• Speech Sciences
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• v.12 no.3
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• pp.35-48
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• 2005

This study was to examine the relationship between maternal interactive behaviors and stuttering behaviors in preschool children who stutter. Participants were twenty-four children who stutter and their mothers. For the purpose of the current study, 5$\sim$10 minutes of 50 minutes videotaped scenes originally collected to develop fluency assessment instrument were re-videotaped. They included mother-child interactions during playing with toys and reading book situations. Mothers-children interactive behaviors were assessed with Maternal Behavior Rating Sroles(MBRS) and Child Behavior Rating Scales (CBRS). And children's stuttering were assessed with Paradise-Fluency Assessment(P-FA). The results were as follows: 1) the maternal interactive behavior did not significantly differ depending on situations, but scores of maternal responsive factor were higher in the play situation than in the reading situation. 2) Maternal responsiveness might influence on promoting the children's pivotal behavior with children who stutter. And 3) the level of maternal responsiveness was the predictor of children's stuttering behaviors. The therapeutic implication of the results were discussed.

• CELLMED
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• v.3 no.3
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• pp.22.1-22.10
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• 2013

Traditional Chinese medicine (TCM) in single herb or formula prescription has been used for thousands of years. Many of them possess antioxidant activity and the activity may contribute the therapeutic effect. This paper would review the relationship of traditional herbal medicine and antioxidant with particular reference to ginseng. This medicinal herb has been used worldwide with extensive tonic effect. The comet assay, a technique for DNA protecting and damaging investigation would be introduced and the application of comet assay on TCM would be discussed.

• Korean Journal of Biological Psychiatry
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• v.6 no.1
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• pp.41-48
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• 1999

This review focused on the pharmacological treatment of alcoholism, especially alcoholism-related mental disorder. The pharmacological agent for alcoholism can be divided into the following categories : anticraving agent, aversive agent, agent to treat acute alcohol withdrawal, agent to diminish drinking by treating associated psychiatric pathology, agent to induce sobriety in intoxicated individuals. Following trends are included in new trends of pharmacological treatment of alcoholism. What are precise conditions amenable to pharmacological intervention? ; How can psychosocial and behavioral intervention be integrated with pharmacotherapy to enhance treatment outcome? ; Is the concept of "matching" specific pharmacotherapy treatment to different aspect of alcoholism more efficacious than a more generalized medicational approach to treatment? One of the most important factors for alcoholics treatment is good and proper therapeutic relationship with patients and setting up individually specialized treatment program is also important.

• Journal of radiological science and technology
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• v.7 no.1
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• pp.35-40
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• 1984

Side-direction scattered dose from various radiation shielding materials was measured at 50cm distance from the central beam of primary ray by used several kinds of added filters for a x-ray deep therapeutic installation, the obtained results were as follows : 1. Dose rate by tube voltage was more increased at heavy filtration than light filtration. 2. Scattered doses produced by constant tube voltage in all shielding materials were decreased at heavier filtration. 3. Scattered doses produced by constant shielding material in all tube voltages were decreased at heavier filtration.

• Korean Journal of Human Ecology
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• v.14 no.2
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• pp.241-250
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• 2005

The purpose of this study is to develop a marital enhancement program based on reality therapy. The program consists of 8 session contents: program orientation, need strength profile between husband and wife, quality world and marital life, perception about marital life, comparison between quality world and perceived world, total behavior in marital life, communication between husband and wife, integration and application. This study mainly focuses on applying counseling theory (choice theory and reality therapy) to family life education for enhancing a conjugal relationship. In this way, participants of Marital Enhancement Program can experience a therapeutic effect as well as an educational effect.

• Journal of Microbiology and Biotechnology
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• v.30 no.1
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• pp.1-10
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• 2020

FK506, also known as tacrolimus, is a clinically important immunosuppressant drug and has promising therapeutic potentials owing to its antifungal, neuroprotective, and neuroregenerative activities. To generate various FK506 derivatives, the structure of FK506 has been modified by chemical methods or biosynthetic pathway engineering. Herein, we describe the mode of the antifungal action of FK506 and the structure-activity relationship of FK506 derivatives in the context of immunosuppressive and antifungal activities. In addition, we discuss the neurotrophic mechanism of FK506 known to date, along with the neurotrophic FK506 derivatives with significantly reduced immunosuppressive activity. This review suggests the possibility to generate novel FK506 derivatives as antifungal as well as neuroregenerative/neuroprotective agents.

• International Journal of Oral Biology
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• v.42 no.3
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• pp.85-90
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• 2017

Mitochondria participate in various intracellular metabolic pathways such as generating intracellular ATP, synthesizing several essential molecules, regulating calcium homeostasis, and producing the cell's reactive oxygen species (ROS). Emerging studies have demonstrated newly discovered roles of mitochondria, which participate in the regulation of innate immune responses by modulating NLRP3 inflammasomes. Here, we review the recently proposed pathways to be involved in mitochondria-mediated regulation of inflammasome activation and inflammation: 1) mitochondrial ROS, 2) calcium mobilization, 3) nicotinamide adenine dinucleotide ($NAD^+$) reduction, 4) cardiolipin, 5) mitofusin, 6) mitochondrial DNA, 7) mitochondrial antiviral signaling protein. Furthermore, we highlight the significance of mitophagy as a negative regulator of mitochondrial damage and NLRP3 inflammasome activation, as potentially helpful therapeutic approaches which could potentially address uncontrolled inflammation.

• Korean Journal of Child Studies
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• v.30 no.4
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• pp.99-117
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• 2009

This study examined the effectiveness of the Filial Therapy program for children with Separation Anxiety Disorder (SAD). Subjects were 8 mother-child dyads each in the experimental and comparison groups. Mann-Whitney U-test and the Wilcoxon Matched-Pairs Signed-Ranks Test were performed following the therapeutic program. After application of the Filial Therapy program, results showed that, compared to the control group, (1) parents of SAD children in the experimental group significantly increased their level of empathic interactions with their children. AND (2) the experimental group children significantly reduced level of somatic complaints, anxious/depressed, and social problems. Conclusions were that Filial Therapy is an effective program for improvement of parent-child relationship of SAD children but not for changing problem behavior of SAD children.

• International Journal of Human Ecology
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• v.7 no.1
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• pp.121-129
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• 2006

This study investigates the impact of the shared environment of pregnant women and their unborn child on the later emotional and behavioral characteristics of a child, extending into his or her adulthood. Using a sample of some 16,000 children from the National Child Development Study, the study demonstrated a positive relationship between the quality of the maternal environment and later emotional and behavioral performances during childhood and adulthood. These findings support the study hypothesis, suggesting that parenting environment such as mother‘s employment, husband’s social class and the mother‘s smoking habits during pregnancy has an affection on the later emotional and behavioral development of the child. The dimensions of the child’s emotional and behavioral well-being may be enhanced by therapeutic interventions and/or by helping pregnant women to develop a positive social network.

• Radiation Oncology Journal
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• v.7 no.1
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• pp.81-83
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• 1989

This study, involving thirty-two patients with carcinoma of uterine cervix treated by high dose rate intracavitary irradiation using a remotely controlled afterloading system, compares the doss at point A and 8 with the Curie-minutes prescription. A linear least-square regression analysis was used to compare the two sets of date. Correlation coefficients between doses at points A and B and the Ci-min prescription are 0.92 (p<0.001) and 0.90 (p<0.001), respectively, and linear relationship is observed between these two system. The limitation and significance of the comparison of the two approaches to intracavitary dosimetry is discussed.