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ULTRASTRUCTURAL STUDY ON THE EFFECTS OF INDOMETHACIN ON 4-NITROQUINOLINE 1-OXIDE (4NQO) INDUCED PALATAL CARCINOMA OF ALBINO RAT. (Indomethacin이 백서의 4-nitroquinoline 1-oxide (4NQO) 유도 구개암 발암과정에서 미세구조에 미치는 영향에 관한 연구)

  • Kim, Hai-Keun
    • Maxillofacial Plastic and Reconstructive Surgery
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    • v.11 no.1
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    • pp.171-186
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    • 1989
  • This study was undertaken to investigate the effects of indomethacin on 4-nitroquinoline 1-oxide (4NQO) induced palatal carcinoma of albino rats. Sixty albino rats about 100 gms of body weight, 6 weeks old-were used classifying as 1) six albino rats of normal group received no treatment, 2) six albino rats of control group treated with propane 1, 2-diol 3 times a week, 3) twenty four albino rats of experimental group I treated with 0.5% 4NQO in propane 1, 2-diol 3 times a week, 4) twenty four albino rats of experimental group II treated with 0.5% of 4NQO in propane 1, 2-diol 3 times a week and administrated 20${\mu}g/ml$ indomethacin in drinking water ad lib. The animals of normal and control groups were sacrificed 7th, 11th, 15th, 19th, 23rd and 27th week, while those of experimental group I and II were sacrificed 7th, 9th, 11th, 13th, 15th, 17th, 19th, 21st, 23rd, 25th, 27th and 29th week after the experiment. The palatal mucosa was excised and examined grossly, light-microscopically and electron-microscopically. Following results were obtained. 1. In control group, there was no specific difference from normal tissue histopathologically. 2. In group I, hyperkeratosis mild acantosis and dyskeratosis in in 7th week, dysplasia in 11th week and severe acantosis in 19th week were observed, but squamous cell carcinoma not observed until 29th week on light-microscope. 3. In group II, hyperkeratosis, mild acantosis in 9th week, dyskeratosis and dysplasia in 21st week, severe acantosis in 27th week and squamous cell carcinoma in 29th week were observed on light-microscope. 4. In group I, widening of intercellular space in 7th week, increasing of desmosome, giant desmosome and tonofilament in cytoplasm in 9th week, severe widening of intercellular space, increasing of mitochondria and vascular degeneration in 11th week, irregular pattern of cell feature and nucleus and prominent nucleoli in 19th week, and continuity of basal lamina in 29th week were observed on electron-microscope. 5. In group II, mild widening of intercellular space in 9th week, increasing of mitochondria, vascular degeneration and tonofilament in cytoplasm in 13th week, increasing of desmosome and giant desmosome in 15th week, irregular pattern of cell surface and nucleus and prominent nucleoli, and in 21st week continuity of basal lamina were observed on electron-microscope which phenomenon occurred little later than group I. After 21st week, however, severe widening of intercellular space, vascular degeneration and continuity of basal lamina were observed as in group I.

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Developmental characteristics of Tenebrio molitor larvae (Coleoptera: Tenebrionidae) in different instars

  • Park, Jong Bin;Choi, Won Ho;Kim, Seong Hyun;Jin, Hyo Jung;Han, Yeon Soo;Lee, Yong Seok;Kim, Nam Jung
    • International Journal of Industrial Entomology and Biomaterials
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    • v.28 no.1
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    • pp.5-9
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    • 2014
  • Tenebrio molitor is a major pest of stored grain, although its larvae have potential for use as food. However, little is known about the characteristics of individual larval instars of this species, and the number of instars remains disputed. Therefore, we assessed T. molitor for the average number of instars and its characteristics at different larval stages. The focus of this study was to establish a foundation for further studies on the characteristics of each larval instar. All of the T. molitor larvae showed incubation periods of 7 to 8 d and a period of 3 to 4 d for the $1^{st}$ instar. Beyond the $1^{st}$ instar, there were relatively large variations in the number of days in each instar period. Before emergence, most of the larvae had typically gone through 15 to 17 instars. The highest rate of pupae formation, 28.32%, was observed in the $17^{th}$ instars. The body length gradually increased with each successive instar, reaching its maximum at the 17th instar. Beyond the $17^{th}$ instar, however, the body length decreased. The larvae were white in the first instar, and gradually turned brown after the $2^{nd}$ instar.

Male Body Image Appearing on the Western Men's Costume in the Baroque Era (바로크(Baroque) 양식 시대 서양 남성복에 나타난 남성의 몸 이미지)

  • Lee, Hyo-Jin
    • The Research Journal of the Costume Culture
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    • v.19 no.4
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    • pp.723-739
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    • 2011
  • This research seeks to analyze western men's costume in the Baroque era in relation to men's physical beauty from its most detailed and interesting perspective to fomulate a plausible reasoning related to the aesthetic sense of body as expressed in men's costume. This research used national and international books, theses and internet data upon which to base a literature review for a correct understanding of Baroque style and at the same time empirical research to analyze the body image expressed in men's costume. The Baroque style expressed in the 17th century costume offered a dynamic feeling through wavy curves, and its brilliant and colorful decorations created a passionate and charming mood resembling a flame. Accordingly, this research studied the body image as it appeared in the form of 17th century western men's costume by dividing it into the contact beauty of the human body and the manner of hiding the architectural beauty of the human body. First, the exposed silhouette by clothing coming into contact with the human body could be found mainly in upper-class men's costume in the first half of the 17th century. The shorter and tighter doublets and knee breeches could be analyzed in terms of erotic imagery that emphasized masculinity, aristocratic imagery that stressed a distinctive status, and geometric imagery that expressed a triangular pattern. Second, the constructive expression by hiding the human body could be found in upper-class men's costume starting in the mid-17 century. The wearing of the justaucorps could be studied in terms of how it came into contact with the beauty of the human body but also how this clothing style the hid the architectural beauty of human body.

Effects of JaUmJeSeupTangKaKam (JUJSTK) on Atopic Dermatitis-like Skin Lesions in NC/Nga Mouse (아토피양(樣)피부염 NC/Nga생쥐에서 자음제습탕가감(滋陰除濕湯加減)의 투여가 피부염에 미치는 영향)

  • Lee, Nam-Yerl;Kim, Yun-Hee;Han, Jae-Kyung
    • The Journal of Pediatrics of Korean Medicine
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    • v.23 no.2
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    • pp.87-101
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    • 2009
  • Objectives : The purpose of this study is to investigate the effect of JUJSTK on atopic dermatitis in an in-vitro experiment using an NC/Nga atopic dermatitis mouse, which has histological and clinical similarities to the humans in terms of health condition. Methods : We evaluated IL-1$\beta$, IL-6, IL-10, TNF-$\alpha$ mRNA, TGF-$\beta$ mRNA, CD4+/IFN-$\gamma$+ and IL-17+CD4+Th17 cells of NC/Nga atopic dermatitis mouse by real-time PCR and intracellular staining in vitro. Results : JUJSTK medicines supressed the activities of IL-1$\beta$, IL-6, TNF-$\alpha$, TGF-$\beta$ mRNA and IL-17+CD4+Th17 cells and it incresed the activities of IL-10 mRNA in B cells. The level of CD4+/IFN-$\gamma$+ in T cells were increased by JUSSTK. Conclusions : JUJSTK on atopic dermatitis might be incredibly effective to the atopic dermatitis treatment.

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Effects of Replacement of Soybean Meal by Cottonseed Meal on Laying Performance and Haemoglobin Levels in Practical Diets for Breeder Japanese Quail, Coturnix coturnix japonica

  • Erturk, M. Mustafa;Ozen , Nihat;Celik, Kemal
    • Asian-Australasian Journal of Animal Sciences
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    • v.17 no.7
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    • pp.980-983
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    • 2004
  • A 16 week feeding trial was conducted to evaluate the effects of replacement of soybean meal (SM) by extracted cottonseed meal (CSM) on laying performance and haemoglobin levels in practical diets for breeder Japanese quail (Coturnix coturnix japonica). One hundred ninety two quails (6 weeks old) were divided randomly into eight groups. The diets were isocaloric containing 2,900 kcal/kg of ME and isonitrogenous (% 20 crude protein) as fed basis. SM was replaced by 0, 2.5, 5.0, 7.5, 10.0, 12.5, 15.0 and 17.5% of CSM, respectively. Average egg production (quail day, %; quail house, %), egg weight (g), daily feed intake (g/bird), feed efficiency ratio (g feed/g egg) data indicated no significant differences among the treatments; while, blood haemoglobin levels (% g Hb) of 7th (15.0% CSM) and 8th (17.5% CSM) group were lower than the control (0% CSM) diet (p<0.05). This experiment indicated that 17.5% CSM could replace SM (providing 44% of SM protein) in practical diets of breeder Japanese quails without any significant impairment on laying performance.

Network Analysis of Korean legislators using Bipartite Network Projection (입법 발의안을 통한 대한민국 국회의원 네트워크 분석)

  • Lee, Ji-Yeon;Jo, Hyun-Joo;Yoon, Ji Won
    • Journal of Internet Computing and Services
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    • v.15 no.4
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    • pp.103-110
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    • 2014
  • In study we analyze the network about the legislators in Korean National Assembly. We focused on 17th National Assembly since there were full of important changes in composition. Mutual cooperation is necessary to pass the bills beyond their given mission in legislation. In order to find out the relationship of legislators based on the introducing bills, total 5728 bills in 17th National Assembly, we used bipartite network projection. We can find who is a highly influential legislator and the difference between a ruling party and a main opposition party in aspects of cooperative behavior.

A Time Series Analysis on Urban Weather Conditions for Constructing Urban Integrated Energy System (차세대에너지시스템 구축을 위한 도시기상조건 시계열분석)

  • Kim, Sang-Ok;Han, Kyung-Min;Yee, Jurng-Jae;Yoon, Seong-Hwan
    • 한국태양에너지학회:학술대회논문집
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    • 2009.11a
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    • pp.26-31
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    • 2009
  • This study was analysed influence of urban higher temperature in Busan about time series analysis of AWS data. The results are as follows. (1) The temperature of Busan show min $13.2^{\circ}C$ ~max $15.8^{\circ}C$ by 50 years, it is on the rise. (2) The seasonal adjustment series, summer appeared min $17.5^{\circ}C$ ~max $28.9^{\circ}C$ with primitive series similarly. The winter was min $-11.4^{\circ}C$ ~max $17.9^{\circ}C$, the minimum temperature was more lowly than primitive series and maximum temperature was more higher than primitive series. The results, seasonal adjustment series is guessed with influence difference urban structural element beside seasonal factor. (3) Regional analytical result, January appeared with range of min 28% ~max 196% of the seasonal factor and August appeared min 90% ~ max 106%. One of the case which is of 100% or more of the seasonal factor January 12nd~17th, August appears at the 15~17th.

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A Survey on Situation-related Communication Educational Needs for Novice Intensive Care Unit Nurses (중환자실 신규 간호사의 의사소통 상황 관련 교육 요구도 조사)

  • Hwang, Wonjung;Ha, Jeongmin;Park, Dahye
    • Journal of Korean Critical Care Nursing
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    • v.17 no.1
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    • pp.17-29
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    • 2024
  • Purpose : This study sought to investigate novice nurses' communication education needs in the intensive care unit (ICU) using Importance-Performance Analysis (IPA) and Borich's need assessment model. This study identified communication challenges in clinical settings to develop a simulation program that enhances communication competencies based on educational requirements. Methods : A descriptive research design and a self-report questionnaire were used. The latter was developed and administered to 121 novice nurses with less than one year of experience in the ICU at various university hospitals in Korea. Data were collected via the online open chatroom from June 24th to July 28th, 2023. The communication education needs were identified using descriptive statistics, t-tests, IPA, and Borich's needs assessment model. Text analysis was used to categorize the participants' communication experience. Results : The results revealed that "communication with physicians," "communication with patients," and "communication with nurse on another shift" domains contained the most substantial educational needs for novice nurses working in the intensive care units. Conclusion : The results provide fundamental data for developing and enhancing customized communication education programs for novice ICU nurses. This valuable information could help ICU nurses and educators improve new nurses' communication skills, which would ultimately contribute to the advancement of nursing education and clinical practice.

The $4^{th}-5^{th}$ Intermetatarsal Angle and the $5^{th}$ Metatarsophalangeal Angle of Young Men in Korea (한국 정상 젊은 남성에서의 제 4-5 중족골간 각 및 제 5 근위-종족골간 각)

  • Lee, Kyung-Tai;Lee, Young-Koo;Yim, Su-Jae;Young, Ki-Won;Park, Shin-Yi;Kim, Hyung-Tae
    • Journal of Korean Foot and Ankle Society
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    • v.13 no.1
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    • pp.46-49
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    • 2009
  • Purpose: The purpose of this study is to find out the normal angles of forefoot for diagnosis of bunionette deformity in Korea. This would be helpful as it would provide a basic angular measurement of bunionette deformity that indicates the need for operation. Materials and Methods: Within a period of four months from January 2007 to April 2007. We have established 300 males and 600 feet without trauma history of foot. The source to image distance is 40 inches and erect weight bearing radiographs are obtained in anteroposterior and lateral projections. The significant angular measurements that define a bunionette deformity are the fourth-fifth intermetatarsal angle, the fifth metatarsophalangeal angle Results: The mean age was 21 years(19-22 years) old. The mean $4^{th}-5^{th}$ intermetatarsal angle was $9.4{\pm}4.7^{\circ}$, the mean $5^{th}$ metatarsophalangeal angle was $7.9{\pm}9.2^{\circ}$. Conclusion: We can consider over the $14.1^{\circ}$ on the $4^{th}-5^{th}$ intermetatarsal angle and over $17.1^{\circ}$ on the $5^{th}$ metatarsophalangeal angle as an operational indication.

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Yeoheon's Spirit of Humanities and the Genealogy of his Prose (여헌(旅軒)의 인문(人文) 정신(精神)과 산문(散文)의 계보(系譜))

  • Ahn, Se-hyun
    • (The)Study of the Eastern Classic
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    • no.41
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    • pp.61-90
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    • 2010
  • In this paper, I focused on analyzing Yeoheon Chang Hyeon-gwang's literary theory and his prose in the genealogy of Confucian scholars in Chosun. Through this study, I would like to examine the trend of concentrating on 16th century when we treat the literary tendency of Confucian scholars. With this goal, I tried to seek the direction which was pursued by Confucian scholars who lived during the 17th century. Yeoheon tried to construct the spirit of humanities cosmically as an aim of his life, study, and literature. And he had a new understanding of human independence by suffering from Japanese invasion in the late of 16th century. He insisted that only human can realize the spirit of humanities on a cosmic base. He also thought that the morality(道) could be settled only by literature(文). We may interpret this concept as a progressive idea about literature comparing to the former Confucian scholars. On the other hands, Yeoheon tried to accept the literary theory of former scholars such like Park Young, Cho Sik, and Seong Woon who embraced Taoism. Yet he erased the color of Taoism in the field of topic, and he also tried to keep his distance from them in the field of literary form. This concept actually came from Lee Hwang's opinion, while Yeoheon tried to rouse scholar's independence. Through above, we may realize that the Confucian scholars of 17th century were not just imitators of 16th century. They tried to examine the former study and also tried to renew the theory.