Microbiological Oxidation of Isophorone to 4-Hydroxyisophorone and Chemical Transformation of 4-Hydroxyisophorone to 2,3,5-Trimethyl-p-benzoquinone

  • Joe, Young-Ae (Department of Pharmacy, Seoul National University) ;
  • Goo, Yang-Mo (Department of Pharmacy, Seoul National University) ;
  • Lee, Youn-Young (Department of Chemistry, Seoul National University)
  • Published : 1989.06.01

Abstract

Oxidation of isophorone by various fungi was examined. Aspergillus niger oxidized isophorone to 4-hydroxyisophorone, 3-hydroxymethyl-5,5-dimethyl-2-cyclohexen-1-one and 5-hydroxymethyl-3,5-dimethyl-2-cyclohexen-1-one. 4-Oxoisophorone obtained by chromic acid oxidation of 4-hydroxyisophorone was transformed to 2,3,5-trimethyl-p-benzoquinone by acid treatment.

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