• Molecules and Cells
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• v.41 no.11
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• pp.953-963
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• 2018

The stepwise development of T cells from a multipotent precursor is guided by diverse mechanisms, including interactions among lineage-specific transcription factors (TFs) and epigenetic changes, such as DNA methylation and hydroxymethylation, which play crucial roles in mammalian development and lineage commitment. To elucidate the transcriptional networks and epigenetic mechanisms underlying T-cell lineage commitment, we investigated genome-wide changes in gene expression, DNA methylation and hydroxymethylation among populations representing five successive stages of T-cell development (DN3, DN4, DP, $CD4^+$, and $CD8^+$) by performing RNA-seq, MBD-seq and hMeDIP-seq, respectively. The most significant changes in the transcriptomes and epigenomes occurred during the DN4 to DP transition. During the DP stage, many genes involved in chromatin modification were up-regulated and exhibited dramatic changes in DNA hydroxymethylation. We also observed 436 alternative splicing events, and approximately 57% (252) of these events occurred during the DP stage. Many stage-specific, differentially methylated regions were observed near the stage-specific, differentially expressed genes. The dynamic changes in DNA methylation and hydroxymethylation were associated with the recruitment of stage-specific TFs. We elucidated interactive networks comprising TFs, chromatin modifiers, and DNA methylation and hope that this study provides a framework for the understanding of the molecular networks underlying T-cell lineage commitment.

• International Journal of Advanced Culture Technology
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• v.11 no.3
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• pp.211-224
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• 2023

This study surveyed 2nd graders of B high school and 1st graders of A university in Gyeongnam on factors such as behavior control and interaction in non-face-to-face classes, easy or difficult concepts presented in chemistry I and general chemistry textbooks. Based on the results of the survey, the effect of changes in the difficulty level of concepts presented in chemistry I and general chemistry and changes in class types (face-to-face and non-face-to-face) on students' academic achievement by level was compared and analyzed. In the face-to-face class, the average score between the first and second semesters was similar according to the change in the difficulty of the concepts presented in chemistry I and general chemistry. In the non-face-to-face class, the average score of chemistry I in the second semester was quite low, and the average score of general chemistry was rather high. In non-face-to-face classes, the average score of chemistry I in the second semester of low-level students was significantly lowered due to changes in the difficulty of the concept and changes in class types on academic achievement by level. In the case of 10% of students at the lower level, the academic achievement of chemistry I decreased in both the second semester regardless of the changes in the difficulty level of concepts and the changes in class types.

• Journal of the Korean Society of Clothing and Textiles
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• v.42 no.4
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• pp.708-725
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• 2018

The advancement of digital technology has made changes in the fashion system and trend development process inevitable. This article clarifies changes in the modern fashion industry system and the causes of comprehensive changes that result from the development of digital technology. The methodology of this study is based on literature and case studies based on the information magazine most used by fashion industry workers. This study classifies fashion systems into 5 types and 14 types in detail. The study results indicate the way to change the fashion style trend schedule per year, fast/ultrafast fashion system, fashion rental system, DTC system and change of fashion system by consumer participation. The causes of the changes in fashion system are indicated that an increase of trend sensitivity due to an increase in the diffusion rate of information, expansion of expression of personality through digital network, increase of possibility of grouping of small number of tastes and change of prosumer possible changes in the environment. This study provides basic data on fashion system research and the construction of an appropriate response strategy for a changing environment.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.23 no.3
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• pp.243-249
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• 2014

Currently, CFRP composites are rapidly replacing steel plates, as they are lighter, stronger, and more elastic; however, they are poorly suited to hygrothermal and impact-collapsed environments because moisture can alter their molecule arrangement and chemical properties. In this study, environments are experimentally simulated in order to investigate changes in the moisture absorption inside a CFRP composite and to determine its weakest point. Moreover, changes in the moisture absorption ratio at temperatures of $60^{\circ}C$ and $80^{\circ}C$ are studied and compared in order to understand how changes in temperature affect moisture absorption inside CFRP composites. Results show that moisture absorption leads to a strength reduction of around 50%. In addition, the moisture absorption rate inside CFRP composites is shown to change rapidly with increasing temperature. Accordingly, it showed that the change in matrix also has a weak point.

• Proceedings of the KSRS Conference
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• v.2
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• pp.555-558
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• 2006

In recent years, urban development has expanded rapidly in Nawabshah City of Pakistan. A major effect associated with this population trend is transformation of the landscape from natural cover types to increasingly impervious urban land. The core objective of this study are to provide time-series information to define and measure the urban land cover changes of Nawabshah, Pakistan between the years 1992 and 2002, and to examine related urbanization impacts on air quality of the study area. Two multi-temporal Landsat images acquired in 1992 and 2002 together with standard topographical maps to measure land cover changes were used in this study. The image processing and data manipulation were conducted using algorithms supplied with the ERDAS Imagine software. An unsupervised classification approach, which uses a minimum spectral distance to assign pixels to clusters, was used with the overall accuracy ranging from 84 percent to 92 percent. Land cover statistics demonstrate that during the study period (1992-2002) extensive transformation of barren and vegetated lands into urban land have taken place in Nawabshah City. Results revealed that land cover changes due to urbanization has not only contaminated the air quality of the study area but also raised the health concerns for the local residents.

• Proceedings of the Korean Geotechical Society Conference
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• 2006.03a
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• pp.1224-1227
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• 2006

It has been recognized unsaturated soil behaviour playing an important role in geomechanics. Up to now, only a few experimental data are available for the technical difficulties related to both volume changes and suction measurements. In this study, the volume changes of unsaturated compacted silty soil were monitored with proximeter (i.e. non-contactable transducer) during various triaxial compression tests, which gave a realistic estimation in the volume changes of unsaturated soil sample. The measurement of volume changes were performed with 0.5% of the maximum error under the axial strain ratio of less than 10%. The experimental results have revealed that the mechanical behaviour of unsaturated soil can be significantly affected by the matric suction. During the shearing processes, the level of maximum deviator stress under the initial suction pressure of 50kPa was higher than that under the initial suction pressure of 10kPa. On the other hand, the volume changes became smaller under the increase in the initial suction pressure.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.16 no.5
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• pp.59-69
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• 2013

Global warming also has effects on the phenology. The limitation of phenology study is an acquisition of phenology data. Satellite images analysis can make up limitation of monitering data. This study is to analyze spatial distribution and characteristics of phenology changes using MODIS images. Research data collected images of 16 day intervals of 11 years from year 2001 to 2010. The data analyzed 228 images of 11 years. It can figure out changes of phenology by analyzing enhanced vegetation index of MODIS image. We made a comparison between changes of phenology and flowering of cherry blossoms. As a results, Startup of season spatially was getting late from southern area to north area. Startup of Phenology was foreshortened 13 days during 11 years, and change ratios of cherry blooming was getting more faster from 0.18 dat to 0.22 day per year during that same period.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.16 no.5
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• pp.49-57
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• 2013

This study was carried out to analysis change of distribution and habitat location environment of Korean Fir which is typically vulnerable species by the climate change in Mt. Jiri and Halla. Korean Fir was decreased 18% during 27 year since year 1981, Mt. Halla was 34% during 15 years since year 1988. In the same periods, Temperature change was increased from 8.56 to $9.36^{\circ}C$, from 11.2 to $12.1^{\circ}C$. Distribution changes by the elevation showed higher change ratio 1,400~1,600m in Mt. Jiri and 1,200~1,900m in Mt. Halla. Changes of Korean Fir each slope aspects was high $180{\sim}360^{\circ}$ in Mt. Jiri, $45^{\circ}$ in Mt. Halla. In slope was $30^{\circ}$ in Mt. Jiri and $20^{\circ}$ in Mt. Halla. Changes by reliefs was 12 in Mt. Jiri, 0 or 15 in Mt. Halla, and Sites of Korean Fir was convex slopes both of two areas. Changes by soils was in the good drainage textures.

• Korean Journal of Food Science and Technology
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• v.14 no.1
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• pp.30-35
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• 1982

Ultrastructural changes in endomysial connective tissue, sarcolemma, transverse ridges and myofibrillar structures with particular attention given to Z-discs. A and I-filaments induced by heating to $80^{\circ}C$ were observed by transmission and scanning electron microscopy. Muscle heated to $80^{\circ}C$ produced granulation of sarcolemma aid ultrastructural changes and coagulation were observed in endomysial and sarcolemmal connective tissue. The edvient changes in myofibrillar structure were an increase in coagulation compactness of the A-band portion of sarcomere and disintegration of the I-bands. Z-discs appeared to be relative resistant to heat but I-filaments were observed to be most heat labile.

• Design & Manufacturing
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• v.17 no.3
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• pp.34-40
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• 2023

In this study, real-time collection of mold vibration signals during injection molding processes was achieved through IoT devices installed on the mold surface. To analyze changes in the collected vibration signals, injection molding was performed under six different process conditions. Analysis of the mold vibration signals according to process conditions revealed distinct trends and patterns. Based on this result, cosine similarity was applied to compare pattern changes in the mold vibration signals. The similarity in time and acceleration vector space between the collected data was analyzed. The results showed that under identical conditions for all six process settings, the cosine similarity remained around 0.92±0.07. However, when different process conditions were applied, the cosine similarity decreased to the range of 0.47±0.07. Based on these results, a cosine similarity threshold of 0.60~0.70 was established. When applied to the analysis of mold vibration signals, it was possible to determine whether the molding process was stable or whether variations had occurred due to changes in process conditions. This establishes the potential use of cosine similarity based on mold vibration signals in future applications for real-time monitoring of molding process changes and anomaly detection.