• Journal of Preventive Medicine and Public Health
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• v.45 no.4
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• pp.251-258
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• 2012

Objectives: The purpose of this paper was to elucidate the potential methylation levels of adjacent normal and cancer tissues by comparing them with normal colorectal tissues, and to describe the correlations between the methylation and clinical parameters in Korean colorectal cancer (CRC) patients. Methods: Hypermethylation profiles of nine genes (RASSF1, APC, $p16^{INK4a}$, Twist1, E-cadherin, TIMP3, Smad4, COX2, and ABCB1) were examined with 100 sets of cancer tissues and 14 normal colorectal tissues. We determined the hypermethylation at a given level by a percent of methylation ratio value of 10 using quantitative methylation real-time polymerase chain reaction. Results: Nine genes' hypermethylation levels in Korean CRC patient tissues were increased more higher than normal colorectal tissues. However, the amounts of $p16^{INK4a}$ and E-cadherin gene hypermethylation in normal and CRC tissues were not significantly different nor did TIMP3 gene hypermethylation in adjacent normal and cancer tissues differ significantly. The hypermethylation of TIMP3, Ecadherin, ABCB1, and COX2 genes among other genes were abundantly found in normal colorectal tissues. The hypermethylation of nine genes' methylation in cancer tissues was not significantly associated with any clinical parameters. In Cohen's kappa test, it was moderately observed that RASSF1 was related with E-cadherin, and Smad4 with ABCB1 and COX2. Conclusions: This study provides evidence for different hypermethylation patterns of cancer-associated genes in normal and CRC tissues, which may serve as useful information on CRC cancer progression.

• Wind and Structures
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• v.22 no.4
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• pp.455-476
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• 2016

In both structural and environmental wind engineering, the vertical variation of wind direction is important as it impacts both the torsional response of the high-rise building and the pedestrian level wind environment. In order to systematically investigate the vertical variation of wind directions (i.e., the so-called 'twist effect') induced by hills with idealized geometries, a series of wind-tunnel tests was conducted. The length-to-width aspect ratios of the hill models were 1/3, 1/2, 1, 2 and 3, and the measurements of both wind speeds and directions were taken on a three-dimensional grid system. From the wind-tunnel tests, it has been found that the direction changes and most prominent at the half height of the hill. On the other hand, the characteristic length of the direction change, has been found to increase when moving from the windward zone into the wake. Based on the wind-tunnel measurements, a descriptive model is proposed to calculate both the horizontal and vertical variations of wind directions. Preliminarily validated against the wind-tunnel measurements, the proposed model has been found to be acceptable to describe the direction changes induced by an idealized hill with an aspect ratio close to 1. For the hills with aspect ratios less than 1, while the description of the vertical variation is still valid, the horizontal description proposed by the model has been found unfit.

• Journal of the Korean Society of Costume
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• v.22
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• pp.313-332
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• 1994

The purpose of this study were as follows : 1) Investigate how to intluence Clothes with time background and trends of art-thought in the twenty century. 2) To understand chronologically how to change hair style Make-up and hair decor-ation. I. 1st and 2nd World War time(1920-1945) The women's social status and their sexual equality was promoted during in this time. 1) African Art Surrealism and Expression art were doninated. 2) The popalar trends were tutular silhoutte (Slim and long) boyish Style and military lookwere popular. 3) The popalar trends of were Eton Crop. short bob gaconne hair style cloche hat. page boy hair style were popular. 4) The trend of make-up which specially. emphasized eye make-up and imitated movie star make-up and make shining redish of lip and nails were popular. II. The stage of modernism(1945-1969) cold war time between communism and capi-talism and promotin of women's human rights were established in this time. 1) Pop art avantgrade art were catched up 2) The popular trends of were new look Kior's line silhoutte mini skirt and young fashion. 3) The popular trend of hair style was french twist. Pill Boxs hat curly bob style were prevalenced and they some what dwarfed hair style. 4) make-up natural make-up was popular. III. The stage of high economic development (1969-1990) Increased population economic development were tend to specialize with anti-social action such as Hippie and Punk groups. 1) Op art Androgynous post-modernism Punk and neo-modernism were catched up. 2) Clothes : classic style of reactionism layered look Punk-fashion avantgrade fashion and pantalon suits were prevalence. 3) Hair Style : Twiggy's short hair style the geometric hair cut natural long hair Spike hair unsex-hair style. 4) Make-up : diversified individuality were prevalence The result of this study indicated that the value's of recognize the importance of total fashion that is the harmonization of clothes hair style and make-up.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.11
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• pp.6305-6309
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• 2013

Background: TIAM2, a Rac guanine nucleotide exchange factor, is closely associated with cell adherence and migration. Here, we aimed to investigate the role of TIAM2 in non-small cell lung cancer (NSCLC) cells. Materials and Methods: A small interference RNA (siRNA) was introduced to silence the expression of TIAM2. Invasion and motility assays were then performed to assess the invasion and motility potential of NSCLC cells. GST-pull down assays were used to detect activation of Rac1. Results: TIAM2 was highly expressed in NSCLC cells. Knockdown of TIAM2 inhibited the invasion and motility, and suppressed activation of Rac1. Further experiments demonstrated that knockdown of TIAM2 could up-regulate the expression of E-cadherin, and down-regulate the expression of MMP-3, Twist and Snail. Conclusions: Our data suggest that TIAM2 can promote invasion and motility of NSCLC cells. Activation of Rac1 and regulation of some EMT/invasion-related genes may be involved in the underlying processes.

• Bulletin of the Korean Chemical Society
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• v.35 no.8
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• pp.2299-2303
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• 2014

Two diastereoisomers of cyclo(Pro-Tyr) have been synthesized simultaneously. The crystal structures and conformations of both cyclo($\small{L}$-Pro-$\small{L}$-Tyr) and a racemic mixture of cyclo($\small{D}$-Pro-$\small{L}$-Tyr) and cyclo($\small{L}$-Pro-$\small{D}$-Tyr), abbreviated as rac-cyclo($\small{D}$-Pro-$\small{L}$-Tyr/$\small{L}$-Pro-$\small{D}$-Tyr), have been determined by a single-crystal X-ray diffraction study at low temperature. The crystals of rac-cyclo($\small{D}$-Pro-$\small{L}$-Tyr/$\small{L}$-Pro-$\small{D}$-Tyr) belong to orthorhombic space group $Pna2_1$ with a = 10.755 (1), b = 12.699 (1), c = 9.600 (1) ${\AA}$ and Z = 4. The tyrosine side chain is folded towards the diketopiperazine (DKP) ring. The DKP ring adopts a twist boat conformation with pseudo symmetry $C_{2v}$. The pyrrolidine ring has an envelope conformation with the N5, C4, C7 and C8 atoms in a plane. The crystal of rac-cyclo($\small{D}$-Pro-$\small{L}$-Tyr/$\small{L}$-Pro-$\small{D}$-Tyr) is stabilized by hydrogen bonds between amide N2-H2 and carbonyl oxygen O2 in the neighbor. The hydroxyl group of tyrosine residue is also hydrogen bonded to the oxygen of the carbonyl group of the DKP ring in the next molecule. The spectroscopic properties of both isomers are also described.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.29 no.5
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• pp.405-411
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• 2016

This paper presented the theory related to a two dimensional linear cross-sectional analysis, recovery relationship and a one-dimensional nonlinear beam analysis for composite beam with initial twist and high aspect ratio. Using VABS including related theory, preceding research data of the composite wing structure has been modeled and compared. Cross-sectional analysis was performed and 1-D beam was modeled at cutting point including all the details of real geometry and material. The 3-D strain distribution and margin of safety at recovery point was calculated based on the global behavior of the 1-D beam analysis and visualize numerical results.

• The Journal of Advanced Prosthodontics
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• v.8 no.6
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• pp.417-422
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• 2016

PURPOSE. The purposes of this study were to evaluate the staining resistance of CAD/CAM resin-ceramics polished with different techniques and to determine the effectiveness of the polishing techniques on resin-ceramics, comparing it with that of a glazed glass-ceramic. MATERIALS AND METHODS. Four different CAD/CAM ceramics (feldspathic ceramic: C-CEREC Blocs, (SIRONA) and three resin-ceramics: L-Lava Ultimate, (3M ESPE), E-Enamic, (VITA) and CS-CeraSmart, (GC)) and one light cure composite resin: ME-Clearfil Majesty Esthetic (Kuraray) were used. Only C samples were glazed (gl). Other restorations were divided into four groups according to the polishing technique: nonpolished control group (c), a group polished with light cure liquid polish (Biscover LV BISCO) (bb), a group polished with ceramic polishing kit (Diapol, EVE) (cd), and a group polished with composite polishing kit (Clearfil Twist Dia, Kuraray) (kc). Glazed C samples and the polished samples were further divided into four subgroups and immersed into different solutions: distilled water, tea, coffee, and fermented black carrot juice. Eight samples ($8{\times}8{\times}1mm$) were prepared for each subgroup. According to CIELab system, four color measurements were made: before immersion, immersion after 1 day, after 1 week, and after 1 month. Data were analyzed with repeated measures of ANOVA (${\alpha}=.05$). RESULTS. The highest staining resistance was found in gl samples. There was no difference among gl, kc and cd (P>.05). Staining resistance of gl was significantly higher than that of bb (P<.05). Staining resistances of E and CS were significantly higher than those of L and ME (P<.05). CONCLUSION. Ceramic and composite polishing kits can be used for resin ceramics as a counterpart of glazing procedure used for full ceramic materials. Liquid polish has limited indications for resin ceramics.

• Korean Journal of Applied Biomechanics
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• v.16 no.1
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• pp.109-117
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• 2006

The purpose of this study was done in order to investigate the Kinematical variables of the Rybalko motion on the Horizontal bar using the 3-dimensional cinematographic method. For this study, three excellent athletes take part in a 2003 Daegue universid game were chosen. The subject,s Rybalko motion was filmed with S-VHS camera at the speed of 60 fields per second and digitized the each fields. And the Kwon3D 3.1 version program was employed to obtain 3-dimensional data. As a result of this study. 1. A total time spent for performing Rybalko skill was Mean $2.52{\pm}0.13sec$. From starting down swing to releasing right hand the Mean $0.84{\pm}0.24sec$ was taken. 2. In the event 3 of Rybalko motion, that is, the moment which the right-hand is released on the bar, the center of mass must is employed at the position above the horizontal line of bar. In this research, the average vertical displacement(z axe) of center of mass shows $47.87{\pm}3.14cm$. 3. In the event 5, that is, the moment which the right-hand is catched again on the bar, the center of mass is employed at the position before the vertical line of bar. In this research, the average horizontal displacement(z axe) of center of mass shows $47.87{\pm}3.14cm$. 4. It has been seen that, at the moment of release of right-hand, lateral variation of center of mass is 13.395cm, vertical variation of center of mass is 7.41cm Thus, it is concluded that lateral variation of center of mass should be reduced for high grade to be acquired. 5. It has been founded that high speed of down swing influences speed of up swing, and that, in the motion of twist, the horizontal speed is little changed.

• Korean Journal of Applied Biomechanics
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• v.31 no.4
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• pp.283-289
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• 2021

Objective: The aim of this study was to analyze the pattern of Kolman technique by five Korean top gymnasts including the three national athletes on horizontal bar. Method: Two digital high-speed camcorders were used with 90 frames/sec and their Kolman motions were filmed in sports science secondary school gymnasium at U city. After the kinematic and kinetic variables were carried out by Kwon3D 3.1 motion package during the whole phase, the optimized release motion was investigated by simulating the body COG path during the aerial phase. Results: Firstly, it was revealed that the average changes of hip, shoulder joint angle were 84 deg, 53 deg respectively during the functional sub-phase and the average swing phaseal time was 1.21 s. Secondly, it was revealed that the average body COG positions and velocities (Y, Z) at release were -0.65 m, 0.48 m, 1.65 m/s, 3.97 m/s respectively and the average release angle, peak height and flight time were 67 deg, 1.29 m, 0.79 s respectively. Thirdly, it was revealed that the directions of somersault of whole and lower body, tilt of lower body were counterclockwise, whereas the directions of tilt of whole body, twist of whole and lower body were clockwise at the ready for re-grasp. Lastly, it was revealed that the body COG paths were different from each other during the aerial phase followed by the different body COG velocities. Conclusion: Korean gymnasts of this study controlled their motions well in terms of the timing of hip·shoulder joint, body position, body angular momentum especially during the functional sub-phase, but their motions were different during the aerial phase. Nonetheless most of them made the adequate body position at the instant of re-grasp. It would be suggested that Korean gymnasts except S3 should increase the vertical velocity.

• Journal of Periodontal and Implant Science
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• v.51 no.3
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• pp.163-178
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• 2021

Purpose: The aim of this study was to evaluate clinical factors affecting the longevity of fixed retainers and the influence of fixed retainers on periodontal health in periodontitis patients. Methods: In total, 52 patients with at least 2 years of follow-up after periodontal and orthodontic treatment were included in this study. After scaling and root planing, orthodontic treatment with fixed appliances or clear aligners was performed. Fixed retainers with twist-flex stainless steel wires were bonded to the palatal or lingual sides of anterior teeth. Changes in clinical parameters, including the plaque index, gingival index, calculus index (CI), probing pocket depth, and radiographic bone levels, were evaluated before bonding of fixed retainers and at a 12-month follow-up. Cumulative survival rates (CSRs) for retainer failure were evaluated according to sex, site, CI, stage of periodontitis, and the severity of the irregularity with the log-rank test and hazard ratios (HRs). Results: Twelve months after bonding of fixed retainers, improvements were observed in all clinical parameters except CI and radiographic bone gain. The overall CSR of the retainers with a CI <1 at the 12-month follow-up after bonding of fixed retainers was significantly higher than that of the retainers with a CI ≥1 at the 12-month follow-up (log-rank test; P<0.001). Patients with stage III (grade B or C) periodontitis had a higher multivariate HR for retainer failure (5.4; 95% confidence interval, 1.22-23.91; P=0.026) than patients with stage I (grade A or B) periodontitis. Conclusions: Although fixed retainers were bonded in periodontitis patients, periodontal health was well maintained if supportive periodontal treatment with repeated oral hygiene education was provided. Nonetheless, fixed retainer failure occurred more frequently in patients who had stage III (grade B or C) periodontitis or a CI ≥1 at 12-month follow-up after bonding of fixed retainers.