• Journal of the Korea Society of Computer and Information
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• v.26 no.5
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• pp.55-60
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• 2021

This study aims to investigate the effects of 4 weeks visual biofeedback training on the knee joint angle and muscle activities of lower extremity. The participants in this study were 15 volunteers with hyperextended knee. To improve the hyperextended knee, visual biofeedback training was used during 4 weeks. The training is an exercise to maintain the balance between the anterior weight bearing and posterior weight bearing of the plantar foot. The knee joint angle significantly increased and the muscle activity of tibialis anterior was significantly decreased after visual biofeedback training. It was confirmed that visual biofeedback training of correcting hyperextended knee through the information on the plantar pressure distribution has a therapeutic effect.

• Journal of the Korea Society of Computer and Information
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• v.26 no.4
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• pp.143-147
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• 2021

The purpose of this study is to investigate how the application of a Thorax belt affects the stability of the spine in subjects with a wide infra-sternal angle. A total of 15 subject with wide infra-sternal angle participated in the experiment. Active Double leg lowering and active one-leg raising were performed with or without a thorax belt. Two spinal stability tests (active double lowering and active one-leg raising) performed with or without thorax belt application showed significant differences between each condition. Based on the results of present study, the application of a thorax belt is considered to be an effective therapeutic tool that can stabilize the spine to subjects with abnormally increased chest cage and spinal or trunk instability.

• Physical Therapy Rehabilitation Science
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• v.11 no.3
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• pp.363-369
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• 2022

Objective: The purpose of this study was to prepare evidence for the prevention and management of nonspecific chronic neck pain (NSCNP) by examining the correlation between activity of daily living and physical activities of office workers with NSCNP. Design: Crossed-sectional study Methods: 89 patients with NSCNP were recruited for this study. But 2 subjects met the exclusion criteria and were dropped out, and 86 subjects finally participated. Numerical pain rating scale (NPRS) and neck disability index (NDI) were used to check the pain intensity and disability of patients with neck pain, respectively. For the activity of daily living, computer use time, sleep time, and driving time were used. To find out the physical activities of the subjects, International Physical Activity Questionnaires (IPAQ-SF) was used. Correlation analysis was performed to find out the correlation of each variable. Results: A clear positive correlation was established between computer use time and pain (p<0.05), and a clear positive correlation was established between computer use time and disability index (p<0.05). The correlation between NPRS and NDI and physical activity total time, high intensity activity score, moderate intensity activity score, and walking score were not statistically significant (p>0.05). Conclusions: In treating patients with NSCNP, it is necessary to reduce the computer usage time as a professional factor or to educate the proper posture. In addition, rather than emphasizing physically comprehensive physical activity, grafting therapeutic exercise directly related to neck pain could have a more positive effect on NSCNP patients.

• Journal of The Korean Society of Integrative Medicine
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• v.3 no.2
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• pp.1-8
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• 2015

Purpose: This study was conducted to know the evidence case to assessment about literatures of extensor carpi radialis therapeutic strategy of tennis elbow about dysfunction wrist extension with anatomy, biomechanic and function. Method: Patient was received the physical therapy program with medication for two weeks. Physical therapy program consists of strengthening exercise, stretching exercise and extracopereal shock wave therapy. Results: Patients could do computer and house works at three weeks significant with improved pain. The amounts used repetitive muscle was reduced slowly over a period of a day or two days for wrist moving. Wrist flexor strengthening exercise and could reduced the wrist extensor injury. Conclusion: Clinicians certainly realized biomechanic effects and anatomy of extensor carpiradialis and elbow joint.

• Journal of Biomedical Engineering Research
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• v.29 no.6
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• pp.415-430
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• 2008

The technologies in medical electronic implant(MEI) devices are developing rapidly, and already, there are various kinds of the MEI devices in the current medical equipments market. Recently, the global market scale of MEI devices have been increased about 13% year by year, and the import amount of MEI devices in Korea is increasing rapidly. In the near future, the demands of MEI devices will be magnificently increasing by the continuous development of the biomedical electronics devices which coupled with neural, brain and other organs will bring us to tremendous effects, such as providing new therapeutic solutions to patients, extension and saving human life, and an important clue of medical development. However, the investment of the research and the activity of developments in this field are still very weak in the Korea. Consequently, this paper introduces about the research trends of MEI devices, and technological problems those must be solved, and then concludes with the suggestions in order to be the leading country in this field.

• The Journal of Korean Society for Radiation Therapy
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• v.3 no.1
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• pp.27-36
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• 1989

In order to calculate the dose on each interest point in five types of irregularly shaped fields used commonly in radiotherapy, the tissue-air ratios (TAR) in these fields for Go-60 gamma radiation were calculated using the newly devised SAR-chart. The TARs calculated from newly method of using the SAR-chart, computer method and approximation method at the interest point were compared to the TARs obtained from measurement. The result are as follows; In case of the interest points on central axis the calculated TARs in irregularly shaped fields by the above mentioned methods were well agreed within the error of $1\%$, whereas for the interest points on off-axis the calculated TARs were resulted in the maximum errors of $2.4\%,\;2.3\%$ and $8.8\%$ respectively. From these results, the accuracy of calculation method of using the SAR-chart was comfirmed.

• Archives of Pharmacal Research
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• v.19 no.3
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• pp.183-190
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• 1996

There are a wide variety of semi-solid ointments used for healing the skin diseases, whose therapeutic and skin penetration abililties may greatly differ from one another depending on the compositions of ointment vehicles. A computer optimization technique was applied to obtain the optimum formula of o/w type ointment giving the in vitro maximum absorption rate through hairless rat skin membrane. Some of the formulations were selected to find out a relationship between skin penetration of ointment and its Theological characteristics. The experimental value of absorption rate obtained from the ointment by optimum formula agreed well with the theoretical value obtained from a polynomial regression analysis, Three kinds of ointments selected among 15 formulations were obtained with a concentric cylinder type rheometer (Model; Rheolab SM-HM Physica, Germany) at 20, 30, 40 and $50^{\circ}C$ for rheograms of rhelolgical properties of o/w type ointments. As the temperature was raised, all products showed a decrease in both shear stress and yield values. The higher skin penetration, the lower shear stress showed.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.4
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• pp.2291-2295
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• 2016

Small molecule tyrosine kinase inhibitors targeting HER 2 receptors have emerged as an important therapeutic approach in inhibition of downstream proliferation and survival signals for the treatment of breast cancers. Recent drug discovery efforts have demonstrated that naturally occurring polyphenolic compounds like delphinidin have potential to inhibit proliferation and promote apoptosis of breast cancer cells by targeting HER2 receptors. While delphinidin may thus reduce tumour size, it is associated with serious side effects like dysphonia. Owing to the narrow therapeutic window of delphinidin, the present study aimed to identify high affinity compounds targeting HER2 with safer pharmacological profiles than delphinidin through virtual screening approaches. Delphinidin served as the query parent for identification of structurally similar compounds by Tanimoto-based similarity searching with a threshold of 95% against the PubChem database. The compounds retrieved were further subjected to Lipinski and Verber's filters to obtain drug like agents, then further filtered by diversity based screens with a cut off of 0.6. The compound with Pubchem ID: 91596862 was identified to have higher affinity than its parent. In addition it also proved to be non-toxic with a better ADMET profile and higher kinase activity. The compound identified in the study can be put to further in vitro drug testing to complement the present study.

• Journal of Digital Convergence
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• v.20 no.2
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• pp.311-316
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• 2022

Tertomotide is a peptide fragment of hTert and developed as a vaccine targeting cancer. It has been reportedly known to ameliorate inflammatory symptoms in clinical tests and in animal studies. However, the therapeutic potential of tertomotide is not supposed to be comparable to conventional anti-inflammatory agents due to low druglikeness In order to treat inflammations present in varous lesion, the structure of tertomotide is required to be modified. In this context, 12 octapeptides were designed based on tertomotide and screened for the anti-inflammatory activity in activated monocyte by measuring TNF-α secretion. As a result, some octapeptides has been exerted anti-inflammatory activity, comparable to or better than tertomotide and estradiol, known anti-inflammatory agents. This result is supposed to be helpful for developing therapeutic purpose exploiting other tertomotide-derived peptides and would be an example for designing novel drug based on active biomolecules with undesirable structure by convergence study of biology and computer-aided medicinal chemistry.

• International Journal of Computer Science & Network Security
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• v.21 no.6
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• pp.319-328
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• 2021

Parallel administration of numerous drugs increases Drug-Drug Interaction (DDI) because one drug might affect the activity of other drugs. DDI causes negative or positive impacts on therapeutic output. So there is a need to discover DDI to enhance the safety of consuming drugs. Though there are several DDI system exist to predict an interaction but nowadays it becomes impossible to maintain with a large number of biomedical texts which is getting increased rapidly. Mostly the existing DDI system address classification issues, and especially rely on handcrafted features, and some features which are based on particular domain tools. The objective of this paper to predict DDI in a way to avoid adverse effects caused by the consumed drugs, to predict similarities among the drug, Drug pair similarity calculation is performed. The best optimal weight is obtained with the support of KHA. LSTM function with weight obtained from KHA and makes bets prediction of DDI. Our methodology depends on (LSTM-KHA) for the detection of DDI. Similarities among the drugs are measured with the help of drug pair similarity calculation. KHA is used to find the best optimal weight which is used by LSTM to predict DDI. The experimental result was conducted on three kinds of dataset DS1 (CYP), DS2 (NCYP), and DS3 taken from the DrugBank database. To evaluate the performance of proposed work in terms of performance metrics like accuracy, recall, precision, F-measures, AUPR, AUC, and AUROC. Experimental results express that the proposed method outperforms other existing methods for predicting DDI. LSTMKHA produces reasonable performance metrics when compared to the existing DDI prediction model.