• Maxillofacial Plastic and Reconstructive Surgery
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• v.40
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• pp.44.1-44.17
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• 2018

Background: Coffee extract has been investigated by many authors, and many minor components of coffee are known, such as polyphenols, diterpenes (kahweol and cafestol), melanoidins, and trigonelline, to have anti-inflammatory, anti-oxidant, anti-angiogenic, anticancer, chemoprotective, and hepatoprotective effects. Therefore, it is necessary to know its pharmacological effect on hepatocytes which show the most active cellular regeneration in body. Methods: In order to determine whether coffee extract has a beneficial effect on the liver, 20 C57BL/6J mice were intraperitoneally injected once with dialyzed coffee extract (DCE)-2.5 (equivalent to 2.5 cups of coffee a day in man), DCE-5, or DCE-10, or normal saline (control), and then followed by histological observation and IP-HPLC (immunoprecipitation high performance liquid chromatography) over 24 h. Results: Mice treated with DCE-2.5 or DCE-5 showed markedly hypertrophic hepatocytes with eosinophilic cytoplasms, while those treated with DCE-10 showed slightly hypertrophic hepatocytes, which were well aligned in hepatic cords with increased sinusoidal spaces. DCE induced the upregulations of cellular proliferation, growth factor/RAS signaling, cellular protection, p53-mediated apoptosis, angiogenesis, and antioxidant and protection-related proteins, and the downregulations of NFkB signaling proteins, inflammatory proteins, and oncogenic proteins in mouse livers. These protein expression changes induced by DCE were usually limited to the range ± 10%, suggesting murine hepatocytes were safely reactive to DCE within the threshold of physiological homeostasis. DCE-2.5 and DCE-5 induced relatively mild dose-dependent changes in protein expressions for cellular regeneration and de novo angiogenesis as compared with non-treated controls, whereas DCE-10 induced fluctuations in protein expressions. Conclusion: These observations suggested that DCE-2.5 and DCE-5 were safer and more beneficial to murine hepatocytes than DCE-10. It was also found that murine hepatocytes treated with DCE showed mild p53-mediated apoptosis, followed by cellular proliferation and growth devoid of fibrosis signaling (as determined by IP-HPLC), and subsequently progressed to rapid cellular regeneration and wound healing in the absence of any inflammatory reaction based on histologic observations.

• Journal of Life Science
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• v.33 no.12
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• pp.1046-1051
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• 2023

Cigarette smoking is one of the major causes of preventable diseases, disability, and death in Korea and worldwide. It has been clearly linked to the most common causes of death among the elderly and contributes to morbidity and disability associated with many chronic illnesses that are common in this age group. The health benefits of smoking cessation for the elderly have been clearly demonstrated. However, few studies have analyzed the relationship between health and smoking by considering the following many factors, especially among disabled people. In this study, we discuss the impacts of many factors on smoking among disabled people. Adults with disabilities are more likely to smoke than their peers. Public health agencies and practitioners should consider what reasonable adjustments may need to be made to policies and interventions to ensure that they are effective for adults with disabilities.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.10 no.5
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• pp.1082-1090
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• 2009

Peak expiratory flow rate(PEF) is a very important diagnostic parameter obtained from the forced vital capacity(FVC) test. The expiratory flow rate increases during the short initial time period and may cause measurement error in PEF particularly due to non-ideal dynamic characteristic of the transducer. The present study evaluated the initial rise slope($S_r$) on the flow rate signal to compensate the transducer output data. The 26 standard signals recommended by the American Thoracic Society(ATS) were generated and flown through the velocity-type respiratory air flow transducer with simultaneously acquiring the transducer output signal. Most PEF and the corresponding output($N_{PEF}$) were well fitted into a quadratic equation with a high enough correlation coefficient of 0.9997. But only two(ATS#2 and 26) signals resulted significant deviation of $N_{PEF}$ with relative errors>10%. The relationship between the relative error in $N_{PEF}$ and $S_r$ was found to be linear, based on which $N_{PEF}$ data were compensated. As a result, the 99% confidence interval of PEF error was turned out to be approximately 2.5%, which was less than a quarter of the upper limit of 10% recommended by ATS. Therefore, the present compensation technique was proved to be very accurate, complying the international standards of ATS, which would be useful to calibrate respiratory air flow transducers.

• Journal of Digital Convergence
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• v.20 no.5
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• pp.671-680
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• 2022

The purpose of this study is to suggest the direction of the funeral culture industry suitable for the age of longevity and well-aging through a study on changes in the perception of funeral culture among the elderly. The survey of this paper was conducted by Gallup Korea, and the survey method was a 1:1 individual interview using a structured questionnaire. The survey was conducted from October 1 to October 25, 2021, targeting 127 elderly people over the age of 65 living in Seoul, Incheon, and Gyeonggi-do. The number of valid subjects was 110, and the sampling method used was allocation by sex/age/income level/religion. As a result of the study, as for the change in the perception of funeral culture among the elderly, women preferred cremation to men (p=0.034). It was investigated that the level of income (p=0.004) and religious status (p=0.020) had an effect on funerals while alive. According to the presence or absence of thoughts about death, there was a significant difference in the membership of the mutual aid product (p=0.008) and the intention to return to a religious organization (p=0.004) when a memorial service was held. The results of this study are expected to be usefully utilized in presenting the direction and policy of the funeral culture industry suitable for the age of well-aging in the future.

• Journal of Digital Convergence
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• v.19 no.5
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• pp.321-331
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• 2021

The purpose of this study is to establish well-dying education, well-dying culture, and industrialization for well-aging. For this, data was collected through Gallup Korea from February 1, 2021 to February 22, 2021. As a result of the study, well-dying education experience was 4.7%, and education satisfaction was surveyed with 2.88 points out of 5. As a result of analyzing the needs of well-dying education according to the age groups, the educational demands of youth and middle-aged were in the order of hospice education and information, life-sustaining medical information, and funeral information. In the case of the young old, it was in the order of hospice education and information, funeral information, and psychological overcoming related to death. In the case of the elderly, the survey was conducted in the order of hospice education and information, funeral information, and life-care related information. The perception of industrialization related to the well-dying culture was inspected in the order of the well-dying café where you can talk about life and death, the well-dying experience such as the entrance experience, and the development of travel products related to culture and art (p<0.05). Such results can be usefully utilized in the development of well-dying education programs for well aging, cultural spreading, and industrialization.

• Journal of Internet of Things and Convergence
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• v.5 no.2
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• pp.47-54
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• 2019

This convergence study was conducted to identify the effect of the awareness enhancing program of the international development cooperation of college students sponsored by the Korea International Cooperation Agency (KOICA). A quasi-experimental study design was used. The participants consisted of one experimental group (n=32) who attended the awareness enhancing class of international development cooperation and the other control group (n=32) who did not participate in the class in a university in C city. The data were collected using online survey before the first class and after the last class in spring semester 2019. Collected data were analyzed by ANCOVA using SPSS WIN Version 20.0 program. The levels of global citizenship (p=.003) and career preparation behavior (p=.013) was higher in the experimental group than in the control group. However, career identity(p=.385) and cooperative efficacy(p=.488) did not show significant difference between the groups. This study proposed the direction for the awareness enhancing program of the international development cooperation of college students by showing its positive effects on the global citizenship and career preparation behavior.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.3
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• pp.2047-2054
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• 2015

The purpose of this study was to define the relationship between job stress contents and smoking habits of manufacturing male workers. The 872 male workers were observed the general characteristics, smoking habits and job stress contents from the JCQ, during the period from February 1st to April 30st, 2012, using the self-administered questionnaires. As a results, the smoking rate of study subjects was 53.0%, and in terms of smoking status by general characteristics, the smoking group was higher in the group of age, job position and job career than their respective counterparts. In terms of smoking status by job stress contents, the smoking group was higher in the group of job demand and supervisor support than their respective counterparts. Based on the results of logistic regression adjusted age, job position and job career, the odds ratio of smoking was significantly increase in the high group of job demand than that of low group, but it was significantly decrease in the low group of supervisor support than that of high group. Above results suggested that the smoking related with the job demand and the supervisor support among the job stress contents.

• Journal of the korean academy of Pediatric Dentistry
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• v.35 no.1
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• pp.159-166
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• 2008

The dental caries can be recovered or worse depending on the velocity of de- and remineralization of tooth. It is possible to remineralize the lesions by fluoride agent, but the results can be distinguished according to one's salivary flow rate, quantity of ion contents, and pH of the saliva. This article presents good results after applying the CPP-ACP paste for the patients who have incipient enamel caries. We instructed the patients to apply the paste everyday in the customed tray. We observed the white spot lesions without getting worse and reducing the size of lesions. After applying the CPP-ACP paste for 6 weeks, we concluded that; 1. It was possible to remineralize the incipient caries without preparation of the teeth. 2. CPP-ACP paste was successful for recovery of the demineralized lesions, especially for mild and moderate caries lesions, not for the severe developemental defects or chronic lesions. 3. CPP-ACP paste was efficient for pediatric patients, and the custumed tray was very useful for patients to apply the paste. 4. The ability of the patients for caring their oral hygiene was improved by routine check up and instructions.

• Journal of Korea Entertainment Industry Association
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• v.15 no.3
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• pp.193-202
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• 2021

The purpose of this study was to examine relation of awareness and education requirement of the 4th industrial revolution in health care students in attempt to provide basic data of determining the principle and education plan. The subject of study were 280 students of health department of H university in Gwangju and analyzed by gender and grade. The female students were positive awareness of the 4th industrial revolution and the level of influence on the major field was highest in lower grade students. The level of negative factors such as generation gap(p<0.05), gap between rich and poor (p<0.01), personal information infringement(p<0.05), decrease in existing jobs(p<0.05), and abuse of artificial intelligence(p<0.05) was highest in male students. In prepration for the 4th industrial revolution, education on bio and medical device(22.2%) was the most desired. The higher positive awareness, the higher educational demand(p<0.001). It is necessary to develop programs and various education to increase positive factors such as the creation of new jobs and improve the quality of life in the era of the 4th industrial revolution.

• The Korean Journal of Mycology
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• v.27 no.6 s.93
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• pp.424-429
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• 1999

This study was conducted to investigate the characteristics of polysaccharides isolated from the fruit body and cultured mycelia of Phellinus linteus IY001. All fractions were extracted by hot water, followed by ethanol precipitation (F-THE and M-HE) or ultrafiltration (M-HU) (F-TH, F-THE; fruit body, M-HE, M-HU; cultured mycelia). Among these fractions, F-TH fraction was obtained at the highest yields of 6.83% and yield of F-THE was at the level 2.79%. The carbohydrates of these fractions was found to be a heteroglucan composed of glucose, galactose, mannose, fructose, ribose and xylose by analysis of gas chromatography. The total carbohydrate contents of M-HE and M-HU fractions were 99.2%, and 86.0% respectively. The glucose content of M-HE, M-HU and F-THE ranged from 54 to 84.8% of the total monosaccharide. Amino acid pattern showed that all fractions contained a large amount of aspartic acid, glycine, glutamic acid, alanine. Serine and threonine were found to be involved in the linkage, O-linked type. These fractions, except F. TH, contained polysaccharides with the molecular weights of 12 kD and showed the characteristics of IR absorption for ${\beta}-glucosides$ at $890\;cm^{-1}$.