• Journal of the Korean Data and Information Science Society
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• v.26 no.6
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• pp.1199-1206
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• 2015

into aging is the most rapidly increasing among the OECD countries. Consequently, this study aims at analyzing the forms of portfolio establishment by group, the factors affecting the old age preparation, and the presence of middle-aged households' preparation for the old ages in order to forestall social problems like the poverty ration of elderly that have been caused by the rapidly aging society. The result shows that the portfolio for the old age preparation can be expanded if a combination product of finance and real estate is developed as a means of old age preparation. Upon the results of the study above, it can be seen that the old age preparations differ according to not only the demographic elements, but also the extent to how much resources one holds. Especially, the various factors affecting the holding resources vary householder by household depending on whether they prepare for the old ages or not.

• Applied Microscopy
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• v.25 no.4
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• pp.26-51
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• 1995

The present study was designed to examine effect of long term weight-training on aging atrophy in the rat skeletal muscle. Male rats of 8, 15, and 24 month old were used. Each age groups included control and weight-training for 5 months by using body press apparatus. The histo- and cytochemical, ultrastructural and stereological changes in aging skeletal muscles of the rat were observed in the present study. During the training period the body weight and muscular weight in all groups except the rectus femoris and the gastrocnemius in young age groups remained constant, but muscular weights were increased in the rectus femoris and the gastrocnemius muscles in young age groups. In trained rat, the volume density of muscle fiber type IIA and IIB were increased, but those of type IIC was decreased. Type I remained constant in 8 and 15 month old age groups, but reduced in the tibialis anterior and the gastrocnemius muscles in the 24 month old groups. Some histotological and ultrastructural changes associated with age were found: numerical increase of cytiplasmic vacuoles, lysosomes, lipofuscins, and irregularity of myofibrils. At 24 month old groups some unusual formation of contraction band and muscle splitting were observed. After weight-training, ultrastructural degenerative changes occured in the type I muscle fiber, such as splitting of muscle fiber, disorganization of myofilaments, swelling of mitochondria, accumulation of many lipid droplets, appearance of many lysosomes and residual bodies and necrotic fibers, in the old age groups. But, in the type II muscle fibers hypertrophy of muscle fiber appeared without any noticible damage as the type I. The activities of $Mg^{++}$ -ATPase decreased with age and this enzyme activities in the trained rat were significantly decreased with age. Activities of the acid phosphatase were increased with age and significantly in the trained rat. In stereological analysis, volume density of the myofibrils and the tubular system were increased, on the other hand there mitochondrial capacity was decreased. These experimental results suggested that old rats are not susceptible to be affected by weight-training as young rats, and that physical capacity of the rats must be considered when old rats are exercised for training.

• Osteoporosis and Sarcopenia
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• v.3 no.3
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• pp.117-122
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• 2017

Sarcopenia is the degenerative loss of muscle mass and function with aging. Recently sarcopenia was recognized as a clinical disease by the International Classification of Disease, 10th revision, Clinical Modification. An imbalance between protein synthesis and degradation causes a gradual loss of muscle mass, resulting in a decline of muscle function as a progress of sarcopenia. Many mechanisms involved in the onset of sarcopenia include age-related factors as well as activity-, disease-, and nutrition-related factors. The stage of sarcopenia reflecting the severity of conditions assists clinical management of sarcopenia. It is important that systemic descriptions of the disease conditions include age, sex, and other environmental risk factors as well as levels of physical function. To develop a new therapeutic intervention needed is the detailed understanding of molecular and cellular mechanisms by which apoptosis, autophagy, atrophy, and hypertrophy occur in the muscle stem cells, myotubes, and/or neuromuscular junction. The new strategy to managing sarcopenia will be signal-modulating small molecules, natural compounds, repurposing of old drugs, and muscle-specific microRNAs.

• Proceedings of the Korea Contents Association Conference
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• 2008.05a
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• pp.754-758
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• 2008

Since our country is rapidly progressing from an aging society to an advanced age society, it already puts in effect basic old-age pension system, hurries training human resources like care-giver, and has ahead offering the aged long-term care insurance. But our country still needs to develop a systematic curriculum in order to train professionals that can fundamentally deal with an aging society problems. In this paper, therefore, we describe the development of a curriculum for training silver-care professionals improving qualities of old person life in order to suit to an aged society and prepare for an advanced age society. It includes a network model of a silver-care curriculum based on subject classifications according to fields and levels.

• Korean Journal of Adult Nursing
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• v.22 no.3
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• pp.239-249
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• 2010

Purpose: The objective of this study was to identify the relationships between family function and successful aging of vulnerable elderly using the circumplex model. Methods: The participants were the elderly (N=401) who were over 65 years old living in H city under the National Livelihood Security Act. Family Adaptability and Cohesion Evaluation Scale III and Successful Aging Instrument were used. Results: The family function perceived by the study subjects was average $43.20{\pm}16.62$ out of maximum 100 points. According to the analysis on family types suggested by circumplex model, there were 183 people for balance family (45.6%) and 218 people (54.4%) for extreme family. The total points on successful aging were $1.67{\pm}0.37$ out of 3 points. When the difference in points on the Successful Aging instrument were analyzed according to the scores on the Family Adaptability and Cohesion Scale those points of the balanced family were statistically significant (t=2.087, p=.038). Conclusion: In case of the balanced family type, the level of perceiving successful aging was relatively higher. For the improvement of family function, it is advised that the successful aging perception among vulnerable elderly can be uplifted through a program that enables effective communication with other family members.

• 한국노년학
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• v.41 no.4
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• pp.527-546
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• 2021

This study examined the effect of past acceptance on suicidal ideation in older adults and verified double mediation effects of attitude to aging and depression. The responses of 329 aged 65 years or older who participate in senior welfare centers in Seoul and Gyeonggi-do were used. As an analysis method, the double mediation effect was confirmed through serial multiple mediation model verification using the SPSS PROCESS macro program. The followings are the results of the study. First, the past acceptance had a significant effect on the aging attitude, the aging attitude on the depression, and the depression on the suicidal ideation, but the direct effect of past acceptance on the suicidal ideation was not significant. Second, double mediation effects of attitude to aging and depression were significant in the relationship between past acceptance and suicidal ideation. Based on these results, practical and policy interventions to prevent suicide in old age were suggested.

• Nutrition Research and Practice
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• v.10 no.1
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• pp.3-10
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• 2016

BACKGROUND/OBJECTIVES: Oligonol, mainly found in lychee fruit, is an antioxidant polyphenolic compound which has been shown to have anti-inflammatory and anti-cancer properties. The detailed mechanisms by which oligonol may act as an anti-aging molecule have not been determined. MATERIALS/METHODS: In this study, we evaluated the ability of oligonol to modulate sirtuin (SIRT) expression in human lung epithelial (A549) cells. Oligonol was added to A549 cells and reactive oxygen species production, mitochondrial superoxide formation, and p21 protein levels were measured. Signaling pathways activated upon oligonol treatment were also determined by western blotting. Furthermore, the anti-aging effect of oligonol was evaluated ex vivo in mouse splenocytes and in vivo in Caenorhabditis elegans. RESULTS: Oligonol specifically induced the expression of SIRT1, whose activity is linked to gene expression, metabolic control, and healthy aging. In response to influenza virus infection of A549 cells, oligonol treatment significantly up-regulated SIRT1 expression and down-regulated viral hemagglutinin expression. Oligonol treatment also resulted in the activation of autophagy pathways and the phosphorylation of AMP-activated protein kinase (AMPK). Furthermore, oligonol-treated spleen lymphocytes from old mice showed increased cell proliferation, and mRNA levels of SIRT1 in the lungs of old mice were significantly lower than those in the lungs of young mice. Additionally, in vivo lethality assay revealed that oligonol extended the lifespan of C. elegans infected with lethal Vibrio cholerae. CONCLUSIONS: These data demonstrated that oligonol may act as an anti-aging molecule by modulating SIRT1/autophagy/AMPK pathways.

• Nutrition Research and Practice
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• v.9 no.4
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• pp.358-363
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• 2015

BACKGROUND/OBJECTIVES: Previous studies have indicated that when compared to young mice, old mice have lower global DNA methylation and higher p16 promoter methylation in colonic mucosa, which is a common finding in colon cancer. It is also known that a Western-style diet (WSD) high in fat and calories, and low in calcium, vitamin D, fiber, methionine and choline (based on the AIN 76A diet) is tumorigenic in colons of mice. Because DNA methylation is modifiable by diet, we investigate whether a WSD disrupts DNA methylation patterns, creating a tumorigenic environment. SUBJECTVIES/METHODS: We investigated the effects of a WSD and aging on global and p16 promoter DNA methylation in the colon. Two month old male C57BL/6 mice were fed either a WSD or a control diet (AIN76A) for 6, 12 or 17 months. Global DNA methylation, p16 promoter methylation and p16 expression were determined by LC/MS, methyl-specific PCR and real time RT-PCR, respectively. RESULTS: The WSD group demonstrated significantly decreased global DNA methylation compared with the control at 17 months (4.05 vs 4.31%, P = 0.019). While both diets did not change global DNA methylation over time, mice fed the WSD had lower global methylation relative to controls when comparing all animals (4.13 vs 4.30%, P = 0.0005). There was an increase in p16 promoter methylation from 6 to 17 months in both diet groups (P < 0.05) but no differences were observed between diet groups. Expression of p16 increased with age in both control and WSD groups. CONCLUSIONS: In this model a WSD reduces global DNA methylation, whereas aging itself has no affect. Although the epigenetic effect of aging was not strong enough to alter global DNA methylation, changes in promoter-specific methylation and gene expression occurred with aging regardless of diet, demonstrating the complexity of epigenetic patterns.

• Development and Reproduction
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• v.14 no.3
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• pp.171-177
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• 2010

A recent report demonstrated that in human aging brain after menopause/andropause luteinizing hormone (LH) is localized in the cytoplasm of pyramidal neurons of hippocampus and a significant increase of LH is also detected in the cytoplasm of pyramidal neurons and neurofibrillary tangles of Alzheimer's disease brain compared to age-matched control brain. It was suggested that the decreased steroid hormone production and the resulting LH expression in the neurons vulnerable to Alzheimer's disease pathology may have some relevance to the development of Alzheimer's disease. It is, however, unclear whether the presence of LH in neurons of human aging and Alzheimer's disease brain is due to intracellular LH expression or to LH uptake from extracellular sources, since gonadotropins are known to cross the blood brain barrier. Moreover, there is no report by using the brain of experimental animal that LH is expressed in such neurons as found in the human brain. In the present study, we found that LH immunoreactivity is localized in the pyramidal neurons of cerebral cortex and hippocampus of 12 and 18 months old rats but can not detect any immunoreactivity for LH in the young adult (3-5 months old) rats. To confirm that these LH immunoreactivity results from de novo synthesis in the brain but not the uptake from extracellular space, we performed RT-PCR and found that mRNA for LH is detected in several regions of brain including cerebral cortex and hippocampus. These findings suggest us that LH expression in old rat brain may play an important role in aging process of rat brain.

• 한국노년학
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• v.39 no.1
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• pp.61-72
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• 2019

The purpose of this study was to find ways to reduce old age anxiety by identifying the differences between old age anxiety, grandparents' connection, filial piety, and characteristics, and by identifying factors that affect old age anxiety. The study participants conveniently labeled college students residing in Seoul, Gyeonggi and Chungcheong provinces, and collected data from 2 April to 15 June 2018 and distributed a total of 250 structured questionnaires and retrieved 235 copies to use part 213 for the final analysis. The analysis used SPSS 20.0 Version to obtain frequency, percentage, average, and standard deviation, and age anxiety according to the characteristics of the subject, grandparents and sense of filial piety were analyzed with t-test and ANOVA, and the correlation between aging anxiety, grandparents' bond and filial consciousness was confirmed as Pearson correlation co-efficient. To check the effects of aging anxiety, polylinearity was diagnosed and analyzed with Stepwise multiple regression. Research found that there were statistically significant differences in age insecurity according to majors, grandparents and ties by gender and filial piety by religion and grandparents. And the lower the bond with grandparents, the higher the filial piety, the higher the anxiety was.