• Earthquakes and Structures
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• v.3 no.3_4
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• pp.341-363
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• 2012

The spectral representation method is a quick and versatile tool for the generation of spatially variable, response-spectrum-compatible simulations to be used in the nonlinear seismic response evaluation of extended structures, such as bridges. However, just as recorded data, these simulated accelerations require processing, but, unlike recorded data, the reasons for their processing are purely numerical. Hence, the criteria for the processing of acceleration simulations need to be tied to the effect of processing on the structural response. This paper presents a framework for processing acceleration simulations that is based on seismological approaches for processing recorded data, but establishes the corner frequency of the high-pass filter by minimizing the effect of processing on the response of the structural system, for the response evaluation of which the ground motions were generated. The proposed two-step criterion selects the filter corner frequency by considering both the dynamic and the pseudo-static response of the systems. First, it ensures that the linear/nonlinear dynamic structural response induced by the processed simulations captures the characteristics of the system's dynamic response caused by the unprocessed simulations, the frequency content of which is fully compatible with the target response spectrum. Second, it examines the adequacy of the selected estimate for the filter corner frequency by evaluating the pseudo-static response of the system subjected to spatially variable excitations. It is noted that the first step of this two-fold criterion suffices for the establishment of the corner frequency for the processing of acceleration time series generated at a single ground-surface location to be used in the seismic response evaluation of, e.g. a building structure. Furthermore, the concept also applies for the processing of acceleration time series generated by means of any approach that does not provide physical considerations for the selection of the corner frequency of the high-pass filter.

• Journal of The Korean Society of Integrative Medicine
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• v.9 no.2
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• pp.131-140
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• 2021

Purpose : The purpose of this study was to systematically review the studies on the effects of social story intervention on the individuals with autism spectrum disorders(ASD) to provide the basis for evidence-based practice. Methods : In order to find out the studies on the effect of social story intervention on individuals with ASD, studies published from 2011 to December 2020 were searched on Google Academic Search. The keywords used were "autism spectrum disorder AND social story". A total of 16,900 studies were searched, and from these, 12 studies were selected based on the application of the selection and exclusion criteria. The included studies comprised of 10 single subject design studies and 2 randomized controlled trials design studies. The included studies were analyzed in accordance to population, intervention, outcome measures and results. Results : As a result of analysing the subjects of the included studies, we found out that pre-school children and adolescents were the most common groups of individuals diagnozsed with ASD. In addition to ASD, the diagnosis of the subjects included intellectual disability, Asperger, and Prader-willi. We found out that there were more interventions that were mixed with other interventions, than just the pure social story interventions. In particular, video modeling was found to be the most frequent intervention. This was followed by photo-based social stories. For outcome measure, autism social skills profile was found to be the most often used standardized assessment. For a non-standardized assessment, social desired behavior was found to be the most frequently evaluated behavior, followed by personal problem behavior. Of all the dependent variables, the dependent variable reported as "effective" was the most, followed by "some effective". Conclusion : This study is organized to help the individuals with ASD, families, researchers, and therapists understand the effects of social story intervention on the individuals with ASD in an easy fashion. Further, therapists can use this study as the basic data for evidence-based practice.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1997.04a
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• pp.40-47
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• 1997

New quinolones generally have a broad antibacterial spectrum against gram-positive, gram-negative, glucose-nonfermenting and anaerobic bacteria. Some of newly developed quinolones have potent activities against S. aureus including MRSA, S.pneumoniae including PRSP, B. fragilis, chlamydiae, mycoplasmas and mycobacteria as well, and show good activities against various strains resistant to antibacterial agents of other classes. Quinolones display postantibiotic effects in vitro and are bactericidal at concentrations similar to or twice that of the minimum inhibitory concentrations (MICs) for susceptible pathogens. In experimental murine infection models including systemic infections with various pathogens such as S. aureus, S. pyogenes, S. pneumoniae, E. coli and P. aeruginosa, quinolones have shown good oral efficacy as well as parenteral efficacy. Good oral absorption and good tissue penetration of quinolones account for good therapeutic effects in clinical settings. The target of quinolones are two structurally related type II topoisomerases, DNA gyrase and DNA topoisomerase IV. Quinolones are shown to stabilize the ternary quinolone-gyrase-DNA complex and inhibit the religation of the cleaved double-stranded DNA. Bacteria can acquire resistance to quinolones by mutations of these target enzymes. Mutation sites and amino acid changes in DNA gyrase and DNA topoisomerase IV are similar in the organisms examined, suggesting that the mechanism of quinolone resistance in the target enzymes is essentially the same among various organisms. Quinolones act on both the target enzymes to different degrees depending on the organisms or agents tested, and bacteria become highly resistant to quinolones in a step-wise fashion. Incomplete cross-resistance among quinolones in some strains of E. coli and S. aureus suggests the possibility of finding quinolones active against quinolone-resistant strains which are prevailing now. To find such quinolones, the potency toward two target enzymes and the membrane permeability including influx and/or efflux systems should be taken into account.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.31 no.1
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• pp.1-12
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• 2021

Objective: The purpose of this study was to contribute to the prevention of occupational diseases through the development of an automatic analysis program for evaluating workers' exposure to hazardous chemical substances. Methods: The authors selected chemical substances that caused occupational disease in Korea and chemical substances that are frequently used in industrial sites as target substances for a GC-MS automatic analysis program. The target substances are organic compounds which can be measured by a passive sampler. The automatic analysis program was studied using various raw data obtained from GC-MS analysis for the target substances. Results: A total of 48 organic compounds that can be measured with a passive sampler were selected as target substances for the GC-MS automatic analysis program. The selected compounds included substances that caused occupational disease, substances related to C1 and D1 in special health examinations, and substances for which work environment measurements have been frequently conducted. The GC-MS automatic analysis program was developed by combining information mainly on retention time and mass spectrum. The GC-MS automatic analysis program is designed to analyze unknown samples by comparing the mass spectrum and retention time of the samples to those of reference materials. To evaluate the stability of the program, samples at about the 30-50% level of OELs were prepared and analyzed with the GC-MS automatic analysis program, resulting in stable results for all 48 organic compounds. Conclusion: An automatic analysis program for a total of 48 organic compounds was developed using a GC-MS system that can analyze organic compounds. Unknown samples that contain the 48 organic compounds can be automatically analyzed by the developed program. It is anticipated that it can contribute to the prevention of occupational diseases through an GC-MS automatic analysis program that can quickly provide workers with information on exposure to chemical substances.

• Journal of Music and Human Behavior
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• v.21 no.3
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• pp.41-64
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• 2024

The purpose of this study is to develop and evaluate the feasibility of a structured music therapy protocol that incorporates Augmentative and Alternative Communication (AAC) devices to enhance communicative behaviors in children with severe and profound autism spectrum disorder (ASD). The developed protocol consists of four stages: optimizing attention and arousal levels, familiarizing with target vocabulary, acquiring target vocabulary through AAC, and applying communicative skills in everyday contexts. In the first stage, music serves as a multisensory medium to enhance attention and arousal, fostering motivation for communication in children with ASD. The second stage introduces target vocabulary through musical elements to facilitate familiarization with the words and support language processing. The third stage involves the use of AAC devices during music-based activities, encouraging children to express their preferences and communicate effectively. The final stage focuses on generalizing communicative skills by applying target vocabulary in real-life situations. The protocol was validated by professionals in music therapy and speech-language therapy. Its clinical applicability was further confirmed through implementation with children with ASD by music therapists who had no prior experience using AAC. The findings suggest that this protocol effectively improves communication in children with severe and profound ASD and provide therapists with practical and evidence-based strategies.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.14 no.10
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• pp.2187-2193
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• 2010

A specific radar system can be implemented more easily using the frequency modulated continuous wave comparing with the pulse Doppler radar. It also has the advantage of LPI (low probability of interception) because of the low power and wide bandwidth characteristics. These radars are usually used to cover the short range area and to obtain the high resolution measurements of the target range and velocity information. The transmitted waveform is used in the mixer to demodulate the received echo signal and the resulting beat signal can be obtained. This beat signal is analyzed using the FFT method for the purpose of clutter removal, detection of a target, extraction of velocity and range information, etc. However, for the case of short signal acquisition time, this FFT method can cause the serious leakage effect which disables the detection of weaker echo signals masked by strong side lobes of the clutter. Therefore, in this paper, the weighting window method is analyzed to suppress the strong side lobes while maintaining the proper main lobe width. Also, the results of FFT beat spectrum analysis are shown under various environments.

• BMB Reports
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• v.45 no.7
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• pp.408-413
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• 2012

Almost all melanoma cells express at least one member of the MAGE-A antigen family, making the cytotoxic T cells (CTLs) epitopes with cross-immunizing potential in this family attractive candidates for the broad spectrum of anti-melanoma immunotherapy. In this study, four highly homologous peptides (P264: FLWGPRALA, P264I9: FLWGPRALI, P264V9: FLWGPRALV, and P264H8: FLWGPRAHA) from the MAGE-A antigens were selected by homologous alignment. All four peptides showed high binding affinity and stability to HLA-A$^*02:01$ molecules, and could prime CTL immune responses in human PBMCs and in HLA-A$^*02:01/K^b$ transgenic mice. CTLs elicited by the four epitope peptides could cross-lyse tumor cells expressing the mutual target antigens, except MAGE-A11 which was not tested. However, CTLs induced by P264V9 and P264I9 showed the strongest target cell lysis capabilities, suggesting both peptides may represent the common CTL epitopes shared by the eight MAGE-A antigens, which could induce more potent and broad-spectrum antitumor responses in immunotherapy.

• Nuclear Engineering and Technology
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• v.34 no.1
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• pp.42-59
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• 2002

In order to transmute long-lived radioactive nuclides such as transuranics(TRU), Tc-99, and I- l29 in LWR spent fuel, a preliminary conceptual design study has been performed for the accelerator driven subcritical reactor system, called HYPER(Hybrid Power Extraction Reactor) The core has a hybrid neutron energy spectrum: fast and thermal neutrons for the transmutation of TRU and fission products, respectively. TRU is loaded into the HYPER core as a TRU-Zr metal form because a metal type fuel has very good compatibility with the pyre- chemical process which retains the self-protection of transuranics at all times. On the other hand, Tc-99 and I-129 are loaded as pure technetium metal and sodium iodide, respectively. Pb-Bi is chosen as a primary coolant because Pb-Bi can be a good spallation target and produce a very hard neutron energy spectrum. As a result, the HYPER system does not have any independent spallation target system. 9Cr-2WVTa is used as a window material because an advanced ferritic/martensitic steel is known to have a good performance under a highly corrosive and radiation environment. The support ratios of the HYPER system are about 4∼5 for TRU, Tc-99, and I-129. Therefore, a radiologically clean nuclear power, i.e. zero net production of TRU, Tc-99 and I-129 can be achieved by combining 4 ∼5 LWRs with one HYPER system. In addition, the HYPER system, having good proliferation resistance and high nuclear waste transmutation capability, is believed to provide a breakthrough to the spent fuel problems the nuclear industry is faced with.

• Journal of Radiation Protection and Research
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• v.43 no.4
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• pp.154-159
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• 2018

Background: To prevent small leakage accidents, a real-time and direct detection system for small leaks with a detection limit below that of existing systems, e.g. $0.5gpm{\cdot}hr^{-1}$, is required. In this study, a small-size beta detector, which can be installed inside the reactor containment (CT) building and detect small leaks directly, was suggested and its feasibility was evaluated using MCNPX simulation. Materials and Methods: A target nuclide was selected through analysis of radiation from radionuclides in the reactor coolant system (RCS) and the spectrum was obtained via a silicon detector simulated in MCNPX. A window was designed to reduce the background signal caused by other nuclides. The sensitivity of the detector was also estimated, and its shielding designed for installation inside the reactor CT. Results and Discussion: The beta and gamma spectrum of the silicon detector showed a negligible gamma signal but it also contained an undesired peak at 0.22 MeV due to other nuclides, not the $^{16}N$ target nuclide. Window to remove the peak was derived as 0.4 mm for beryllium. The sensitivity of silicon beta detector with a beryllium window of 1.7 mm thickness was derived as $5.172{\times}10^{-6}{\mu}Ci{\cdot}cc^{-1}$. In addition, the specification of the shielding was evaluated through simulations, and the results showed that the integrity of the silicon detector can be maintained with lead shielding of 3 cm (<15 kg). This is a very small amount compared to the specifications of the lead shielding (600 kg) required for installation of $^{16}N$ gamma detector in inside reactor CT, it was determined that beta detector would have a distinct advantage in terms of miniaturization. Conclusion: The feasibility of the beta detector was evaluated for installation inside the reactor CT to detect small leaks below $0.5gpm{\cdot}hr^{-1}$. In future, the design will be optimized on specific data.

• The Journal of the Acoustical Society of Korea
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• v.38 no.2
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• pp.168-176
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• 2019

When an array receives a signal with a frequency higher than the design frequency, there is an ambiguity in beamforming due to spatial aliasing. In order to overcome this problem, Abadi proposed frequency-difference beamforming. However, there is a constraint that the minimum frequency bandwidth is required according to the value of the difference frequency. In this paper, we propose a method to find the direction of the target signal with spatial aliasing based on the frequency-wavenumber spectrum combined with Radon transform. The proposed method can estimate the direction of the target without ambiguities when the signal has nonnegligible bandwidth. We tested the algorithm by simulating a broadband signal and verified the results with the frequency-difference beamforming method using SAVEX15 (Shallow Water Acoustic Variability EXperiment 2015)'s shrimp noise data.