• International Journal of Computer Science & Network Security
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• v.21 no.1
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• pp.152-161
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• 2021

The paper focuses on Device-to-device (D2D) Architectures evaluation frameworks. D2D communication and discovery can improve spectrum usage efficiency and optimize the tradeoffs between throughput and energy consumption. The target operation modes involve both indirect communication between two nodes via a base station or the direct communication among proximal nodes, enabling use cases that can support communications out of cellular coverage, as well as low end-end delay requirements. The paper will present the architectural evolution of D2D networks within 3GPP standardization and will highlight key network functionalities and signaling protocols. It will also identify key analytical and simulation models that can be used to assess the performance and energy efficiency of resource allocation strategies, and it will present a suitable cross-layer integrated framework.

• Journal of the Semiconductor & Display Technology
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• v.22 no.3
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• pp.52-61
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• 2023

We designed a novel ultra-miniaturized microcolumn structure having an stigmator to significantly improve throughput per unit time, which is the biggest disadvantage of microcolumns. We adopted the structure of the stigmator in the form of an electrostatic octupole electrode, and used an electrostatic quadrupole deflector with a relatively simple structure considering the increase in wiring due to the introduction of the stigmator. We have dramatically reduced the effect of astigmatism that occurs when the electron beam probe is scanned to the periphery of the target by introducing the stigmator between the control electrode and the deflector. As our numerical analysis simulation results, the field of view obtained as a result of this study is about 46.3% improved compared to our previous study, and the electron beam probe size of less than 10 nm was achieved in the entire field of view.

• Bioinformatics and Biosystems
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• v.1 no.1
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• pp.28-37
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• 2006

Recent studies in molecular biology and proteomics have identified a significant number of novel diagnostic, prognostic, and therapeutic disease markers. However, validation of these markers in clinical specimens with traditional histopathological techniques involves low throughput and is time consuming and labor intensive. Tissue microarrays (TMAs) offer a means of combining tens to hundreds of specimens of tissue onto a single slide for simultaneous analysis. This capability is particularly pertinent in the field of cancer for target verification of data obtained from cDNA micro arrays and protein expression profiling of tissues, as well as in epidemiology-based investigations using histochemical/immunohistochemical staining or in situ hybridization. In combination with automated image analysis, TMA technology can be used in the global cellular network analysis of tissues. In particular, this potential has generated much excitement in cardiovascular disease research. The following review discusses recent advances in the construction and application of TMAs and the opportunity for developing novel, highly sensitive diagnostic tools for the early detection of cardiovascular disease.

• The Journal of the Korea Contents Association
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• v.16 no.11
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• pp.83-90
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• 2016

In this paper, we performed the analysis of transmission performance for Collision Free Period(CFP) supported by the low-power communication technology, IEEE 802.15.4 MAC (Media Access Control). For the analysis, periodic traffic, original service target of CFP, is considered and, according to the Quality of Service required, packet arrival pattern to MAC layer is categorized as batch and non-batch, and analysis on throughput, delay, and energy is performed for those patterns. On the basis of the obtained analysis, performance comparison with Collision Avoidance Period(CAP) is carried out for the health care applications that generate periodic traffic such as Pedometer, ECG, EMG. The evaluation confirms that CFP is more energy efficient for healthcare applications that generate periodic and time-critical traffic and moreover for the application with high bandwidth requirement CFP achieves up to 46% energy savings compared to CAP.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.39 no.1
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• pp.153-161
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• 2016

Semiconductor manufacturing has suffered from the complex process behavior of the technology oriented control in the production line. While the technological processes are in charge of the quality and the yield of the product, the operational management is also critical for the productivity of the manufacturing line. The fabrication line in the semiconductor manufacturing is considered as the most complex part because of various kinds of the equipment, re-entrant process routing and various product devices. The efficiency and the productivity of the fabrication line may give a significant impact on the subsequent processes such as the probe line, the assembly line and final test line. In the management of the re-entrant process such as semiconductor fabrication, it is important to keep balanced fabrication line. The Performance measures in the fabrication line are throughput, cycle time, inventory, shortage, etc. In the fabrication, throughput and cycle time are the conflicting performance measures. It is very difficult to achieve two conflicting goal simultaneously in the manufacturing line. The capacity of equipment is important factor in the production planning and scheduling. The production planning consideration of capacity can make the scheduling more realistic. In this paper, an input and scheduling rule are to achieve the balanced operation in semiconductor fabrication line through equipment capacity and workload are proposed and evaluated. New backward projection and scheduling rule consideration of facility capacity are suggested. Scheduling wafers on the appropriate facilities are controlled by available capacity, which are determined by the workload in terms of the meet the production target.

• Journal of KIISE:Computing Practices and Letters
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• v.11 no.1
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• pp.92-99
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• 2005

In this paper, we present a high-level design methodology applied on a network system-on-a-chip(SOC) using SystemC. The main target of our approach is to get optimum performance parameters for high network address translation(NAT) throughput. The Fast Ethernet media access controller(MAC) and its direct memory access(DMA) controller are modeled with SystemC in transaction level. They are calibrated through the cycle-based measurement of the operation of the real Verilog register transfer language(RTL). The NAT throughput of the model is within $\pm$10% error compared to the output of the real evaluation board. Simulation speed of the model is more than 100 times laster than the RTL. The validated models are used for intensive architecture exploration to find the performance bottleneck in the NAT router.

• Journal of Korea Port Economic Association
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• v.19 no.2
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• pp.1-32
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• 2003

The purpose of this study is to identify and evaluate the competitiveness of ports in ASEAN(Association of Southeast Asian Nations), which plays a leading role in basing the hub of global logistics strategies as a countermeasure in changes of logistics environments. This region represents most severe competition among Mega Hub ports in the world in terms of container cargo throughput at the onset of the 21st century. The research method in this study accounted for overlapping between attributes, and introduced the HFP method that can perform mathematical operations. The scope of this study was strictly confined to the ports of ASEAN, which cover the top 100 of 350 container ports that were presented in Containerization International Yearbook 2002 with reference to container throughput. The results of this study show Singapore in the number one position. Even when we compare with major ports in Korea (after getting comparative ratings and applying the same data and evaluation structure), the number one position still goes to Singapore and then Busan(2) and Manila(2), followed by Port Klang(4), Tanjung Priok(5), Tanjung Perak(6), Bangkok(7), Inchon(8), Laem Chabang(9) and Penang(9). In terms of the main contributions of this study, it is the first empirical study to apply the combined attributes of detailed and representative attributes into the advanced HFP model which was enhanced by the KJ method to evaluate the port competitiveness in ASEAN. Up-to-now, none has comprehensively conducted researches with sophisticated port methodology that has discussed a variety of changes in port development and terminal transfers of major shipping lines in the region. Moreover, through the comparative evaluation among major ports in Korea and ASEAN, the presentation of comparative competitiveness for Korean ports is a great achievement in this study. In order to reinforce this study, it needs further compensative research, including cost factors which could not be applied to modeling the subject ports by lack of consistently quantified data in ASEAN.

• Journal of KIISE:Information Networking
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• v.29 no.4
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• pp.358-367
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• 2002

The IETF Differentiated Services (Diffserv) WG focused on Providing service differentiation on the Internet. One problem of the Diffserv Assured Services (AS) architecture is that it cannot guarantee fairness and throughput assurance. In this paper, we propose two schemes for guaranteeing fairness among the various target rates in the AS architecture. One is a variant of RED with IN and OUT (RIO), called the improved RIO (IRIO). The other is a variant of Time Sliding Window (TSW), called the improved TSW (ITSW). To validate the Proposed schemes, their behaviors are then examined under various simulation environments. The simulation results showed that IRIO and ITSW improved fairness and the throughput assurance in the AS architecture.

• Journal of Veterinary Science
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• v.24 no.5
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• pp.73.1-73.16
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• 2023

Background: Highly pathogenic avian influenza virus (HPAIV) is considered a global threat to both human health and the poultry industry. MicroRNAs (miRNA) can modulate the immune system by affecting gene expression patterns in HPAIV-infected chickens. Objectives: To gain further insights into the role of miRNAs in immune responses against H5N1 infection, as well as the development of strategies for breeding disease-resistant chickens, we characterized miRNA expression patterns in tracheal tissues from H5N1-infected Ri chickens. Methods: miRNAs expression was analyzed from two H5N1-infected Ri chicken lines using small RNA sequencing. The target genes of differentially expressed (DE) miRNAs were predicted using miRDB. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis were then conducted. Furthermore, using quantitative real-time polymerase chain reaction, we validated the expression levels of DE miRNAs (miR-22-3p, miR-146b-3p, miR27b-3p, miR-128-3p, miR-2188-5p, miR-451, miR-205a, miR-203a, miR-21-3p, and miR-200a3p) from all comparisons and their immune-related target genes. Results: A total of 53 miRNAs were significantly expressed in the infection samples of the resistant compared to the susceptible line. Network analyses between the DE miRNAs and target genes revealed that DE miRNAs may regulate the expression of target genes involved in the transforming growth factor-beta, mitogen-activated protein kinase, and Toll-like receptor signaling pathways, all of which are related to influenza A virus progression. Conclusions: Collectively, our results provided novel insights into the miRNA expression patterns of tracheal tissues from H5N1-infected Ri chickens. More importantly, our findings offer insights into the relationship between miRNA and immune-related target genes and the role of miRNA in HPAIV infections in chickens.

• Molecules and Cells
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• v.27 no.5
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• pp.577-582
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• 2009

The development of a high-throughput functional genomic screening provides a novel and expeditious approach in identifying critical genes involved in specific biological processes. Here we describe a cell-based cDNA screening system to identify the transcription activators of BiP, an endoplasmic reticulum (ER) chaperone protein. BiP promoter contains the ER stress element which is commonly present in the genes involved in unfolded protein response (UPR) that regulates protein secretion in cells. Therefore, the positive regulators of BiP may also be utilized to improve the recombinant protein production through modulation of UPR. Four BiP activators, including human UDP-glucose:glycoprotein glucosyltransferase 1 (HUGT1), are identified by the cDNA screening. Overexpression of HUGT1 leads to a significant increase in the production of recombinant erythropoietin, interferon ${\gamma}$, and monoclonal antibody in HEK293 cells. Our results demonstrate that the cDNA screening for BiP activators may be effective to identify the novel BiP regulators and HUGT1 may serve as an ideal target gene for improving the recombinant protein production in mammalian cells.