• Tuberculosis and Respiratory Diseases
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• v.40 no.6
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• pp.659-668
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• 1993

Background: p53 is currently considered as a tumor suppressive gene product, and its alterations are suggested to be involved in several human malignancies, including non-small cell lung cancers. p53 expression rates are variable in many reports and among cell types. Also, whether the phase of p53 expression is early or late during carcinogenesis is not certain. Thus, We have investigated to evaluate p53 expression rates of the various cell types and tissues and identify expression phase (early or late). Method: We obtained 71 tissue from 50 non-small cell lung cancer patients and performed the simple immunohistochemical staining using nonspecific monoclonal antibody(NCL-p53DO7). Results: 1) In non-small cell lung cancer patients. the expression rate of lungs(46.5%) is higher than that(25.0%) of lymph nodes. But, there is no significant difference between two groups. 2) Among the various cell types, p53 expression rates in squamous cell carcinoma and adenocarcinoma are 58.3% and 50.0% respectively without significant difference. 3) p53 expression rates in various stages are 33.3%, 60.0%, 40.0%, 60.0% and 66.7% in stage I, II, IIIa, IIIb and IV, respectively with no significant difference. 4) p53 expression rates in the various T parameters are 33.3%, 50.0%, 16.7% and 100% in T1, T2, T3 and T4, respectively and p53 expression rates in the various N parameters are 27.3%, 22.2% and 25.0% in N1, N2 and N3, respectively. There are no significant differences in the expression rates among varous T & N parameters. 5) p53 expression rates of lymph nodes in patients who have positive stains in lungs are 12.5% and 50.0% in N1 and N2. 6) p53 expression rates of all lymph nodes in patients who have negative stains in lungs are 0.0%. Conclusion: The above results show that p53 expression rate in non-small cell lung cancers is not correlated with cell type and progression of stage and it is thought to need further investigations about at what phase p53 expression influences the development and progression of lung cancers.

• Journal of Veterinary Clinics
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• v.31 no.4
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• pp.272-277
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• 2014

This retrospective study evaluated the effect of somatic cell count (SCC) in milk during early lactation on reproductive performance in dairy cows. Data were collected on 774 cows from six dairy farms, including cow parity, dates of previous calving, artificial insemination, pregnancy diagnosis, incidence of postpartum endometritis, reproductive performance (the intervals from calving to first insemination and conception), milk production and SCC. Data on 774 lactations were grouped based on the average first 3 months postpartum linear somatic cell score (SCS) as T1 (< 3.0, n = 521), T2 (3.0 ${\leq}$ and < 4.0, n = 113), and T3 (${\geq}$ 4.0, n = 140) groups. The odds ratio (OR) for the probability of endometritis increased 1.6 (p < 0.05) and 3.2 times (p < 0.0001) in the T2 and T3 groups, respectively, compared with that in the T1 group. The hazard of first insemination by 150 days in milk (DIM) was lower in the T3 group (hazard ratio [HR]: 0.76, p < 0.01) than in the T1 group. First insemination conception rate did not differ among the 3 groups (28.7-34.2%, p > 0.05). The hazard of pregnancy by 365 DIM in the T3 group was lower (HR: 0.75, p < 0.05 respectively) than in the T1 and T2 groups. The SCS during 4 to 7 months postpartum differed (p < 0.0001) among the 3 groups. Farm and cow parity were important risk factors for higher SCS (${\geq}$ 4.0). Multiparous cows were more likely to have a higher SCS (OR: 2.26, p = 0.0005) compared with primiparous cows. In conclusion, higher SCS (${\geq}$ 4.0) during early lactation was associated with decreased reproductive performance of dairy cows.

• Journal of the Korean GEO-environmental Society
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• v.15 no.4
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• pp.29-36
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• 2014

The purpose of this study investigates the delivery characteristics according to the load of pollutants by calculating the delivery rate of targeted areas on pollutants in Sapkyo reservoir. The main rivers of Sapkyo reservoir are Namwoncheon, Dogocheon, Sapkyocheon, Muhancheon and Gokgyocheon. The delivery rate and their characteristics of five major rivers during rainfall season are investigated. As th result, biochemical oxygen demand (BOD), total nitrogen (T-N) and total phosphorous (T-P) of total delivery rate are calculated by 0.40, 0.34 and 0.08, respectively. The delivery rate of T-P compares to other water quality is investigated relatively low. Looked at the overall characteristics of the watershed, the delivery rate of T-N and T-P is little change in the rate of the year, too. The delivery rate of T-N is calculated from 0.2 to 0.3 in the dry season, and from 0.31 to 0.39 in a flood, respectively. The delivery rate of T-P is calculated to more than 0.3 in the dry season, and 0.11 in a flood. It is similar values which the average annual delivery rate of T-P is 0.08. Therefore, the measured delivery rate of Sapkyo reservoir can be applicable such as a delivery rate of similar features of the terrain and land use.

• Journal of The Korean Society of Agricultural Engineers
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• v.53 no.5
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• pp.35-42
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• 2011

This study is to check the applicability of SWAT-APEX (Soil and Water Assessment Tool-Agricultural Policy / Environmental eXtender) model as combined watershed and field models by applying the APEX to paddies in a watershed (465.1 $km^2$) including Yedang reservoir. Firstly, the SWAT were calibrated with 3 years (2000~2002) daily streamflow and monthly water quality (T-N and T-P) data, and validated for another 3 years (2003~2005) data. The average Nash-Sutcliffe model efficiency (ME) of streamflow during validation was 0.73, and the coefficient of determination ($R^2$) of T-N and T-P were 0.77 and 0.73 respectively. Next, running the SWAT-APEX model with the SWAT calibrated parameters for paddies, the $R^2$ of T-N and T-P were 0.80 and 0.76 respectively. The results showed that SWAT-APEX model was more correctly predicted for T-N and T-P loads than SWAT model. The difference results between watershed and field models was predicted to have substantial impact on NPS loads, especially on T-N and T-P loads. Therefore, to improve negative NPS load simulations should be considered the model characteristics as simulating mechanism to properly select the NPS model for agricultural watershed.

• Korean Journal of Soil Science and Fertilizer
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• v.44 no.3
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• pp.400-407
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• 2011

To evaluate the aquatic ecological characteristics in Sinpyongcheon constructed wetlands for treating nonpoint source pollution, the removal rates of nutrients in water, the total amounts of T-N and T-P uptakes by water plants, and chemical characteristics of T-N and T-P in sediment were investigated. The concentrations of BOD, COD, SS, T-N and T-P in inflow were 0.07~1.47, 0.60~2.65, 0.50~4.60, 1.38~6.26 and $0.08{\sim}0.32mg\;L^{-1}$, respectively. The removal rates of BOD, COD, SS, T-N, and T-P were 14%, 6%, 18%, 24%, and 10%, respectively. The maximum amount of T-N uptake by water plants in August was $813mg\;plant^{-1}$ for Phragmites communis TRIV in $2^{nd}$ bed, $1,172mg\;plant^{-1}$ for Typha orientalis PRESL in $3^{rd}$ bed, respectively. The maximum amount of T-P uptake by water plants in August was $247mg\;plant^{-1}$ for Phragmites communis TRIV in $2^{nd}$ bed, $359mg\;plant^{-1}$ for Typha orientalis PRESL in $3^{rd}$ bed, respectively. Organic matter, T-N, and T-P contents in sediments were high in the order of $1^{st}$ bed > $2^{nd}$ bed > $3^{rd}$ bed. Microbial biomass C/N/P ratios in sediments in $1^{st}$, $2^{nd}$, and $3^{rd}$ were 78~110/3~6/1, 73~204/1~6/1, and 106~169/1~6/1, respectively.

• Korean Journal of Agricultural Science
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• v.41 no.3
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• pp.213-220
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• 2014

This study was conducted to evaluate the effects of high n-3 or n-6 diet on free fatty acid profile and meat quality traits of pork loin. The 20 heads of commercial $Landrace{\times}Yorkshire{\times}Duroc(LYD)$ crossbreed pigs ($90.9{\pm}2.4BWkg$) were divided into four groups by added fat and oils, such as 5% tallow (Control), 5% linseed oil (T1), 5% safflower oil (T2), and mixture of linseed oil (2.5%) + safflower oil (2.5%) (T3), then reared 4 weeks. Pork loins were taken after slaughter, then sliced in 2 cm thickness and put in low-density polyethylene (LDPE) bag for analysis. T1 showed significantly high concentration of linolenic acid ($2.35{\pm}0.21%$) (p<0.05). The total amount of saturated fatty acids (SFA), mono-unsaturated fatty acids (MUFA) and poly-unsaturated fatty acid (PUFA) was significantly high in T1 ($36.05{\pm}1.18%$), C ($22.60{\pm}2.11%$) and T2 ($47.80{\pm}1.29%$), respectively (p<0.05). However, the ratio of n-6:n-3 was significantly low in T1 ($11.57{\pm}0.90$) than that of T2 ($37.56{\pm}12.51$) (p<0.05). There was no signigicant difference in lightness, redness, pH, water holding capacity and cooking loss between treatments (p>0.05). However, the yellowness of T2 was significantly higher than others (p<0.05). From those results, it was considered that feeding high n-3 and n-6 fatty acid diet to pig enables modify fatty acid profile of pork without any side effect on meat quality.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.14 no.1_2
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• pp.97-104
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• 1992

This is a report of three cancer patients treated with the different methods of neck dissection considering the state of the each patient. 1. A 76-year old femals patient who showed $T2_N0_M0$ squamous cell carcinoma received the regional neck dissection with resection of primary lesion. The postoperative result was uneventful without recurrence for 3.6 years. 2. A 52-year old male patient who was diagosed $_T3_N1_M0$ squamous cell carcinoma was treated with the bilateral neck dissection and radical resection of primary lesion. Metastasis was noticed on the right scapular area 8 months postoperatively. We treated him with radiation and chemotherapy, but he died 13 months postoperatively. 3. A 55-year old male patient who showed $_T2_N1_M0$ squamous cell cvarcinoma was treated with the classical neck dissection and the radical resection of primary lesion. The postoperative result was good with no recurrence for 4 years.

• Journal of Gastric Cancer
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• v.20 no.1
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• pp.41-49
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• 2020

Purpose: Patients with pathological stage T1N+ or T2-3N0 gastric cancer may experience disease recurrence following curative gastrectomy. However, the current Japanese Gastric Cancer Treatment Guidelines do not recommend postoperative adjuvant chemotherapy for such patients. This study aimed to identify the prognostic factors for patients with pT1N+ or pT2-3N0 gastric cancer using a multi-institutional dataset. Materials and Methods: We retrospectively analyzed the data obtained from 401 patients with pT1N+ or pT2-3N0 gastric cancer who underwent curative gastrectomy at 9 institutions between 2010 and 2014. Results: Of the 401 patients assessed, 24 (6.0%) experienced postoperative disease recurrence. Multivariate analysis revealed that age ≥70 years (hazard ratio [HR], 2.62; 95% confidence interval [CI], 1.09-7.23; P=0.030) and lymphatic and/or venous invasion (lymphovascular invasion (LVI): HR, 7.88; 95% CI, 1.66-140.9; P=0.005) were independent prognostic factors for poor recurrence-free survival. There was no significant association between LVI and the site of initial recurrence. Conclusions: LVI is an indicator of poor prognosis in patients with pT1N+ or pT2-3N0 gastric cancer.

• Proceedings of the Korea Water Resources Association Conference
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• 2016.05a
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• pp.510-510
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• 2016

농업 비점오염원의 영향을 분석하고 여러 가지 대안(관리정책)이 수계의 수질에 미치는 영향을 평가하기 위해서 유역모형의 적용이 필요하다. 이러한 유역모형에는 모형의 복합성, 계산시간 등에 따라 simple method, mid-range model, detail model로 나눌 수 있다. Simple methods는 요구되는 자료가 작으나 그 결과의 정확성은 떨어진다. 반면에 detail model는 정확한 결과를 획득할 수 있으나 그만큼 방대한 자료와 모니터링을 요구하며, 보정 및 검증에 많은 시간과 노력을 필요로 한다. 특히, 복잡한 유역특성 및 축산오염원을 포함한 복잡한 특성들을 고려해서 모델링하기 위해서는 detail model이 필요하며 본 연구에서는 HSPF모델을 이용해서 그 영향을 분석하고자 하였다. 따라서 본 연구에서는 농업에 미치는 영향을 평가하기 위해서 청미천 유역 및 덕천천 유역을 대상유역으로 선정하여 그 영향을 분석하였다. 농업에 미치는 영향을 평가하기 위해서 유역내 투입된 비료사용량을 통계청 자료를 활용하여 산정후 적용하였으며, 축산 부산물중 자원화되는 축산 액비 및 퇴비량을 산정하여 그 영향에 대해 분석하였다. 또한 기존에 광범위하게 활용되고 있는 수질오염총량관리제도에서 산정되는 배출부하량에 유달율을 고려하여 점오염으로 입력하였으며, 직접방류되는 하수처리장도 함게 고려하여 구축하였다. 청미천 유역의 청미천1 지점의 BOD, T-N, T-P에 대한 보정기간의 평균 관측값은 4.205mg/L, 3.844mg/L, 0.137mg/L이며 검정기간의 관측값은 2.741mg/L, 4.638mg/L, 0.144mg/L로 나타났다. BOD, T-N, T-P에 대한 보정기간의 NSE는 -0.58, -0.20, -0.33이며, 검정기간의 NSE는 -0.26, -1.35, -3.54로 분석되었다. BOD, T-N, T-P에 대한 보정기간의 RMSE는 2.65, 1.63, 0.12이며, 검정기간의 RMSE는 1.36, 1.64, 0.07로 나타났다. 덕천천 유역의 경우 국가관측망이 없어 동진강의 제일 말단 지점인 동진강3 지점의 BOD, T-N, T-P에 대한 보정기간 평균관측값은 2.891mg/L, 3.455mg/L, 0.096mg/L이며, 검정기간의 관측값은 2.293mg/L, 3.223mg/L, 0.104mg/L로 나타났다. BOD, T-N, T-P에 대한 보정기간의 NSE는 -0.20, -0.56, -0.49이며, 검정기간의 NSE는 0.24, -0.06, -0.19으로 분석되었다. BOD, T-N, T-P에 대한 보정기간의 RMSE는 1.53, 2.12, 0.05이며, 검정기간의 RMSE는 1.05, 0.98, 0.06으로 나타났다. 본 연구의 분석결과는 점오염원, 축산계비점오염, 토지계비점오염, 시비량, 배경부하로 구분하여 분석을 실시하였으며 분석결과 청미천 유역의 비점오염 기여율이 약 65%를 차지하고 있는 것으로 평가되었으며, 덕천천 말단에서는 약 37.7%의 비점오염물질이 하천수질에 영향을 미치는 것으로 나타났다. 또한, 기존 수질오염 총량관리제도에서 점오염의 감소에 의한 비점오염비중이 커지는 것으로 평가되었으며, 그 중 축산이 차지하는 비중이 상대적으로 높은 것으로 평가되고 있지만, 본 연구의 결과에서는 그보다 적은 수준이 수계에 영향을 미치는 것으로 분석되었다.

• Korean Journal of Bronchoesophagology
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• v.8 no.1
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• pp.81-86
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• 2002

Background and objectives : There may be frequent lymphatic neck metastasis among supraglottic cancer patients after their primary surgery. The aim of this study was to evaluate the effectiveness of prophylactic neck dissections in supraglottic cancer patients to lower the neck metastasis. Material and method : The authors retrospectively reviewed medical records of 52 patients (7 females. 45 males) who had received the operations for the supraglottic cancer from 1995 to 2000. They were preoperatively examined with Computer Tomographic images, and also examined by the cervical neck palpations. Postoperative pathologic specimens were reviewed and the Pathologic stagings were confirmed by the pathologist. Results : Among 52 patients who received surgery for supraglottic carcinoma, 5 patients received ipsilateral neck dissection, 12 patients received ipsilateral neck dissection with postoperative radiation therapy, 10 Patients received bilateral neck dissection and 25 patients received bilateral neck dissection with postoperative radiation treatment. In comparison of the data of N0 to N+ conversion rate of neck, there were 11 ipsilateral T3 N0 patients and 2 patients(18%) were converted to N+ status, and there were 8 Patients with T4 N0 stages, and 3 patients(38%) were converted to N+ status. In comparing the data of contralateral neck dissection on N0 patient, there were 8 patients of T3 N0 patients, and there was 1 patient (13%) who showed recurrence. There were 5 patients of T4 N0 stages and there was 1(20%) patient with recurrences. When the ipsilateral N stages were N2a, and N2b, there 1 case of contraleral N+ conversions, respectively. In recurrences, there were 2 patients of N2b staged patients and 1 patient of N2c patient that showed recurrence during the follow up period. Conclusion : This data shows that at least an ipsilateral neck dissection is necessary in order to prevent the recurrences, and also suggests that bilateral neck dissection is necessary for the higher T stage. Since the higher N staged patients showed higher rate of recurrence, so that neck dissection is mandatory for the higher N staged patients.