• Archives of Pharmacal Research
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• v.27 no.10
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• pp.997-1000
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• 2004

A series of 1,3-dioxoindan-2-carboxylic acid arylamides were synthesized and evaluated for in vitro cytotoxicity against four human cancer cell lines (HOP62, SK-OV-3, MD-MB-468 and T- 47D). The most active was compound 3e (1.2 ${\mu}M$ against SK-OV-3 cell line) bearing a 4- methyl substituent.

• Archives of Pharmacal Research
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• v.4 no.2
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• pp.123-127
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• 1981

The method extracts of Patriniae radix, Dianthii herba, Melandrii herba, Echinopii radix, Siegesbeckiae herba and Magnoliae cortex showed a significant elevation of serum transam inase activity accompanied by fatty degeneration and Kupffer accompanied by fatty degeneration and Kupffer cell activation in hepatic cells.

• Archives of Pharmacal Research
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• v.13 no.1
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• pp.103-104
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• 1990

An alkaloid was isolated from the roots of Glycyrrhiza uralensis Fisch. It was identified as 3-methyl-6, 7, 8-trihydro-pyrrolo[1, 2-alpyrimidin-2-one(I) by spectral analysis. The compounds is first found in the plant kingdom.

• Archives of Pharmacal Research
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• v.29 no.7
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• pp.556-562
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• 2006

Ten semi-synthetic derivatives of asiatic acid were prepared and their wound healing effects were evaluated by employing a tensile strength assay and a wound area assay. Among them, ethoxymethyl 2-oxo-3,23-isopropylidene-asiatate (12) showed the strongest and the fastest wound healing activity. Furthermore, it left the smallest scar after healing.

• Archives of Pharmacal Research
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• v.12 no.4
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• pp.257-258
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• 1989

Glutathione was converted by $HNO_2$ into a S-nitrosothiol which was stable in solution and atypically so even as a solid. FAB/MS and IR data have been obtained for the confirmation of structure of S-nitrosogulathione in the crystalline state.

• Archives of Pharmacal Research
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• v.15 no.4
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• pp.374-375
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• 1992

The marine sterol (22R, 23R)-methylenecholesterol 1 has been synthesized from readily available C-22 steroidal ester 2 utilizing an intermolecular acyclic ester enolate alkylation as the key step.

• Archives of Pharmacal Research
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• v.13 no.4
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• pp.367-370
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• 1990

A novel method for the microdetermination of vitamin A in its pure state and pharmaceutical preparation using NBS is reported. The new method is easy, simple and accurate.

• Archives of Pharmacal Research
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• v.20 no.6
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• pp.602-609
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• 1997

A new series of 1, 3, 4-oxadiazoles, 1, 3, 4-thiadiazoles and 1, 2, 4-triazoles incorporated directly and/or indirectly into a xanthenone moiety at position-2-were synthesized. Some of the newly prepared compounds were biologically tested as schistosomicides in experimental animals.

• Archives of Pharmacal Research
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• v.12 no.2
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• pp.73-78
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• 1989

Oxidation of isophorone by various fungi was examined. Aspergillus niger oxidized isophorone to 4-hydroxyisophorone, 3-hydroxymethyl-5,5-dimethyl-2-cyclohexen-1-one and 5-hydroxymethyl-3,5-dimethyl-2-cyclohexen-1-one. 4-Oxoisophorone obtained by chromic acid oxidation of 4-hydroxyisophorone was transformed to 2,3,5-trimethyl-p-benzoquinone by acid treatment.

• Archives of Pharmacal Research
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• v.9 no.4
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• pp.215-217
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• 1986

Steroidal nitrosoureas have been synthesized and their antitumor activity on L 1210 cells was evaluated, N-(2-Chloroethyl)-N-nitrosocarbamoyl-3-aza-A-homo-5$\alpha$-cholestane (5a) showed significantly low $ED_{50}$ value of 1.6 $\nu$g/ml whose activity is equivalent to that of methyl-CCNU ($ED_{50}$ = 1.7 mg/ml).