• Journal of Pharmaceutical Investigation
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• 제32권2호
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• pp.127-133
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• 2002

Levosulpiride is the 1evo-enantiomer form of racemic sulpiride, a benzamide derivative selectively inhibiting dopaminergic $D_2$ receptors at the trigger zone both in the central nervous system and in the gastrointestinal tract. The purpose of the present study was to evaluate the bioequiva1ence of two levosulpiride tablets, Levopride (SK Pharmaceutical Co., Ltd.) and Levopid (Dae Won Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). The levosulpiride release from the two levosulpiride tablets in vitro was tested using KP VII Apparatus II method with various different kinds of dissolution media (pH 1.2, 4.0, 6.8 buffer solution and water). Twenty eight normal male volunteers, $23.82{\pm}3.26$ years in age and $69.13{\pm}8.58$ kg in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After one tablet containing 25 mg of levosulpiride was orally administered, blood was taken at predetermined time intervals and the concentrations of levosulpiride in serum were determined using HPLC method with fluorescence detector. The dissolution profiles of two levosulpiride tablets were very similar at all dissolution media. Besides, the pharmacokinetic parameters such as $AUC_t,\;C_{max}\;and\;T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_t\;and\;C_{max}$ and untransformed $T_{max}$. The results showed that the differences in $AUC_t,\;C_{max}\;and\;T_{max}$ between two tablets based on the Levopride were -1.17%, 1.20% and -1.09%, respectively. There were no sequence effects between two tablets in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.25) $(e.g.,\;log(0.93){\sim}log(1.07)\;and\;log(0.90){\sim}log(1.14)\;for\;AUC_t\;and\;C_{max}$, respectively). The 90% confidence interval using untransformed data was within ${\pm}20%$ $(e.g.,\;-19.47{\sim}16.20\;for\;T_{max})$. All parameters met the criteria of KFDA guideline for bioequivalence, indicating that Levopid tablet is bioequivalent to Levopride tablet.

• International Journal of Industrial Entomology and Biomaterials
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• 제12권2호
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• pp.81-86
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• 2006

Of all factors that govern productivity in sericulture, the role of silkworm egg is of prime importance. The production of silkworm seed involves a long chain of interdependent and highly specialized conditions. Female moths of Bombyx mori L. commence egg deposition immediately when the moths were decoupled. More than 60% of eggs are deposited within 4 hrs after decoupling i.e. 62.33% in CSR-3, 61.67% in CSR-6, 62.50% in CSR-16 and 63.28% in CSR-17. Almost 90% of eggs were laid in the first 12 hrs (93.13% in CSR-3, 90.81% in CSR-6, 89.71% in CSR-16 and 93.17% eggs in CSR-17) after decoupling. Almost 8 to 10% of more eggs were laid when oviposition period was prolonged upto 48 hrs instead of 24 hrs. The present investigation showed that a significant increase of 45 (8.34%), 50 (9.98%), 41 (8.26%) and 45 (8.30%) (P < 0.01) numbers of more eggs were found between 24 to 48 hrs (T6 to T9) in CSR-3, CSR-6, CSR-16 and CSR-17 races respectively. The findings of present investigation is very important for sericulture industry while producing layings to keep for different hibernation schedule especially for autumn/late autumn crop, female may be allowed for prolonged oviposition to get 8 -10% more eggs and farmer may fetch 8 -10 kg. more cocoon yield/l00 dfls with more income.

• 약학회지
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• 제49권5호
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• pp.392-398
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• 2005

In this study, we evaluated the stability of amoxicillin (AMX) and clavulanic acid (CLA) in aqueous solution, and compared the stability of AMX and CLA in commercial combination products. In aqueous solutions, the degradation of AMX ($t_{90}=8.88\;day\;at\;10^{circ}C$) and CLA ($t_{90}=3.53\;day\;at\;10^{circ}C$) occurred rapidly. From the pH-rate profile, AMX and CLA were the most stable at the range of pH 5.5 and 6.0. After reconstitution of commercial dry syrups, the contents of AMX and CLA in suspensions were gradually decreased for 7 days. However, AMX and CLA in dispersible tablet were not changed at all. The contents of CLA in the dispersible tablet ($87.92\%$) and dry syrups (2.16 and $3.91\%$) were remained in the accel­erated stability test ($75\%\;RH,\;at\;40^{circ}C$) after 10 hours. And the colors of the dry syrups were rapidly changed from white to yellow. From these results, we concluded that the dispersible tablet could overcome the stability problems of dry syrups.

• 천문학회보
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• 제35권2호
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• pp.76.2-76.2
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• 2010

We present the final results of our study on the mass-loss rate of donor stars in cataclysmic variables (CVs). Observed donors are oversized in comparison with those of isolated single stars of the same mass, which is thought to be a consequence of the mass loss. Using the empirical mass-radius relation of CVs and the homologous approximation for changes in effective temperature T2, orbital period P, and luminosity of the donor with the stellar radius, we find the semi-empirical mass-loss rate M2dot of CVs as a function of P. The derived M2dot is at ~10-9.5-10-10 $M\odot$/yr and depends weakly on P when P > 90 min, while it declines very rapidly towards the minimum period when P < 90 min. The semi-empirical M2dot is significantly different from, and has a less-pronounced turnaround behavior with P than suggested by previous numerical models. The semi-empirical P-M2dot relation is consistent with the angular momentum loss due to gravitational wave emission, and strongly suggests that CV secondaries with 0.075 $M\odot$ < M2 < 0.2 $M\odot$ are less than 2 Gyrs old. When applied to selected eclipsing CVs, our semi-empirical mass-loss rates are in good agreement with the accretion rates derived from the effective temperatures T1 of white dwarfs. Based on the semi-empirical M2dot, SDSS 1501 and 1433 systems that were previously identified as post-bounce CVs have yet to reach the minimal period.

• 한국환경과학회지
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• 제21권10호
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• pp.1203-1212
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• 2012

Yongsan ward is located at central place connecting south and north ecology axis of seoul. Various environment-friendly Yongsan development could pose positive effects on NPS(non pollutant source) pollutant reductions and water quality improvement at Han-rive because BOD, T-N, and T-P NPS discharges took 90% of total pollutant from this area. In this study, direct runoff and NPS pollutant loads were evaluated before and after development using spatio-tamporal change in CN(curve number) and EMC(event mean concentration) data. It was found that direct runoff value is $23,584,724m^3$, and BOD, T-N and T-P loads are 104,456 kg/year, 111,483 kg/year and 7,500 kg/year under pre-development condition, respectively. Annual runoff, BOD, T-N and T-P reducing rate were 12.9%, 33.3%, 35.6% and 40.7% under integrated post-development condition, respectively. Based on the results obtained in this study, environment-friendly urban development could be achieved at Yongsan area.

• 대한간호
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• 제33권3호
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• pp.79-91
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• 1994

The purpose of this study was to identify the meaningful nursing diagnosis in maternity unit and to suggest formally the basal data to the nursing service with scientific approach. The subject for this paper were 64 patients who admitted to Chung Ang University Hospital, Located in Seoul, from Mar. 10, to July 21, 1993. The results were as follows: 1. The number of nursing diagnosis from 64 patients were 892 and average number of nursing diagnosis per patient was 13.9. 2. Applying the division of nursing diagnosis to Roy's Adaptation Model, determined nursing diagnosis from the 64 patients were 621 (69.6%) in physiological adaptation mode and (Comfort, altered r/t), (Injury, potential for r/t), (Infection, potential for r/t), (Bowel elimination, altered patterns r/t), (Breathing pattern, ineffective r/t), (Nutrition, altered r/t less than body requirement) in order, and 139 (15.6%) in role function mode, (Self care deficit r/t), (Knowledge deficit r/t), (Mobility, impaired physical r/t) in order, 122 (13.7%) in interdependence adaptation mode, (Anxiety r/t), (Family Process, altered r/t) in order, 10(1.1%) in self concept adaptation mode, (Powerlessness r/t), (Grieving, dysfunctional r/t) in order. 3. Nursing diagnosis in maternity unit by the medical diagnosis, the average hospital dates were 3.8 days in normal delivery and majority of used nursing diagnosis, (Comfort, altered r/t) 64.6%, (Self care deficit r/t) 13.6% in order, and the average hospital dates were 9.6 days in cesarean section delivery and majority of used nursing diagnosis, (Comfort, altered r/t) 51.6%, (Self care deficit r/t) 15.2%, (Infection, potential for r/t) 9.9%, (Injury, potential "for r/t) 8.1%, (Anxiety r/t) 5.0%, (Mobility, impaired physical r/t) 3.3% in order, and the average hospital dates were 15.8days in preterm labor and majority of used nursing diagnosis, (Comfort, altered r/ t), (Anxiety r/t), (Injury, potential for r/t) in order, and the average short-term hospital dates were 2.5days, long-term hospital dates were 11.5days in gynecologic diseases and majority of used nursing diagnosis, (Comfort, altered r/t). (Self care deficit r/t), (Injury, potential for r/t), (Infection, potential for r/t) in order.

• Journal of Oral Medicine and Pain
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• 제37권1호
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• pp.19-25
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• 2012

2010년부터 2011년까지 양산부산대학교 치과병원 구강내과에 초진 내원한 외래환자 중 재발성 아프타성 구내궤양(RAU)으로 임상 진단된 환자 20명과 구강편평태선으로 임상진단 된 환자 33명, 부산대학교 치의학전문대학원생 59명을 대조군으로 정하고 간이정신진단검사를 시행하여 다음과 같은 결론을 얻었다. 1. RAU 환자군과 편평태선 환자군, 대조군은 9개 증상차원 기본척도의 T 점수 평균값은 모두 65 이하로 정상범위 내에 있었다. 2. RAU 환자군은 정상 대조군에 비하여 SOM 지수가 유의하게 높았으며 (P<0.05), DEP 지수에서 높은 경향을 보였다. 3. RAU의 여성 환자군은 여성 대조군에 비하여 SOM, DEP, HOS 지수가 유의하게 높았고 (P<0.05), ANX 지수에서 높은 경향을 보였다. 4. RAU 환자군은 편평태선 환자군에 비하여 HOS 지수가 유의하게 높았으며 (P<0.05), O-C, I-S, DEP 지수에서 높은 경향을 보였다.

• Journal of Radiation Protection and Research
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• 제22권1호
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• pp.15-21
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• 1997

인체 T-림프구에서 감마선과 대표적 화학 독성물질인 pentachlorophenol(PCP)의 돌연변이 효과를 hypoxanthine phosphoribosyl transferase(hprt) 유전자의 돌연변이 빈도로써 측정하였다. 감마선은 $^{137}$Cs원을 사용하여 세포의 초기배양 시기에 0-3.0 Gy를 조사하였고, PCP는 세포의 초기배양시 최종농도 0-100 ppm으로 24시간 투여하였다. 돌연변이세포는 6-thioguanine을 처리 하에 세포가 성장하는 능력으로 분류하였다. 방사선에 의한 돌연변이빈도는 1.0 Gy, 2.0 Gy와 3.0 Gy 선량에서 대조군보다 약40%, 400%와 750% 증가하였고 0.2 Gy와 0.5 Gy의 선량에서는 유의성 있는 변화가 없었다. PCP를 15 ppm, 25 ppm 그리고 50 ppm을 처리하였을 때 대조군보다 각각 30%, 90% 및 520%정도 증가하였다.

• Journal of Pharmaceutical Investigation
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• 제35권1호
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• pp.45-50
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• 2005

The purpose of the present study was designed to evaluate the bioequivalence of two ofloxacin tablets, Tarivid (Jeil Pharm. Co., Ltd.) and Favid (ILHWA Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). Twenty-four normal male volunteers, $23.67{\pm}3.12$ year in age and $68.50{\pm}7.23$ kg in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After four tablets containing 100 mg of ofloxacin were orally administered, blood was taken at predetermined time intervals and concentrations of ofloxacin in plasma were determined using HPLC. Pharmacokinetic parameters such as $AUC_t$, $C_{max}$ and $T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_t$ and $C_{max}$ and untransformed $T_{max}$. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals for the log transformed data were acceptance range of log 0.8 to log 1.25 (e.g., $log0.94{\sim}log1.04\;and\;log0.90{\sim}log1.07\;for\;AUC_t\;and\;C_{max}$, respectively). The major parameters, $AUC_t$, and $C_{max}$, met the criteria of KDFA for bioequivalence indicating that Favid tablet is bioequivalent to Tarivid tablet.

• 지역사회간호학회지
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• 제1권1호
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• pp.503-517
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• 1989

This study is to analyze factors affecting the school nurse's activities. The survey was undertaken during Sept. 1-Nov. 30, 1986. The subjects were 137 school nurses from elementary, junior-high, and senior-high schools in Daegu City and Kyungppk Province. The results are as follows: 1. Correlational findings between school nurse's self-confidence and their general characteristics 1) Program Planning & Evaluation: Health Experinece(r=-0.1803, p<0.05) Salary Step(r=-0.1741, p<0.05) 2) Clinic Management: Salary STep(r=-0.2580, p<0.01) 3) Health Education: Salary Step(r=-0.1929, p<0.05) 4) Management of School Environment: Salary Step(r=-0.2501, p<.05) 5) Health Care Services: Health Experience(r=0.1901, p<0.05) Salary Step(r=-0.2424, p<0.05) 2. The degrees of school nurse's self-confidence(high: 4 point, low: 1 point) 1) Clinic Management: 2.92 2) Health Education: 2.86. 3) Program Planning & Evaluation: 2.74 4) Health Care Services: 2.73 5) Management of School Environment: 2.67 6) Operating of School Health Organization: 2.42 3. Significances to self-confidence on school nurse's activities 1) Program Planning as Evaluation: Expending Times for Health Care Services (r=-0.2262, p<0.05) Expending Times for Health Education (r=0.2943, p<0.05) Size of Clinic(r=0.2163, p<0.05) Location of Clinic(t=2.43, gH0.047) Use of Clinic(t=2.06, p<0.007) 2) Clinic Management: Location of Clinic (t=3.36, p<0.010) 3) Health Education: Purchase of Medicine(r=-0.1736, p<0.05) No, of Classes (r=-0.1794, p<0.05) (4) Management of School Environment: School Health Budget(r=0.1731, p<0.05) Home Message(r=0.1805, p<0.05) Location of Clinic(t=4.46, p<0.0001) 5) Operating of School Health Organization: School Health Budget(r=0.1878, p<0.05) Use of Clinic(t:1.90, p<0.018) 6) Health Care Services: School Health Budget(r=1.90, p<0.018) Expending Times for Health Education(r=0.2577, p<0.05) Size of Clinic(r=0.4336, p<0.001) Location of Clinic(t:5.10, p<0.001)