• Journal of Environmental Science International
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• v.15 no.9
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• pp.819-827
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• 2006

We study on the dynamic interaction with a simulated physical-biological coupled model response to nutrient reduction scenario in Jinhae Bay. According to the low relative errors, high regression coefficients of COD and DIN, and realistic distribution in comparison to the observation, our coupled model could be applicable for assessing the marine ecosystem response to nutrient input reduction in Jinhae Bay. Due to the new construction and expansion of sewage treatment plant from our government, we reduce 50% nutrient inputs near Masan Bay and sewage treatment plant. COD achieves Level II in Korea standard of the water quality from the middle of the Masan Bay to all around Jinhae Bay except the inner Masan Bay remaining at Level III. When our experiment reduces 50% nutrient inputs near Masan Bay and Dukdong sewage treatment plant simultaneously, COD decreases to about 0.1-1.2 mg/L $(128^{\circ}30'{\sim}128^{\circ}40'\;E,\;35^{\circ}05'{\sim}35^{\circ}11'\;N)$. The COD from the middle of the Masan Bay to Jinhae Bay achieves Level II.

• Journal of the Earthquake Engineering Society of Korea
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• v.18 no.6
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• pp.279-289
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• 2014

Considering a rigorously fluid-structure interaction, a method for an earthquake response analysis of a floating offshore structure subjected to vertical ground motion from a seaquake is developed. Mass, damping, stiffness, and hydrostatic stiffness matrices of the floating offshore structure are obtained from a finite-element model. The sea water is assumed to be a compressible, nonviscous, ideal fluid. Hydrodynamic pressure, which is applied to the structure, from the sea water is assessed using its finite elements and transmitting boundary. Considering the fluid-structure interaction, added mass and force from the hydrodynamic pressure is obtained, which will be combined with the numerical model for the structure. Hydrodynamic pressure in a free field subjected to vertical ground motion and due to harmonic vibration of a floating massless rigid circular plate are calculated and compared with analytical solutions for verification. Using the developed method, the earthquake responses of a floating offshore structure subjected to a vertical ground motion from the seaquake is obtained. It is concluded that the earthquake responses of a floating offshore structure to vertical ground motion is severely influenced by the compressibility of sea water.

• Bulletin of the Korean Chemical Society
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• v.25 no.10
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• pp.1559-1563
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• 2004

The topoisomerase II poisoning effect of certain protoberberine alkaloids is associated with anti-cancer activity. Structure-activity relationships of protoberberine analogues substituted on the ring protons reveal that substitution at the C19 position is an important determinant of biological activity. In this study, the effects of substituent modification at the C19 position on the interaction of protoberberines with DNA are determined using UV and NMR spectroscopy. The line broadening effect on aliphatic resonances, chemical shift changes of the imino protons of HP14 upon berberine and berberrubine binding to HP14, and the rate of the exchange process between protoberberine analogs bound indicate that berberrubine binds HP14 more specifically than berberine. In addition, the free HP14 is altered by the substituent at the 19-position. UV spectra of berberrubine have shown a hypochromic effect together with a slight red shift, which are usually regarded as characteristics of DNA intercalation. These results are consistent with our previous report that the berberrubine is partially intercalated with HP14 with molar ratio 1 : 1, whereas a non-specific interaction is predominant between the berberine and HP14.

• Proceedings of the Korea Database Society Conference
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• 2001.06a
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• pp.183-192
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• 2001

eCRM은 인터넷 상의 고객의 행동을 파악, 가치있는 고객 세그먼트를 찾아내고, 이들에게 타겟 마케팅을 실시함으로써 기업의 수익성을 높이거나, 마케팅활동을 자동화함으로써 고객관리 프로세스의 효율성을 높이는 일련의 과정 (중략)

• Journal of Information Technology Applications and Management
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• v.13 no.4
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• pp.197-214
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• 2006

This study explores factors to facilitate web-based collaborative learning and the effect of learning, based on the PBL(Problem Based Learning) from the constructivist approach in e-learning. A research model, using the key variables such as situations, interactions, and systems, was developed. In order to test this proposed model, experimental design and post-survey was conducted to the learners who took on-line and off-line course with team project. In the research model, situation category was divided into instructor's support, unstructured problem, and self-directed learning. Interaction category was divided into three factors; 'interaction between learners', 'interaction between learner and instructor', and 'interaction between learner and technology'. System category was divided into.monitoring and incentives. As a result, it was found that collaborative learning can be improved by situations, interactions, and systems, and the effectiveness of learning can be improved by situations and interactions in PBL.

• Korean Institute of Interior Design Journal
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• v.13 no.6
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• pp.29-38
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• 2004

The purpose of this study is to provide design guidelines on office layouts to improve workers' concentration and communication behavior while supporting work processes. Among the present office types, benzene-type was preferred the most was providing better concentration. Regarding communication, link and benzene were preferred types. In present office types, workers were satisfied in communication more than concentration. To increase concentration level, acoustical privacy was indicated as the most important factor In conclusion, to support both concentration and communication in office, the team area should be divided into smaller sub-team areas. The sub-team areas may support interaction within a group while preventing unnecessary distraction. The major circulation of work process should be formed outside of the sub-team areas to provide concentration within the groups.

• 한국금형공학회:학술대회논문집
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• 2008.06a
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• pp.175-181
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• 2008

The technologies of mold design, manufacturing, injection molding process and computer aided engineering(CAE) are developed rapidly with the growth of plastic product market. Injection molding process optimum design can not be easily determined. This study was determined factors and levels which carried out to analyze an influence of narrow pitch BGA socket warpage and performed investigating the main effect and interaction effect between factors using design of experiment. The result of this paper is injection time and packing pressure are affect on narrow pitch BGA socket warpage at injection molding.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.62 no.6
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• pp.886-890
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• 2013

Uplift of contact wire and dynamic characteristics between pantograph and contact wire are key interaction performance of OCS (Overhead Catenary System). These two evaluation items are the approval criteria for the performance between OCS and pantograph. A telemetry system or DAQ (Data Acquisition) System based on wireless communication make it monitor a dynamic behavior which is measured directly in a 25 kv like parts. While permissible working time is too short time to install is too long. In this paper, it is described that optimization the telemetry measurement system for OCS and increasing accuracy, easy adaptation, and faster handling can be also achieved through the study.

• Proceedings of the KIEE Conference
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• 2003.07d
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• pp.2055-2057
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• 2003

This paper describes the results of RBD(Reliability Block Diagram) analysis of control rod control system, which is being developed as part of KNICS project. The results of RBD indicate unavailability of control cabinet for control rod control system. A purpose of RBB is to evaluate unavailability of control cabinet, identify the design drawbacks of control cabinet, and propose design improvement to a designer to help design the more reliable control rod control system. This RBD defines the logical interaction of failure within a system.

• Mass Spectrometry Letters
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• v.7 no.4
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• pp.106-110
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• 2016

Ginseng, a traditional herbal drug, has been used in Eastern Asia for more than 2000 years. Various ginsenosides, which are the major bioactive components of ginseng products, have been shown to exert numerous beneficial effects on the human body when co-administered with drugs. However, this may give rise to ginsenoside-drug interactions, which is an important research consideration. In this study, acassette assay was performed the inhibitory effects of 12 ginsenosides on seven cytochrome P450 (CYP) isoforms in human liver microsomes (HLMs) using LC-MS/MS to predict the herb-drug interaction. After incubation of the 12 ginsenosides with seven cocktail CYP probes, the generated specific metabolites were quantified by LC-MS/MS to determine their activities. Ginsenoside Rb1 and F2 showed strong selective inhibitory effect on CYP2C9-catalyzed diclofenac 4'-hydroxylation and CYP2B6-catalyzed bupropion hydroxylation, respectively. Ginsenosides Rd showed weak inhibitory effect on the activities of CYP2B6, 2C9, 2C19, 2D6, 3A4, and compound K, while ginsenoside Rg3 showed weak inhibitory effects on CYP2B6. Other ginsenosides, Rc, Rf, Rg1, Rh1, Rf, and Re did not show significant inhibitory effects on the activities of the seven CYPs in HLM. Owing to the poor absorption of ginsenosides after oral administration in vivo, ginsenosides may not have significant side effects caused by interaction with other drugs.