Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Synthesis of Steroidal Nitrosoureas as Antitumor Activity

  • Kim, Jack-C. (Department of Chemistry, Pusan National University) ;
  • Choi, Soon-Kyu (Department of Chemistry, Pusan National University) ;
  • Moon, Sung-Hwan (Department of Chemistry, Pusan National University)
  • Published : 1986.12.01
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Abstract

Steroidal nitrosoureas have been synthesized and their antitumor activity on L 1210 cells was evaluated, N-(2-Chloroethyl)-N-nitrosocarbamoyl-3-aza-A-homo-5$\alpha$-cholestane (5a) showed significantly low $ED_{50}$ value of 1.6 $\nu$g/ml whose activity is equivalent to that of methyl-CCNU ($ED_{50}$ = 1.7 mg/ml).

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