• Title/Summary/Keyword: TEP

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Expressional Profiling of Telomerase and Telomere-Associated Molecules in the Rat Testis and Seminal Vesicle during Postnatal Developmental Period

  • Seo, Hee-Jung;Lee, Seong-Kyu;Baik, Haing-Woon;Cheon, Yong-Pil;Chun, Tae-Hoon;Choi, In-Ho;Lee, Ki-Ho
    • Journal of Animal Science and Technology
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    • v.53 no.3
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    • pp.195-202
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    • 2011
  • Maintenance of adequate telomere length in developing cells is the most important concern to preserve the integrity of the genome. The length of telomere is strictly regulated by numerous telomere-binding proteins and/or interacting factors. Even though the expression of telomerase in the male reproductive tract has been characterized, developmental expressional profiling of telomerase and other telomere-associated proteins has not been determined in detail. The present study was attempted to examine expression patterns of catalytic subunit (Tert) and RNA component (Terc) of telomerase and two telomerase associated factors, telomerase associated protein 1 (Tep1) and TERF1 (TRF1) interacting nuclear factor 2 (Tinf2) in the testis and seminal vesicle of male rat during postnatal development. The real-time PCR analysis was utilized to quantify mRNA expression of molecules. The abundance of Tep1 mRNA in the testis and seminal vesicle was the highest at 5 months of age. Expressional fluctuation of Tinf2 during postnatal development was found in the testis, while expression of Tinf2 in the seminal vesicle was gradually increased until 5 months of age and then significantly decreased later. mRNA level of Tert gene in the testis was significantly increased at the adult and the elder, while the highest expression of Tert gene in the seminal vesicle was found at 5 months of age. Expression of Terc transcript in the testis and seminal vesicle was the highest at 5 months of age, followed by significant reduction at 1 and 2 years of ages. Such differential gene expression of telomere-associated factors and telomerase components in different male reproductive tissues during postnatal development indicates that maintenance of telomere length would be regulated in tissue- and/or age-specific manners.

Antimicrobial and Antitumoral Activities of Candida kefyr TEP 7 Isolated from Tibetan Fermented Milk (티벳산 발효유로부터 분리한 Candida kefyr TFP 7의 항균활성 및 항암활성)

  • 윤원호;나영미;김창한
    • Food Science of Animal Resources
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    • v.23 no.1
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    • pp.80-85
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    • 2003
  • This study was carried out to investigate antimicrobial and antitumoral activities of Candida kefyr TFP7 isolated from Tibetan fermented milk Strains of TFP1∼10 were isolated from Tibetan fermented milk by agar diffusion method using potato dextrose agar(PDA). Antimicrobial activities were examined against 18 microorganisms of food-related bacteria, yeast, algae, fungi and actinomycetes isolated from soil. Antitumor activities were examined against 9 human tumor cell lines. Strains of TFP2∼10 showed strong antimicrobial activities against Micrococcus luteus ATCC l1880, and strains of TFP6∼10 to actinomycetes, Streptomyces murinus JCM 4333. In antitumor test, all isolated strains(TEP1∼10) showed the growth inhibition of SNU-5 and SW-534 by 60% and 70%, respectively. Among those, the strain TFP7 showed the most antitumor activity, which was 77.5% for SNU-5 and 76.5% for SW-534. The strain was identified as Candida kefyr by use of API 20C AUX kit and scanning electron micrograph.

Modeling and Simulation of Target Existence Probability in Tactical Guidance Missile Seeker Image (영상탐색기 적용 전술유도무기 영상 내 표적존재확률 분석을 위한 M&S 설계 및 분석)

  • Seol, SangHwan
    • Journal of the Korea Society for Simulation
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    • v.24 no.4
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    • pp.43-49
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    • 2015
  • Maximum lock-on distance in tactical guidance missile using seeker image is estimated by seeker's FOV, resolution and performance of tracking algorithm. In case, a missile is launched beyond the maximum lock-on distance, the missile is guided by INS pure navigation until it enters the lock-on possible zone. However, the probability of a target's existence within seekers images decreases as flight time goes by. Therefore, it is crucial to determine the distance that satisfies a certain target existence probability (TEP) and the maximum lock-on distance in order for an operator to take over the navigation role between two distances. In this paper, simulation which can analyse TEP in tactical guided missile seeker image is designed.

Design and Characterization of Low Viscosity Epoxy Based on Flame Retardant Phosphorus Epoxy (난연성 인계 에폭시를 기반으로 한 저점도 에폭시 설계 및 특성 분석)

  • Park, Jun-Seong;Woo, Je-Wan
    • Applied Chemistry for Engineering
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    • v.32 no.4
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    • pp.449-455
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    • 2021
  • Composite materials are substances that are configured to have excellent physical properties by combining the properties of a single substance, and are in the limelight as materials that exceed the performance of metals and polymers. However, it has the disadvantages of long cycle time and high unit price, and much research is being performed to overcome these disadvantages. In this study, we developed an epoxy resin curing agent that can shorten the time required for mass production of composite materials, and tried to expand the applicability of objections by imparting flame retardancy. The epoxy resin used as a basic substance utilized two types of bisphenol F and resorcinol structure, which was further modified using 9,10-dihydro-9-oxa-10-phosphaphenantrene-10-oxide (DOPO) to impart flame retardancy. Triethylphosphate (TEP) and bis [(5-ethyl-2-methyl-1,3,2-dioxaphosphorinan-5-yl)methyl] methyl phosphonate P,P'-dioxide (FR-001) were used as additives, seven kinds of compositions were blended, thermal characteristics (gelation time, glass transition temperature) and flame retardant performance were evaluated. We successfully developed an epoxy matrix that can be applied to high pressure resin transfer molding (HP-RTM) process.

Transmission System Expansion Planning Considering Outage Cost (공급지장비를 포함한 송전계통계획)

  • Choi, Jae-Seok;Oh, Tae-Gon;Lim, Jin-Taek;Cho, Kyeong-Hee;Jeon, Don-Hoon;Hong, Sung-Eun
    • Proceedings of the KIEE Conference
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    • 2011.07a
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    • pp.361-363
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    • 2011
  • This paper proposes a method for choosing the best transmission system expansion(TEP) plan considering an annual outage cost and a probabilistic transmission system reliability criterion ($_RLOLE_{TS}$). The objective method minimizes a total cost which are an investment budget for constructing new transmission lines and an annual outage cost, subject to the probabilistic transmission system reliability criterion, which consider the uncertainties of power system facilities. Test results on an existing 21-bus system are included in the paper. It demonstrated the suitability of the proposed method for solving the transmission system expansion planning problem subject to practical future uncertainties.

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Estimation of the Visual Neuro-Pathway by the Source Tracing Method (신경전류추적법을 이용한 뇌의 시각신경로 추정)

  • Bae, B.H.;Kim, D.W.;Choi, J.M.;Kim, S.Y.
    • Proceedings of the KOSOMBE Conference
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    • v.1994 no.05
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    • pp.65-68
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    • 1994
  • 시각자극에 의해 머리표면에서 발생하는 Transient Evoked Potential을 검출하여 Source Tracing Method를 이용하여 뇌의 시각인지영역을 추정하였다. 본 과정에서 TEP검출방식은 average method를 이용하였고, 신경흥분에 대한 물리적 모델로 Single Current Dipole Model을 이용하고, 머리기하에 대한 3중구각모델을 이용하여 Forward Problem을 풀었다. Inverse Problem은 current dipole의 6개의 parameter에 대한 Least Square Error Method를 이용하여 신경흥분의 위치를 추정하였다. 이러한 결과와 생리학적으로 밝혀진 시각경로와의 비교결과 유사성이 확인되었다.

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Fire Retardancy of Recycled Polyurethane Foam Containing Phosphorus Compounds (인계화합물을 포함한 재활용 폴리우레탄폼의 난연성)

  • Chung, Yeong-Jin
    • Journal of the Korean Applied Science and Technology
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    • v.24 no.2
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    • pp.182-189
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    • 2007
  • Used polyurethane was chemically degraded by treatments with flame retardants such as tris(3-chloropropyl) phosphate (TCPP), triethyl phosphate (TEP), and trimethyl phosphate (TMP). The structure of degraded products (DEP) was analyzed by FT-IR and P-NMR and it turned out to be phosphorus containing oligourethanes. Rigid polyurethane foam was produced by using the degraded products (DEP) as flame retardants. The flammability of recycled rigid polyurethane was investigated. The recycled polyurethane shows a reduced flammability over virgin polyurethane. In order to evaluate flame retardant properties of the recycled polyurethane foams with various amounts of DEP, the combustion parameters of the foam was measured by a cone calorimeter. Scanning electron micrograph of recycled PU shows the same uniform cell morphology as virgin PU.

T-DMB multimedia service system development using IPv6 (IPv6를 이용한 T-DMB 멀티미디어 서비스 시스템 개발)

  • Jang, Jeong-Uk;In, Chi-Ho
    • 한국ITS학회:학술대회논문집
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    • v.2006 no.10
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    • pp.199-202
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    • 2006
  • 본 논문에서는 IPv6를 이용한 새로운 T-DMB 멀티미디어 서비스 시스템을 설계 및 구현하였다. 본 논문에서 제안한 방식은 IPv6의 듀얼스택 기술인 DSTM 방식을 T-DMB 패킷 전송 서비스에 접목시켰다. IPv6의 주소 체계 방식을 이용하여 기존의 T-DMB와의 호환성을 유지하면서 T-DMB 단말 내에 DSTM 패킷 전송을 위한 어플리케이션 데이터 테이블을 배치하여 T-DMB in IPv6 터널링을 통한 서비스를 실행할 수 있게 하였다. 또한, T-DMB Client 와 DSTM TEP를 단말에 배치하여 패킷 전송을 가능하게 하였다. T-DMB in IPv6 터널링 기술을 도입하여 T-DMB 방송 시스템의 성능 평가를 실시한 결과, 기존의 T-DMB 방송 서비스보다 약 2배 정도의 전송 용량 증가 및 채널 용량 증가가 효과를 바로 볼 수 있었고, 패킷 크기 따른 전송 효과는 기존의 방송 서비스보다 약 3%정도 증가된 결과 값을 얻을 수 있었다.

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System requirement verification process and facilitating template (시스템 요구사항 검증 절차 및 수행 템플릿)

  • Jang, Jae Deuck;Lee, Jae Chon
    • Journal of the Korean Society of Systems Engineering
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    • v.2 no.2
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    • pp.33-38
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    • 2006
  • It is well known that efficient management and thorough implementation of stakeholder requirements is vital for a successful development of a large-scale and complex system. Equally important is to make sure that all the requirements be correctly realized in the developed system. For the purpose, verification requirements are derived with traceability from the system requirements. This paper discusses a step by step process for constructing the requirements verification model which includes : 1) the schema modeling both requirements and their traceability; 2) the template documenting the verification requirements; 3) the verification model constructed from the schema; and 4) the test and evaluation plan that can be printed automatically.

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HPLC Detection of Free Malonaldehyde for Rapid Measurement of Lipid Oxidation Development

  • Key Whang;Kim, Chang-Min
    • Preventive Nutrition and Food Science
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    • v.5 no.1
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    • pp.7-9
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    • 2000
  • Variouss concentrationss of free malonaldehyde were prepared from 1,1,3,3-tetraethoxy propane (TEP). Spectrophoto-metric determination and HPLC analysis of free malonaldehyde instead of malonaldehyde-thiobaribituric acid (MA-TBA) complex were conducted. Malonaldehyde was well separated on a $\mu$Bondapak C18 column. The absorbances at 254 nm and the HPLC peak areas of free malonaldehyde increased with the increase in its concentration. The correlation coefficient between absorbances and peak areas was 0.998. The total time elapsed to conduct the whole procedure was less than 15 minutes. This method directly measured the amount of free malonaldehyde in a short period of time successfully. This procedure is expected to be used as a rapid, accurate and specific means to de-termine the development of lipid oxidation in food.

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