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Effects of Physical Activity and Melatonin in a Rat Model of Depression Induced by Chronic Stress (자유로운 신체운동과 멜라토닌이 우울장애 동물모델에 미치는 효과)

  • Seong, Ho Hyun;Jung, Sung Mo;Kim, Si Won;Kim, Youn Jung
    • Journal of Korean Biological Nursing Science
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    • v.17 no.1
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    • pp.37-43
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    • 2015
  • Purpose: Stress, depending on its intensity and duration, results in either adaptive or maladaptive physiological and psychological changes in humans. Also, it was found that stressful experiences increase the signs of behavioral despair in rodents. On the other hand, exercise and melatonin treatment is believed to have many beneficial effects on health. Thus, this study was designed to evaluate the anti-depressant effects of physical activity and melatonin against chronic stress-induced depression in rats. Methods: Adult male Sprague-Dawley(SD) rats(200-250g, 7 weeks of age) were subjected to depression induced by chronic stress. Chronic depression was induced with forced-swim stress (FSS) and repeated change of light-dark cycle for 4 weeks. In the last 2 weeks, some rats were confined in a cage enriched with a running wheel, seesaw and chewed a ball from 19:00 to 07:00 every day. Melatonin was injected intra-peritoneally (I.P), and the rats received intraperitoneal injections of melatonin (15 mg/kg). The Forced Swim Test (FST) was performed to evaluate the immobility behaviors of rats for a 5 min test. Results: It was found that, the immobility time in FST was significantly (p<.05) lower in physical exercise ($M=58.83{\pm}22.73$) and melatonin ($M=67.33{\pm}37.73$) than in depressive rats ($M=145.93{\pm}63.16$) without physical activity. Also, TPH positive cell in dorsal raphe was significantly (p<.05) higher in exercise ($M=457.38{\pm}103.21$) and melatonin ($M=425.38{\pm}111.56$) than in depressive rats ($M=258.25{\pm}89.13$). Conclusion: This study suggests that physical activity and melatonin produces antidepressant-like effect on stress-induced depression in rats. So, physical exercise and melatonin may be a good intervention in depression patients.

Effect of Kidney Tonification of Saam Acupuncture in Parkinson's Disease Mouse Model (파킨슨병 동물 모델을 이용한 신정격 사암침법의 도파민성 신경세포 보호 효과 연구)

  • Kim, Seungtae;Lee, Sang-Hyup;Kim, Bo-Kyung
    • Korean Journal of Acupuncture
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    • v.39 no.1
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    • pp.8-15
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    • 2022
  • Objectives : Saam acupuncture is one of the indigenous therapeutic modalities in traditional Korean medicine. In this study, the neuroprotective effect of Saam acupuncture of kidney tonification was investigated using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice. Methods : Twelve-week-old male C57BL/6 mice were intraperitoneally administered with 30 mg/kg of MPTP at 24-h intervals for 5 days and acupuncture stimulation at LU8, KI7, SP3 and KI3 was performed once a day for 12 days from the first MPTP injection. The pole test and the rotarod test were performed to evaluate motor function, and dopaminergic neuronal survival in the substantia nigra (SN) and striatum was evaluated using tyrosine-hydroxylase immunohistochemistry. Results : MPTP administration caused behavioral impairment and dopaminergic neuronal death in the nigrostriatal pathway. Whereas the Saam acupuncture treatment alleviated the MPTP-induced motor dysfunction and dopaminergic neuronal death in the SN and striatum. Conclusions : Saam acupuncture of kidney tonification can alleviate the MPTP-induced motor dysfunction and dopaminergic neuronal death in the nigrostriatal pathway, suggesting a possible role for acupuncture in the treatment of Parkinson's disease.

A Study on the Influencing Factors of Falling Disaster in Small and Medium-sized Construction Sites (중소형 건설현장의 추락재해 영향요인 분석 연구)

  • Lee, Ji-Yeob;Lee, Jae-Hyeon;Son, Seunghyun;Kim, Ji-Myong;Son, Kiyoung
    • Journal of the Korea Institute of Building Construction
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    • v.23 no.6
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    • pp.821-830
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    • 2023
  • This research aims to identify risk factors for fall accidents at small and medium-sized construction sites through a comprehensive regression analysis. Initially, the study involved collecting a decade's worth of fall accident data from these sites. A t-test confirmed a significant variation in the treatment duration following fall accidents between two distinct groups: small and medium-sized versus large construction sites. Subsequently, a regression analysis was conducted to establish a model highlighting the risk factors associated with safety accidents. The factors influencing fall accidents were determined to be, in descending order of impact, the time of the accident, the day of the accident, and the occupational classification. The findings from this study are expected to serve as foundational data for enhancing policies and conducting statistical analyses tailored to construction site sizes. They also provide crucial information for future research on risk quantification at small and medium-sized construction sites.

Analysis of eating behavior of Indonesian women from multicultural and non-multicultural families

  • Ulya Ardina;Su-In Yoon;Jin Ah Cho
    • Journal of Nutrition and Health
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    • v.57 no.2
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    • pp.228-243
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    • 2024
  • Purpose: This study aimed to identify the distinctions in dietary and health-related behaviors among Indonesian women who marry Koreans or into multicultural families (MF) and those who marry Indonesians living in Korea (IK) and in Indonesia (II). Methods: The study was performed with 192 subjects using an online questionnaire regarding food choice, dietary and health behavior, and nutrition quotient (NQ). The analysis used Pearson's chi-squared test, the Fisher's exact test, multinomial logistic regression, and the general linear model. Results: The MF group consumed Korean food more than once a day and Indonesian food 1-2 times monthly (p < 0.001). The main challenge for the IK and II groups in consuming Korean food was the presence of pork and the different food flavors (p < 0.001). The MF group tended to have normal body mass index, consumed more vitamin and mineral supplements (p = 0.014), and exercised regularly ≥150 min/week compared to the IK and II groups (p < 0.001). However, the MF group had the highest rate of skipping breakfast (p = 0.040). When evaluating the NQ of the participants, the MF group consumed more vegetables (p = 0.026), mixed grains (p = 0.031), and spicy and salt soups (p = 0.006). The II group consumed more fish (p = 0.005), beans (p = 0.009), and nuts (p = 0.003). The IK group checked the nutrition labels the most (p = 0.005), while their consumption of vegetables, fish, beans, and nuts was lowest. The MF group had a higher balance score, which resulted in a substantially more nutritious food intake compared to the other two groups (p = 0.037). Conclusion: The MF group consumed more vegetables and mixed grains, adequate fish, beans, and nuts, and engaged in longer daily physical activity. However, the IK group had a relatively low-quality diet and nutritional intake status compared to the other two groups, and this needs to be improved in the future.

Cybertrap : Unknown Attack Detection System based on Virtual Honeynet (Cybertrap : 가상 허니넷 기반 신종공격 탐지시스템)

  • Kang, Dae-Kwon;Hyun, Mu-Yong;Kim, Chun-Suk
    • The Journal of the Korea institute of electronic communication sciences
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    • v.8 no.6
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    • pp.863-871
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    • 2013
  • Recently application of open protocols and external network linkage to the national critical infrastructure has been growing with the development of information and communication technologies. This trend could mean that the national critical infrastructure is exposed to cyber attacks and can be seriously jeopardized when it gets remotely operated or controlled by viruses, crackers, or cyber terrorists. In this paper virtual Honeynet model which can reduce installation and operation resource problems of Honeynet system is proposed. It maintains the merits of Honeynet system and adapts the virtualization technology. Also, virtual Honeynet model that can minimize operating cost is proposed with data analysis and collecting technique based on the verification of attack intention and focus-oriented analysis technique. With the proposed model, new type of attack detection system based on virtual Honeynet, that is Cybertrap, is designed and implemented with the host and data collecting technique based on the verification of attack intention and the network attack pattern visualization technique. To test proposed system we establish test-bed and evaluate the functionality and performance through series of experiments.

Characteristics of Settlement for Non-woven Geotextile through Cyclic Loading Model Test (원형토조 시험을 통한 반복하중에 따른 부직포의 침하특성)

  • Choi, Chan-Yong;Lee, Jin-Wook;Kim, Hyun-Ki
    • Journal of the Korean Geosynthetics Society
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    • v.8 no.2
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    • pp.47-54
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    • 2009
  • The ballast track, the most common type of conventional railroad track in Korea, is deteriorated by abrasion of ballast, it's penetration into roadbed, and rugged surface of roadbed caused by cyclic loading of train. Persistent occurrence of those phenomena lead to insufficient drain capacity, one of major factors in track design, and it increases pore water pressure and decreases of shear strength under rainfall condition leading to unstable roadbed. In this study, cylindrical model tests are executed for 3 types of geotextile applying cyclic loading in order to observe the characteristics of displacement and bearing capacity of geotextile, and undrained condition has been applied for 0 day, 3 days and 7 days to each geotextiles. The results showed that there was about 1% difference at the final displacement rates between reinforced soils and nature soils and the displacement of the ground surface increases along with the degrees of the saturation. And in case that water contents exceeds the threshold, it is also apparent that weight and tensile strength of geotextile influences displacement of the ground surface. And the larger weight of geotextile is, the smaller plastic displacement. It is evaluated that non-woven fabric comes into effect on reducing the bearing capacity but, the weight of geotextile has little influence on it.

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Diagnostic Variables Related to Elementary School Students' Weight Control - Based on the PRECEDE model - (초등학생의 비만 관련 요인에 대한 진단적 연구 - PRECEDE 모형을 근간으로 -)

  • Yoo Jae Soon
    • Journal of Korean Public Health Nursing
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    • v.19 no.1
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    • pp.95-107
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    • 2005
  • With the aim of diagnostic research on health education. the health promoting behaviors related to elementary school students' weight control. life satisfaction. health state. self-efficacy. parent's interest and knowledge about weight control and school health education of weight control were investigated on the basis of the PRECEDE model. The data for this study were collected from a sample at an elementary school in Chongju for 5 days in July. 2004. In analyzing the data. t-test. one-way ANOVA. chi-square test and multiple regression analysis were done by using SPSS 10.1 The results were as follows : 1. The elementary school students' level of life satisfaction was above half of the full point. The score difference of life satisfaction was statistically significant by grade and academic achievement(F=4.646. p=.010. F=16.042. p=.000). 2. The perceived level of health state was moderate for all students. Normal weight students' level was significantly higher than obese students' (t=3.667. p=.000). 3. The perceived level of health promoting behaviors related to weight control was above the moderate. The perceived level of health promoting behaviors related to weight control in the obese students was significantly higher than that in normal weight students(t=-2.225. p=.027). The students used computer for 1.48 hours and watched TV for 2.52 hours a day. 4. The score of health promoting behavior self-efficacy in this subject was 70.61. 5. The parents' level of interest in the obese students' weight control was significantly higher than that in the normal weight students(t=-4.86. p=.000). 6. Sixty-six percent of the students learned about weight control education in school. 7. The health promoting behavior self-efficacy among the educational diagnostic variables was the most influential variable in students' health promoting behaviors related to weight control. This research diagnosed the needs of weight control education in elementary school by assessing various factors related to weight control behaviors. The research findings suggest that we can enhance the prevention of childhood obesity by strengthening the related factors such as parents' knowledge and interest, health promoting behaviors and self-efficacy related to weight control in school health education.

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The Prognostic Value of the Charlson's Comorbidity Index in Patients with Prolonged Acute Mechanical Ventilation: A Single Center Experience

  • Song, Seung Eon;Lee, Sang Hee;Jo, Eun-Jung;Eom, Jung Seop;Mok, Jeong Ha;Kim, Mi-Hyun;Kim, Ki Uk;Lee, Min Ki;Lee, Kwangha
    • Tuberculosis and Respiratory Diseases
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    • v.79 no.4
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    • pp.289-294
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    • 2016
  • Background: The aim of our study was to evaluate the prognostic value of Charlson's weighted index of comorbidities (WIC) in patients with prolonged acute mechanical ventilation (PAMV, ventilator care ${\geq}96$ hours). Methods: We retrospectively enrolled 299 Korean PAMV patients who were admitted in a medical intensive care unit (ICU) of a university-affiliated tertiary care hospital between 2008 and 2013. Survivors were defined as patients who survived for 60 days after ICU admission. Results: The patients' mean age was $65.1{\pm}14.1$ years and 70.6% were male. The mean ICU and hospital length of stay was $21.9{\pm}19.7$ and $39.4{\pm}39.1$ days, respectively. In addition, the 60-day mortality rate after ICU admission was 35.5%. The mean WIC was $2.3{\pm}1.8$, with significant differences between nonsurvivors and survivors ($2.7{\pm}2.1$ vs. $2.1{\pm}1.7$, p<0.05). The area under the curve of receiver-operating-characteristics curve for WIC was 0.593 (95% confidence interval [CI], 0.523-0.661; p<0.05). Based on Kaplan-Meier curves of 60-day survival, WIC ${\geq}5$ had statistically lower survival than WIC <5 (logrank test, p<0.05). In a multivariate Cox proportional hazard model, WIC ${\geq}5$ was associated with poor prognosis (hazard ratio, 1.901; 95% CI, 1.140-3.171; p<0.05). The mortality rate of patients with WIC ${\geq}5$ was 54.2%. Conclusion: Our study showed a WIC score ${\geq}5$ might be helpful in predicting 60-day mortality in PAMV patients.

Analysis of Working Capacity of a Hand-fed Transplanter (반자동정식기 작업 성능 분석)

  • 문성동;민영봉;박중춘
    • Journal of Bio-Environment Control
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    • v.6 no.3
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    • pp.159-167
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    • 1997
  • To cope with the mass-production and supply of plug seedling, the supply of transplanters is necessary. In the study, a transplanting test was carried out to find the optimum working condition in the mechanizd transplantation and to acquire the basic data for the improvement of transplanters by the research and analysis of working capacity of the local manual transplanters. The size of hopper affected transplanting stand and rate. Re-irrigation was required for the transplanted seedlings because they wilt 1 day after the transplanting if soil compaction is incomplete. Consequently, back-forth-left-right compaction method was good for soil covering and compaction. It may be thought to increase the amount of irrigation water at the time of transplanting by double-irrigation mechanism, but it needs to increase the larger water tank which makes the operation uneasy. So, assuming the working model by 1 or 2 operators with the machine size as small as possible, it seemed that eliminating of automatic irrigation method was desirable in view of efficiency. Though semiautomatic transplanter needs some structural improvements, it seemed still suitable for transplanting of plug seedlings such as 45-day red pepper seedlings in 128-hole tray and 25-day Chinese cabbage seedling in 128-hole tray. If traveling speed of the transplanter is limited to less than 14 m/min, with the transplanting depth of 2~3cm and transplanting space of 30cm.

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An Empirical Analysis of Stock Price Reaction to M&A in Liner Shipping Companies (정기선사 M&A와 주가수익률 실증분석)

  • Park, Seon-Na;Lee, Ki-Hwan
    • Journal of Korea Port Economic Association
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    • v.28 no.1
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    • pp.179-201
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    • 2012
  • Since 1993, M&A activities have been frequent in Liner shipping market. This study examines the effect of M&A on stock price reaction for acquiring firms listed on the market. The study covers the period from 1993 to 2009 and uses 61 daily closing prices of the acquiring firms before and after the M&A announcement day and is analyzed through the market-adjusted model in an event study. After calculating short-term performance using abnormal returns(AR) and cumulative average abnormal returns(CAR) before and after 30 days from the day of event, the results on the test show that the firm's values slightly increased through the M&A, but it does not attest to the statistical significance. In addition, this study investigates the AR difference between estimating windows and post-event windows for the 3 cases of each period before and after 30 days, 15 days, and 7 days from the event day to analyse the impact of M&A on the addition of acquiring firm's value. Our findings suggest that the M&A between Liner shipping companies is targeted for the long-term business strategy instead of the instant rise in the value of the firm involved.