• Title/Summary/Keyword: TdT

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Correlation Between Tumorigenic Doses and the Maximum Tolerated Dose of Carcinogens (발암물질의 발암용량과 최대내성용량의 상관관계)

  • 이병무;김근종
    • Environmental Mutagens and Carcinogens
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    • v.19 no.2
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    • pp.108-111
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    • 1999
  • Correlation between the tumorigenic dose (TD) and the maximum tolerated dose (MTD) was examined to search for the most relevant TD values related to the MTD. Using benzo(a)pyrene (B(a)P) 2-yr bioassay data, correlation coefficients between values of $TD_{1-}$50/ and the MTD were estimated from linearized or non-linearlized dose-response curves. The highest correlation coefficients (0.9966-1.0000) were obtained from T $D_{1-}$10/ in linearized dose-response curves while the highest (0.9966-1.0000) were estimated from $TD _{5-}$10/ in non-linearized dose-response eurves. These data suggest that TDs-lo were more closely related to the MTD than the ,$TD_{5-}$10/ in B(a)P 2-yr bioassay and that in lieu of the $TD_{50}$ they could be efficiently applicable to risk assessment and management.ent.

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A Study on Evaluation of Accuracy and Precision on B, T, X Analysis Using Thermal Desorption/Gas Chromatograph/Flams Ionization Detector (열탈착/GC/FID를 이용한 B, T, X 분석의 정확도 및 정밀도 평가)

  • 박정근;유기호
    • Journal of Korean Society for Atmospheric Environment
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    • v.16 no.3
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    • pp.265-275
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    • 2000
  • By using thermal desorption/gas chromatograph/flame ionization detector(TD/GC/FID), this study was carried out to evalute an accuracy and a precision on Benzene(B), Toluene(T), o-Xylene(X) analysis in an industrial hygiene laboratory. Limits of detection of TD/GC/FID on B, T, X were showed 13.75ng/sample or less. For the accuracy of the method by concentration levels, overall bias was showed 7.7% as an absolute value, and the pooled coefficient of variation showed 3.51%. For the precision on repeatability of peak area and retention time between within-run and between-run of analytical system, it is showed the results of within-run gave better than those of between-run. Also the accuracy by sorbents(Tenax TA and Chromosorb 106)was evaluated, and the precision on reproducibility between MDHS72 and this study was compared. It is showed it is possible for TD/GC/FID to evaluate accurately B, T, X concentration levels of less than 1ppm at indoor or outdoor of workplaces in Korea.

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Performance Analysis of TD-CDMA Systems with Cell Synchronization Error (기지국간 동기오차를 고려한 TD-CDMA 시스템 성능 분석)

  • 한진규;권동승;이명원;박한규
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.26 no.12B
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    • pp.1648-1655
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    • 2001
  • TD-CDMA is based on a combination of CDMA, TDMA, and TDD technologies, and it is proposed to support TDD mode for IMT-2000 service. To analyze the performance of TD-CDMA, we have to establish a modeling technique that takes into account the interference that can occur in each scheme. There is special interference in TDD mode, e.g. interference from base station to base station and from mobile to mobile. In this paper, we present an interference model for analyzing the performance of TD-CDMA systems and the slot allocation strategies. This model includes the cell synchronization error. As a result, this paper shows that almost equal slot allocation and low cell synchronization error guarantee desirable performance in TD-CDMA.

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Characteristics analysis of momentum transfer cross section and electron energy distribution funtions of $CO_2$ gas ($CO_2$기체의 운동량 변환충돌단면적 및 전자에너지분포함수 특성해석)

  • 하성철;윤상호
    • Electrical & Electronic Materials
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    • v.6 no.1
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    • pp.63-68
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    • 1993
  • CO$_{2}$기체의 운동량변환, 진동여기, 전자여기 및 전리충돌 단면적의 결정은 온도 293[.deg.K], 상대전계의 세기 E/N은 1.0[Td].leq.E/N.leq.200[Td]의 범위에서 볼츠만 방정식을 Backward-Prolongation 방법으로 해석하여 전자 이동속도의 계산값을 산출하고 이것을 M. T. Elford에 의해 실험적으로 측정된 이동속도의 값과 비교하였다. 본 연구에서 운동량변환충돌단면적은 Hake & Phelps의 값을 기초로 하였으며 온도 293[.deg.K], 상대전계의 세기 E/N은 3.0[Td].leq.E/N.leq.50[Td]인 범위 전자에너지분포함수 및 전자특성에너지는 상대전계의 세기 E/N이 1.0[Td].leq.E/N.leq.200[Td]인 범위에서 산출하였다.

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Experimental Formability Investigation for FSW Sheets with Respect to Base Material's Directional Combination (모재의 방향성에 따른 마찰교반용접 판재의 성형성에 관한 실험적 연구)

  • Kim, Dae-Yong;Lee, Won-Oh;Kim, June-Hyung;Kim, Chong-Min;Chung, Kwan-Soo
    • Transactions of Materials Processing
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    • v.18 no.1
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    • pp.73-79
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    • 2009
  • In order to investigate the formability of friction stir welded(FSW) tailor welded blanks(TWB) with respect to the base material's directional combination, aluminum alloy AA6111-T4 sheets were welded with three different conjoining types: RD-RD, TD-RD and TD-TD. Here, RD and TD represent rolling and transverse directions, respectively. For experimental formability study, three tests with gradual complexity were performed: the simple tension test with various weld line directions for uni-axial elongation, the hemisphere dome stretching test for biaxial stretching and the cylindrical cup deep drawing test. As a result, all three forming tests showed that RD-RD type samples exhibited the best formability, while TD-TD type sheets showed the least formability performance.

Linear Temperature Dependence of Magnetic Penetration Depth Length at Low T in an Isotropic Superconductor

  • Nam, Sang-Boo
    • Progress in Superconductivity
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    • v.2 no.1
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    • pp.11-14
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    • 2000
  • The notion of the finite pairing interaction energy range Td is shown to result in a linear temperature dependence of the London magnetic penetration depth length, ${\Delta}{\lambda}{/\lambda}(0)=(T/Td)2/\pi)ln2$ at low T in the case of the s-wave pairing state, accounting for data of high Tc superconductor by Hardy et al.

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Effects of Deamido-$\textrm{NAD}^{+}$ on Self-splicing of Primary Transcripts of Phage T4 Thymidylate Synthase Gene

  • Park, In Kook
    • Animal cells and systems
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    • v.4 no.2
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    • pp.141-144
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    • 2000
  • Effects of deamido-$\textrm{NAD}^{+}$on self-splicing of primary transcripts of the phage T4 thymidylate synthase gene (td) was investigated. The self-splicing was not affected by deamido-$\textrm{NAD}^{+}$- at concentrations up to 2 mM. However, it began to decrease at 5 mM and the formation of splicing products such as the linear intron, intron-exon 2 and exon 1-exon 2, was slightly reduced. At 20 mM the self-splicing activity was almost completely abolished. This analog of the coenzyme $\textrm{NAD}^{+}$- inhibits the self-splicing of td intron RNA although it does not possess a guanidine group in its structure. The analysis of inhibitory concentrations and structural examination suggests that the key structural features of deamido-$\textrm{NAD}^{+}$ responsible for the inhibition of splicing may be the ADP-ribose moiety.

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Modified T-RFLP Methods for Taxonomic Interpretation of T-RF

  • Lee, Hyun-Kyung;Kim, Hye-Ryoung;Mengoni, Alessio;Lee, Dong-Hun
    • Journal of Microbiology and Biotechnology
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    • v.18 no.4
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    • pp.624-630
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    • 2008
  • Terminal restriction fragment length polymorphism (T-RFLP) is a method that has been frequently used to survey the microbial diversity of environmental samples and to monitor changes in microbial communities. T-RFLP is a highly sensitive and reproducible procedure that combines a PCR with a labeled primer, restriction digestion of the amplified DNA, and separation of the terminal restriction fragment (T-RF). The reliable identification of T-RF requires the information of nucleotide sequences as well as the size of T-RF. However, it is difficult to obtain the information of nucleotide sequences because the T-RFs are fragmented and lack a priming site of 3'-end for efficient cloning and sequence analysis. Here, we improved on the T-RFLP method in order to analyze the nucleotide sequences of the distinct T-RFs. The first method is to selectively amplify the portion of T-RF ligated with specific oligonucleotide adapters. In the second method, the termini of T-RFs were tailed with deoxynucleotides using terminal deoxynucleotidyl transferase (TdT) and amplified by a second round of PCR. The major T-RFs generated from reference strains and from T-RFLP profiles of activated sludge samples were efficiently isolated and identified by using two modified T-RFLP methods. These methods are less time consuming and labor-intensive when compared with other methods. The T-RFLP method using TdT has the advantages of being a simple process and having no limit of restriction enzymes. Our results suggest that these methods could be useful tools for the taxonomic interpretation of T-RFs.

Investigation of Properties of the PET Film Dependent on the Biaxial Stretching (PET 필름의 이축연신에 따른 물성변화 연구)

  • Lee, Jung-Gyu;Park, Sang-Ho;Kim, Seong-Hun
    • Polymer(Korea)
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    • v.34 no.6
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    • pp.579-587
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    • 2010
  • To investigate the properties of PET films, PET films were extruded at various temperature above $T_m$ and quenched at $18^{\circ}C$ for amorphous sheet, and stretched along a direction defined as the machine direction (MD) with a transverse direction (TD) above $T_g$ at various stretching ratios and then annealed at various temperatures produced by SKC PET line. Thermal shrinkage of MD and TD increased with decreasing annealing temperature and extruding temperature, and increasing stretching ratio. The degree of crystallinity, density, heat of fusion (${\Delta}H$) and pre-melting point ($T_m'$) increased with increasing annealing temperature and extruding temperature. Number average molecular weight ($M_n$) and intrinsic viscosity decreased with increasing extruding temperature. Tensile strength and modulus increased with increasing stretching ratio, however decreased with increasing annealing temperature. Reflective index of both stretching and thickness direction increased with increasing stretching ratio and annealing temperature.

A Comparison of the Density Functional Theory Based Methodologies for the Triplet Excited State of 𝛑-Conjugated Molecules: Time-Dependent DFT (TD-DFT), TD-DFT within Tamm-Dancoff Approximation (TDA-DFT), and Spin-Unrestricted DFT (UDFT) (𝛑-공액계 분자의 삼중항 여기 상태에 대한 Density Functional Theory (DFT)에 기반한 계산 방법들의 비교: 시간-의존 DFT (TD-DFT), Tamm-Dancoff 근사법을 적용한 DFT (TDA-DFT), 스핀-비제한 DFT (UDFT))

  • Ahn, Chang Hwan;Kim, Dongwook
    • Journal of the Korean Chemical Society
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    • v.63 no.2
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    • pp.73-77
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    • 2019
  • We compared methodologies based on the density functional theory (DFT), e.g., time-dependent DFT (TD-DFT), TD-DFT within Tamm-Dancoff approximation (TDA-DFT), and spin-unrestricted DFT (UDFT), that are usually employed to optimize the geometries of ${\pi}$-conjugated molecules in their lowest lying triplet excited ($T_1$) state. As a model system for ${\pi}$-conjugated molecules, we employed 1,2,3,4,5-pentacyano-6-phenyl-benzene. In conjunction with 6-31G(d) basis sets, we made use of gap-tuned range-separated ${\omega}B97X$ functional which is often employed recently in the calculations of molecular excited states. Near the equilibrium geometries, we found that the important difference between the geometries derived at UDFT level and those at TD-DFT or TDA-DFT methods: more stable ground-state energies but higher triplet excitation energies for UDFT derived geometries. In the studies, we discuss such differences in more detail.