을 확인하였다.

• 한국정보통신학회논문지
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• 제6권2호
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• pp.315-322
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• 2002

반도체 제조공정과 미세가공 기술을 이용하여 30$0^{\circ}C$의 동작온도에서 약 60㎽의 전력소모를 갖는 산화물 반도체 박막 가스센서 어레이를 제조하였다. 멤브레인의 우수한 열적 절연은 0.1$\mu\textrm{m}$ 두께의 Si$_3$N$_4$와 1$\mu\textrm{m}$ 두께의 PSG의 이중 층에 의한 것으로, 각각 LPCVD(저압화학 기상증착)와 APCVD(대기압 화학 기상증착)에 의해 제조되었다. 센서 어레이의 4가지 산화물 반도체 박막 감지물질로는 1wt.%Pd가 도핑된 SnO$_2$, 6wt.% $Al_2$O$_3$가 도핑된 ZnO, WO$_3$, ZnO를 이용하였으며, 제조된 초소형 산화물 반도체 박막 가스센서 어레이는 여러 가지 가스의 노출시 유용한 저항 변화를 나타내었고 감도는 감지 물질에 강하게 의존함을 알 수 있었다. 센서 소자의 공정 수율을 증진시키기 위하여 히터 부위를 함몰하는 공정 방법을 취하였으며, 그 결과 월등한 수율 개선을 도모할 수 있었다.

• 마이크로전자및패키징학회지
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• 제15권1호
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• pp.7-18
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• 2008

This paper reviews the current development of an ultra-slim SiP for Radio Frequency (RF) application, in which three flip chips, additional passive components and Surface Acoustic Wave (SAW) filters are integrated side-by-side. A systematic investigation is carried out for the design optimization, process and reliability improvement of the package, which comprises several aspects: a design study based on the 3D thermo-mechanical finite element analysis of the packaging, the determination of stress, warpage distribution, critical failure zones, and the figuration of the effects of material properties, process conditions on the reliability of package. The optimized material sets for manufacturing process were determined which can reduce the number of testing samples from 75 to 2. In addition the molded underfilling (MUF) process is proposed which not only saves one manufacturing process, but also improves the thermo-mechanical performance of the package compared with conventional epoxy underfilling process. In the end, JEDEC's moisture sensitivity test, thermal cycle test and pressure cooker tests have also been carried out for reliability evaluation. The test results show that the optimized ultra-slim SiP has a good reliability performance.

• 동력기계공학회지
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• 제13권5호
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• pp.95-102
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• 2009

A steam generator (boiler) in thermal power plants, consisting of more than 30,000 parts and components, can lead to the plant shutdown with damage to even the small part of the components; esp., like weld failures on boiler tubes. Consequently it is greatly demanded to improve the quality of the weld on the boiler tube for the stable operation of the power plants. Because of the feature of the welding, which is done past by melting the work pieces and adding a filler material that cools to become a strong coalescence, there is a great possibility that weld failures take place. As a result, it is regulated to make a non-destructive testing, like radiography test, to detect defects and flaws in the weld. The current film radiography test provides a lower image quality exceeding 2.0% of a basic quality level for a penetrameter, it is very likely to fail to detect micro defect. As a result, the prevention for the boiler tube failure has not been made effectively. In this study, computed radiography technology has been applied as a digital radiography test to the boiler tube weld, and Se-75 radiation source was used to improve the image quality, instead of Ir-192 source. As a result of this study, it is proven to save the time and cost for test and to enhance the quality level of penetrameter penetrating image, which enables to upgrade the quality of radiography test to the boiler tube weld.

• 마이크로전자및패키징학회지
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• 제11권4호
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• pp.13-22
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• 2004

MEMS 소자의 패키지는 일반적으로 패키징 과정에서 큰 온도변화를 받게 되는데, 이에 의한 패키지의 변형은 패키지 및 소자의 신뢰성에 큰 영향을 미칠 수 있다. 본 논문에서는 진동형 MEMS 자이로스코프 센서의 패키지를 대상으로 하여, 온도변화로 인한 열변형 거동에 대한 광학실험과 해석을 수행하였다. 이를 위하여 실시간 모아레 간섭계를 이용하여 각 온도단계에서 변위분포를 나타내는 간섭무늬를 얻고, 그로부터 MEMS 패키지의 굽힘변형 거동 및 인장변형에 대한 해석을 수행하였다. MEMS 칩과 EMC 및 PCB의 열팽창계수 차이로 인하여 패키지는 $125^{\circ}C$ 이하에서는 전체적으로 아래로 볼록한 굽힘변형이 발생하였으며, 온도 $140^{\circ}C$를 정점으로 그 이상의 온도에서는 반대의 굽힘변형이 발생하였다. MEMS의 주파수에 영향을 줄 수 있는 칩 자체의 수축변형률은 약 $481{\times}10^{-6}$로 측정되어서 MEMS 설계시 이를 고려하여야 함을 알 수 있다.

• International Journal of Oral Biology
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• 제34권3호
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• pp.157-164
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• 2009

We recently described a novel animal model of trigeminal neuropathic pain following compression of the trigeminal ganglion (Ahn et al., 2009). In our present study, we adapted this model using male Sprague-Dawley rats weighing between 250-260 g and then analyzed the behavioral responses of these animals following modified chronic compression of the trigeminal ganglion. Under anesthesia, the rats were mounted onto a stereotaxic frame and a 4% agar solution ($10{\mu}L$) was injected in each case on the dorsal surface of the trigeminal ganglion to achieve compression without causing injury. In the control group, the rats received a sham operation without agar injection. Air-puff, acetone, and heat tests were performed at 3 days before and at 3, 7, 10, 14, 17, 21, 24, 30, 40, 55, and 70 days after surgery. Compression of the trigeminal ganglion produced nociceptive behavior in the trigeminal territory. Mechanical allodynia was established within 3 days and recovered to preoperative levels at approximately 60 days following compression. Mechanical hyperalgesia was also observed at 7 days after compression and persisted until the postoperative day 40. Cold hypersensitivity was established within 3 days after compression and lasted beyond postoperative day 55. In contrast, compression of the trigeminal ganglion did not produce any significant thermal hypersensitivity when compared with the sham operated group. These findings suggest that compression of the trigeminal ganglion without any injury produces prolonged nociceptive behavior and that our rat model is a useful system for further analysis of trigeminal neuralgia.

• Journal of Microbiology and Biotechnology
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• 제30권5호
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• pp.662-667
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• 2020

Epidermal growth factor receptor (EGFR) mutations are not only genetic markers for diagnosis but also biomarkers of clinical-response against tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer (NSCLC). Among the EGFR mutations, the in-frame deletion mutation in EGFR exon 19 kinase domain (EGFR exon 19-del) is the most frequent mutation, accounting for about 45% of EGFR mutations in NSCLCs. Development of sensitive method for detecting the EGFR mutation is highly required to make a better screening for drug-response in the treatment of NSCLC patients. Here, we developed a fluorometric tandem gene amplification assay for sensitive detection of low-abundance EGFR exon 19-del mutant genomic DNA. The method consists of pre-amplification with PCR, thermal cycling of ligation by Taq ligase, and subsequent rolling circle amplification (RCA). PCR-amplified DNA from genomic DNA samples was used as splint DNA to conjugate both ends of linear padlock DNA, generating circular padlock DNA template for RCA. Long stretches of ssDNA harboring multiple copies of G-quadruplex structure was generated in RCA and detected by thioflavin T (ThT) fluorescence, which is specifically intercalated into the G-quadruplex, emitting strong fluorescence. Sensitivity of tandem gene amplification assay for detection of the EGFR exon 19-del from gDNA was as low as 3.6 pg, and mutant gDNA present in the pooled normal plasma was readily detected as low as 1% fraction. Hence, fluorometric detection of low-abundance EGFR exon 19 deletion mutation using tandem gene amplification may be applicable to clinical diagnosis of NSCLC patients with appropriate TKI treatment.

• Asian Journal of Atmospheric Environment
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• 제11권1호
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• pp.1-14
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• 2017

For the quantitative analysis of volatile organic compounds (VOC), the use of a proper solvent is crucial to reduce the chance of biased results or effect of interference either in direct analysis by a gas chromatograph (GC) or with thermal desorption analysis due to matrix effects, e.g., the existence of a broad solvent peak tailing that overlaps early eluters. In this work, the relative performance of different solvents has been evaluated using standards containing 19 VOCs in three different solvents (methanol, pentane, and hexane). Comparison of the response factor of the detected VOCs confirms their means for methanol and hexane higher than that of pentane by 84% and 27%, respectively. In light of the solvent vapor pressure at the initial GC column temperature ($35^{\circ}C$), the enhanced sensitivity in methanol suggests the potential role of solvent vapor expansion in the hot injector (split ON) which leads to solvent trapping on the column. In contrast, if the recurrent relationships between homologues were evaluated using an effective carbon number (ECN) additivity approach, the comparability assessed in terms of percent difference improved on the order of methanol (26.5%), hexane (6.73%), and pentane (5.24%). As such, the relative performance of GC can be affected considerably in the direct injection-based analysis of VOC due to the selection of solvent.