• 재활치료과학
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• 제12권2호
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• pp.99-107
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• 2023

목적 : 본 연구는 가슴 가동성 제한을 가지고 있는 대상자에게 가슴 가동성 운동이 가슴 가동성, 호흡 패턴 및 호흡 용량에 미치는 영향을 알아보고자 하였다. 연구방법 : 13명의 가슴 가동성 제한을 가진 남/녀 대상자를 대상으로 가슴 가동성 운동(갈비뼈 가동성 운동)을 시행하여 가슴 가동성, 호흡 패턴 및 호흡량에 어떠한 변화가 있는지를 알아보았다. 가슴 가동성 운동 전/후에 연구 참여 대상자의 가슴 가동성(들숨-날숨 간 가슴 확장 길이 측정), 호흡 패턴 형태(가슴 움직임 수직 이동거리 측정) 및 호흡량(forced vital capacity, forced expiratory volume in 1 second)을 측정하였다. 가슴 가동성, 호흡 패턴 및 호흡 용량을 비교하기 위하여 짝-검정을 사용하였다. 통계적 유의성 검정을 위한 유의수준은 .05였다. 결과 : 가슴 가동성과 호흡 패턴은 통계적으로 유의한 차이가 있지만, 호흡 용량은 유의한 차이가 없었다(p < .05). 결론 : 본 연구의 결과를 토대로 갈비뼈 가동화 기법을 이용한 가슴 가동성 운동은 가슴 가동성 개선과 가슴 올림이 유발되는 비정상적인 호흡 패턴을 정상화시킬 수 있는 방법이라고 여겨진다.

• 대한중풍순환신경학회지
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• 제12권1호
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• pp.68-72
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• 2011

본 증례에서는 경항통에 대해 음양균형장치를 포함한 침치료, 한약치료를 통해 양호한 치료효과를 관찰했다.

• Journal of Chest Surgery
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• 제37권3호
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• pp.235-244
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• 2004

동맥전환술은 대혈관전위증이나 Taussig-Bing 기형의 가장 보편적인 수술법으로 인정되고 있다. 동맥전환술 후 수술사망에 영향을 미치는 위험인자와 함께 관상동맥 이식 수기변형의 유효성을 알아보고자 하였다. 1994년부터 2002년 7월까지 동맥전환술을 동아대학교 병원에서 한 명의 외과의에 의하여 시행된 85예의 대혈관전위증과 양대혈관 우심실기시증 환아를 대상으로 후향적 조사를 하였다. 관상동맥이식 수기변형 등 수술(병원)사망에 관여한다고 생각하는 여러 인자들을 다변량 회귀분석을 통해 수술사망에 미치는 위험인자들을 파악하였다. 전체 수술사망(병원사망)은 모두 17예(20%)였으며 수술사망률이 98년 이전은 31.0% (13/42), 98년 이후는 9.3% (4/43)로 감소하였다. 대동맥궁 기형을 동반하지 않은 경우는 전체 사망률이 12.5% (9/72)였으나 동반된 경우는 61.5% (8/13)로 높은 사망률을 보였다. 관상동맥이식 수기변형을 하지 않은 경우 사망률은 28.1%(18/64)를 보인 반면 관상동맥이식 수기변형을 한 경우는 4.8% (1/21)로 많은 사망률의 감소가 관찰되었다. 다변량 회귀분석에서 심폐기가동시간($\geq$ 250분), 대동맥차단시간($\geq$ 150분), 대동맥궁기형이 동반된 경우, 수술 전 사건(event)이 있었던 경우, 개방 관상동맥 이식술(open coronary reimplantation technique)이 수술사망의 위험인자로 파악되었다. 동맥전환술의 수술사망률은 수술시기가 경과함에 따라 감소하였으며, 대동맥궁 기형의 동반과 술 전 사건(event)이 수술사망의 중요 위험인자였다. 비전형적 관상동맥 형태는 수술사망의 위험요소가 아니었으며 관상동맥 이식의 수기변형이 수술사망을 낮추는 데 매우 유효하였던 것으로 생각된다.

• Radiation Oncology Journal
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• 제1권1호
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• pp.55-60
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• 1983

To evaluate the usefulness of computed tomography (CT) in radiotherapy treatment planning in malignant tumors of thoracic cage, the computer generated dose distributions were compared between plans based on conventional studies and those based on CT scan. 22 cases of thoracic malignancies, 15 lung cancers and 7 esophageal cancers, diagnosed and treated in Department of Therapeutic Radiology of Seoul National University Hospital from September, 1982 to April, 1983, were analyzed. In lung cancers, dose distribution in plans using AP, PA parallel opposing ports with posterior spinal cord block and in plans using box technique both based on conventional studies were compared with dose distribution using AP, PA and two oblique ports based on CT scan. In esophageal cancers, dose distribution in plans based on conventional studies and those based on CT scans, both using 3 port technique were compared. The results are as follows: 1. Parallel opposing field technique were inadequate in all cases of lung cancers, as portion of primary tumor in 13 of 15 cases and portion of mediastinum in all were out of high dose volume. 2. Box technique was inadequate in 5 of 15 lung cancers as portion of primary tumor was not covered and in every case the irradiated normal lung volume was quite large. 3. Plans based on CT scan were superior to those based on conventional studies as tumor was demarcated better with CT and so complete coverage of tumor and preservation of more normal lung volume could be made. 4. In 1 case of lung cancer, tumor localization was nearly impossible with conventional studies, but after CT scan tumor was more clearly defined and localized. 5. In 1 of 7 esophageal cancers, the radiation volume should be increased for marginal coverage after CT scan. 6. Depth dose correction for tissue inhomogeneity is possible with CT, and exact tumor dose can be calculated. As a result radiotherapy treatment planning based on CT scan has a pteat advantage over that based on conventional studies.

• Animal cells and systems
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• 제3권3호
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• pp.337-341
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• 1999

Hepatitis C virus (HCV) is a positive strand RNA virus of the Flaviviridae family and the major cause of post-transfusion non-A, non-B hepatitis. Vaccine development for HCV is essential but has been slowed by poor understanding of the type of immunity that naturally terminates HCV infection. The DNA-based immunization technique offers the potential advantage of including cellular immune responses against conserved internal proteins of a virus, as well as the generation of antibodies to viral surface proteins. Here, we demonstrate that cell lines expressing the HCV core and/or NS3 proteins can induce a specific CTL response in mice, and these results suggest a possibility that the HCV core and NS3 DNA can be used to induce CTL activity against the antigen in mice and can be further developed as a therapeutic and preventive DNA vaccine.

• 재활간호학회지
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• 제18권1호
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• pp.38-45
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• 2015

Purpose: This study was attempted in order to verify the effects of moxibustion on aged back pain and activities of daily living. Methods: A research design is quasi-experiment with pre-post test design in nonequivalent control group. As for data collection and experimental treatment, it accidentally sampled totally 50 people with 24 people for the experimental group and 26 people for the control group who appeal for chronic back pain aged over 60 who visited 4 senior centers where are located in N city from November 7, 2012 to December 3, 2012. Experimental treatment was carried out moxibustion totally 12 times by 3 times for 4 weeks in the experimental group. Data analysis was made by using SPSS program. As an analytical technique, the experimental group and the control group were analyzed the homogeneity verification with t-test, Fisher's exact test and $x^2$ test and the hypothesis verification with t-test. Results: The back pain level was reduced in the experimental group than the control group. The disability of daily living activities was reduced in the experimental group than in the control group. Conclusion: Moxibustion was considered to be likely useful therapeutic method for effects of chronic back pain and disability of daily living activities in aged.

• Asian Pacific Journal of Cancer Prevention
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• 제13권2호
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• pp.447-450
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• 2012

Video-assisted thoracic surgery (VATS) has been recommended as more optimal surgical technique than traditional thoracotomy for lobectomy in lung cancer, but it is not well defined. Here, we compared VATS and traditional thoracotomy based on clinical data. From November 2008 to November 2010, 180 patients underwent lobectomy for non-small-cell lung cancer (NSCL) identified by computerized tomography. Of them, 83 cases were performed with VATS and 97 by thoracotomy. Clinical parameters, consisting of blood loss, operating time, number of lymph node dissection, days of pleural cavity drainage, and length of stay were recorded and evaluated with t test. No significant difference was observed between the VATS and thoracotomy groups in the average intraoperative blood loss, number of lymph node dissections, and days of pleural cavity drainage. While the average operating time in the VATS group was significantly longer than that in thoracotomy group, recurrence was only present in one case, as opposed to 7 cases in the thoracotomy group In conclusion, similar therapeutic effects were demonstrated in VATS and thoracotomy for NSCL. However, VATS lobectomy was associated with fewer complications, recurrence and shorter length of stay.

• KSBB Journal
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• 제19권5호
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• pp.374-380
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• 2004

Production of therapeutic proteins by transgenic plant cell suspension cultures is an attractive system alternative to the other expression system. However, plant cell cultures have shown low expression level of foreign proteins and decreased cell viability by the changes of culture conditions. Therefore, it is necessary to enhance cell viability during the culture period. In this study, a quantitative analysis technique was designed to measure relative cell viability for plant suspension cells which have cell wall and aggregates. It was found that the programmed cell death of plant cells by apoptosis was essentially linked with the apoptotic pathway of animal cells. Therefore, effects of nicotinamide, 3-aminobenzamide and antioxidants on cell viability and apoptosis were examined in transgenic Nicotiana tabacum cells producing hGM-CSF. With those additives, cell viability could be maintained and apoptosis could be redued. In the result, the extracellular production of hGM-CSF could be enhanced 2.5 fold. It was also found that the supplementation of glutathione and ascorbic acid suppressed both the cold stress-induced decrease in cell viability and the increase of total genomic DNA fragmentation.

• 한국의학물리학회:학술대회논문집
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• 한국의학물리학회 2003년도 제27회 추계학술대회
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• pp.73-73
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• 2003

Purpose: To determine the motor cortex dysfunction in hemiparetic patients due to deep intracerebral hematoma, authors performed proton magnetic resonance spectroscopy (lH MRS) for the evaluation of biochemical changes in the cortex on affected hemisphere according to axonal injury at the level of internal capsule. Methods: Ten control subjects and 14 patients with documentable hemiparesis of varying severity hemiparesis were included. All the hemiparesis was caused by deep intracerebral hematoma (putaminal and thalamic hemorrhage). In vivo 1H MRS study was performed on a 3T MRI/MRS system using STEAM sequence. As a single-voxel technique, Spectral parameters were: 20 ms TE, 2000 ms TR, 128 averages, 2500 Hz spectral width, and 2048 data points. Results: We found that the mean N-acetylaspartate (NAA)/phosphocreatine (Cr) and NAA/choline (Cho) ratios were significantly decreased in the motor cortex of the hemiparesis patients compared with control subjects. Conclusions: 1H MRS examinations of the motor cortex might help to differentiate distinct clinical entities of hemiparesis and to monitor pharmacological effects in therapeutic trials, providing a quantitative biological marker for motor neuron dysfunction. Acknowledgement: This study was supported by a grant of the Center for Functional and Metabolic Imaging Technology, Ministry of Health & Welfare, Republic of Korea. (02-PJ3-PG6-EV07-000).

• 말소리와 음성과학
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• 제3권2호
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• pp.99-105
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• 2011

The treatment for patients with mutational dysphonia typically is useful with vegetative phonation, but has not yet been studied. This study attempts to identify the effect of $SKTCLP^{(R)}$ using throat clearing and laughing in patients with mutational dysphonia. The study, which was designed by the author, included 26 patients aged from 14 to 32 years (mean: 18.7 years) who had been diagnosed with mutational dysphonia between January 2007 and June 2010. Voice therapy for these patients included $SKTCLP^{(R)}$, ranging from two to seven sessions (mean: 3.8 sessions). Results were evaluated by videostroboscopy, perceptual evaluation of GRBAS scale, aerodynamic test, and acoustic analysis before and after therapy. Most patients could phonate with low pitch from the beginning and sustain with normal pitch sound in the last session. We had found that glottic gap reduced after therapy and anterior-posterior compression of superior laryngeal part at the first time, and these patients had complete closure of the glottis after treatment. The results of acoustic and aerodynamic measures after treatment indicated significant decreases in Fo, Jitter, Shimmer, SFF, and SPI, and increases in MPT, Psub, and vocal efficiency (p<.05). $SKTCLP^{(R)}$ may be a useful treatment method in managing mutational dysphonia. We can suggest this technique may be useful in improving the voice quality of other functional dysphonia having glottal chink or functional aphonia.