• 가정과삶의질연구
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• 제33권5호
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• pp.103-115
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• 2015

The purpose of this study is, first, to develop a Therapy Competency Enhancement Program for Novice Play-therapists Using Traditional Play to enhance therapy Competency and second, to examine the program's effectiveness. The program consists of 10 sessions and each session employs a variety of traditional plays. The Therapeutic relationship Scale and Playfulness Scale were used as a pre-test and post-test respectively. The data were analyzed by the SPSS 18.0 program, which applied the Mann-Whiteney U test and Wilcoxon rank sum test. Twelve novice play therapists participated in ten sessions of the Therapy Competency Enhancement Program, and were compared with the control group of twelve novice play therapists who did not receive treatment. The treatment group statistically showed significant enhancement in therapeutic relationships, and playfulness in comparison to the control group. It was concluded that the Therapy Competency Enhancement Program for Novice Play-therapists Using Traditional Play was effective for enhancing therapeutic relationships and playfulness. This study has significance in its attempt to develop a Therapy Competency Enhancement program to improve the therapeutic relationship, and playfulness of novice play therapists by Traditional Play.

• 부모자녀건강학회지
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• 제12권2호
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• pp.119-130
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• 2009

Purpose: This study was designed to examine the effects of Therapeutic Play Program on the pre-operative anxiety of the preschoolers. The design of this study is a quasi experimental study of non-equivalent control group pre-test/post-test design. Method: The subjects of this study were the hospitalized preschoolers receiving an operation in C University Hospital. These totalled 60 and were divided into a 30-person-control-group and a 30-person-experimental-group. The data was collected from June 1 to October 5, 2002. The Experimental treatment was carried out according to Therapeutic Play Program developed by Researcher. The instruments used in this study were the observational records for Hospitalized preschooler's Anxiety behavior response, pulse rate, and respiration rate of the preschooler's. The collected data were analyzed with real numbers, percentage, t-test, and $X^2$-test, using SPSS WIN 11.0 program. Result: Hypothesis, "The experimental group provided with a Therapeutic Play Program would show a lower score of the pre-operative anxiety behavior(t=13.79, p=.00), pre-operative pulse(t=4.50, p=.00) and pre-operative respiration rate(t=4.29, p=.00) response than when the control group was not provided", was supported. Conclusion: Therapeutic Play Program is determined to be useful for reducing Pre-operative anxiety of the preschoolers.

• Child Health Nursing Research
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• 제8권1호
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• pp.5-19
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• 2002

The purpose of this study was to identify therapeutic play need and the degree of the nurses's therapeutic play performances perceived by hospitalized children's mothers, and then to compare the difference between the degree of the need and perceived performances. The subjects of this study consist of 121 hospitalized children's mothers. A questionaire for this study was 29 item likert type 4 point scale developed on the basis of literature review, hospitalized children's mother interview and researcher's clinical experiences. Data was analyzed by Paired t-test, t-test, ANOVA & Duncan's comparison. Results of this study are summarized as follows : 1. The degree of the therapeutic play need was measured to be high (3.20). The degree of perceived therapeutic play need by five components were followed as : physiologic suffering relief & enhancing play (3.39), growth & development facilitating play (3.26), instructional play (3.24), emotional well-being promoting play (3.18) and providing play tool & environment(2.97). 2.The degree of the nurse's therapeutic play performances perceived by mothers was measured to be low (1.60). The degree of perceived performances of the therapeutic play by the five components were followed as : physiologic suffering relief & enhancing play (1.87), instructional play (1.74), emotional well-being promoting play (1.64), providing play tool & environment (1.44) and growth&development facilitating play (1.42). 3. The difference between the degree of the therapeutic play need and nurese's perfor- mances perceived by hospitalized children's mothers were significant statistically (t= 38.54, p=.0001). Also, five components of therapeutic play were significant statistically (p=.0001). Therapeutic play has unique benefits among health care intervention for children. These findings will help in building of the theoretical framework of therapeutic play and enhancing the quality of nursing care for hospitalized children. Therapeutic play program for hospitalized children according to child growth & development and physiologic status are recommended to be developed.

• 아동학회지
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• 제27권6호
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• pp.107-121
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• 2006

Based on the 10 week filial therapy model developed by Landreth (1991) for parents in lower income families, this study used the pre- and post- test model applied to an experimental group of 9 individuals. The program was implemented in three hour sessions, once a week for eight weeks. T-tests were performed following the therapeutic program. Results were that all four subcategories of parent's acceptance capability (respect for children's emotion and emotional expression management, understanding of children's unique temperament, understanding of children's desire for autonomy, and unconditional love for children) showed statistically significant differences between the pre- and post- tests (p< .001). Differences between the pre- and post test on parents' stress approached significance.

• IMMUNE NETWORK
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• 제20권1호
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• pp.3.1-3.20
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• 2020

Immune checkpoint inhibitors (ICIs), including anti-PD-1 and anti-CTLA-4 therapeutic agents, are now approved by the Food and Drug Administration for treatment of various types of cancer. However, the therapeutic efficacy of ICIs varies among patients and cancer types. Moreover, most patients do not develop durable antitumor responses after ICI therapy due to an ephemeral reversal of T-cell dysfunction. As co-stimulatory receptors play key roles in regulating the effector functions of T cells, activating co-stimulatory pathways may improve checkpoint inhibition efficacy, and lead to durable antitumor responses. Here, we review recent advances in our understating of co-stimulatory receptors in cancers, providing the necessary groundwork for the rational design of cancer immunotherapy.

• 한국동물위생학회지
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• 제35권4호
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• pp.327-332
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• 2012

This study aimed to see if as companion animals living with human beings, dogs could provide emotional stability or play a therapeutic role for human beings. Of 12 middle school boys as victims of school violence, 6 were assigned to the experimental group that was provided with an animal-assisted therapy program over a total of 12 sections, one section per week, 60 minutes per section, between September and November 2011, followed by post-test 1 and, one month later, post-test 2. In the experimental composition, the remaining 6 boys were assigned to the comparison group that was allowed to read freely. Analysis was performed by using the scales of depression and self-esteem, and the results showed that the experimental group provided with the animal-assisted therapy program generated more significant therapeutic effects than the comparison group. The therapeutic effects were found to persist one month after the completion of the program. Therefore, it is believed that sensitive adolescents who suffer from depression or have lost self-esteem because of school violence can significantly benefit from an animal-assisted therapy program by reducing the recovery time or by getting lots of help with emotional stability. Further research on the basis of this study is expected to help adolescents with emotional therapy in other areas.

• 한국임상약학회지
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• 제21권1호
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• pp.14-21
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• 2011

Drug Utilization Review (DUR) is known to play an important role to improve appropriateness of drug prescriptions. This retrospective, observational study was conducted to compare prescription patterns after installation of Computerized DUR Program (Drug Information Framework-$Korea^{TM}$) (Jan-Mar 2008; After) to before DUR program (Jan-Mar 2007: Before). 8 physicians affiliated in the S University Hospital were enrolled in the study and their 3 months' prescription data were analysed for drug prescription trends and DUR conflict events per 7 DUR screening modules (drugdrug interaction, therapeutic duplication, allergy, dosing, disease contra-indication, geriatric contra-indication, pediatric contra-indication). Average rate of DUR modules usage in 2008 (After) were 0.72. Average number of prescription drug per patient were reduced from 5.6 (Before) to 3.8 (After), and DUR program seemed to effect positively on physician's prescription related decision process. Overall DUR conflict events occurred by 8 physicians for 3 months were 17,923 Before and 20,057 After DUR program, and DUR conflict events per prescription were 2.8 Before and 2.9 After, respectively. Therapeutic duplication (37%), geriatric contra-indication (34%) and dosing (18%) were high ranked DUR conflicts. As the study was not sufficient to show a consistent trend to reduce DUR conflicts After, another study to confirm it's effectiveness would be recommended. This study would be of help to develop awareness of DUR program to healthcare providers.

• Molecules and Cells
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• 제42권12호
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• pp.828-835
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• 2019

PIWI Argonaute proteins and Piwi-interacting RNAs (piRNAs) are expressed in all animal species and play a critical role in cellular defense by inhibiting the activation of transposable elements in the germline. Recently, new evidence suggests that PIWI proteins and piRNAs also play important roles in various somatic tissues, including neurons. This review summarizes the neuronal functions of the PIWI-piRNA pathway in multiple animal species, including their involvement in axon regeneration, behavior, memory formation, and transgenerational epigenetic inheritance of adaptive memory. This review also discusses the consequences of dysregulation of neuronal PIWI-piRNA pathways in certain neurological disorders, including neurodevelopmental and neurodegenerative diseases. A full understanding of neuronal PIWI-piRNA pathways will ultimately provide novel insights into small RNA biology and could potentially provide precise targets for therapeutic applications.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제17권2호
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• pp.79-90
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• 2006

Social deficits are the most critical and core deficits of the children with Autistic Spectrum Disorder(ASD) and they are qualitatively as well as qualitatively different from typically developing children. It is proposed that the attachment between the mother and the autistic child should be promoted foremost and early as possible, to improve social deficits, just like early social developments in normal children depend largely on interactions between the mother and the child who are attached to each other we have developed an interventional program, 'Attachment Promotion Therapy', largely based on the attachment theory. The Attachment promotion Therapy mandates the participation of both the mother and the autistic child, and consists of mutually enjoying play activities, close physical contacts and parental training on intense mother-child interactions, focusing on improving maternal sensitivity, responsiveness, and nurturing behaviors during their interactions. The program was found to be effective in improving attachment behaviors, attachment security and acquiring joint attention skills. Attachment Promotion Therapy is therefore proposed here as the important earliest intervention method for children with ASD and could become the base for many other educational and therapeutic interventions.

• 한국사회복지학
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• 제45권
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• pp.250-287
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• 2001

This study concerns therapeutic effects and long-term effects of Therapy Dog Assisted Program (TDAP) on autistic children. Subjects participating in this study are two groups of Korean elementary school boys of the same age (twelve years old) : an experimental group and a controlled group of equal number of children (six children in total). The thirteen different sessions of the first intervention and eight different sessions of the second intervention were performed over six months (from April 20th to October 27th, 2000). Two standard instrument (ASIEP, E-CLAC) are used as major instruments in order to evaluate the effectiveness of TDAP. Evidene from the present study indicates that the children participating in TDAP program achieved a greater degree of improvement in their social interaction in comparison with the counterpart. The present study also demonstrates that, in general, the effectiveness of TDAP somewhat decreased after the termination of TDAP with some exceptions. However we also found that the effectiveness of TDAP were maintained in the some behavioral area such as bowing to teacher, play for cooperation with peers, which activities were sufficiently offered TDAP to the children. The questions of possible influence of parental support and other family background of each individual autistic child on the effect and long-term effect of TDAP need to be addressed in future study.