• Journal of Pharmaceutical Investigation
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• v.32 no.2
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• pp.73-80
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• 2002

Cefuroxime axetil is a cephalosporin antibiotic having a high activity against a wide spectrum of Grampositive and Gram-negative microorganisms. It is a cephalosporin antibiotic which exist as 2 diastereoisomers: diastereoisomer A and B. It shows polymorphism of three forms: a crystalline form having a melting point of about $180^{\circ}C$, a substantially amorphous form having a high melting point of about $135^{\circ}C$ and a substantially amorphous form having a low melting point of about 70^{\circ}C$. The crystalline form of cefuroxime axetil is slightly soluble in water because diastereoisomer A has lower solubility than B in water. Substantially amorphous form of which there are no difference in solubility between diastereoisomer A and B has better solubility than crystalline form, but it forms a thicker gel than crystalline form upon contact with an aqueous medium. Based on this reason, cefuroxime axetil is not readily absorbable in the gastrointestinal tract, rendering its bioavailability on oral administration very low. The object of this study was to develop an improved non-crystalline cefuroxime axetil composition having a high physicochemical stability and bioavailability. A non-crystalline cefuroxime axetil solid dispersant showing no peak on a Differential Scanning Calorimetry (DSC) scan is prepared by dissolving cefuroxime axetil and a surfactant in an organic solvent; suspending a water-insoluble inorganic carrier in the resulting solution; and spray drying the resulting suspension to remove the organic solvent, said solid dispersant having an enhanced dissolution and stability of cefuroxime axetil and being useful for the preparation of a pharmaceutical composition for oral administration. Tablet was formulated with this cefuroxime axetil solid dispersant, disintegrants and other ingredients. It disintegrated and dissolved easily and dynamically in dissolution medium, so showed a good dissolution profile.

• Journal of Pharmaceutical Investigation
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• v.20 no.3
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• pp.51-76
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• 1990

It is sometimes said lately that the pH of the human gastric juice is significantly different among individuals. Thus, the dissolution behavior of coated solid dosage forms should preferably be independent of the pH of the test solution. With these points as a background, the effect of pH on the dissolution velocity of coated tablets was studied to compare that of Pharmacoat with other gastric soluble film coating materials. Three viscosity types of Pharmacoat have been available(3, 6 and 15cP) until now. the 6cP type has been considered to be the most suitable for a tablet coating amongst the three types. The 3 cP type with a low degree of polymerization, is capable of providing high concentration, but the film strength is so inferior that sometimes cracking of the film may occur. On the other hand, in the case of the 15cP type, high polymer concentration cannot be achieved because of the high dgree of polymerization, and thus it is uneconomical for coating. Now, there is a strong demand to reduce the coating time even when HPMC is used in the 6cP type in order to reduce the coating cost. In order to improve this problem, we have concentrated our attention on reducing the viscosity value of HPMC to an allowable lower limit from 6cP. As a result of this study, it was found that the reduction of the viscosity value to around 4.5cP enabled the use of a higher solution concentration and an incidental shorter coating time without giving any substantial adverse effects on the properties of coated preparations. These experiment results are presented in the later part of this presentation. Based on this study, we have added the viscosity type of 4.5cP as one of the Pharmacoat products as Pharmacoat-645.

• Journal of Advanced Navigation Technology
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• v.13 no.3
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• pp.426-431
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• 2009

Recently, the application of E-learning is changing the method that is able to process the learning to learner more efficiently and conveniently. For this purpose, the application research of U-learning that is able to support the learning using mobile device such as PDA, NetBook, Tablet PC and so on is actively processing. But lots of U-learning framework is only considering the change to fit the exist learning contents the mobile device without SCORM that is able to support to make and process the learning contents by regular forms. In this paper, we proposed the learning contents interconnection of U-learning framework considering SCORM. For this purpose, we have to construct the learning by learning object and asset within SCORM. And this method can support learning information that was reconstructed it by learning contents to fit the mobile device as used the mobile device meta-data.

• Journal of Korea Multimedia Society
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• v.14 no.10
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• pp.1311-1322
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• 2011

Gesture is applied in many applications such as smart-phone, tablet-PC, and web-browser since it is a fast and simple way to invoke commands. For gesture applications, a gesture designer needs to consider both user and system during designing gestures. In spite of development of gesture design tools, some difficulties for gesture design still remains as followings; first, a designer must design every gesture manually one by one, and, second, a designer must repeatedly train gestures. In this paper, we propose a gesture proposal system that automates gesture training and gesture generation to provide more simple gesture design environment. Using automation of gesture training, a designer does not need to manually train gestures. Proposed gesture proposal system would decrease difficulties of gesture design by suggesting gestures of high recognition possibility that are generated based on mahalanobis distance calculation among generated and pre-existing gestures.

• Journal of Digital Convergence
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• v.11 no.6
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• pp.43-55
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• 2013

This study was to examine the operation strategy of terrestrial broadcasting system on channel image and N-screen service. Nowadays, terrestrial broadcasting system provides video streaming service based on internet. In other words, terrestrial broadcasting system provides N-screen service through TV-PC-Smart phone-Tablet PC. But it is different for terrestrial broadcasting system to analysis the choice criterion of program. Only, channel image of terrestrial broadcasting system expanded into N-screen. Finally, channel image of terrestrial broadcasting system is the competition strategy. It is necessary for terrestrial broadcasting system to prepare the strategy of program choice for users, original contents, new platform and service in connection with N-screen.

• Korean Journal of Agricultural Science
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• v.40 no.4
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• pp.311-316
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• 2013

This study was conducted to evaluate the efficacy of two different formulations and application timings of benzobicyclon+penoxsulam+pyrzaosulfuron-ethyl (BPP) in rice field. BPP granule (GR) and tablet (TB) controlled more than 90% of four weed species 10 and 15 days after sowing in direct seeding when compared with untreated control. BPP TB was highly effective to control herbicide resistant Scirpus juncoides and Monochoria vaginalis both 10 and 15 days after transplanting (DAT). BPP GR controlled 94.0 and 96.5% of S. juncoides and M. vaginalis, respectively 10 DAT, but its efficacy decreased to 88.5 and 49.8% respectively 15 DAT. When compared with untreated control, no visual injuries were detected at 255 and 510 g a.i./ha of BPP. The yield of rice increased in both BPP GR and TB in transplanting and direct seeding rice cultivation when compared with untreated control. Based on these data, early application (10 DAT) of BPP GR and TB can be applied to provide effective weed control, especially in the field infested with herbicide resistant weed species.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.17 no.5
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• pp.111-117
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• 2017

The National Competency Standards (NCS) was designed to implement a competence-based society and solve the problem of inconsistency between the industrial field and education, training, and certification system. This study designed and developed the Korean NCS core vocational competence system, in accordance with the NCS, as an infrastructure to solve fundamental problems such as re-education and the social costs that are incurred in the workplace. Further, this study designed and developed standard indicators to evaluate the technical performance of the system for the global advancement of the Korean NCS core vocational competence system. The NCS core vocational competence system has been developed as an appropriate response type for multiple devices such as computers, tablet PCs, and cellular phones. For the global advancement of the Korean NCS core vocational competence system, this study designed and developed 10 performance evaluation indicators in accordance with 10 global standards, such as linkage-target operating system, interface protocol, packet format, encryption, class component, simultaneous access number, supervisor-to-testtaker response speed, server-to-admin response speed, auto-recovery speed for test answers, and real-time answer transmission speed.

• Composites Research
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• v.30 no.1
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• pp.65-70
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• 2017

Carbon fiber reinforced composites have light weight and high mechanical properties. These materials are only applicable in limited shape structure cause by complex curing process and low drapability. To solve this problem, Long Fiber Prepreg Sheet (LFPS) has been proposed. In this research, electric device cover plate was selected and designed by using LFPS. Before the design process, we analyzed the target structure to which the rib structures were applied. And 8-inch tablet PC product was selected. For FE analysis, simple loading and boundary conditions were applied. Stiffness of rib structure was investigated according to the rib pattern and shape changes. Rib pattern and shape were selected based on fixed volume condition analysis results. And uneven rib width model was selected for the best case whose deflection was reduced 6~10% than uniform rib model.

• Biomolecules & Therapeutics
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• v.15 no.3
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• pp.187-191
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• 2007

This study was conducted to compare the bioavailability of two brands of atenolol (50 mg) tablets, which are a generic product of $Ditent^{\circledR}$ (Daewon Pharmaceutical Co., Ltd., Korea) and an innovator product $Tenormin^{\circledR}$ (Hyundai Pharm. Ind. Co., Ltd., Korea), in 20 healthy Korean male volunteers. The volunteers received a single 50 mg dose of each atenolol formulation according to a randomized, two-way cross-over design. The washout period between treatments was 1 week. Plasma samples were obtained over a 24-hour interval, and atenolol concentrations were determined by HPLC with a fluorescence detector. From the plasma atenolol concentration vs. time curves, the following parameters were compared: area under the plasma concentration-time curve ($AUC_{0-24}$), peak plasma concentration ($C_{max}$), time to reach peak plasma concentration ($T_{max}$), and terminal first order elimination half-life ($t_{1/2}$). No statistically significant difference was obtained between the $T_{max}$ values, and the logarithmic transformed $AUC_{0-24}$ and $C_{max}$ values of the two products. The 90% confidence interval for the ratio of the logarithmically transformed AUC and $C_{max}$ values of $Ditent^{\circledR}$ over those of $Tenormin^{\circledR}$ were calculated to be between 0.85 and 1.04, and 0.89 and 1.07, respectively; both were within the bioequivalence limit of 0.80-1.25. The mean of $T_{max}$ in $Tenormin^{\circledR}$ group was 3.1 hour, and that in Ditent$^{\circledR}$ group was 3.2 hour. The values of $t_{1/2}$ between the two products were found comparable, and the mean values were 5.2 hour in the both products. Based on these results, it was concluded that $Ditent^{\circledR}$ was comparable to $Tenormin^{\circledR}$ in both the rate and extent of absorption, indicating that $Ditent^{\circledR}$ was bioequivalent to the reference product, $Tenormin^{\circledR}$.

• Journal of Biosystems Engineering
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• v.39 no.1
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• pp.57-67
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• 2014

Purpose: The modern IT can give enormous impacts on the agricultural production and consumption. However, farmer's ability to use IT devices has been known as one of the critical factors on success of IT in agriculture. This survey study was performed to evaluate the informatization status of farmers and to draw a strategy to develop and distribute a ubiquitous agricultural information system. Methods: A survey questionnaire with 19 questions on the degree of IT devices such as computers and smartphones and their utilization were developed. The survey was questioned 3 groups of farmers in Gyounggi Province and analyzed statistically by the ${\chi}^2$ test. Results: The order of IT devices distribution were computers, smartphones, smart TVs and tablet PCs in all groups. The ratios of ownerships of the devices are 97.7, 78.6%, 31.4%, 17.8% respectively. The active farmers in this survey showed higher informatization level than that of native and the general farmers. Conclusions: The ubiquitous agricultural information system was judged to be developed for the computer because spread and use of it exceeds the other devices. Also, the information system based on the smartphone could be a complementary way if the rapid of the smartphones continues and proper education on use of the phone is provided.