• The Journal of Korean Institute of Communications and Information Sciences
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• v.40 no.6
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• pp.1148-1156
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• 2015

The maritime cognitive radio networks (MCRNs) provide the high throughput with a low communication cost because the secondary ships opportunistically access to unused licensed bands of primary ships. In the ground cognitive radio networks, the busy and idle state of a primary user during a frame is not nearly changed because the state of the primary user are slowly changed. However, the state of the primary ship in the MCRNs may be frequently changed in the frame. Therefore, this paper evaluates the throughput of a primary ship and secondary ships in the MCRNs taking the state change of a primary ship into consideration when the fusion center uses the cooperative spectrum sensing. The simulation results show that trade-off between the throughput of a primary ship and that of secondary ships according to the system parameter such as the cooperative spectrum sensing scheme, the number of secondary ships, and the target detection probability.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.40 no.5
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• pp.871-885
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• 2015

The improved DFSA for 2.4GHz multi-tags active RFID is suggested in 2 different ways: 1) simplified tag collection and Ack procedure using query command and 2) modified Schoute's method to control the number of slots in the frame. To evaluate the performance of the improved system we develop the simulation model. Varying the number of tags in the system we track the performance measures such as throughput, recognition time for multi-tags and tag recognition rate during a given time. The suggested method shows the best performance over all measures. Simplification of collection and Ack commands using query commands contributes to reducing tag recognition time. And the modified Schoute's method which controls the frame size using $k_1$ and $k_2$ contributes to throughput improvement and reduces target cognition time by reducing the number of collection rounds.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.31 no.8A
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• pp.745-751
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• 2006

The transmitter requires knowledge of the channel status information in order to adopt the adaptive modulation and coding scheme(AMC) for OFDM system. But in the outdoor environment which the users have high mobility, the channel status information from the users is outdated, so that it induces the degradation of system throughput and packet error rate(PER) performance. To solve this problem, researches about applying channel prediction technique to the AMC scheme have been proceeded. Most channel prediction techniques assume that there is no channel variation in the predefined time duration, e.g., a slot. As a result, those techniques cannot compensate the degradation of PER performance resulting from the rapid variation of channel during the slot duration. This paper introduces a novel channel prediction technique for OFDM/FDD system to support adaptive modulation and coding scheme over rapidly time-varying multipath fading channel. The proposed channel prediction technique considers the time-varying nature of channel during the slot duration. Simulation results show that the AMC scheme of OFDM/FDD system utilizing the proposed channel prediction technique can guarantee the target PER of 1% without any loss of system throughput compared with the case supported by the conventional channel prediction under ITU-R Veh A 30km/h.

• Journal of Pharmacopuncture
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• v.18 no.3
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• pp.11-18
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• 2015

Objectives: Systems biology is a novel subject in the field of life science that aims at a systems' level understanding of biological systems. Because of the significant progress in high-throughput technologies and molecular biology, systems biology occupies an important place in research during the post-genome era. Methods: The characteristics of systems biology and its applicability to traditional medicine research have been discussed from three points of view: data and databases, network analysis and inference, and modeling and systems prediction. Results: The existing databases are mostly associated with medicinal herbs and their activities, but new databases reflecting clinical situations and platforms to extract, visualize and analyze data easily need to be constructed. Network pharmacology is a key element of systems biology, so addressing the multi-component, multi-target aspect of pharmacology is important. Studies of network pharmacology highlight the drug target network and network target. Mathematical modeling and simulation are just in their infancy, but mathematical modeling of dynamic biological processes is a central aspect of systems biology. Computational simulations allow structured systems and their functional properties to be understood and the effects of herbal medicines in clinical situations to be predicted. Conclusion: Systems biology based on a holistic approach is a pivotal research methodology for understanding the mechanisms of traditional medicine. If systems biology is to be incorporated into traditional medicine, computational technologies and holistic insights need to be integrated.

• Proceedings of the PSK Conference
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• 2003.10a
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• pp.92-92
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• 2003

The drug discovery landscape is changing rapidly in the post-genomic era. Mapping of the human genome has led to an abundance of potential drug targets. Drug discovery times and costs can be significantly reduced by developing methods for high throughput target identification/ validation, multiplexed assay development and high efficient combinatorial chemistry. (omitted)

• Proceedings of the KIEE Conference
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• 2004.07c
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• pp.2128-2130
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• 2004

High throughput analysis using a DNA chip microarray is powerful tool in the post genome era. Less labor-intensive and lower cost-performance is required. Thus, this paper aims to develop the multi-channel type label-free DNA chip and detect SNP (Single nucleotide polymorphisms). At first, we fabricated a high integrated type DNA chip array by lithography technology. Various probe DNAs were immobilized on the microelectrode array. We succeeded to discriminate of DNA hybridization between target DNA and mismatched DNA on microarray after immobilization of a various probe DNA and hybridization of label-free target DNA on the electrodes simultaneously. This method is based on redox of an electrochemical ligand.

• BMB Reports
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• v.50 no.11
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• pp.554-559
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• 2017

MicroRNAs (miRNAs) are ~22nt-long single-stranded RNA molecules that form a RNA-induced silencing complex with Argonaute (AGO) protein to post-transcriptionally downregulate their target messenger RNAs (mRNAs). To understand the regulatory mechanisms of miRNA, discovering the underlying functional rules for how miRNAs recognize and repress their target mRNAs is of utmost importance. To determine functional miRNA targeting rules, previous studies extensively utilized various methods including high-throughput biochemical assays and bioinformatics analyses. However, targeting rules reported in one study often fail to be reproduced in other studies and therefore the general rules for functional miRNA targeting remain elusive. In this review, we evaluate previously-reported miRNA targeting rules and discuss the biological impact of the functional miRNAs on gene-regulatory networks as well as the future direction of miRNA targeting research.

• BMB Reports
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• v.50 no.11
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• pp.535-536
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• 2017

A novel approach has been used to identify functional interactions relevant to human disease. Using high-throughput human-yeast genetic interaction screens, a first draft of disease interactome was obtained. This was achieved by first searching for candidate human disease genes that confer toxicity in yeast, and second, identifying modulators of toxicity. This study found potentially disease-relevant interactions by analyzing the network of functional interactions and focusing on genes implicated in amyotrophic lateral sclerosis (ALS), for example. In the subsequent proof-of-concept study focused on ALS, similar functional relationships between a specific kinase and ALS-associated genes were observed in mammalian cells and zebrafish, supporting findings in human-yeast genetic interaction screens. Results of combined analyses highlighted MAP2K5 kinase as a potential therapeutic target in ALS.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.17 no.4
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• pp.410-414
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• 2004

High throughput analysis using a DNA chip microarray is powerful tool in the post genome era. Less labor-intensive and lower cost-performance is required. Thus, this paper aims to develop the multi-channel type label-free DNA chip and detect SNP (Single nucleotide polymorphisms). At first, we fabricated a high integrated type DNA chip array by lithography technology. Various probe DNAs were immobilized on the microelectrode array. We succeeded to discriminate of DNA hybridization between target DNA and mismatched DNA on microarray after immobilization of a various probe DNA and hybridization of label-free target DNA on the electrodes simultaneously. This method is based on redox of an electrochemical ligand.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2006.06a
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• pp.410-411
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• 2006

High throughput analysis using a DNA chip microarray is powerful tool in the post genome era. Less labor-intensive and lower cost-performance is required. Thus, this paper aims to develop the multi-channel type label-free DNA chip and detect SNP (Single nucleotide polymorphisms). At first, we fabricated a high integrated type DNA chip array by lithography technology. Various probe DNAs were immobilized on the microelectrode array. We succeeded to discriminate of DNA hybridization between target DNA and mismatched DNA on microarray after immobilization of a various probe DNA and hybridization of label-free target DNA on. the electrodes simultaneously. This method is based on redox of an electrochemical ligand.