Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Development of Non-Immunosuppressive FK506 Derivatives as Antifungal and Neurotrophic Agents

  • Jung, Jin A (Department of Chemistry and Nanoscience, Ewha Womans University) ;
  • Yoon, Yeo Joon (Department of Chemistry and Nanoscience, Ewha Womans University)
  • Received : 2019.11.06
  • Accepted : 2019.11.13
  • Published : 2020.01.28
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Abstract

FK506, also known as tacrolimus, is a clinically important immunosuppressant drug and has promising therapeutic potentials owing to its antifungal, neuroprotective, and neuroregenerative activities. To generate various FK506 derivatives, the structure of FK506 has been modified by chemical methods or biosynthetic pathway engineering. Herein, we describe the mode of the antifungal action of FK506 and the structure-activity relationship of FK506 derivatives in the context of immunosuppressive and antifungal activities. In addition, we discuss the neurotrophic mechanism of FK506 known to date, along with the neurotrophic FK506 derivatives with significantly reduced immunosuppressive activity. This review suggests the possibility to generate novel FK506 derivatives as antifungal as well as neuroregenerative/neuroprotective agents.

Keywords

References

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