• 약학회지
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• 제57권3호
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• pp.205-212
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• 2013

Dissolution test has been performed to control drug quality and to predict in vivo drug release profile of solid dosage forms, so there's a drift towards setting dissolution test instead of disintegration test. However, some solid dosage forms in Korea Pharmaceutical Codex (KPC) are not established the dissolution test yet, so these monographs are necessary to set the specification of dissolution test. In this study, we developed the specification and test method of dissolution test for itopride hydrochloride tablets and tiropramide hydrochloride tablets which are not established the dissolution test yet. According to the "Manual for Guideline Application for Validation of Analytical Procedures" and "Guidelines on Specification of Dissolution test for Oral dosage form" of Korean Pharmacopoeia (KP), we validated and established each development method. Based on the preliminary dissolution profile, we set the dissolution condition(paddle apparatus, pH 1.2 media, 50 rpm). For this condition, we performed the main dissolution test to determine the specification (45 min, 85%). Finally, we validated each analytical method by specificity, linearity, accuracy and precision. These developed methods will be included the next supplement of KPC and also contributed to the quality control of medicines.

• 한국학교수학회논문집
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• 제16권3호
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• pp.479-498
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• 2013

교육격차를 완화하여 국가 경쟁력을 높이고 평생학습 사회에서 개인의 장래 성장과 발전의 기틀을 마련하기 위하여 모든 학생들의 기초학력을 보장하려는 움직임이 다양하게 전개되고 있다. 본 논문에서는 학생들의 기초학력을 결정짓는 성취수준 설정의 의미와 방법을 알아보고, 2013년 초등학교 3학년을 대상으로 실시되는 기초학력 진단평가의 '기초수학' 과목에 대한 성취수준과 분할점수 설정 방법을 살펴보고자 한다. 학교현장에서 활용할 수 있는 성취수준 설정 방법과 적용 사례의 제시는 준거참조평가에서 성취수준 설정 시 고려해야 하는 것에 대한 시사점을 제공할 수 있으리라 기대된다.

• 한국환경보건학회지
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• 제43권1호
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• pp.23-41
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• 2017

Objectives: In this study, we seek to perform a priority selection for test substances for chronic inhalation toxicity studies, including acute and subchronic inhalation toxicity studies, which are to be performed after the construction of a chronic/carcinogenicity inhalation toxicity study facility and enactment of pertinent legislation. Methods: Through this study, qualitative and quantitative priority evaluation of test substances according to acute, subchronic and chronic categories were respectively performed and priorities were suggested by expert group review, redundancy and other methods. Meanwhile, a draft on test substance selection criteria, procedures and methods referring to the National Toxicology Program (NTP) system was proposed. Results: This study selected priorities for candidate substances for chronic inhalation toxicity studies to be conducted from 2016. Conclusions: In the future, by assessing in advance the toxicological effects of chemicals to which workers can be potentially exposed in the workplace via long-term inhalation, expected health disturbances among workers will be reduced and it is anticipated that occupational disease induced by chemicals will be effectively prevented.

• 한방안이비인후피부과학회지
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• 제21권2호
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• pp.142-153
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• 2008

Objective : Etiologically, stress is a important factor to immune system and skin disease. Human body is controled to keep his homeostasis from stress by autonomic nerve system. So we investigated autonomic nerve balance and stress level of patients with skin disease by heart rate variability(HRV) test. Research Methods and Procedures : Fifty two patient(from 15 years old to 35 years old) who visited Dept. of Oriental medical Dermatology, Kyunghee university at first and had an examination by HRV test, were selected as the subject of our study. We checked items of HRV test(such as SDNN, RMSSD, VLF, LF, HF, TP, norm-LF, norm-HF, LF/HF ratio, LnHF and LnHF), and analyzed time and frequency domain by sex, age, onset, color on end of patient's tongue, sweating and sleep condition. Results and Conclusion : Men showed significant higher SDNN, RMSSD, LF, norm-LF, norm-HF, LF/HF ratio, LnLF and LnHF than women(p <0.05). Patients who were attacked by skin disease within 6 months, showed significant higher TP and VLF than over 6 months(p <0.05). Patients with normal color on the end of their tongue showed significant higher TP and VLF than with flare color. We analyzed correlation to color on the end of tongue and RMSSD. Prevalence risk(RMSSD <20ms) in the case of normal color on the end of tongue was 5 times as high as in the case of flare color(p <0.1). And we analyzed correlation to age and LF/HF ratio. Prevalence risk(LF/HF ratio <1) of patients from 15 years old to 25 years old was 1.467 times as high as from 26 years old to 35 years old(p <0.1).

• Journal of Preventive Medicine and Public Health
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• 제51권4호
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• pp.181-187
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• 2018

Objectives: To identify factors responsible for potentially clinically unnecessary cervical cancer screenings in women with prior hysterectomy. Methods: A retrospective cross-sectional study was conducted using the Centers for Disease Control and Prevention's Behavioral Risk Factor Surveillance System (BRFSS). This study targeted adult women and examined whether they received a both a Papanicolaou (Pap) test and undergone a hysterectomy in the last three years. We conducted multivariate analyses, including weighted proportions and odds ratios (ORs), based on the modified BRFSS weighting method (raking). The inclusion criteria were adult women (>18 years old) who reported having received a Pap test within the last 3 years. Results: Of all women (n=252 391), 72 366 had received a Pap test, and 32 935 of those women (45%, or 12.5 million, weighted) had a prior hysterectomy. We found that age, race/ethnicity, marital status, family income, health status, time since last routine checkup, and health insurance coverage were all significant predictors. Black, non-Hispanic women were 2.23 times more likely to receive Pap testing after a hysterectomy than white women (OR, 2.23; 95% confidence interval [CI], 1.99 to 2.50). Similarly, the odds for Hispanic women were 2.34 times higher (OR, 2.34; 95% CI, 1.97 to 2.80). The odds were also higher for those who were married (OR, 1.17; 95% CI, 1.08 to 1.27), healthier (OR, 1.24; 95% CI, 1.14 to 1.35), and had health insurance (OR, 1.54; 95% CI, 1.28 to 1.84), after controlling for confounders. Conclusions: We conclude that women may potentially receive Pap tests even if they are not at risk for cervical cancer, and may not be adequately informed about the need for screenings. We recommend strategies to disseminate recommendations and information to patients, their families, and care providers.

• 비파괴검사학회지
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• 제20권1호
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• pp.18-26
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• 2000

화력발전소 보일러 고온배관인 주증기관, 헤드 및 증기드럼 등의 설비들은 장시간동안 고온고압의 가혹한 조건으로 운전됨에 따라 크리프손상에 의해 열화되고 있다. 이들 설비의 크리프손상측정에 적용되는 종래의 비파괴기법인 레프리카법, 전기저항법 및 경도법 등은 복잡한 측정절차 및 접근성, 검사결과의 신뢰도 및 측정정도 등 여러가지면에서 단점이 많다. 따라서 본 논문에서는 화력발전소 주요 고온배관에서 발생되는 경년열화인 크리프손상에 대한초음파 측정연구를 수행한 결과로서, 고온배관재료인 Cr-Mo강의 크리프 인공열화재를 대상으로 이들에 대한 크리프손상 상태별 초음과 음속(sound velocity) 및 감쇠(attenuation)의 초음파 신호특성을 평가하였다.

• 한국도로학회논문집
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• 제9권1호
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• pp.47-56
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• 2007

교통하중하의 포장구조에 대한 설계나 비선형 해석에 있어 도로하부 재료의 회복변형 특성이 활용되고 있다. 그러나 국내에서의 관련 연구가 매우 미진한 실정이다. 또한 매우 제한적인 범위의 자료만이 노상토의 회복탄성계수를 추정하는데 활용되고 있다. 이에 본 논문에서는 시험도로 입상 노상토를 대상으로 비선형 특성을 알아보기 위하여 반복재하 회복탄성계수 시험을 수행하였다. 현장조건을 반영하여 함수비와 응력조건을 고려한 회복탄성계수 구성방정식을 제안하였다. 이를 통하여 응력조건을 고려한 회복탄성계수 예측모델과 적합한 응력의존 모델을 결정하고 계절적인 함수비 변화가 고려된 회복탄성계수 모델을 각각 비교하였다.

• Archives of Plastic Surgery
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• 제39권2호
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• pp.143-149
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• 2012

Background : Axillary osmidrosis is characterized by an unpleasant odor, profuse sweating, and in some instances, staining of clothes that may socially and psychologically impair affected individuals. Various types of surgical procedures have been developed for the treatment of axillary osmidrosis. This study was undertaken to evaluate the effectiveness of subcutaneous pulsed neodymium: yttrium-aluminum-garnet (Nd-YAG) laser treatment for the treatment of axillary osmidrosis. Methods : Twenty-nine patients with axillary osmidrosis were included in this study. Patients were categorized according to the results of an axillary malodor grading system, and a subcutaneous pulsed Nd-YAG laser was applied to all patients. The treatment area for the appropriate distribution of laser energy was determined using the iodine starch test (Minor's test) against a grid pattern composed of $2{\times}2cm$ squares. The endpoint of exposure was 300 to 500 J for each grid, depending on the preoperative evaluation results. The results were evaluated by measurement of axillary malodor both pre- and postoperatively using the grading system and iodine starch test. Results : The average follow-up period was 12.8 months. Nineteen patients had a fair-to-good result and ten patients had poor results. The postoperative Minor's test demonstrated that there were remarkable improvements for patients with mild to moderate symptoms. Complications including superficial second degree burns (n=3) were treated in a conservative manner. A deep second degree burn (n=1) was treated by a surgical procedure. Conclusions : Subcutaneous pulsed Nd-YAG laser has many advantages and is an effective noninvasive treatment for mild to moderate axillary osmidrosis.

• 펄프종이기술
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• 제44권2호
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• pp.18-28
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• 2012

This study was to develop a novel automatic system for measuring St$\ddot{o}$ckigt sizing degree and contact angle at a time. The conventional methods to measure sizing degree had serious problems in obtaining significant differences according to different dosages of a sizing agent, and moreover they disclosed unique limitation due to liquid types used and tester's subjectivity. However, the newly developed system could get reproducible results through total automation of all procedures including liquid dropping, image acquisition and measurement of both St$\ddot{o}$ckigt sizing degree and contact angle. For the St$\ddot{o}$ckigt sizing test, the automatic system could measure sizing degree with more definite differences according to different dosage of AKD, compared to the conventional method. For the contact angle test, the automatic system showed a similar trend to the conventional method but had smaller contact angles due to distortion of an image focus by a sheet curl than the conventional testing machine. The problem from the image out of focus due to specimen curl will be overcome with adopting a new specimen holder for the future system.

• 한국가정과교육학회지
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• 제17권2호
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• pp.129-143
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• 2005

본 연구의 목적은 Tschannen-Moran(2000)이 개발한 Ohio State Teacher Efficacy Scale(OSTES)를 중등학교 가정과교사를 대상으로 교사 효능감 하위 요인들을 알아보고, 확인적 요인분석을 통해 교사 효능감 문항들의 타당성과 신뢰성을 규명하여 교사 효능감 문항들의 모형 적합성을 검증하는데 있다. 먼저 교사 효능감의 요인들에 대한 심리 측정학적 타당성을 검증하기 위해 263명의 가정과교사를 대상으로 교사 효능감 요인의 신뢰도와 요인 구조를 검사하였다. 중등학교 가정과교사의 교사 효능감 요인을 분석한 결과, 하위요인은 학급운영 효능감, 요구대처 효능감, 교수전략 효능감, 환경지원 효능감, 학습지원 효능감으로 나타났다. 그리고. 요인구조로 나타난 문항들의 요인 적합성을 판단하기 위해 교사 효능감의 5개 요인에 대한 확인적 요인 분석을 실시한 결과, 5개 하위요인이 타당한 것으로 지지되었다.