• 제목/요약/키워드: T.K.E.

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부산지역 유흥업소 종사여성으로부터 분리된 HPV16형의 발암유전자(E6/E7) 돌연변이 유형 분석 (Intratypic Variants of HPV-16 E6jE7 Oncogene Isolated from Sexually High-Risk Women in Busan.)

  • 민상기;김성순;최병선;장대호;이미옥;최성화;김남호;박연경;정영아;김성준;빈재훈;박호국
    • 생명과학회지
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    • 제19권6호
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    • pp.765-769
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    • 2009
  • HPV-16형의 염기배열 변이는 지역적, 인종적으로 특징적인 차이가 있으며 특히 HPV-16형 E6/E7 유전자의 특정 염기 서열변이는 자궁경부암 및 자궁상피내 신생종양물의 발생을 일으키는 고위험 요인으로 알려져 있다. 본 연구는 2007년 부산지역 유흥업소 종사여성으로 분리된 HPV-16형 19건을 대상으로 E6/E7 유전자 영역(nt 34-880)을 표적으로 지역적 염기 서열 변이를 조사하였다. nucleotide 수준에서 HPV16형 E6 유전자는 T178G (n=11), T178A (n=1), T350G (n=4), A442C (n=2), A104T, A111G, C116T, G145T, T183G, C335T, G522C 등 11종의 변이주가 발견되었고, E7 유전자는 A647G (n=12), A645C, A777C, G663A, T732C, T760C, A775T, T789C, T795G 등 9종의 변이주가 발견되었다. 아미노산 수준에서는 HPV-16형 E6 단백질의 경우 D25E (n=12), L83V (n=4), E113D (n=2), MIL, Q3R, P5S, Q14H, D25N, 127R, H78Y, C140S 등 11종의 변이주를, HPV16형 E7 단백질의 경우 N29S (n=12), L28F, T72S 등 3종의 변이주를 관찰할 수 있었다. 본 연구 결과, 부산지역의 HPV-16형 E6/E7 우점 돌연변이주는 E6 D25E (75%), E7 N29S (78%)로 각각 나타났다. 앞으로 자궁경부암 환자 및 일반여성을 포함한 더 많은 모집 단을 대상으로 HPV-16형 E6/E7의 intratypic variants를 비교 조사하여 실제 HPV-16형 E6/E7 어떤 변이주가 자궁경부암 유발 위험성과의 관련성은 더 많이 연구되어져야 할 것으로 사료된다.

Growth curve estimates for wither height, hip height, and body length of Hanwoo steers (Bos taurus coreanae)

  • Park, Hu-Rak;Eum, Seung-Hoon;Roh, Seung-Hee;Sun, Du-Won;Seo, Jakyeom;Cho, Seong-Keun;Lee, Jung-Gyu;Kim, Byeong-Woo
    • 농업과학연구
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    • 제44권3호
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    • pp.384-391
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    • 2017
  • Growth curves in Hanwoo steers were estimated by Gompertz, Von Bertalanffy, Logistic, and Brody nonlinear models using growth data collected by the Hanwoo Improvement Center from a total of 6,973 Hanwoo (Bos taurus coreanae) steers 6 to 24 months old that were born between 1996 and 2015. The data included three parameters: A, mature size of body measurement; b, growth ratio; and, k, intrinsic growth rate. Nonlinear regression equations for wither height according to Gompertz, Von Bertalanffy, Logistic, and Brody models were $Y_t=144.7e^{-0.5869e^{-0.00301t}}$, $Y_t=145.3(1-0.1816e^{-0.00284t})^3$, $Y_t=143.1(1+0.7356e^{-0.00352t})^{-1}$, and $Y_t=146.8(1+0.4700e^{-0.00249t})^1$, respectively, while those for hip height were $Y_t=144.5e^{-0.5549e^{-0.00312t}}$, $Y_t=145.0(1-0.1724e^{-0.00295t})^3$, $Y_t=143.1(1+0.6863e^{-0.00360t})^{-1}$, and $Y_t=146.2(1+0.4501e^{-0.00263t})^1$, respectively. Equations for body length $Y_t=174.1e^{-0.8342e^{-0.00289t}}$, $Y_t=175.8(1-0.2500e^{-0.00265t})^3$, $Y_t=170.0(1+1.1548e^{-0.00363t})^{-1}$, and $Y_t=180.3(1+0.6077e^{-0.00215t})^1$, respectively, for the same models. Among the four models, the Brody model resulted in the lowest mean square error, with mean square errors of 31.79, 30.57, and 42.13, respectively, for wither height, hip height, and body length. Also, an estimated birth wither height, birth hip height, and birth body length (77.98, 80.57, and 70.97 cm, respectively) were lower in the Brody model than in other models. An inflection point was not observed during the growth phase of Hanwoo steer according to the growth curves calculated using Gompertz, Von Bertalanffy, and Logistic models. Based on the results, we concluded that the regression equation using the Brody model was the most appropriate among the four growth models. To obtain more accurate parameters, however, using data from a wider production period (from birth to shipping) would be required, and the development of a suitable model for body conformation traits would be needed.

CONDITIONAL FORUIER-FEYNMAN TRANSFORM AND CONVOLUTION PRODUCT FOR A VECTOR VALUED CONDITIONING FUNCTION

  • Kim, Bong Jin
    • Korean Journal of Mathematics
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    • 제30권2호
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    • pp.239-247
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    • 2022
  • Let C0[0, T] denote the Wiener space, the space of continuous functions x(t) on [0, T] such that x(0) = 0. Define a random vector $Z_{\vec{e},k}:C_0[0,\;T] {\rightarrow}{\mathbb{R}}^k$ by $$Z_{\vec{e},k}(x)=({\normalsize\displaystyle\smashmargin{2}{\int\nolimits_0}^T}\;e_1(t)dx(t),\;{\ldots},\;{\normalsize\displaystyle\smashmargin{2}{\int\nolimits_0}^T}\;ek(t)dx(t))$$ where ej ∈ L2[0, T] with ej ≠ 0 a.e., j = 1, …, k. In this paper we study the conditional Fourier-Feynman transform and a conditional convolution product for a cylinder type functionals defined on C0[0, T] with a general vector valued conditioning functions $Z_{\vec{e},k}$ above which need not depend upon the values of x at only finitely many points in (0, T] rather than a conditioning function X(x) = (x(t1), …, x(tn)) where 0 < t1 < … < tn = T. In particular we show that the conditional Fourier-Feynman transform of the conditional convolution product is the product of conditional Fourier-Feynman transforms.

기어 소음 품질 안정화를 위한 전달오차 측정 시스템 개발 및 전달오차 스펙 개발에 대한 연구 (A Research for the Development of the Transmission Error Measuring System and Transmission Error Specification for the Gear Noise Quality)

  • 이상화;이현구;강석찬;김시웅;유동규;원광민;채금묵;이태휘
    • 한국소음진동공학회논문집
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    • 제24권6호
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    • pp.470-475
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    • 2014
  • In the past, transmission error(T.E.) has been identified as one of the main sources of gear whine noise, which cause serious passengers irritation at high frequency. In this study, to identify the correlation of the T.E. and gear whine noise, a T.E. measuring system was developed. By comparing the T.E. and gear whine noise level, T.E. target value which can represent the gear noise was proposed. The conclusions are followed: (I) It is possible to measure T.E. of the gear pairs (II) Similar trends are observed between T.E. and gear whine noise. (III) By observing the T.E. pattern, presence of sideband noise can be predicted. (IV) Proposed T.E. target value can be adopted to the gear manufacturing for gear noise quality management.

OSCILLATION AND NONOSCILLATION THEOREMS FOR NONLINEAR DIFFERENTIAL EQUATIONS OF SECOND ORDER

  • Kim, Rak-Joong;Kim, Dong-Il
    • 대한수학회지
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    • 제44권6호
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    • pp.1453-1467
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    • 2007
  • By means of a Riccati transform some oscillation or nonoscillation criteria are established for nonlinear differential equations of second order $$(E_1)\;[p(t)|x#(t)|^{\alpha}sgn\;x#(t)]#+q(t)|x(\tau(t)|^{\alpha}sgn\;x(\tau(t))=0$$. $$(E_2),\;(E_3)\;and\;(E_4)\;where\;0<{\alpha}$$ and $${\tau}(t){\leq}t,\;{\tau}#(t)>0,\;{\tau}(t){\rightarrow}{\infty}\;as\;t{\rightarrow}{\infty}$$. In this paper we improve some previous results.

한국근해 병어류의 자원생물학적 연구 3. 동지나해산 덕대의 연령과 성장 (Studies on the Fishery Biology of Pomfrets, Pampus spp. in the Korean Waters 3. Age and Growth of Korean Pomfret, Pampsu echinogaster, from the East China Sea)

  • 강용주;이동우;홍병규;김영섭
    • 한국수산과학회지
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    • 제22권5호
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    • pp.281-290
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    • 1989
  • 1987년 $1\~2$월에 걸쳐 동지나해에서 대형기저쌍끌이어업에 의해 어획된 덕대를 대상으로 연령, 성장에 관하여 조사하였다. 연령사정은 추체로 하였으며, 추체경에 대한 연역지수에 의한 윤문의 형성은 $9\~10$월에 걸쳐 연1회 형성되었다. 추체경(R)에 대한 체장(FL)과의 관계는 암컷 : $FL=8.8262R^{0.7709}$ 수컷 ; $FL=8.9676R^{0.7976}$ 전체 ; $FL=8.7883R^{0.7681}$과 같다. 체장(FL)에 대한 체중(BW)과의 관계는 암컷 : $BW=0.0093FL^{3.3795}$ 수컷 ; $BW=0.0081FL^{3.4153}$ 전체 : $BW=0.0084FL^{3.4125}$와 같다. 연령(t)에 대한 체장($L_t$)의 버틀란피 성장식은 암컷 : $$L_t=29.17(1-e xp(-0.3213(t+0.7601)))$$ 수컷 ; $$L_t= 28.21(1-e xp(-0.3L69(t+0.8284)))$$ 전체 : $$L_t=29.00(1-e xp(-0.3228(t+0.7361)))$$와 같다. 연령(t)에 대한 체중($W_t$)의 버틀란피 성장식은 암컷; $$W_t=829.4(1-e xp(-0.3213(t+0.7601)))^{3.3795}$$ 수컷; $$W_t=747.6(1-e xp(-0.3169(t+0.8284)))^{3.4154}$$ 전체 : $$W_t=816.8(1-e xp(-0.3228(t+ 0.7361)))^{3.4125}$$와 같다. 월별 연령별 평균체장($L_t$)에 대한 주기변동 버틀란피 성장식은 암컷 : $$L_t=29.2(1-e xp(-0.3458(t+0.8182)+(0.3458/2\pi) sin2\pi(t+0.027)))$$ 수컷 : $$L_t=28.2(1-e xp(-0.2789(t+1.5193)+(0.2789/2\pi) sin2\pi(t-0.1062)))$$와 같다.

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AN ACTION OF A GALOIS GROUP ON A TENSOR PRODUCT

  • Hwang, Yoon-Sung
    • 대한수학회논문집
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    • 제20권4호
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    • pp.645-648
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    • 2005
  • Let K be a Galois extension of a field F with G = Gal(K/F). Let L be an extension of F such that $K\;{\otimes}_F\;L\;=\; N_1\;{\oplus}N_2\;{\oplus}{\cdots}{\oplus}N_k$ with corresponding primitive idempotents $e_1,\;e_2,{\cdots},e_k$, where Ni's are fields. Then G acts on $\{e_1,\;e_2,{\cdots},e_k\}$ transitively and $Gal(N_1/K)\;{\cong}\;\{\sigma\;{\in}\;G\;/\;{\sigma}(e_1)\;=\;e_1\}$. And, let R be a commutative F-algebra, and let P be a prime ideal of R. Let T = $K\;{\otimes}_F\;R$, and suppose there are only finitely many prime ideals $Q_1,\;Q_2,{\cdots},Q_k$ of T with $Q_i\;{\cap}\;R\;=\;P$. Then G acts transitively on $\{Q_1,\;Q_2,{\cdots},Q_k\},\;and\;Gal(qf(T/Q_1)/qf(R/P))\;{\cong}\;\{\sigma{\in}\;G/\;{\sigma}-(Q_1)\;=\;Q_1\}$ where qf($T/Q_1$) is the quotient field of $T/Q_1$.

Signal transduction of C-terminal phosphorylation sites for equine follicle stimulating hormone receptor (eFSHR)

  • Seong, Hoon-Ki;Choi, Seung-Hee;Byambaragchaa, Munkhzaya;Min, Kwan-Sik
    • 한국동물생명공학회지
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    • 제35권2호
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    • pp.155-162
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    • 2020
  • Equine follicle stimulating hormone receptor (eFSHR) has a large extracellular domain and an intracellular domain containing approximately 10 phosphorylation sites within the G protein-coupled receptor. This study was conducted to analyze the function of phosphorylation sties at the eFSHR C-terminal region. We constructed a mutant of eFSHR, in which the C-terminal cytoplasmic tail was truncated at residue 641 (eFSHR-t641). This removed 10 potential phosphorylation sites from the C-terminal region of the intracellular loop. The eFSHR-wild type (eFSHR-wt) and eFSHR-t641 cDNAs were subcloned into the pCMV-ARMS1-PK2 expression vector. These plasmids were transfected into PathHunter CHO-K1 Parental cells expressing β-arrestin 2 enzyme acceptor fusion protein and analyzed for agonist-induced cAMP response. The cAMP response in cells expressing eFSHR-t641 was lower than the response in cells expressing eFSHR-wt. EC50 values of eFSHR-wt and eFSHR-t641 were 1079 ng/mL and 1834 ng/mL, respectively. eFSHR-t641 was approximately 0.58-fold compared with that of eFSHR-wt. The maximal response in eFSHR-wt and eFSHR-t641 was 24.7 nM and 16.7 nM, respectively. The Rmax value of phosphorylation sites in eFSHR-t641 was also decreased to approximately 68.4% of that in eFSHR-wt. The collective data implicate that the phosphorylation sites in the eFSHR C-terminal region have a pivotal role in signal transduction in PathHunter CHO-K1 cells, and indicate that β-arrestin is involved in coupling the activated receptors to the internalization system.

중소병원의 교육훈련 프로그램 특성 및 조직상황적 특성이 직무전이에 미치는 영향에 관한 연구 (A Study on the influence of job transfer in E&T programs characteristics & organizational situational characteristics of the medium and small-sized hospitals)

  • 김용혁
    • 한국병원경영학회지
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    • 제16권4호
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    • pp.131-160
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    • 2011
  • The purpose of this study was 1) to understand the job transfer in education & training(E&T) programs & organizational situational characteristics, and 2) to analyze the effects of the E&T programs & organizational situational characteristic groups on each of the levels of job transfer. There is intimate relationship between E&T programs characteristics & organizational situational characteristics and job transfer, so we can't think of them separately. With this point of view the most frequently discussed problem is how to apply the theory in actual job, but in reality it's true that the improvement of job transfer can't reach the expectations of the E&T programs. In literature view study, the concepts of job transfer in E&T, the general theory on E&T, and the actual condition and points at issue of the existing E&T practices in the medium and small-sized hospitals were defined. As the results from empirical analysis, we could find followings: First, in evaluation of the job transfer, demographic characteristics (seniority, occupational category, position) variables have a significant different. Second, in degree of the job transfer, E&T programs characteristics(contents of E&T, design of E&T, conditions of E&T, teaching ability of lecturer, methods of E&T) variables have a different influence upon each of the evaluation levels of E&T. Third, support of CEO variables have a different influence on the job transfer according to contents, design, conditions of the E&T programs. Fourth, support of co-works variables have a different influence on the job transfer according to design, conditions, method of the E&T programs. Fifty, support of organizational atmosphere variables have a different influence on the job transfer according to contents, design, conditions of the E&T programs.

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