• Korean Journal of Clinical Pharmacy
• /
• v.20 no.3
• /
• pp.193-199
• /
• 2010

Tacrolimus, an immunosuppressant prescribed against graft-versus-host disease (GVHD) in patients with allogeneichematopoietic stem cell transplantation (HSCT), is affected to change its pharmacokinetic properties by various factors. For this reason, it is needed a close monitoring to adjust dosage amount in order to optimize the blood concentration of tacrolimus is located within the effective range. According to our in-house study, 62% of HSCT-patients were needed dosage-adjustment and it is necessary to optimize the current immunosuppressive regimen in clinical settings. A retrospective study was designed to evaluate the dosing regimen (converting ratio of IV:PO=1:4) of tacrolimus in HSCT patients (n=62). After collecting data from patient's profile and medical record, pharmacokinetic parameters were calculate and compared between the estimated and the actual values in the selected subjects (n=58). It was found that the bioavailabilty (BA) of oral tacrolimus was 40.5% very much different from that is known as 25%. It implies that the current protocol has a potent risk causes dose-related toxicities to the patients. Furthermore, analyses among factors demonstrated that there was no statistical significance between BA of tacrolimus and the variable factors. In the clinical perspectives, the current converting ratio of tacrolimus in patients with HSCT to be re-considered and an appropriate and optimal alternative regimen should be adopted to prevent GVHD and to increase the quality of life of patients.

• Proceedings of the Korean Institute Of Construction Engineering and Management
• /
• 2006.11a
• /
• pp.448-452
• /
• 2006

Remodeling is deemedto be very important from the perspective of the recycling of resources, instead of scrapping the existing structure, and the creation of 'value added' which is equivalent to the 'value added' from the new construction. In addition, the selection of the appropriate construction method assures the saving of construction cost, the shortening of construction period, and the improvement of quality. Moreover, the selection of the construction method for the remodeling construction is far more important than the current new construction work, considering that the characteristicsof construction site and the structure have a great effect on the construction in case of the remodelingconstruction. Current selection of the construction method, however, does not reflect the construction information, but just adheres to the construction method which was commonly applied previously. Therefore, this study proposes the measure to embody the tool that assists the decision making in selecting the construction method.

• Journal of Korean Society of Industrial and Systems Engineering
• /
• v.40 no.4
• /
• pp.55-66
• /
• 2017

Korean small and medium sized software companies have tried to export their solutions or services to overseas markets. In 2016, exports of the software industry increased by 6.0% from the previous year, and the value added of the industry was 2.2 times higher than that of the manufacturing industry. From a long-term perspective, it is important to secure a global competitive advantage in order to sustain the export high value-added of the software industry. The obstacles to entry into the overseas market of small to medium enterprises are as follows: first, difficulty in product development and localization of marketing; second, lack of investment for overseas expansion; and finally, competitiveness of software technology. In particular, To overcome such obstacles, Korean small and medium sized software companies should increase the technical perfection and secure software export competitiveness. The paper presents a payment settlement framework enabling adaptive reuse and semiautomatic development of global payment settlement services. The quantitative and qualitative evaluation results are presented with domestic and overseas case studies as follows: Firstly, semi-automatic development is realized successfully by applying the framework. Secondly, it is possible to maintain consistent quality of software and to deliver maintenance services without relying on the internal human resources. Thirdly, it is possible to reduce the project duration of the same development cope to less than 50% by applying the framework. Finally, because it is based on BPMN 2.0, which is a high level design diagram, it is expected that it will be easy to implement through components connection and reduce difficulties in technology transfer and localization. Also, at the time of runtime operation, it will be effective to understand the design idea easily and to carry out additional developments without human resource who participated in the initial project.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
• /
• v.21 no.7
• /
• pp.68-74
• /
• 2007

For carnation productivity improvement, compact-low cost discharge lamp type ozonizer using pulse power source is designed and manufactured. This paper describes the discharge characteristics and the ozone generation characteristics with variation of the output voltage of pulse power source, the quantity of flowing air and the operating number of ozonizer. The important conclusions are as follows. The discharge voltage and current values are proportional to the output voltage of pulse power source. The ozone concentration and generation are proportional to the output voltage of pulse power source and the number of ozonizer. The maximum value of the ozone concentration and generation of the discharge lamp type ozonizer can be obtained 890[ppm] and 59.7[mg/h] respectively. In the carnation productivity house, when the discharge lamp type ozonizer is used the carnation is good quality in the uniformity of the carnation stalk thickness and increased the productivity through improvement of the air and the soil.

• Korean Institute of Interior Design Journal
• /
• v.25 no.1
• /
• pp.3-12
• /
• 2016

This study analyses characteristics of space to facilitate community centering on cases of collective houses in Japan and uses the results as basic data to activate collective houses as an alternative form of housing in our country. To identify the characteristics of space for active communities with collective living space, this study conducted a theoretical examination on collective houses and housing, derived territoriality, accessibility, comfort and safety as factors of community activation and analysed various cases, and the results are presented as follows: First, territoriality is a necessary condition for formation of community, and a confined and physical space. It indicates the proper size of a space and diverse spacial areas which meet the needs of residents with the proper size and amount of space (space which can accommodate diverse generations including women, the aged and the young, flexible space which changes according to the purposes and program, space which supports leisure and hobby activities, and space which can accommodate outsiders). Second, accessibility indicates an environment which supports residents' easy use of space. As the more accessible it is, the higher the frequency of its use, spatial factors (piloti, backyards, benches and tables) should be provided, community space should be arranged in a central or decentralized way and community living space should be made for each floor. As for exits, accessibility should be considered in every way; entrances connected with community spaces, open entrances and entrances accessible from outside or individual living spaces. Third, comfort satisfies the physical and mental needs of residents through separation of floors and flows between the community and individual spaces for privacy and formation of eco-friendly spaces including vegetable gardens, gardens and plant arrangements. Fourth, safety should be considered for a higher quality environment with psychological stability and comfort, for which the following are recommended: installation of hand-rails, removal of thresholds, spacial design for the socially weak, duplex and open type structures for community space, open stages and halls, as well as indoor and outdoor openness through the use of windows.

• Journal of the Korean housing association
• /
• v.27 no.2
• /
• pp.21-31
• /
• 2016

In recent rural areas, unlike the past, the young population is increasing with the growth of the agricultural industry and the quality of life-focused trend. Therefore, the rural areas need to more actively respond to the housing demands of the young generations. In this regard, this study aimed to research the housing conditions of the households with children and identify any problems. The study targeted 16 families with children in Deokpo-ri, Yeongwol-gun, Gangwon Province. The research was conducted based on the on-site case study, specifically face-to-face in-depth interview and on-site monitoring using the checklist by residential spaces. The research findings are as follows: The discovered issues include the storage size and safety issues in the movement space, failure to provide the space tailored to the characteristics of the children and the insufficient size and storage space in the living space and the size and safety issues in the sanitary space. Overall, it was identified that small and insufficient storage space in the house pointed out as the main issue in this research was getting the residents' life more uncomfortable and unreasonable, and the activities of the children made their parents do unnecessary behaviors and stressed out during the process of childrearing. Therefore, it is necessary to consider the space arrangement considering the organizing system, caring system and the behavioral characteristics of the children during the process of child-rearing.

• Journal of the Korean Institute of Rural Architecture
• /
• v.19 no.4
• /
• pp.57-65
• /
• 2017

Life quality in farming areas is declining these days on account of decrease in population with the outflow of young generations, advent of aging society, and also lack of social and physical infrastructure. To reverse this, the central and local governments have been devising policies in many ways; however, the vulnerable class in farming area suffering from financial difficulty is not supported with that properly. The results of applying insulation materials applicable to rural houses, EPS, e-board, and glass wool, actually to rural houses are summed as follows. EPS is the most inexpensive among the three installations in terms of material cost and expenses. The indoor and outdoor temperature difference increased from $0.9^{\circ}C$ to $2.5^{\circ}C$, and the temperature change reduced as $0.04^{\circ}C$. With e-board, the indoor and outdoor temperature difference increased from $3.3^{\circ}C$ to $7.5^{\circ}C$; however, the temperature change increased as $0.09^{\circ}C$. Unlike the other two methods, glass wool requires the additional installation of wooden frames. The material cost is highest, and the indoor and outdoor temperature difference increased from $1.1^{\circ}C$ to $8.0^{\circ}C$, and the temperature change reduced as $0.01^{\circ}C$. According to the results of measuring temperature, glass wool's temperature difference is measured to be the highest, but temperature change is found to be the most effective in EPS. Among the three insulation methods, EPS is the most economically advantageous as the material supply is easy and the cost is low. The material is easily processible, so ordinary town residents can install it easily, and it is effective at improving insulation performance, too. But this method cannot be applied when the house has walls that are not even. Also, as the insulator is thick, after the installation, the living space may be narrower as a result.

• International Journal of Industrial Entomology and Biomaterials
• /
• v.33 no.1
• /
• pp.15-23
• /
• 2016

One major constraint in the development and implementation of a successful and cost-effective area-wide integrated pest management (AW-IPM) programme with a SIT component for Bactrocera oleae (Diptera: Tephritidae) is the ability to produce a large number of high quality mass-reared individuals. The aim of this study was to develop a more efficient and practical egg collection system in an attempt to improve the mass-rearing of this species. The following basic parameters were examined: egg production per female, egg hatch, pupal recovery, pupal weight, adult emergence and percentage of fliers. Three different strains (Israel wild-type, France wild-type, and Greece laboratory) were tested and each strain was evaluated for six generations. Female flies of the Israel strain produced significantly more eggs per female than the other two strains, but egg hatch was significantly lower. Egg hatch of the France wild type and the Greece laboratory strain was similar. For all other parameters, there was no significant difference between strains; however, there was a significant generational effect for all parameters observed. As a result of this study, a protocol was developed for the mass-rearing of this species that included the use of large adult holding cages that could house up to 96,000 flies per cage. The newly developed method of egg collection using a flat wax panel as one of the sides of an adult holding cage proved to be cost-effective, efficient, making colony growth easier for industrial mass-rearing.

• Journal of the Korean housing association
• /
• v.20 no.4
• /
• pp.31-38
• /
• 2009

In our country, the application of the design method of face to face dimension in wall-slab apartment has passed 10 years. So MC(Modular Coordination) design method has fixed in the design step to some degree. In Design and Work Execution of House the exclusive area of the apartment was calculated by face to face dimension. And the term of face to face dimension was known broadly to clients, construction company, etc. But design method of face to face dimension is not to simply extend the room size so far as wall depth in design process but to ensure the actual space should be considered with efficient use and assembly of building components. That is to say, Design method of face to face dimension is not to be defined by design step but to be related with construction and maintenance. However in construction process the point of face to face design method was not understood even now. So the purpose of this study was to extract the effect and question of face to face design method in construction process by survey of actual condition of structure and construction quality, and compare this result with existing construction method. The following project of this study is to survey of actual condition of interior components such as gypsum board, windows & doors etc. Therefore this study is to induce architectural long-life through architectural standardization construction and component's exchange, and, by the subject of the study on Apartment to have design guideline and basis for joining part between Gypsumboard and windows.

• Proceeding of Spring/Autumn Annual Conference of KHA
• /
• 2009.04a
• /
• pp.230-235
• /
• 2009

In our country, the application of the design method of face to face dimension in wall-slab apartment has passed 10 years. So MC design method has fixed in the design step to some degree. In Design and Work Execution of House the exclusive area of the apartment was calculated by face to face dimension. And the term of face to face dimension was known broadly to clients, construction company, etc. But design method of face to face dimension is not to simply extend the room size so far as wall depth in design process but to ensure the actual space should be considered with efficient use and assembly of building components. That is to say, Design method of face to face dimension is not to be defined by design step but to be related with construction and maintenance. However in construction process the point of face to face design method was not understood even now. So the purpose of this study was to extract the effect and question of face to face design method in construction process by survey of actual condition of structure and construction quality, and compare this result with existing construction method. The following project of this study is to survey of actual condition of interior components such as gypsum board, windows & doors etc. Therefore this study is to induce architectural long-life through architectural standardization construction and component's exchange, and, by the subject of the study on Apartment to have design guideline and basis for joining part between Gypsumboard and windows.